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Methyl 5-hydroxyhaematommate (XIX) and methyl 5-hydroxy-β-orcinolcarboxylate (XII) are conveniently made by the application of paranuclear oxidation using methyl haematommate and methy β-orcinol carboxylate respectively. These undergo preferential acylation of the hydroxyl in the meta (5) position and by employing this property, syntheses of dimethyl thamnolate (XVIII) and dimethyl hypothamnolate (VII) have been accomplished. 相似文献
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[reaction: see text] Dimethyl sulfomycinamate, the oxazole-thiazole-pyridine product generated in the methanolysis of the thiopeptide antibiotic sulfomycin I, is prepared in 13 steps and 8% overall yield by the Bohlmann-Rahtz heteroannulation of 1-(oxazol-4-yl)enamines and methyl 4-(trimethylsilyl)-2-oxobut-3-ynoate. 相似文献
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P. Sreejith Shankar Serena Bigotti Paolo Lazzari Ilaria Manca Marco Spiga Monica Sani Matteo Zanda 《Tetrahedron letters》2013
Tubulysins are potent anti-mitotic natural compounds and a scalable and efficient synthetic route for generation of its analogues has been developed and extended to the synthesis of diastereoisomers and N-terminal analogues of tubulysin-U. Structure–activity-relationship studies on these synthetic analogues reaffirmed the significance of native stereochemistry of tubulysins for optimal biological activity and cytotoxicity. However, while modification of Tup stereochemistry has only minor effect on the tubulysins cytotoxicity, Tuv stereochemistry is critically important and modification of either Tuv stereocentre produced a dramatic drop in cytotoxicity. 相似文献
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Harald Grger Davoud Tehranfar Jürgen Martens Jens R. Goerlich Holger Thnnessen Peter G. Jones Reinhard Schmutzler 《Heteroatom Chemistry》1997,8(3):207-215
The addition of dimethylphosphine oxide and its trimethylsiloxyphosphorus(III) derivative, generated in situ, to 3-thiazolines was found to yield dimethyl 4-thiazolidinylphosphine oxides via three different synthetic routes. The structures of two products were confirmed by X-ray analysis; common features include approximate envelope conformations of the five-membered rings and hydrogen bonding of the form N–H· · ·O=P. © 1997 John Wiley & Sons, Inc. Heteroatom Chem 8 : 207–215, 1997. 相似文献
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A series of vulpinic acids differing by the aryl or heteroaryl groups placed in the ester α-position were prepared by Suzuki-Miyaura cross-coupling involving a common iodide and the corresponding aryl boronates. The preparation of the iodide precursor from (+)-dimethyl l-tartrate required four steps: the esterification of one hydroxyl group, a Dieckmann cyclization allowing the construction of the tetronic acid moiety, a dehydration leading to the installation of the exocyclic double bond and lastly, an N-iodosuccinimide-mediated iodation of the alkene obtained. 相似文献
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A facile route for the synthesis of dimethyl adipate (DAP) from cyclopentanone and dimethyl carbonate (DMC) in the presence of solid base catalysts has been developed.It was found that the intermediate carbomethoxycyclopentanone (CMCP) was produced from cyclopentanone with DMC in the first step,and then CMCP was further converted to DAP by reacting with a methoxide group.The role of the basic catalysts can be mainly ascribed to the activation of cyclopentanone via the abstraction of a proton in the α-position by base sites,and solid bases with moderate strength,such as MgO,favor the formation of DAP. 相似文献
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I. M. Bukrina V. P. Krasnov V. Kh. Kravtsov V. N. Biyushkin L. V. Alekseeva 《Russian Chemical Bulletin》1989,38(9):1910-1914
Fractional crystallization and column chromatography have been used to obtain the enantiomers and diastereoisomeric racemates of diemthy N-phthaloyl-4-bromoglutamate. The steric configurations of these compounds were established by PMR and x-ray diffraction analysis.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2077–2081, September, 1989. 相似文献
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N. I. Svintsitskaya O. A. Aimakov A. V. Dogadina B. I. Ionin 《Russian Journal of General Chemistry》2009,79(7):1461-1466
A new phosphorylated ynamine, dimethyl anabasylethynephosphonate, was synthesized by reaction of dimethyl chloroacetylenephosphonate
with anabasine. Anabasylethynephosphonate obtained was shown to react under mild conditions with primary aromatic amines like
p-chloroaniline, p-anisidine, and p-aminoacetophenone, whose pK
b values are in the range of 9–13, to form new asymmetrical phosphorylated acetamidines in high yields. Structure of the compounds
obtained was proved by 1H, 13C, and 31P NMR spectroscopy. 相似文献
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Dimethyl acetylenedicarboxylate (DMAD) is a very important and useful reagent for the preparation of dimethyl heterocyclic‐o‐dicarboxylates, which are key intermediates in the synthesis of fused pyridazine derivatives. The synthesis of thiopyranes by the Diels‐Alder reaction of dithiocarboxylate derivatives, synthesis of various cyclazines by [2 + 8] cycloaddition reactions, and synthesis of dimethyl pyrazolo[3,4‐b]pyridine‐5,6‐dicarboxylates and polycyclic heterocycles containing the 1,6‐naphthyridine ring system by the reaction of o‐aminonitrile compounds with DMAD are described here. 相似文献
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N. V. Kolesnichenko L. E. Kitaev Z. M. Bukina N. A. Markova V. V. Yushchenko O. V. Yashina G. I. Lin A. Ya. Rozovskii 《Kinetics and Catalysis》2007,48(6):789-793
Zeolite H-TsVM has been loaded with palladium by different methods. The properties of the resulting catalysts in gasoline synthesis from syngas via dimethyl ether depend on the way in which palladium was introduced. The catalysts have been characterized by ammonia temperature-programmed desorption (TPD), temperature-programmed reaction with hydrogen, and X-ray photoelectron spectroscopy. According to ammonia TPD data, use of a palladium ammine complex instead of palladium chloride reduces the concentration of strong acid sites and raises the concentration of medium-strength acid sites, thereby reducing the yield of C1–C4 hydrocarbons and increasing the yield of gasoline hydrocarbons. At T = 340°C, P = 100 atm, and GHSV = 2000 h?1, the dimethyl ether conversion is 98–99%, the gasoline selectivity is >60%, the isoparaffin content of the product is ~61%, and the arene content is not higher than 29%. 相似文献
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聚甲氧基二甲醚的合成及其物理化学性质表征 总被引:1,自引:0,他引:1
聚甲氧基二甲醚的合成及其物理化学性质表征 《燃料化学学报》2017,45(7):837-845
聚甲氧基二甲醚(H3CO(CH2O)nCH3, PODEn或DMMn, n ≥ 2)具有独特的物理化学性质;作为一种柴油添加剂,可以有效提高油品燃烧效率并达到节能减排的目的。首先合成了一系列聚合度n为2、3、4和5单一组分的聚甲氧基二甲醚,采用NMR、FT-IR、Raman和DFT计算等手段对每个聚甲氧基二甲醚单体的化学结构进行表征,并对其在298.15-323.15K温度的密度和黏度进行了测试。结果表明,聚甲氧基二甲醚的密度和黏度随着温度的升高而逐渐降低,随着聚合度的增加而逐渐升高。同时,聚甲氧基二甲醚PODEn(n =2-5)的闪点和倾点以及溶解热和凝固热均随着聚合度的增加而提高。 相似文献
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The syntheses of dimethyl 2,2'-bithiophene-4,4'-dicarboxylate (3), dimethyl 2,2'-bithiophene-3,4'-dicarboxylate (4), and dimethyl 2,2'-bithiophene-3,3'-dicarboxylate (5) are described. Single-crystal X-ray structural analysis of these compounds shows that the thiophene rings in 3 and 4 are nearly coplanar (dihedral angle close to 0 degrees ) and they adopt the anti sulfur conformation in the solid state. Further, the structure of 4 is in agreement with our previous suggestion that there is an electrostatic stabilization of the planar structure due to attraction of the 3-carbonyl oxygen to the sulfur of the distal ring. In 5, however, the thiophene rings are nearly perpendicular (dihedral angle 75 degrees ), indicating considerable steric hindrance between the two large ester groups at the 3- and 3'-positions. Unlike compounds 3 and 4, where the thiophene rings have the sulfur atoms anti, the sulfur atoms in 5 are completely syn. This is the first instance where a bithiophene has been shown to adopt a conformation where the sulfur atoms are completely syn. The solid-state conformations of 3, 4, and 5 are in agreement with ab initio theoretical calculations on these compounds; particularly, the planar conformations of 3 and 4 reflect the previously calculated low rotation barriers of these molecules. 相似文献
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分子筛催化剂催化合成聚甲氧基二甲醚 总被引:8,自引:0,他引:8
以甲醇、甲缩醛和三聚甲醛为原料,考察了分子筛孔道结构、晶粒粒径、酸性及反应体系对合成聚甲氧基二甲醚反应性能的影响,并筛选出最佳反应条件。结果表明,HMCM-22分子筛具有良好的催化性能。在最佳反应条件下,以甲醇与三聚甲醛为原料,DMM2~8的选择性为65.1%;而以甲缩醛和三聚甲醛为原料,DMM2~8的选择性则达到90.6%。NH3-TPD结果表明,弱酸位有利于三聚甲醛解聚为甲醛,中强酸位促进长链分子生成,而强酸位导致DMM为主要产物。 相似文献
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A. V. Mashkina V. N. Yakovleva L. N. Khairulina 《Reaction Kinetics and Catalysis Letters》1991,43(2):405-411
In the presence of zeolites, dimethyl sulfide is produced either through CH3OH interaction with H2S or via CH3SH decomposition. In accordance with their activities, in both reactions, zeolites arrange in the same sequence: HZSMHNaY>NaXNaY. Realization of the reaction CH3OH+H2S is more difficult compared to methanethiol decomposition.
CH3OH H2S CH3SH. : HZSMHNaY>NaXNaY. CH3OH+H2S , .相似文献
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G. V. Ponomarev S. M. Nasralla A. G. Bubnova R. P. Evstigneeva 《Chemistry of Heterocyclic Compounds》1973,9(2):186-190
The dimethyl esters of protoporphyrin IX and pemtoporphyrin were synthesized by cyclization ofa,c-biladienes to the corresponding porphyrins, which contain -diethylaminoethyl groups as potential vinyl substituents, and subsequent Hofmann degradation of them to vinylporphyrins in high yields.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 202–206, February, 1973. 相似文献