共查询到20条相似文献,搜索用时 31 毫秒
1.
Dr. Shan Sun Qiao Chen Zhongdi Tang Chuang Liu Prof. Zhongjun Li Prof. Aiguo Wu Prof. Hengwei Lin 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(47):21227-21234
A method is developed to fabricate tumor microenvironment (TME) stimuli-responsive nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling photosensitizer (chlorine e6, Ce6) modified carbon dots (CDs-Ce6) and Cu2+. The as-obtained nanoassemblies (named Cu/CC nanoparticles, NPs) exhibit quenched FL and photosensitization due to the aggregation of CDs-Ce6. Their FL imaging and photodynamic therapy (PDT) functions are recovered efficiently once they entering tumor sites by the stimulation of TME. Introducing of Cu2+ not only provides extra chemodynamic therapy (CDT) function through reaction with hydrogen peroxide (H2O2), but also depletes GSH in tumors by a redox reaction, thus amplifying the intracellular oxidative stress and enhancing the efficacy of reactive oxygen species (ROS) based therapy. Cu/CC NPs can act as a FL imaging guided trimodal synergistic cancer treatment agent by photothermal therapy (PTT), PDT, and thermally amplified CDT. 相似文献
2.
《中国化学快报》2023,34(11):108224
Finding more effective and safe non-viral vectors to transfer genes into cancer cells has become the key of immune gene therapy for cancer. Herein a triblock compound MPEG2000–PDLLA4000–MPEG2000 modified by cationic liposome DOTAP was used as a non-viral vector DOTAP/MPEG2000–PDLLA4000–MPEG2000 (DMPM) to effectively transfer interleukin (IL)-12 plasmid (pIL-12) into tumor tissue. IL-12 produced by transfected tumor cells successfully inducing lymphocyte proliferation and promoting interferon-γ (IFN-γ) secretion, which resulted in tumor cells death. The ability of DMPM to transfer pIL-12 and the immune effect induced by IL-12 in cells had been explored. The anti-tumor effect, mechanism and safety of pIL-12/DMPM in mice cancer model were investigated in this study. Our results showed that the pIL-12 transferred by DMPM was highly expressed both in CT26 cells and B16-F10 cells. IL-12 expressed in the culture supernatant of transfected tumor cells stimulated lymphocyte proliferation and promoted IFN-γ secretion. The experimental result confirmed that pIL-12/DMPM therapy significantly reduced tumor growth in mice model. We designed the nanocomposite DMPM to deliver pIL-12 for cancer treatment and explored its therapeutic efficacy and the underlying anti-tumor mechanism. Our study suggested pIL-12 loaded by DMPM complex would be an effective strategy for cancer treatment. 相似文献
3.
Mahsa Moshari Mahboubeh Rabbani Rahmatollah Rahimi 《Research on Chemical Intermediates》2016,42(6):5441-5455
A one-step green-chemistry method was applied to prepare sulfur/reduced graphene oxide (S/RGO). The synthesized S/RGO was modified by 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) and Fe3O4 nanoparticles to form TCPP–Fe3O4@S/RGO. The prepared composites were investigated by X-ray diffraction (XRD) analysis, Fourier-transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray (EDX) mapping, and transmission electron microscopy (TEM) and scanning electron microscopy (SEM) imaging. Diffuse reflectance spectroscopy (DRS) was used to determine the photocatalytic ability of S/RGO and TCPP–Fe3O4@S/RGO. In addition, photocatalytic degradation of a hazardous dye (methylene blue) by the TCPP–Fe3O4@S/RGO composite under visible-light irradiation is reported. The results demonstrate synthesis of TCPP–Fe3O4@S/RGO by an environmentally friendly method with excellent degradation effect. 相似文献
4.
A Multifunctional Biomaterial with NIR Long Persistent Phosphorescence,Photothermal Response and Magnetism
下载免费PDF全文
![点击此处可从《化学:亚洲杂志》网站下载免费的PDF全文](/ch/ext_images/free.gif)
There are many reports on long persistent phosphors (LPPs) applied in bioimaging. However, there are few reports on LPPs applied in photothermal therapy (PTT), and an integrated system with multiple functions of diagnosis and therapy. In this work, we fabricate effective multifunctional phosphors Zn3Ga2SnO8: Cr3+, Nd3+, Gd3+ with NIR persistent phosphorescence, photothermal response and magnetism. Such featured materials can act as NIR optical biolabels and magnetic resonance imaging (MRI) contrast agents for tracking the early cancer cells, but also as photothermal therapeutic agent for killing the cancer cells. This new multifunctional biomaterial is expected to open a new possibility of setting up an advanced imaging‐guided therapy system featuring a high resolution for bioimaging and low side effects for the photothermal ablation of tumors. 相似文献
5.
T. Poursaberi S. Ghadernia M. Hassanisadi K. Torkestani M. Mirrahimi 《Journal of the Iranian Chemical Society》2013,10(1):13-20
A new sorbent comprising 3-aminopropyltriethoxy-silane-coated magnetic nanoparticles functionalized with organic moieties containing the cobalt(III) porphyrin complex Co (TCPP) [TCPP: 4,4′,4″,4″′-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis (benzoic acid)], was prepared, for nitrite removal from drinking water. Fe3O4 nanoparticles were synthesized by co-precipitation of Fe2+ and Fe3+, then surface of the Fe3O4 nanoparticles was modified with APTES and Co (TCPP). The sorbent was characterized using FTIR, TGA, XRD, SEM and TEM analysis. The batch experiments showed that the proposed sorbent can effectively be used to remove nitrite from water. Various parameters such as pH of the solution, contact time, sorbent dosage, concentration of desorbing reagent, and influence of other interfering anions have been investigated. Under optimal conditions for a nitrite concentration of 10 mg L?1 (i.e., contact time 15 min, pH 5.5 and nanosorbents dosage 100 mg), the percentage of the extracted nitrite ions was 92.0. Nitrite sorbing material was regenerated with 10 mM NaOH up to 97.0 %. The regeneration studies also showed that nanosorbents are regenerable and can be used for a couple of times. 相似文献
6.
Strong Stokes and Upconversion Luminescence from Ultrasmall Ln3+‐Doped BiF3 (Ln=Eu3+, Yb3+/Er3+) Nanoparticles Confined in a Polymer Matrix
下载免费PDF全文
![点击此处可从《化学:亚洲杂志》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Heavy metal fluorides like BiF3 as a host for lanthanide ions are of interest as bismuth is the only heavy metal that is nontoxic. In this work, we report the synthesis of highly water‐dispersible ultrasmall BiF3 nanoparticles about 6 nm in size within a poly(vinyl pyrrolidone) matrix by a hydrothermal method. Microscopy analysis reveals that the nanoparticles are well separated and confined within the polymer network. These nanoparticles were found to be excellent hosts for lanthanide (Ln3+) ions. Through suitable Ln3+ doping, BiF3 exhibits strong emissions in the visible region upon both UV and near infrared (NIR) excitations. The non‐toxicity of both bismuth and PVP can be advantageous for the potential use of BiF3 nanoparticles in drug delivery and bioimaging. 相似文献
7.
Supraparticles(SPs), such as assembly of inorganic components with organic, have made tremendous attention in biochemical analysis, which represents a novel but challenging research orientation. Herein, a single-SPs multifunctional fluorescent sensor array has been developed for high-throughput detection of heavy metal ions in biofluids, which is based on an inorganic/organic hybrid SPs consisting of carbon dots(CDs) and an easily available porphyrin [5,10,15,20-tetra(4-carboxyphenyl)porphyrin(T... 相似文献
8.
In this paper, electroanalytical method of tetrakis (4-carboxylphenyl) porphyrin (TCPP) has been established. In a supporting electrolyte of KH2PO4-Na2HPO4 (pH 7.0), a sensitive second derivative reduction peak of TCPP was found by single-sweep oscillopolarography. The potential peak is −0.70 V (versus SCE).The relationship between peak height and the concentration of TCPP is linear from 1×10−7 to 2×10−5 mol l−1, the relative standard deviation (R.S.D.) was 0.41% (n=8), and the recovery of TCPP varied from 95.8-105.4%.The interaction of cyclodextrins (CD) with TCPP in NH3-NH4Cl (pH 8.0) has been studied by polarography. The TCPP can form the 1:1 inclusion complex with β-CD, γ-CD, hydroxylpropyl-β-CD, sulfurbutylether-β-CD and trimethyl-β-CD. “Current method” has been used to determine the formation constants of TCPP with five CDs. The result shows that the inclusion ability of hydroxylpropyl-β-CD is very strong. Moreover, modified β-CD has stronger inclusion capacity than native β-CD. The formation constant of TCPP with γ-CD is much greater than that of TCPP with β-CD, because the γ-CD has a bigger cavity that can match with the size of the meso-phenyl of TCPP. The supramolecular data will provide useful information for further application of TCPP. 相似文献
9.
Yu Ye Libo Sun Chenghui Zhang Jianfeng Du Yuchuan Liu Xiaowei Song Zhiqiang Liang 《应用有机金属化学》2019,33(12)
A novel luminescent metal–organic framework ( Zn‐TCPP/BPY ) with pillared structure based on 2,3,5,6‐tetrakis(4‐carboxyphenyl)pyrazine (H4TCPP) and 4,4′‐bipyridine (BPY) has been designed and synthesized through a solvothermal reaction. The [Zn2(COO)4] paddlewheel units are linked by TCPP4? ligands to form two‐dimensional layers and further connected by BPY ligands as pillars to construct the twofold interpenetrating three‐dimensional framework. Interestingly, Zn‐TCPP/BPY possesses outstanding stability in organic solvents and water as well as maintains its structural rigidity in aqueous solutions of different pH values (3–12). After activation, Zn‐TCPP/BPY possesses permanent porosity with Brunauer–Emmett–Teller surface area of 630 m2 g–1. Remarkably, Zn‐TCPP/BPY displays excellent fluorescent property in virtue of the aggregation‐induced emission effect of the H4TCPP ligand, which can be highly active and quenched by small amounts of 2,4,6‐trinitrophenol (TNP) and Fe3+ ions. Furthermore, the detection effect of Zn‐TCPP/BPY remains basically the same even after five cycles. The excellent stability, high sensitivity, and recyclability of Zn‐TCPP/BPY make it an outstanding chemical sensor for detecting TNP and Fe3+ ions. 相似文献
10.
Jingguo Li Hao Jiang Zhiqiang Yu Hongyan Xia Prof. Gang Zou Qijin Zhang Yue Yu 《化学:亚洲杂志》2013,8(2):385-391
Multimodal imaging and simultaneous therapy is highly desirable because it can provide complementary information from each imaging modality for accurate diagnosis and, at the same time, afford an imaging‐guided focused tumor therapy. In this study, indocyanine green (ICG), a near‐infrared (NIR) imaging agent and perfect NIR light absorber for laser‐mediated photothermal therapy, was successfully incorporated into superparamagnetic Fe3O4@mSiO2 core–shell nanoparticles to combine the merit of NIR/magnetic resonance (MR) bimodal imaging properties with NIR photothermal therapy. The resultant nanoparticles were homogenously coated with poly(allylamine hydrochloride) (PAH) to make the surface of the composite nanoparticles positively charged, which would enhance cellular uptake driven by electrostatic interactions between the positive surface of the nanoparticles and the negative surface of the cancer cell. A high biocompatibility of the achieved nanoparticles was demonstrated by using a cell cytotoxicity assay. Moreover, confocal laser scanning microscopy (CLSM) observations indicated excellent NIR fluorescent imaging properties of the ICG‐loaded nanoparticles. The relatively high r2 value (171.6 mM ?1 s?1) of the nanoparticles implies its excellent capability as a contrast agent for MRI. More importantly, the ICG‐loaded nanoparticles showed perfect NIR photothermal therapy properties, thus indicating their potential for simultaneous cancer diagnosis as highly effective NIR/MR bimodal imaging probes and for NIR photothermal therapy of cancerous cells. 相似文献
11.
Tatsuya Nakamura Fuminori Sugihara Hisashi Matsushita Yoshichika Yoshioka Shin Mizukami Kazuya Kikuchi 《Chemical science》2015,6(3):1986-1990
Multifunctional mesoporous silica nanoparticles (MSNs) are good candidates for multimodal applications in drug delivery, bioimaging, and cell targeting. In particular, controlled release of drugs from MSN pores constitutes one of the superior features of MSNs. In this study, a novel drug delivery carrier based on MSNs, which encapsulated highly sensitive 19F magnetic resonance imaging (MRI) contrast agents inside MSNs, was developed. The nanoparticles were labeled with fluorescent dyes and functionalized with small molecule-based ligands for active targeting. This drug delivery system facilitated the monitoring of the biodistribution of the drug carrier by dual modal imaging (NIR/19F MRI). Furthermore, we demonstrated targeted drug delivery and cellular imaging by the conjugation of nanoparticles with folic acid. An anticancer drug (doxorubicin, DOX) was loaded in the pores of folate-functionalized MSNs for intracellular drug delivery. The release rates of DOX from the nanoparticles increased under acidic conditions, and were favorable for controlled drug release to cancer cells. Our results suggested that MSNs may serve as promising 19F MRI-traceable drug carriers for application in cancer therapy and bio-imaging. 相似文献
12.
Chao Wang Fengjuan Cao Yudi Ruan Xiaodan Jia Wenyao Zhen Xiue Jiang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(29):9951-9955
The generation of singlet oxygen (1O2) during photodynamic therapy is limited by the precise cooperation of light, photosensitizer, and oxygen, and the therapeutic efficiency is restricted by the elevated glutathione (GSH) levels in cancer cells. Herein, we report that an ultrathin two‐dimensional metal–organic framework of Cu‐TCPP nanosheets (TCPP=tetrakis(4‐carboxyphenyl)porphyrin) can selectively generate 1O2 in a tumor microenvironment. This process is based on the peroxidation of the TCPP ligand by acidic H2O2 followed by reduction to peroxyl radicals under the action of the peroxidase‐like nanosheets and Cu2+, and their spontaneous recombination reaction by the Russell mechanism. In addition, the nanosheets can also deplete GSH. Consequently, the Cu‐TCPP nanosheets can selectively destroy tumor cells with high efficiency, constituting an attractive way to overcome current limitations of photodynamic therapy. 相似文献
13.
Xiahui Lin Shuya Liu Xuan Zhang Rong Zhu Shan Chen Prof. Xiaoyuan Chen Prof. Jibin Song Prof. Huanghao Yang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(4):1699-1705
Sonodynamic therapy (SDT) has the advantages of high penetration, non-invasiveness, and controllability, and it is suitable for deep-seated tumors. However, there is still a lack of effective sonosensitizers with high sensitivity, safety, and penetration. Now, ultrasound (US) and glutathione (GSH) dual responsive vesicles of Janus Au-MnO nanoparticles (JNPs) were coated with PEG and a ROS-sensitive polymer. Upon US irradiation, the vesicles were disassembled into small Janus Au-MnO nanoparticles (NPs) with promoted penetration ability. Subsequently, GSH-triggered MnO degradation simultaneously released smaller Au NPs as numerous cavitation nucleation sites and Mn2+ for chemodynamic therapy (CDT), resulting in enhanced reactive oxygen species (ROS) generation. This also allowed dual-modality photoacoustic imaging in the second near-infrared (NIR) window and T1-MR imaging due to the released Mn2+, and inhibited orthotopic liver tumor growth via synergistic SDT/CDT. 相似文献
14.
《中国化学快报》2023,34(3):107291
Herein, we report a new metal-organic framework with an AIE ligand (H4TCPP = 2,3,5,6-tetra-(4-carboxyphenyl)pyrazine) and Mg2+ ions, that is, [Mg2(H2O)4TCPP]·DMF·5CH3CN (Mg-TCPP, TCPP = tetra-(4-carboxyphenyl)pyrazine) for detection of nitroaromatic explosives. Due to the coordination effect and restricted intramolecular rotation, Mg-TCPP exhibits bright blue light. As a fluorescent sensor, Mg-TCPP exhibits high selectivity and sensitivity for sensing 2,4,6-trinitrophenol (TNP) by quenching behaviors with the Stern-Volmer quenching constant (KSV) of 3.63×105 L/mol and achieves the low limit of detection of 25.6 ppb, which is beyond most of the previously reported fluorescent materials. Notably, the portable Mg-TCPP films are prepared and it can be used for rapid and sensitive TNP detection in a variety of environments including organic solvent and aqueous solution. Moreover, TNP vapor can be detected within 3 min by naked eye and the film could be regenerated under simple solvent cleaning. 相似文献
15.
Meng Li Chenyao Nie Dr. Liheng Feng Dr. Huanxiang Yuan Dr. Libing Liu Dr. Fengting Lv Prof. Dr. Shu Wang 《化学:亚洲杂志》2014,9(11):3121-3124
The outstanding optical properties and biocompatibility of fluorescent conjugated polymer nanoparticles (CPNs) make them favorable for bioimaging application. However, few CPNs could achieve stable cell membrane labeling due to cell endocytosis. In this work, conjugated polymer nanoparticles (PFPNP‐PLE) encapsulated with PFP and PLGA‐PEG‐N3 in the matrix and functionalized with the small‐molecule drug plerixafor (PLE) on the surface were prepared by a mini‐emulsion method. PFPNP‐PLE exhibits excellent photophysical properties, low cytotoxicity, and specific cytomembrane location, which makes it a potential cell membrane labeling reagent with blue fluorescence emission, an important component for multilabel/multicolor bioimaging. 相似文献
16.
Dr. Yong Yang Qiang Wang Dr. Zhenping Su Prof. Jun Li Prof. Ning Wang 《欧洲无机化学杂志》2023,26(10):e202200776
Due to the synergistic effect of central metal and halide anion, cationic metalloporphyrins and derivatives exhibit outstanding catalytic activities for the cycloaddition reaction of epoxides and carbon dioxide. Herein, a generic strategy was developed to synthesize the benzimidazolium-containing metalloporphyrin molecule and polymer. To demonstrate the method feasibility, we firstly synthesized the molecule 1H , in which the benzimidazole groups were in-site constructed by the cyclization of 5,10,15,20-(4-carboxyphenyl)-porphyrin ( H2TCPP ) with o-diaminobenzene ( PEA ). After post-synthetic ionization and metallization, I− and Zn2+ were introduced as the nucleophile and Lewis acid, respectively. The structure of 1ZnIL was confirmed by single crystal X-ray diffraction analysis. By using the similar conditions of model reaction, H2TCPP was copolymerized with 1,2,4,5-tetraaminobenzene ( BTA ) to prepare the polymer P-1ZnIL . The prepared cationic molecule 1ZnIL and polymer P-1ZnIL showed comparable activities in catalyzing the cycloaddition of carbon dioxide with epoxides to cyclic carbonates compared to the reported bifunctional catalysts based on metalloporphyrins. 相似文献
17.
Xiuyan Wan Hui Zhong Wei Pan Yanhua Li Yuanyuan Chen Na Li Bo Tang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(40):14272-14277
Dihydroartemisinin (DHA) has attracted increasing attention as an anticancer agent. However, using DHA to treat cancer usually depends on the synergistic effects of exogenous components, and the loss of DHA during delivery reduces its effectiveness in cancer therapy. Reported herein is a programmed release nanoplatform of DHA to synergistically treat cancer with a Fe‐TCPP [(4,4,4,4‐(porphine‐5,10,15,20‐tetrayl) tetrakis(benzoic acid)] NMOF (nanoscale MOF) having a CaCO3 mineralized coating, which prevents DHA leakage during transport in the bloodstream. When the nanoplatform arrives at the tumor site, the weakly acidic microenvironment and high concentration of glutathione (GSH) trigger DHA release and TCPP activation, enabling the synergistic Fe2+‐DHA‐mediated chemodynamic therapy, Ca2+‐DHA‐mediated oncosis therapy, and TCPP‐mediated photodynamic therapy. In vivo experiments demonstrated that the nanoplatform showed enhanced anticancer efficiency and negligible toxicity. 相似文献
18.
Yongmei Wen Qingyan Jia Fuchun Nan Xiuli Zheng Weimin Liu Jiasheng Wu Haohui Ren Jiechao Ge Pengfei Wang 《化学:亚洲杂志》2019,14(12):2162-2168
Carbon dots (CDs), a kind of phototheranostic agent with the capability of simultaneous bioimaging and phototherapy [i.e., photodynamic therapy (PDT) or photothermal therapy (PTT)], have received considerable attention because of their remarkable properties, including flexibility for surface modification, high biocompatibility, low toxicity and photo‐induced activity for malignant tumor cells. Among numerous carbon sources, it has been found that natural biomass are good candidates for the preparation of CD phototheranostic agents. In this study, pheophytin, a type of Mg‐free chlorophyll derivative and also a natural product with low toxicity, was used as a raw carbon source for the synthesis of CDs by using a microwave method. The obtained hydrophobic CDs exhibited a maximum near‐infrared (NIR) emission peak at approximately 680 nm, and high singlet oxygen (1O2) generation with a quantum yield of 0.62. The self‐assembled CDs from the as‐prepared CDs with DSPE‐mPEG2000 retained efficient 1O2 generation. The obtained carbon dot assembly was not only an efficient fluorescence (FL) imaging agent but also a smart PDT agent. Our studies indicated that the obtained hydrophilic CD assembly holds great potential as a new phototheranostic agent for cancer therapy. This work provides a new route for synthesis of CDs and proposes a readily available candidate for tumor treatment. 相似文献
19.
Rongjin Sun Ting Yin Peng Huang Guo Gao Joseph George Shapter Yulan Shen Jingjing Zhang Daxiang Cui 《中国化学会会志》2016,63(12):977-984
In this paper, we report the development of a facile one‐pot hydrothermal method for the controlled synthesis of monodispersed BaGdF5 :Yb/Er nanoparticles for computed tomography (CT) and magnetic resonance (MR) imaging. The as‐prepared nanoparticles have uniform size with a diameter of 20–25 nm. MTT tests show that the cell viability surpasses 90% even with a concentration of nanoparticles of 500 µg/mL, suggesting that the as‐prepared BaGdF5 :Yb/Er nanoparticles possess low toxicity. For both BaGdF5 :Yb/Er nanoparticles and iopromide, the Hounsfield unit (HU) values increase with the their concentration. The slope of BaGdF5 :Yb/Er nanoparticles is about 26.47, which is much higher than that of iopromide (16.98), indicating a better CT imaging effect. Interestingly, we find that the synthesized BaGdF5 :Yb/Er nanoparticles exhibit paramagnetism. Our in vitro and in vivo imaging experiments demonstrate that the synthesized monodispersed BaGdF5 :Yb/Er nanoparticles can serve as effective contrast agents for CT and MR imaging. 相似文献
20.
Synthesis and magnetic properties of the γ-Fe2O3/poly-(methyl methacrylate)-core/shell nanoparticles
《Solid State Sciences》2004,6(8):879-885
The synthesis of γ-Fe2O3/poly-(methyl methacrylate)-core/shell nanoparticles and their magnetic properties are reported. Specific γ-Fe2O3 nanoparticles capable of initiating atom transfer radical polymerization (ATRP) were prepared by a ligand exchange reaction of ((chloromethyl)phenylethyl)-dimethylchlorosilane and caprylate-capped γ-Fe2O3 nanoparticles of 4 nm in diameter, and the ATRP of methyl methacrylate was carried out subsequently. These nanoparticles were characterized with Fourier transform infrared spectroscopy, transmission electron microscopy and Mössbauer spectroscopy. Low temperature magnetic properties investigated with SQUID magnetometry revealed that the coercivity and the blocking temperature changed slightly owing to surface effects. 相似文献