一个方酸内鎓盐衍生物合成机理的理论研究

用ＰＭ３方法对新近合成的一个方酸内Ｗｅｎｇ盐衍生物：２－（Ｎ,Ｎ－二羟乙基）胺基－４－二甲胺苯基方酸内Ｗｅｎｇ盐的微观反应机理进行了研究,计算结果表明：以（Ｎ,Ｎ－二羟乙基）胺基负离子,二甲胺一方酸制备该方酸内Ｗｅｎｇ盐有邻位和对位两种产物,且对位更易生成,同时,还探讨了提高光致材料产率的可能方法。     

1,2-二硒-3，4-二硫方酸的从头计算

在RHF／STO－3G、STO－3G和3－21G（仅对ZE型）水平上，用abinitioSCF方法优化得到1，2－二硒－3，4－二硫方酸（3，4－二巯基－3－环丁烯－1，2－二硒酮）三种平面异构体的平衡构型，进一步用3－21G／／STO－3G（对ZZ和EE型）方法计算总能量，发现三种平面导构体中ZZ型是最稳定构象，ZE型次之，并与1，2－二硒方酸和3，4－二硫方酸从头算结果作了比较，用abinitio数值方法在STO－3G水平上计算了三种异构体的谐振动频率．     

N-芳基氮氧方酸的合成研究

N-芳基氮氧方酸(3-芳胺基-4-羟基-3-环丁烯二酮)是合成不对称方酸衍生物的关键中间体之一，开展了对其合成方法的研究，发现并实现了方酸与芳伯胺在水中的脱水反应，制得17个N-芳基氮氧方酸3a～3q，其中N-8'-喹啉基氮氧方酸(3q)具有热致变色性质，根据实验事实，提出了可能的反应历程。该合成方法产率较高，产物易于分离纯化，是制备N-芳基氮氧方酸简便有效的好方法。     

新型多臂方酸菁化合物的合成及光谱性质

合成了引入多甘醇醚链的５－Ｎ，Ｎ－双（２－羟乙基）胺基－１，３－间苯二酚及其衍生物，使之与方酸发生缩合反应，获得了７种新型多臂方酸菁化合物，研究了它们的光谱性质     

烷基膦酸二烷基酯的固—液相转移催化合成及其阻燃性能

烷基膦酸二烷基酯的固－液相转移催化合成及其阻燃性能王筱梅＊杨平蔡庆华鲍猛（山东建筑材料工业学院应用化学系济南２５００２２）关键词烷基膦酸二烷基酯，合成，相转移催化，阻燃性１９９６－０８－１２收稿，１９９７－０３－０３修回烷基膦酸二烷基酯是一类具有实用...     

不对称芳基取代的方酰胺和异方酰胺的合成

Ｎ－芳基氮氧方酸的活性羟基能够被芳伯胺取代。利用这一特性，可在方酸四碳环上引入另一不同的芳胺基，即可获得不对称芳基取代的方酰胺或异方酰胺。以乙醇等为介质，芳伯胺与７种Ｎ－芳基氮方酸反应，制得２５个不对称的方酰胺和２４个不对称的异方酰胺。该合成方法优点突出，反应简便有效，通用性强。     

3，4－二硫方酸的从头算研究

在６－３１Ｇ水平上对３，４－二硫方酸（３，４－二巯基－３－环丁烯－１，２－二酮）的３种平面构象异构体进行ＳＣＦ计算．结果表明，ＺＺ型异构体最稳定，ＺＥ型次之，从等键反应能量分析３，４－二硫方酸的稳定性，与苯作比较探讨其芳香性．并在６－３１Ｇ水平上计算了３种构象的振动频率．     

苯酚和草酸二甲酯在不同分子筛催化下的酯交换反应

研究了以TS－1、H－ZSM－5、Hβ和H－丝光沸石等不同分子筛为催化剂，苯酚和草酸二甲酯酯交换合成草酸二苯酯反应。通过对催化剂进行吸附吡啶的红外光谱和NH3－TPD表征，考察了不同分子筛催化剂的酸性和酸强度对草酸二苯酯合成反应的影响，确定了催化剂上的弱酸中心是催化苯酚和草酸二甲酯酯交换合成草酸二苯酯反应的活性位，且催化剂的酸性中心越多，酸量越大，催化活性越好。催化剂上的强酸中心促进了副产物苯甲醚的生成。     

冠醚方酸碲碳菁染料的合成研究

合成了不对称冠醚方酸碲碳菁染料和对称冠醚方酸碲碳菁染料，并探讨了对称冠醚方酸碲碳菁的合成方法及反应条件，提出了其可能的反应机理。     

DL-β-(4-噻唑基)-α-乙酰氨基丙酸含成方法的改进

报道了由（４－噻唑基）－甲基乙酰氨基雨二酸二乙酯通过碱性水解并脱羧来合成外消旋β－（４－噻唑基）－α－乙酰氨基丙酸的新路线，产率可达８０％，同时对前几步中间产物的合成进行了有效的改进。     

左旋薄荷醇的合成现状及进展

阐述了左旋薄荷醇的理化性质及其应用现状和全球生产状况. 介绍了薄荷醇的合成思路、已经工业化的合成路线和一些有较高工业应用价值的路线, 并介绍了关于这些路线的最新研究进展. 最后对所介绍的路线进行了总结, 展望了其发展前景.     

Complementary regioselective synthesis of 3,5-disubstituted isoxazoles from ynones

Two regioselective synthetic routes towards 3,5-disubstituted isoxazoles from ynones are reported. One route takes place via first converting the ynones to ynone O-methyl oximes, followed by a palladium-catalyzed intramolecular cyclization. The other involves the formation of 5-hydroxy-4,5-dihydroisoxazoles by a cyclocondensation between ynones and hydroxylamine, and subsequent acid mediated dehydration. The two routes are not only both highly regioselective, but also complementary to each other as a pair of regioisomeric 3,5-disubstituted isoxazoles are readily prepared from one single ynone substrate. The efficiency of the two routes are further evaluated and demonstrated in the synthesis of three representative 3,5-disubstituted isoxazoles.     

Surfactant-free nonaqueous synthesis of metal oxide nanostructures

Surfactant-free nonaqueous (and/or nonhydrolytic) sol-gel routes constitute one of the most versatile and powerful synthesis methodologies for nanocrystalline metal oxides with high compositional homogeneity and purity. Although the synthesis protocols are particularly simple, involving only metal oxide precursors and common organic solvents, the obtained uniform nanocrystals exhibit an immense variety of sizes and shapes. The small number of reactants in these routes enables the study of the chemical mechanisms involved in metal oxide formation. Nonhydrolytic routes to inorganic nanomaterials that used surfactants as size- and shape-controlling agents have been discussed recently. This Minireview supplements this topic by discussing surfactant-free processes, which have become a valuable alternative to surfactant-assisted as well as to traditional aqueous sol-gel chemistry routes.     

三尖杉碱全合成研究的新进展

三尖杉碱是抗癌药物——三尖杉酯类化合物的母体。它的全合成研究一直受到众多学者的亲睐。近几年来,取得了三条新的合成路线。共同特点是:采用单环或二环小分子为原料,巧妙地合成了具有独特五环结构的三尖杉硷(1)。其中的 Kuehne 路线,产率达到41%。     

Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions

Two straightforward and convenient routes for the synthesis of the antimalarial agents FR900098 and fosmidomycin are described. In the key steps N- or P-alkylation reactions are used. The best overall yields of FR900098 and fosmidomycin in 15 mmol scale are 83% and 68%, respectively. These routes utilize readily available materials and avoid harsh conditions.     

碳一化工路线制备乙二醇研究进展

乙二醇(EG)是一种重要的化工原料,主要用来生产新型聚酯纤维.近年来由于我国聚酯产业发展迅速,极大的推动了对乙二醇的需求.碳一化工路线以资源丰富、价格便宜的天然气或煤为原料合成乙二醇,有着诱人的工业化前景.综述了以合成气为原料合成乙二醇的研究进展,包括合成气直接合成法、甲醛羰化法、CO偶联法、甲醛氢甲酰化法以及甲醛缩合法等.     

New catalysts for the polymerization of cyclic olefins

Various routes to high T_g thermoplastic materials based on the Ziegler-Natta catalyzed polymerization of norbornene-type monomers are described. These routes involve both ring-opening metathesis polymerization (ROMP) and addition polymerization. New catalysts, and a new catalytically-active metal (cobalt), for both ROMP and the addition homopolymerization of norbornene-type monomers are reported.     

Novel Synthesis of (+/−)-cis-4-Amino-2-cyclopentene-1-methanol,a Key Intermediate in the Preparation of Carbocyclic 2′,3′-Didehydro-2′,3′-dideoxy Nucleosides

Abstract

Novel synthetic routes directed toward the preparation of (+/?)-cis -4-amino-2-cyclopentene-1-methanol are described. The routes investigated involve azide openings of chiral and non-chiral cyclopentyl epoxides.     

Design and elaboration of colloidal molecules: an overview

The concept of colloidal molecules was first evoked by van Blaaderen in 2003 for describing small non-spherical colloids made of the aggregation of a small number of particles. He predicted original properties to the complex assemblies of such colloids, in particular in optics. This critical review deals with the different strategies reported for creating robust clusters of spherical particles which could mimic the space-filling models of simple conventional molecules. These routes concern either the controlled clustering of preformed colloids directed by coalescence, physical routes, chemical routes, or 2-D/3-D geometrical confinement, or strategies starting from a single colloid which is decorated by satellite colloids by taking advantage of controlled phase separation or nucleation and growth phenomena. These routes are compared from the viewpoint of the accessible shapes, their tunability and scalability (146 references).     

Synthetic Approaches to α-, β-, γ-, and δ-Lycoranes

Lycorane is a pentacyclic core presented in alkaloids isolated from the Amaryllidaceae family of herbaceous flowering plants. Members of this class of natural products have shown to display important biological properties including analgesic, antiviral, and antiproliferative activities. This review presents the known synthetic routes toward α-, β-, γ-, and δ-lycoranes. α-(19 routes), β-(10 routes), γ-(38 routes), and δ-(6 routes).