Three new C_(19)-diterpenoid alkaloids from Delphinium laxicymosum var. pilostachyum

Three new lycoctonine-type C19-diterpenoid alkaloids, laxicymine 1, laxicymisine 2, and laxicyminine 3 have been isolated from the whole herb of Delphinium laxicymosum var. pilostachyum W.T. Wang. Their structures were established by spectra data.     

Two new C19-diterpenoid alkaloids from Aconitum hemsleyanium var. circinacum

Two new C19-diterpenoid alkaloids, circinadines A (1) and B (2), were isolated from the roots of Aconitum hemsleyanium var. circinacum. Their structures were elucidated by chemical evidence and spectral analyses, including ESI-MS, HR-EI-MS, 1D- and 2D-NMR.     

Three new C_(20)-diterpenoid alkaloids from Delphinium anthriscifolium var.savatieri

Three new C20-diterpenoid alkaloids, designated as anthriscifolmines A-C (1-3), together with two known alkaloids denudatine and delgramine, were isolated from the whole herb of Delphinium anthriscifolium var. savatieri. The structures of these new alkaloids were elucidated on the basis of spectral data.     

Two novel aconane-type diterpenes derived from C-nor-C_(19)-diterpenoid alkaloid

Two novel C-nor-B-homo aconane-type diterpenes 4 and 5.featuring a unique eight-membered ring system,were obtained by the treatment of C-nor-C19-diterpenoid alkaloid 3 with HNO2 in 8%and 21%yields,respectively.Structures of these two compounds were established based on the combination of spectroscopic data,including HRESIMS,1D and 2D NMR data.A plausible mechanism for the formation of 4 and 5 is also presented.     

Two new C18-norditerpenoid alkaloids from Aconitum delavayi

Further phytochemical investigation of the unique C18-norditerpenoid alkaloids from the roots of Aconitum delavayi Franch ledto the isolation of two new norditerpenoid alkaloids,delavaconitine F 1 and delavaconitine G 2.Their structures were determinedfrom spectroscopic evidence.     

A new C<Subscript>19</Subscript>-diterpenoid alkaloid,habaenine C,from <Emphasis Type="Italic">Aconitum habaense</Emphasis>

A new C₁₉-diterpenoid alkaloid, habaenine C (1), together with the two known compounds vilmorrianine C and crassicauline A, were isolated from Aconitum habaense. The structure of the new compound was elucidated on the basis of spectral analysis, including 2D NMR spectroscopy. Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 265–266, May–June, 2008.     

New C19-diterpenoid alkaloids from the parent roots of Aconitum carmichaelii

Aconitum carmichaelii is a widely used traditional Chinese medicine and important source of clinical drugs. The parent roots of A. carmichaelii were investigated resulting in the isolation and identification of five new C₁₉-diterpenoid alkaloids; 14α-benzoyloxy-N-ethyl-15α-hydroxy-1α,6α,8β,16β,18-pentamethoxyaconitane formate (1), 14α-benzoyloxy-8β-butoxy-N-ethyl-13β,15α-dihydroxy-1α,6α,16β,18-tetramethoxyaconitane formate (2), 14α-benzoyloxy-8β-butoxy-N-ethyl-3α,13β,15α-trihydroxy-1α,6α,16β,18-tetramethoxylaconitane (3), 14α-benzoyloxy-8β-butoxy-3α,13β,15α-trihydroxy-1α,6α,16β,18-tetramethoxyl-N-methylaconitane (4) and 8β,14α-dibenzoyloxy-N-ethyl-13β,15α-dihydroxy-1α,6α,16β,18-tetramethoxyaconitane (5).     

C19-二萜生物碱贡乌生的结构研究

毛茛科植物贡嘎乌头 ( Aconitum liljestrandii)具有镇痛、镇静、祛风湿等功效 ,产于我国西藏东部及四川西部 [1] .我们从其块根中分得 1 8个单体 ,其中 1 6个为已知生物碱 [2 ,3] ,2个为新生物碱 [3] .本文报道新的 C19-二萜生物碱贡乌生 ( Liljestrandisine) 1的结构 .1　实验部分1 .1　仪器与试剂　 Boetius微量熔点测定仪 ;Nicolet FTIR2 0 0 SXV型红外光谱仪 ,KBr压片 ;BrukerAC- E2 0 0和 Varian Unity INOVA40 0 /5 4核磁共振仪 ,溶剂为 CDCl3,TMS为内标 ;VG Autospec30 0 0型和 VG70 A型质谱仪 ;Pekin Polarimete…     

Four new diterpenoid alkaloids with antitumor effect from Aconitum nagarum var. heterotrichum

Four new diterpenoid alkaloids,nagaconitines A-D(1-4),were isolated from the roots of Aconitum nagarum var.heterotrichum.Their structures were elucidated as 8-(4'-hydroxylbutyryl) aconitine(1),15-oxo-13-deoxyludaconitine(2),15-hydroxyldelphisine(3),and 14-hydroxyl-2- acetoxyspiradine C(4)based on extensive UV,IR,MS,1D NMR and 2D NMR analyses.Compounds 3-4 showed inhibition of cancer cell line SK-OV-3 with 31%(IC_(50) 43.78 μmol/L) and 24%(IC_(50) 32.14 μmol/L),respectively.     

天然产C19-二萜生物碱的单晶X-射线衍射分析

本文综述了2002年以前45个天然产C19-二萜生物碱的单晶X-射线衍射分析结果及其结构特点。     

Two New C19‐Diterpenoid Alkaloids with Anti‐inflammatory Activity from Aconitum iochanicum

Two new C₁₉ ‐diterpenoid alkaloids, 7,8‐epoxy‐franchetine ( 1 ) and N(19)‐en‐austroconitine A ( 2 ), were isolated from Aconitum iochanicum . Compound 1 was a new C₁₉ ‐diterpenoid alkaloid with a 7,8‐epoxy unit. Their structures were elucidated by comprehensive spectroscopic analyses including UV , IR , MS , 1D and 2D NMR . Biological activity tests indicated that two new compounds exhibited inhibitory activity against nitric oxide (NO ) production in LPS ‐activated RAW264 .7 macrophages. Compared with positive control, the two new compounds showed weak anti‐inflammatory effects with the inhibition rate of 27.3% and 29.2%, respectively.     

Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii

Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons, named aconidenusulfonine A (1) and 12,16-secoaconidenusulfonine A (2), respectively, were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii (“Fu Zi”). The structures of 1 and 2, representing the first two C₂₁-diterpenoid alkaloids from nature, were determined by analysis of various spectroscopic data and chemical transformation, of which 1 was further proved by single-crystal X-ray diffraction. Especially, 1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi.     

Diterpenoid Alkaloids from Aconitum racemulosum Franch var. pengzhouense

FromthewholeplantsofAconitumracemulosumFranchvar.pengzhounense,wehaveisolatedanewditerpenoidalkaloidracemulodinel,togetherwithatisinumhydrochloride,isotalatizidine,nevadenine,virescenine,14-acetylvirescenineandanthranoyllycoctonine'.Inthispaper,wereportthestructuralelucidationofthenewditerpenoidalkaloidracemulodine1.Racemulodine12wasisolatedascolorlessneedles,anditsmolecularformula,C,,H=,NO.,inferredfromitsMSand13CNMRspectra.TheiRandNMRspectraofIrevealedthatitbelongstothehetidine-typedi…     

A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang

A new denudatine-type C₂₀-diterpenoid alkaloid, designated as sinchianine (1), together with eight known diterpenoid alkaloids, 12-acetyl-12-epi-napelline (2), 12-epi-napelline (3), neoline (4), talatisamine (5), 14-O-acetylsenbusine A (6) and benzoylaconine (7), songorine (8) and aconitine (9), were isolated from the whole herb of Aconitum sinchiangense W. T. Wang. Their structures were elucidated on the basis of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature.     

两个特殊骨架的C_(20)－二萜生物碱的全部~1H(~(13)C)核磁共振信号指定

两个具有特殊骨架的C_(20)-二萜生物碱北乌灵（kusnezoline）和峨翠灵（ omeieline）分别分自中国特产毛茛科植物北草乌（Aconitum hkusnezoffii Paritz）、彭州岩乌头（A. racemulosum var. pengzhouense）和峨眉翠雀花（ Delphinium omeiense W. T. Wang）。应用2D NMR技术(~1H-~1H COSY, HMQC, HMBC, NOESY)全面归属了这两个生物碱的~1H和~(13)C信号的化学位移。     

Puberunine and puberudine, two new C18-diterpenoid alkaloids from Aconitum barbatum var. puberulum

Two C(18)-diterpenoid alkaloids, puberunine (1) and puberudine (2), together with four other new alkaloids, including the first examples having β-oriented substitution at C-3 and a rare chloro-substituent were isolated from Aconitum barbatum var. puberulum. Their structures were elucidated by spectroscopic methods. Puberunine and puberudine, which possess a unique rearranged E ring and an opened A ring, respectively, represent new subtypes of the C(18)-diterpenoid alkaloids. A plausible biosynthetic pathway of 1 and 2 was proposed.     

New C(19)-diterpenoid alkaloids from the roots of Delphinium potaninii var. jiufengshanense

From the roots of Delphinium potaninii var. jiufengshanense, two new lycoctonine-type C(19)-diterpenoid alkaloids called jiufengdine (1) and jiufengtine (4) have been isolated. The structures of the new alkaloids (1, 4) were established by 1D and 2D NMR spectra.     

Diterpenoid Alkaloids from Aconitum Nagarum var. Lasiandrum

Aconitum species have been used as a traditional chinese medicine having analgesic activity. Several groups 1-3 have studied the components of the roots of Aconitum nagarum var. lasiandrum W.T. Wang. Further chemical investigation of this plant led to isolate two new diterpenoid alkaloids, nagadine 1 and 14-benzoylsachaconitine 2. This type of norditerpenoid alkaloid has not been reported before.Nagadine 1, +43.0 (c, 0.00273, CHCl3), was isolated as white amorphous powder. The HREIMS of …     

Two New C19-Diterpenoid Alkaloids from Delphinium davidii Franch.

Two new C19-diterpenoid alkaloids, davidisines A (1) and B (2) along with thirteen known alkaloids were isolated from the whole herb of Delphinium davidii Franch. Their structures were established by spectral methods, especially 2D NMR techniques.     

Two new steroidal alkaloids from Veratrum nigrum var. ussuriense

<正>Two new steroidal alkaloids,veraussines A(1) and B(2) were isolated from the roots and rhizomes of Veratrum nigrum var.ussuriense.Their structures were determined as N-(ethoxycarbonyl)- 1α,2β,3α,15α-tetrahydroxy-5β-jervanin- 12-en- 11-one(1) andN-(methoxycarbonyl)- 1α,2β,3α,15α-tetrahydroxy-5β-jervanin- 12-en- 11 -one(2) by spectroscopic analysis.