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This review summarized the recent progress on the synthesis, morphologies and properties of DNA-mediated metal nanomaterials including nanoparticles and nanoclusters. Moreover, their applications to environmental and biological analysis were introduced with the developing prospect in analytical chemistry. 相似文献
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Liang S Xu Z Xu X Zhao X Huang C Wei Y 《Combinatorial chemistry & high throughput screening》2012,15(3):221-231
The mass spectrometry (MS)-based quantitative proteomics is powerful to discover disease biomarkers that can provide diagnostic, prognostic and therapeutic targets, and it also can address important problems in clinical and translational medical research. The current status of MS-based quantification strategy and technical advances of several main quantitative assays (two-dimensional (2-D) gel-based methods, stable isotope labeling with amino acids in cell culture (SILAC), isotope-coded affinity tag (ICAT), the isobaric tags for relative and absolute quantification (iTRAQ), 1?O labeling, absolute quantitation and label-free quantitation) have been summarized and reviewed. At present, except 2-D gel-based methods, several stable isotope labeling quantitative techniques, including SILAC, ICAT and iTRAQ, etc, have been widely applied in identification of differential expression of proteins, post-translational modifications and protein-protein interactions in order to look for novel candidate cancer biomarkers from different physiological states of cells, body fluids or tissue samples. Also, the advantages and challenges of different quantitative proteomic approaches are discussed in identification and validation of candidate targets. 相似文献
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Three‐Dimensional Characterization of Noble‐Metal Nanoparticles and their Assemblies by Electron Tomography
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Prof. Dr. Sara Bals Dr. Bart Goris Prof. Dr. Luis M. Liz‐Marzán Prof. Dr. Gustaaf Van Tendeloo 《Angewandte Chemie (International ed. in English)》2014,53(40):10600-10610
New developments in the field of nanomaterials drive the need for quantitative characterization techniques that yield information down to the atomic scale. In this Review, we focus on the three‐dimensional investigations of metal nanoparticles and their assemblies by electron tomography. This technique has become a versatile tool to understand the connection between the properties and structure or composition of nanomaterials. The different steps of an electron tomography experiment are discussed and we show how quantitative three‐dimensional information can be obtained even at the atomic scale. 相似文献
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本文主要概述了近年来核酸工具酶辅助的基于金属稳定同位素标记的电感耦合等离子体质谱(ICP-MS)检测方法在生物分析中的发展和应用,简要介绍了该方法在蛋白质、核酸及一些生物小分子检测中的应用。最后对核酸工具酶辅助的基于金属稳定同位素标记的电感耦合等离子体质谱(ICP-MS)检测方法的发展前景做了展望。 相似文献
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Playing tag with quantitative proteomics 总被引:1,自引:0,他引:1
There is steady need for new proteomic strategies on quantitative measurements that provide essential components for detailing
dynamic changes in many cellular functions and processes. Stable isotope labeling is a rapidly evolving field, which can be
used either after protein extraction with chemical labeling, or in cell culture with metabolic incorporation. In this review,
we explore the most frequently utilized quantitation techniques with particular attention paid to chemical labeling using
different isotopic tags, including a recent labeling strategy—soluble polymer-based isotopic labeling (SoPIL)—that achieves
efficient labeling in homogeneous conditions. Special care should be devoted to the selection of appropriate quantitation
approaches according to the needs of the sample and overall experimental design. We evaluate recent advances in quantitative
proteomics using stable isotope labeling and their applications to current insightful biological inquiries.
Figure Chemical modules of isotopic tags for quantitative proteomics. 相似文献
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《中国化学快报》2023,34(3):107523
The increasing pollution and human demand for a cleaner environment have made achieving the environmental sustainability a current research focus. As a “green” technology, semiconductor photocatalysis is of great significance to the environmental purification. Benefiting from the unique anisotropic crystal structure and electronic properties, layered photocatalytic nanomaterials show great potential for efficient photocatalytic environmental treatment. This review comprehensively summarizes the recent progress on layered photocatalytic nanomaterials for oxidation or reduction of pollutants in water and air along with the basic understanding of related mechanisms and developments in this field. First, the existing diversified layered photocatalysts are classified, and their different synthesis and modification strategies are discussed in detail to provide a comprehensive view of the material design that affects their photocatalytic performance. Subsequently, the extensive applications of the above-mentioned layered photocatalytic nanomaterials in environmental fields are systematically summarized, including photooxidation of water and air pollutants, and photoreduction of heavy metal pollutants, NO3?, BrO3? and CO2. Finally, based on the current research achievements in layered photocatalysts for environmental remediation, the future development direction and challenges are proposed. 相似文献
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Hui Miao Zhenyuan Teng Prof. Dr. Chengyin Wang Dr. Hui Chong Dr. Guoxiu Wang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(4):929-944
Nowadays, microorganisms, including bacteria and viruses, are regarded as new environmental pollutants and pose serious threats to public health. Yet, traditional disinfection approaches for bacteria and viruses are generally ineffective. Furthermore, they exhibit the disadvantages of high-energy consumption, environmental pollution, high cost, and toxic byproduct generation. In this respect, nanomaterials display promising antimicrobial capabilities due to their unique properties and provide solutions to the abovementioned issues. Herein, recent progress in the development of 2D nanomaterials displaying antimicrobial capabilities is highlighted. The structures, morphologies, and performances of essential metal, graphene, and nitride-based 2D antibacterial nanomaterials are summarized in detail. In addition, possible antimicrobial mechanisms and the relationship between structure and antimicrobial efficiency are elaborated. 相似文献
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Developing simple, rapid, and environmentally friendly synthetic methodologies for the preparation of functional nanomaterials is of great importance for broadening and improving their potential applications. In comparison with other methods, the microwave-assisted hydrothermal method possesses and combines the merits of microwave and hydrothermal methods, which can achieve the high temperature and high pressure for a short time from several minutes to several hours in a closed reaction system. In this review, the synthesis of various types of functional nanomaterials such as metals oxides, metal composite oxides, inorganic biomaterials (hydroxyapatite and calcium carbonate), and metal sulfides via the microwave-assisted hydrothermal method is summarized. The special properties and applications of functional nanomaterials by the microwave-assisted hydrothermal method are compared with others methods. The future developments of this promising method are put forward. 相似文献
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Anxiang Guan Chao Yang Yueli Quan Hanchen Shen Na Cao Tengfei Li Yali Ji Gengfeng Zheng 《化学:亚洲杂志》2019,14(22):3969-3980
Electroreduction of CO2 into valuable molecules or fuels is a sustainable pathway for CO2 reduction as well as energy storage. However, the premature development stage of electrocatalysts with high activity, selectivity, and durability still remains a significant bottleneck that hinders this field. One‐dimensional (1D) nanomaterials, including nanorods, nanotubes, nanoribbons, nanowires, and nanofibers, are generally considered as high‐activity and stable electromaterials, due to their unique uniform structures, orientated electronic and mass transport, and rigid tolerance to stress variation. During the past several years, 1D nanomaterials and nanostructures have been extensively studied due to their potentials in serving as CO2 electroreduction catalysts. In this minireview, recent studies and advances in 1D nanomaterials for CO2 eletroreduction are summarized, from the viewpoints of both computational and experimental aspects. Based on the composition, the 1D nanomaterials are studied in four categories, including metals, transition‐metal oxides/nitrides, transition‐metal chalcogenides, and carbon‐based materials. Different parameters in tuning 1D materials are also summarized and discussed, such as the crystal facets, grain boundaries, heteroatoms doping, additives and the electrochemical tuning effects. Finally, the challenges and prospects in this direction will be discussed. 相似文献
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Information in the literature on the use of fluorescence spectroscopy for the study of the chemistry of fulvic acid and its interactions with metal ions and organic chemicals is discussed. Basic principles, instrumentation, procedures, methodology and limitations of the fluorescence technique and the fluorescence polarization method are briefly summarized. This is followed by an extended discussion on the direct information that fluorescence spectra can furnish on the properties and nature of fluorescing structures in fulvic acids. The effects of molecular parameters and environmental factors (molecular weight, concentration, pH, ionic strength, temperature and redox potential) on the fluorescence behaviour of fulvic acids are discussed. Particular attention is devoted to the indirect information that fluorescence quenching and fluorescence polarization studies provide on molecular and quantitative aspects of the chemistry of fulvic acid in solution, especially in relation to molecular conformation and binding with metal ions and organic chemicals. The potential advantage of this non-separative, non-destructive technique for the study of environmental samples such as fulvic acids is emphasized. 相似文献
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The excessive use of pesticides in agricultural or non-agricultural fields causes the emergence of environmental and human health problems. Therefore, there is a need to develop simple, fast, sensitive, selective, and low-cost methods for analyzing pesticides from different matrices. Although many analysis methods have been developed to determine pesticides, nanomaterial-based electroanalytical methods offer numerous advantages such as rapid and low cost of analysis, low sample volume requirement, field deployability, and miniaturization to improve the performance of the developed methods. Among different nanomaterials, bimetallic nanomaterials such as gold, platinum, palladium, nickel, and iron-based nanomaterials in combination with other metals have been extensively used as electrode modification agents due to their electrocatalytic characteristics and the synergistic effect of two metals. In this review, firstly, the basic information of pesticides and bimetallic nanomaterials was summarized. Properties, synthesize, and architectures of bimetallic nanomaterials and their nanocomposites were explained in detail. Current applications and utilization of bimetallic nanomaterials for pesticides detection were reviewed by selected studies with working range, the limit of detection, sensitivity, analytical application, and some experimental conditions. In conclusion, the current challenges and future trends for analyzing pesticides based on electroanalytical methods combined with bimetallic nanomaterials were highlighted. 相似文献
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Farré M Gajda-Schrantz K Kantiani L Barceló D 《Analytical and bioanalytical chemistry》2009,393(1):81-95
Nanotechnology is a major innovative scientific and economic growth area. However nanomaterial residues may have a detrimental
effect on human health and the environment. To date there is a lack of quantitative ecotoxicity data, and recently there has
been great scientific concern about the possible adverse effects that may be associated with manufactured nanomaterials. Nanomaterials
are in the 1- to 100-nm size range and can be composed of many different base materials (carbon, silicon and metals, such
as gold, cadmium and selenium) and they have different shapes. Particles in the nanometer size range do occur both in nature
and as a result of existing industrial processes. Nevertheless, new engineered nanomaterials and nanostructures are different
because they are being fabricated from the “bottom up”. Nanomaterial properties differ compared with those of the parent compounds
because about 40–50% of the atoms in nanoparticles (NPs) are on the surface, resulting in greater reactivity than bulk materials.
Therefore, it is expected that NPs will have different biological effects than parent compounds. In addition, release of manufactured
NPs into the aquatic environment is largely an unknown. The surface properties and the very small size of NPs and nanotubes
provide surfaces that may bind and transport toxic chemical pollutants, as well as possibly being toxic in their own right
by generating reactive radicals. This review addresses hazards associated and ecotoxicological data on nanomaterials in the
aquatic environment. Main weaknesses in ecotoxicological approaches, controversies and future needs are discussed. A brief
discussion on the scarce number of analytical methods available to determinate nanomaterials in environmental samples is included. 相似文献
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Much research on the use of nanomaterials in different applications is being conducted in areas such as water treatment, catalysis, oil processing, medicine, food, sensors, energy storage, building materials, constructions, and others. Nanoparticles are ultra-small particles with exceptional properties, but some nanoparticles and nanomaterials may exhibit harmful properties when leaked into the environment. Due to the lack of analytical methods for the detection and analysis of nanoparticles in complex matrices, not much is known about the potential risks associated with nanomaterials. Therefore, more knowledge is needed of the sampling and analysis of nanomaterials (NMs) as environmental contaminants. This review is undertaken to identify and assess key characteristics in potential sampling and analysis methods for identifying and quantifying the occurrence of NMs in numerous types of environmental media. To select suitable sampling and analysis methods, information on NM sources and transformation in environmental media is essential and thus is also discussed. This provides more information about the negative impacts of NMs on the environment. Challenges and future perspectives on the determination of NMs are also discussed. 相似文献
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基于2DE的蛋白质定量分析技术通过对不同样品蛋白质表达差异的比较,定量地解析了蛋白质的动态变化,为了解和阐明细胞蛋白质功能及活动机制等提供了重要信息。本文简单介绍了传统2DE 的“一个样品一块胶”模式的定量分析技术,指出其因为耗时、繁琐及重复性较差等,在常规2DE定量分析应用中受到了制约;阐述了近年来发展的“多样品共分离”模式的定量技术,包括荧光胶内差示电泳(DIGE)、“不同胶曝光”以及稳定同位素标记技术,这类技术因有效克服了传统技术的局限性,由此提高了定量分析的能力;分别对每种蛋白质定量技术及其优缺点作了比较和评述,并对2DE定量分析技术的未来发展方向做出了展望。 相似文献
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