前、后路手术治疗颈脊髓损伤的效果比较

目的比较前、后路手术治疗颈脊髓损伤的临床效果。方法选取78例颈脊髓损伤患者,抽签随机分为两组,其中39例采用前路手术治疗患者记为前路术组,另外39例采用后路手术治疗记为后路术组,观察两组手术相关指标并结合术后有效随访比较治疗综合效果。结果前路术组手术时间(75.4±10.2)min、术中出血量(206.3±31.5)m L较后路术组明显较低,术后1年颈椎功能JOA评分(14.4±1.8)分较后路术组显著较高(P0.05);前路术组不良结果发生率5.13%较后路术组低(P0.05)。结论同后路手术相比,前路手术具有手术时间短、术中出血量少的特点,且能有效减少术后不良结果的发生,对病情康复和改善预后具有重要意义。     

康复综合治疗颈椎病116例

用多种康复手段综合治疗１１６例颈椎病，疗效令人满意。     

脊髓损伤修复再生支架材料研究进展

综述了近几年用于脊髓损伤修复的支架材料,包括可注射水凝胶和预制成型用天然聚合物、去细胞基质以及合成材料,并分析了材料种类、制备技术以及体内外应用现状与发展趋势。     

功能高分子材料促进脊髓损伤后再生修复的研究进展

脊髓损伤后损伤区域神经纤维束的破坏,导致损伤区域以下长久的感觉和运动功能丧失.损伤区域恶劣的微环境是脊髓损伤难以修复的一大问题,大量的炎症细胞聚集、细胞死亡、抑制因子的分泌等,进一步导致损伤区域神经细胞的二次死亡、胶质细胞过度增生、胶原纤维沉积等.不利的微环境不仅限制轴突的再生,同时损伤神经干细胞的功能,不利于神经干细...     

脊髓损伤模型中胞外抗坏血酸浓度的活体在线分析

利用活体微透析技术结合在线高选择性抗坏血酸电化学检测技术,以实验性胸10节段脊髓钳夹损伤为动物模型,研究了脊髓损伤过程中胞外抗坏血酸的变化规律.结果表明,微透析探针植入及钳夹损伤瞬间,均存在脊髓抗坏血酸浓度高峰,随后浓度回到稳定水平,对照组大鼠脊髓细胞外液中抗坏血酸的平均基础浓度为(26.17±1.25)μmol/L(n=8).实验组脊髓钳夹损伤后,胞外抗坏血酸水平显著增加,达到(53.24±1.95)μmol/L(n=8),这种显著性升高可能与继发性脊髓损伤保护机制导致胞内抗坏血酸外流相关.本研究结果为抗坏血酸参与调节继发性脊髓损伤提供了直接的实验证据.     

脑卒中综合治疗与康复48例报告

对４８例脑卒中患者的综合治疗及康复情况进行了观察和研究。治疗结果表明，通过正规、系统的综合治疗３￣６个月后，４７例有不同程度疗效。还对治疗方法进行了讨论。     

磁共振TSE-DWI序列表观扩散系数对急性脊髓损伤的诊断价值

本文探讨磁共振TSE-DWI序列表观扩散系数(ADC)在急性脊髓损伤诊断中的价值.选取68例急性脊髓损伤患者作为观察组,其中轻中度损伤40例、重度损伤28例,同时选取体检健康者50例作为对照组,均给予TSE-DWI序列扫描.观察组与对照组比较,病变部位ADC值明显低于正常部位(P＜0.05).观察组重度损伤患者病变部位...     

脑卒中的早期中西医结合康复治疗

通过观察脑卒中患者的神经功能缺损积分,日常生活活动能力、生存质量,以探讨早期中西医结合康复治疗脑卒中的临床疗效。     

中西医结合治愈脊髓蛛网膜炎1例

用中西医结合治疗脊髓蛛网膜炎1例,取得满意效果,并总结了治疗体会。     

脑卒中临床治疗康复ADL的应用

介绍了日常生活活动在脑卒中临床治疗和康复中中的应秀，提出了评价ＡＤＬ的注意事项的对ＡＤＬ恢复的影响因素的认识。     

Neuroactive Peptide Nanofibers for Regeneration of Spinal Cord after Injury

The highly complex nature of spinal cord injuries (SCIs) requires design of novel biomaterials that can stimulate cellular regeneration and functional recovery. Promising SCI treatments use biomaterial scaffolds, which provide bioactive cues to the cells in order to trigger neural regeneration in the spinal cord. In this work, the use of peptide nanofibers is demonstrated, presenting protein binding and cellular adhesion epitopes in a rat model of SCI. The self‐assembling peptide molecules are designed to form nanofibers, which display heparan sulfate mimetic and laminin mimetic epitopes to the cells in the spinal cord. These neuroactive nanofibers are found to support adhesion and viability of dorsal root ganglion neurons as well as neurite outgrowth in vitro and enhance tissue integrity after 6 weeks of injury in vivo. Treatment with the peptide nanofiber scaffolds also show significant behavioral improvement. These results demonstrate that it is possible to facilitate regeneration especially in the white matter of the spinal cord, which is usually damaged during the accidents using bioactive 3D nanostructures displaying high densities of laminin and heparan sulfate‐mimetic epitopes on their surfaces.     

A Perspective: Electrospun Fibers for Repairing Spinal Cord Injury

Patients with spinal cord injury(SCI) are suffering disability and accompanying complications. Due to the complex biological processes and inhibitory microenvironment after SCI, advances in clinical treatment show obvious limitations for achieving a successful repair. Herein, we summarize recent advances in engineering strategies of using electrospun nanofibers to promote the neural regeneration and functional recovery after SCI. We firstly introduce the pathological mechanism of SCI and thus point out the challenges on the regeneration of the nerve. We then discuss the regenerative approaches by combining electrospun nanofibrous scaffolds with physical cues, biochemical cues(e.g., cells, growth factors and other biomolecules), external stimuli, and supporting materials filling in the inner lumen of the scaffolds. All these strategies have indicated their potentials to enhance the efficacy of repairing the SCI. At last, we provide a perspective on the future direction for designing the electrospun nanofibrous scaffolds in combination with imaging systems to realize the in-situ monitoring of regeneration progress for further improving the treatment outcome.     

Evaluation of Traumatic Spinal Cord Injury in a Rat Model Using 99mTc-GA-5 as a Potential In Vivo Tracer

Spinal cord injury (SCI) refers to the damage suffered in the spinal cord by any trauma or pathology. The purpose of this work was to determine whether ^99mTc-GA-5, a radiotracer targeting Glial Fibrillary Acidic Protein (GFAP), can reveal in vivo the reactivation of astrocytes in a murine model with SCI. A method for the ^99mTc radiolabeling of the mouse anti-GFAP monoclonal antibody GA-5 was implemented. Radiochemical characterization was performed, and radioimmunohistochemistry assays were used to evaluate the integrity of ^99mTc-GA-5. MicroSPECT/CT was used for in vivo imaging to trace SCI in the rats. No alterations in the GA-5’s recognition/specificity ability were observed after the radiolabeling. The GA-5’s radiolabeling procedure implemented in this work offers a practical method to allow the in vivo following of this monoclonal antibody to evaluate its biodistribution and specificity for GFAP receptors using SPECT/CT molecular imaging.     

中医养生理论对脑卒中恢复期患者康复效果的研究

目的对脑卒中恢复期患者行中医养生理论护理,观察康复效果。方法择取佛山市禅城区中心医院于2015年1月—2016年5月期间收治的脑卒中恢复期患者102例,参考随机双盲法,将患者划分为研究组与对照组,每组各51例。对照组患者接受常规护理干预,研究组患者接受常规护理干预+中医养生理论护理,比较两组患者的康复效果。结果研究组患者的NIHSS评分、FIM评分以及健康状况评分均显著优于对照组,即相应数据比较,组间差异统计学意义具有显著性(P0.05)。结论对脑卒中恢复期患者行中医养生理论护理,可以改善患者的健康状况,促进患者恢复,进而优化患者生存质量,值得临床推广与应用。