Si-OSO3H catalyzed one-pot three-component synthesis of 1,3-oxazines

A simple and an efficient method for the synthesis of six membered nitrogen containing heterocyclic compounds—1,3-oxazines from diethyl acetylene dicarboxylate, substituted anilines or amines and formaldehyde is reported. A versatile, economical and eco-friendly heterogeneous reagent silica sulfuric acid (Si-OSO₃H) is used as a catalyst for this reaction.     

Tungstate sulfuric acid catalyzed one-pot synthesis of a new class of aroylamido coumarins under solvent-free conditions

A one-pot synthesis of novel aroylamido coumarins from the reaction of 4-hydroxycoumarin with aryl glyoxals and benzamides in the presence of a catalytic amount of tungstate sulfuric acid (TSA) is described. The method is operationally simple and provides access to a variety of aroylamido coumarins in good yields.     

Enantioselective one-pot three-component synthesis of propargylamines

[reaction: see text] A copper(I) complex of i-Pr-pybox-diPh has been found to be an efficient catalyst for an enantioselective one-pot three-component synthesis of propargylamines from aldehydes, amines, and alkynes. The reaction has been applied to a wide variety of aromatic aldehydes with excellent yields (up to 99%) and enantiomeric excesses (up to 99% ee). A transition-state model has been proposed to explain the stereochemical outcome of the reaction.     

Copper-catalyzed three-component one-pot synthesis of quinazolines

Two efficient approaches to multi-substituted quinazolines by the three-component one-pot reaction of o-bromo aromatic ketones/aldehydes, ammonia water and aromatic aldehydes, or primary alcohols catalyzed by CuCl have been developed.     

Cellulose sulfuric acid as a bio-supported and recyclable solid acid catalyst for the one-pot synthesis of 2,4,5-triarylimidazoles under microwave irradiation

Abstract

A simple, rapid, and highly efficient method has been attempted for the three-component condensation of benzil/benzoin, aldehydes, and ammonium acetate under microwave irradiation in the presence of a catalytic amount of bio-supported cellulose sulfuric acid under solvent-free conditions to afford the 2,4,5-triarylimidazole derivatives. The catalyst is easily prepared, inexpensive, separated simply by filtration, gives excellent yield of products with shorter reaction times, and is recyclable several times.     

Baker’s yeast catalyzed one-pot three-component synthesis of polyfunctionalized 4H-pyrans

Baker’s yeast catalyzed one-pot three-component cyclocondensation of aryl aldehydes, malononitrile, and β-dicarbonyls in organic medium has been carried out to obtain polyfunctionalized 4H-pyrans. The reaction has been carried out at room temperature in organic solvent, dimethylacetamide and the products obtained in good to moderate yields with simple work up procedure.     

Rhodium catalyzed three-component reaction of aldehyde,boronic acid,and sulfonamides: a facile one-pot synthesis of diarylmethylamines

Rhodium(I) catalyzed three-component reaction for the one pot synthesis of diarylmethylamines in excellent yields were achieved by using aldehyde, boronic acid, and sulfonamides. The use of hyper-valent bis(trifluoroacetoxy)iodobenzene as an additive plays a key role in the chemo selective formation of amines instead of alcohols.     

Nickel chloride-catalyzed one-pot three-component synthesis of pyrazolophthalazinyl spirooxindoles

A direct and efficient approach for the preparation of pyrazolophthalazinyl spirooxindoles has been developed through one-pot three-component reaction of easily available isatin, malononitrile or cyanoacetic ester, and phthalhydrazide catalyzed by nickel chloride in polyethylene glycol 600. Desired products were obtained in high to excellent yields using a simple workup procedure.     

Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by silica sulfuric acid

2-Substituted benzothiazoles have been synthesized via one-pot reaction from aromatic aldehydes and o-aminothiophenol catalyzed by silica sulfuric acid in absolute methanol at room temperature. The remarkable advantages offered by this method are an environmentally friendly and reusable catalyst, a simple procedure, mild conditions, short reaction times, and good to excellent yields of products.     

Stereoselective one-pot, three-component synthesis of 4-amidotetrahydropyran

The reaction of aldehyde with allylsilane in acetonitrile mediated by boron trifluoride etherate generated 4-aminotetrahydropyrans in good yields. The product is highly stereoselective.     

Novel isocyanide-based three-component one-pot synthesis of cyanophenylamino-acetamide derivatives

A one-pot multicomponent synthesis of a novel class of cyanophenylamino-acetamides through the conversion of primary amides to the corresponding nitriles, starting from simple and readily available inputs including 2-aminobenzamide, an aldehyde, and an isocyanide in the presence of p-toluenesulfonic acid as a catalyst, in excellent yields at room temperature in ethanol as a green reaction medium is described.     

AcOH catalyzed three-component synthesis of spirooxindole derivatives

An efficient one-pot synthesis of hereto unknown indenoquinoline-spirooxindole derivatives by a three-component reaction of isatins, indan-1,3-dione, and 3-aminocyclohex-2-enone under the catalysis of acetic acid was developed. The procedure had the advantages of simplicity and efficiency.     

Solvent-free synthesis of dihydropyrimidinones catalyzed by alumina sulfuric acid at room temperature

A simple, efficient and practical procedure for the Biginelli reaction using alumina sulfuric acid (ASA) as a novel acid catalyst is described under solvent-free conditions. The catalyst exhibited remarkable reactivity at room temperature. The method offers several advantages including high yields, environmentally friendly procedure, short reaction times and simple work up procedure.     

A one-pot, three-component synthesis of thiazolidine-2-thiones

An efficient method for the synthesis of thiazolidine-2-thiones is described via regiospecific iodocyclization of an allyl amine, carbon disulfide, and iodine. Dehydrohalogenation of the iodo-derivatives gives thiazole-2(3H)-thiones. In addition, nucleophilic substitution of the iodine in the products is accomplished using NaN₃, thiophenol, or dithiocarbamate.     

Iodine-catalyzed three-component one-pot synthesis of naphthopyranopyrimidines under solvent-free conditions

Iodine is found to be a highly efficient catalyst for the three-component coupling (3CC) of aldehydes, β-naphthol, and 1,3-dimethylbarbituric acid under solvent-free conditions to afford the corresponding 8,10-dimethyl-12-aryl-12H-naphtho[1′,2′5,6]pyrano[2,3-d]pyrimidine-9,11-diones in good yields with high selectivity. The use of readily available iodine makes this method very simple, convenient, and cost-effective.     

Aqua one-pot,three-component synthesis of dihydropyrano[3,2-c]chromenes and amino-benzochromenes catalyzed by sodium malonate

Research on Chemical Intermediates - The widespread biological properties of dihydropyrano[3,2-c]chromenes, 2-amino-4-aryl-4H-benzo[h]chromenes, and 3-amino-1-aryl-1H-benzo[f]chromenes have led to...     

Consecutive condensation, C-N and N-N bond formations: a copper- catalyzed one-pot three-component synthesis of 2H-indazole

2H-Indazoles are synthesized using copper-catalyzed, one-pot, three-component reactions of 2-bromobenzaldehydes, primary amines, and sodium azide. A copper catalyst plays the key role in the formation of C-N and N-N bonds. This method has a broad substrate scope with a high tolerance for a variety of functional groups.     

Nano-sphere silica sulfuric acid: novel and efficient catalyst in the one-pot multi-component synthesis

In this report, synthesis, characterization and application of nano-sphere silica sulfuric acid as a novel and heterogeneous catalyst for the synthesis of β-acetamido ketone derivatives at room temperature are described. The catalyst has been identified using various techniques (XRD, SEM, TEM, EDX, TGA, FT-IR), and results show that it has a spherical shape and its particle size is between 60 and 90 nm.