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Under microwave irradiation and solvent‐free conditions, rare‐earth metal chlorides (RECl3) have been efficient catalysts for one‐pot synthesis of quinoline derivatives to give products in good to excellent yields through the multi‐component reactions of aldehydes, amines, and alkynes. The rare‐earth metal chlorides can be recycled for six times without notable loss of catalytic activities. This new synthetic approach has prominent features of a short reaction time, high yields of products, operational simplicity, broad substrate scopes, environmentally friendly property and commercially available catalysts. It extends the applications of rare‐earth metal compounds as catalysts in organic synthesis. 相似文献
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A fast, general, environmentally friendly, and facile method for preparation of 5, 5-disubstituted hydantoins from the reaction between ketone (or aldehyde) derivatives with KCN and ammonium carbonate under microwave irradiation is presented. The microwaves remarkably accelerated this reaction, the reaction times decreased dramatically, the reaction conditions were milder, and the yields were also greater. Also a comparative study of microwave versus classical conditions has been done. All the products were characterized by infrared, NMR, and CHN analysis, and their melting points are identical to those of the known compounds reported in the literature. This method might be useful in the future for the preparation of similar derivatives. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resources: Full experimental and spectral details.] 相似文献
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The functionalized arylidene bis(3‐arylaminoacrylates) were efficiently prepared by FeCl3 catalyzed one‐pot domino reactions of primary amines, methyl propiolate and aromatic aldehydes. When isatins were utilized under similar conditions, only 2‐oxoindolinyl 3‐arylaminoacrylates were obtained in moderate yields. 1H NMR data and single crystal structures indicated that this reaction has high diastereoselectivity. 相似文献
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Regina Westphal Eclair Venturini Filho Laiza Bruzadelle Loureiro Cludio Francisco Tormena Claudia Pessoa Celina de Jesus Guimares Mariana Palmeira Manso Rodolfo Goetze Fiorot Vinicius Rangel Campos Jackson Antnio Lamounier Camargos Resende Fabrizio Medici Sandro Jos Greco 《Molecules (Basel, Switzerland)》2022,27(22)
In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds. The reaction conditions considered ideal were determined from a methodological study varying solvent, catalyst, amount of catalyst, temperature, and heating mode. Finally, the generality of the methodology was evaluated by exploring the scope of the reaction, varying the starting materials (isatin, malononitrile, and barbituric acid). Overall, the twelve spiro compounds were synthesized in good yields (43–98%) and the X-ray structure of compound 1b was obtained. In addition, the in vitro antiproliferative activities of the spirocycles against four types of human cancer cell lines including HCT116 (human colon carcinoma), PC3 (prostate carcinoma), HL60 (promyelocytic leukemia), and SNB19 (astrocytoma) were screened by MTT-based assay. It is noteworthy that spiro compound 1c inhibited the four cell lines tested with the lowest IC50 values: 52.81 µM for HCT116, 74.40 µM for PC3, 101 µM for SNB19, and 49.72 µM for HL60. 相似文献
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N-Hydroxylacridinedione derivatives were synthesized by three-component reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and hydroxylamine hydrochloride using triethylbenzylammonium chloride (TEBA) as the catalysis in water. The reaction has many advantages including good yields, easy to be separated and environmental friendliness. 相似文献
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标题化合物(C25H16Cl2O2S)通过3-(2-(4-氯苯基)-2-氧代乙烯基)吲哚-2-酮和1-(4-氯苯基)-2-硫氰酸乙酮以体积比1∶2的比例反应,在N,N-二甲基甲酰胺做溶剂,叔丁醇钾为碱性促进剂作用下,经微波辐射合成得到.其结构通过单晶X-射线衍射法确定,晶体属三斜晶系.晶体结构用直接法解出,经全矩阵最小二乘法对原子参数进行修正,最终的偏离因子为R1=0.054 4,wR2=0.125 6.经分析得出,在晶体结构中新形成的噻吩环为共平面结构. 相似文献
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BALALAIE Saeed CHADEGANI Fatemeh DARVICHE Fatemeh BIJANZADEH Harnid Reza 《中国化学》2009,27(10):1953-1956
A new and efficient method for the synthesis of 1,8‐dioxo‐9‐aryl‐decahydroacridine derivatives was developed via a one‐pot three component reaction of dimedone, aromatic aldehydes and ammonium acetate in the presence of ammonium chloride, or Zn(OAc)2·2H2O or L‐proline separately in water in the short period of time and high yields. 相似文献
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The arylidienes of fluorinated spiro thiazolidines (5) containing α,β-unsaturated function have been used as component of Micheal addition with equimolar amount of 2-aminopyridine (6a) to give novel fluorinated spiro [indole-3,2′-pyrido[1,2-a]thiazolo[5,4-e]pyrimidines] (7) in a single step under microwaves in presence of montmorillonite KSF as solid support. The new improved synthetic method for fluorinated spiro [indole-3,2′-thiazolo[4,5-d]pyrimidines] (8) has also been developed involving the reaction of (5) with thiourea under monomode microwave reactor. Comparison with conventional synthesis and multimode microwave oven indicated the enhanced yield with faster reactions under monomode microwave reactor. Structure-activity relationships between the chemical structures and the antimycobacterial, antifungal activity of the evaluated compounds are also discussed. 相似文献
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SongQingWANG OmarA.IBRAHIMI PanLI KangZHAO 《中国化学快报》2004,15(1):1-4
Intramolecular cyclization of N-alkoxyl amines are studied for the stereoselective preparation of 2, 4-disubstituted pyrrolidine derivatives. Reduction of oximes under acidic conditions by NaBH3CN afforded the corresponding nucleophilic hydroxylamine derivatives,which subsequently cyclized via SN2‘ mechanism to give the desired N-alkoxyl pyrrolidines. 相似文献
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A series of highly timctionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde,malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL)as catalyst in DMSO.This protocol is featured by mild reaction conditions,simple operation and environmental acceptability. 相似文献
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在超声波促进下,未保护的吡喃糖依次与乙酸酐(或苯甲酸酐),乙酰溴,锌粉和PEG-600反应,"一锅法"合成了一系列乙酰化烯糖(或苯甲酰化烯糖).收率46%~89%,其结构经1H NMR确认. 相似文献