Benzoxazolinones. II. Synthesis of 3-vinylbenzoxazolinones and 3-vinylbenzoxazolinethione

A method has been developed for obtaining 3-vinylbenzoxazolinones and 3-vinylbenzoxazolinethione. It has been shown that it is also possible to obtain 3-methylbenzoxazolinethione by this method in good yield (76%).     

Benzoxazolinones. II. Synthesis of 3-vinylbenzoxazolinones and 3-vinylbenzoxazolinethione

A method has been developed for obtaining 3-vinylbenzoxazolinones and 3-vinylbenzoxazolinethione. It has been shown that it is also possible to obtain 3-methylbenzoxazolinethione by this method in good yield (76%).Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 553–556, July–August, 1980.     

Halogenbenzaldehyde, 3. Mitt.

Zusammenfassung Mittels der Konversion aromatischer Amine in die entsprechenden Benzaldehyde, einer Methode, die vonBeech entwickelt und von uns auf Haloaniline erweitert wurde, werden in einfacher, eleganter Weise zwei Halogenbenzaldehyde dargestellt.2. Mitt.:S. D. Jolad undS. Rajagopal, Naturwiss.48, 645 (1961).     

226. Aminonucleosides. 3. Derivatives of 3-amino-3,5-dideoxy-D-lyxo- and D-ribo-pentoses

The 3-amino-3,5-didesoxy-1,2-O-isopropylidene-α-D -ribofuranose and -β-D -lyxo-furanose and several derivatives thereof have been prepared by hydride reduction of the corresponding oximes.     

Thalidomid-Analoga, 3. Mitt.

Zusammenfassung Zur Untersuchung möglicher Struktur-Wirkungs-Beziehungen in der Reihe der verbrückten Thalidomid-Analoga wurden 36 offenkettige und verkürzte Abkömmlinge der Testsubstanz K 2004 (2) synthetisiert. Die pharmakologische Untersuchung der hergestellten Verbindungen ergab in keinem Falle eine signifikante sedative Aktivität. Dies legt den Schluß nahe, daß die intakte Glutarimid-Struktur bei1 und2 für das Zustandekommen der schlafinduzierenden Wirkung unentbehrlich ist.

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Thalidomide analogues

For the evaluation of possible structure-activity relationships in the series of bridged thalidomide analogues 36 openchain and shortended congeners of the test substance K 2004 (2) have been synthesized. The pharmacological evaluation of these compounds revealed in no case any significant sedative activity. This leads to the conclusion that the intact glutarimide structure must be essential for the sleep-inducing activity of1 and2.

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Herrn Prof. Dr.M. Pailer zum 60. Geburtstag gewidmet.     

The i.r. spectra of 3-methyl-2-butenenitrile and 3-methyl-3-butenenitrile

A commercial sample of supposedly 3-methyl-3-butenenitrile was separated by gas chromatography into two components. Analysis of the i.r. and NMR spectra of these two components showed that the original mixture contained 25% 3-methyl-3-butenenitrile and 75% 3-methyl-2-butenenitrile, and that an i.r. spectrum recently reported in this journal [1] for 3-methyl-3-butenenitrile was actually that of 3-methyl-2-butenenitrile. Thus, the spectral data reported for 3-methyl-3-butenenitrile [1] and the resulting conclusions regarding the nature of the conformational equilibrium in this molecule should be disregarded.     

Non-steroidal antiinflammatory agents. 3. Synthesis of 3-hydroxy-3-hydroxyphenyl-2,4-dioxo-1,2,3,4-tetrahydroquinolines

The acid-catalyzed condensation of quinisatines 5a-c or their aminals 4a-c with phenols 6a-i led to a number of 3-hydroxy-3-hydroxyphenyl-2,4-dioxo-1,2,3,4-tetrahydroquinolines 7a-s which were considered as potential antiinflammatory agents.     

3. Interface Science

Referate

Grenzflächenerscheinungen     

3. Pharmazeutische Produkte

Ohne Zusammenfassung