非线性声参量成像及其在医学诊断中应用

本文介绍了我们对于反射模式非线性参量B／A的成像技术的研究结果，包括：(1)基于二次谐波的非线性参量层析成像(2)基于参量阵差频波的非线性参量层析成像(3)非线性参量的等深度C-扫成像。利用这三种成像方法对多种生物组织，特别对正常和病变的生物组织进行非线性参量成像。结果表明，非线性声参量成像可以比线性声参量更容易地判别生物组织的病理状态，从而展示了它在医学超声诊断中的应用前景。     

Testing for inhomogeneity of the nonlinear parameter in an acoustic medium by ultrasonic phase conjugation

The principle of applying a selective phase conjugation of the second harmonic of a focused ultrasonic wave to diagnosing inhomogeneity of the nonlinear parameter in an acoustic medium is considered. A solution to the three-dimensional problem of harmonic generation by phase-conjugated waves in a nonlinear medium with a localized isoechogenous inclusion is obtained. The signal amplitudes detected by a transmitting-receiving transducer at the second and forth harmonics of a probe wave are calculated for varying position of the inclusion relative to the focus.     

Study of acoustic nonlinearity parameter imaging methods in reflection mode for biological tissues

Three novel methods for acoustic nonlinearity parameter B/A imaging in reflection mode are developed in this paper. They are: (1) the acoustic nonlinearity parameter B/A tomography by detecting reflective second harmonic wave, (2) the B/A tomography in reflection mode via the measurement of the difference frequency wave generated by a parametric array, and (3) the C-scan imaging of B/A via the measurement of the echo second-harmonic signal. A theoretical analysis and the experimental imaging of normal and pathological biological tissues by using these methods are also present and discussed. Results show that using the acoustic nonlinearity parameter imaging we can more easily distinguish the diseased tissue from the normal one than using the linear acoustic parameters.     

Acoustic nonlinearity parameter tomography for biological tissues via parametric array from a circular piston source--theoretical analysis and computer simulations

The acoustic nonlinearity parameter B/A describes the nonlinear features of a medium and may become a novel parameter for ultrasonic tissue characterization. This paper presents a theoretical analysis for acoustic nonlinear parameter tomography via a parametric array. As two primary waves of different frequencies are radiated simultaneously from a circular piston source, a secondary wave at the difference frequency is generated due to the nonlinear interaction of the primary waves. The axial and radial distributions of sound pressure amplitude for the generated difference frequency wave in the near field are calculated by a superposition of Gaussian beams. The calculated results indicated that the difference frequency component of the parametric array grows linearly with distance from the piston source. It therefore provides a better source to do the acoustic nonlinearity parameter tomography because the fundamental and second harmonic signals both have a near field that goes through many oscillations due to diffraction. By using a finite-amplitude insert substitution method and a filtered convolution algorithm, a computer simulation for B/A tomography from the calculated sound pressure of the difference frequency wave is studied. For biological tissues, the sound attenuation is considered and compensated in the image reconstruction. Nonlinear parameter computed tomography (CT) images for several biological sample models are obtained with quite good quality in this study.     

一维非线性声波传播特性

针对一维非线性声波的传播问题进行了有限元仿真和实验研究. 首先推导了一维非线性声波方程的有限元形式, 含有高阶矩阵的非线性项导致声波具有波形畸变、谐波滋生、基频信号能量向高次谐波传递等非线性特性. 编制有限元程序对一维非线性声波进行了计算并对仿真得到的畸变非线性声波信号进行处理, 分析其传播性质和物理意义. 为验证有限元计算结果, 开展了水中的非线性声波传播的实验研究, 得到了不同输入信号幅度激励下和不同传播距离的畸变非线性声波信号. 然后对基波和二次谐波的传播性质进行详细讨论, 分析了二次谐波幅度与传播距离和输入信号幅度的变化关系及其意义, 拟合出二次谐波幅度随传播距离变化的方程并阐述了拟合方程的物理意义. 结果表明, 数值仿真信号及其频谱均与实验结果有较好的一致性, 证实计算方法和结果的正确性, 并提出了具有一定物理意义的二次谐波随传播距离变化的简单数学关系. 最后还对固体中的非线性声波传播性质进行了初步探讨. 本研究工作可为流体介质中的非线性声传播问题提供理论和实验依据.     

Nonlinear imaging of isoechogenic phantoms using phase conjugation of the second acoustic harmonic

Experiments on nonlinear C-scan acoustic imaging were performed using phase conjugation of the second harmonic of a focused incident beam. This method made it possible to obtain images of objects with close linear properties but with different nonlinear parameters. Nonlinear backward propagation of the conjugate wave was also considered and improvement of the image contrast was demonstrated for this case. The results obtained were generally in agreement with the theoretical predictions.     

非线性声波方程二次谐波高阶近似解及实验验证

非线性声波方程的传统二次谐波二阶近似解不够精确,对测量材料的非线性系数造成较大误差.利用摄动法展开非线性声波方程得到一系列非齐次偏微分方程,根据低阶解的性质拟定高阶特解的形式,通过符号计算求出高次谐波特解,对所有二次谐波成分求和最终获得二次谐波的高阶近似解.在水中开展非线性声学实验验证高阶近似解,结果表明:二次谐波相对...     

应用角谱方法研究聚焦声束在层状生物组织中的非线性声传播

应用角谱方法理论研究了聚焦声束在层状生物组织中的非线性传播特性，将声波分解为角谱，可计算垂直于声轴的任意平面的非线性声场。在圆形平面活塞聚焦换能器的焦区中插入多种生物组织样品，数值计算了样品内部及外部的二次谐波声场，并通过实验测量验证了理论方法的有效性。基于快速傅氏变换的角谱方法可直观地描述非线性声传播，对非线性声成像有指导作用。     

Diagnostics of elastic properties of a planar interface between two rough media using surface acoustic waves

The results of experimental studies on the nonlinear elastic properties of a planar interface between two media are presented—an optically polished glass substrate and flat samples with different degrees of roughness. The nonlinear elastic properties of the interfaces between two media were investigated by the spectral method using surface acoustic waves (SAWs). The effect of external pressure applied to the interface on the efficiency of the generation of the second SAW harmonic was studied. Using the measured amplitudes of the first and second harmonics of the SAW that passes along the interface, the second-order nonlinear acoustic parameter was calculated as a function of the external pressure applied to the sample at a fixed amplitude of a probing wave. It was revealed that the nonlinear parameter of the SAW is a nonmonotonic function of the pressure at the boundary. The results were analyzed on the basis of an elastic contact nonlinearity, and it is concluded that these results can be used in nondestructive testing for roughness and waviness of surfaces of flat solids.     

Nonlinear acoustic properties of the B95 aluminum alloy and the B95/nanodiamond composite

Research results for the nonlinear acoustic properties of the B95 polycrystalline aluminum alloy and the B95/nanodiamond composite have been described. The nonlinear properties of the alloys have been studied by the spectral method that measures the efficiency of generation of the second harmonic of a bulk acoustic wave at a frequency of 2f = 10 MHz in the field of a finite-amplitude longitudinal acoustic wave at a frequency of f = 5 MHz. The results derived by this method have been compared with the results of studies of the nonlinear acoustic properties of the test alloys using the Thurston–Brugger quasi-static method.     

PARAMETRIC SIMULTONS IN ONE-DIMENSIONAL NONLINEAR LATTICES

Parametric simultaneous solitary wave (simulton) excitations are shown to be possible in nonlinear lattices. Taking a one-dimensional diatomic lattice with a cubic potential as an example, we consider the nonlinear coupling between the upper cut-off mode of acoustic branch (as a fundamental wave) and the upper cut-off mode of optical branch (as a second harmonic wave). Based on a quasi-discreteness approach the Karamzin－Sukhorukov equations for two slowly varying amplitudes of the fundamental and the second harmonic waves in the lattice are derived when the condition of second harmonic generation is satisfied. The lattice simulton solutions are given explicitly and the results show that these lattice simultons can be nonpropagating when the wave vectors of the fundamental wave and the second harmonic waves are exactly at π/a (where a is the lattice constant) and zero, respectively.     

非线性有限束光声效应理论

当一束受正弦调制的激光入射于光声腔中的固体样品上时,由于非线性的光声效应,在光声腔中不仅能接收到基频成份的声信号,还能接收到其二次谐波成份。本文提出一个非线性热波束方程及其相应的非线性边界条件。借助于逐步近似法在光源为高斯径向分布的情形下,求解这一方程。利用Hankel变换获得这一方程的一级与二级近似解。解析结果表明,二次谐波的热波束仍然维持高斯径向分布,而其高斯半径比基频成份小。分析还表明,二次谐波的振幅不仅与线性热参数,而且也与非线性热参数有关。后者或许能提供样品的更多的有意义的信息。综合其各种特点, 关键词：     

Contrast harmonic imaging

The behavior of ultrasound contrast agents depends highly on the acoustic pressure of the insonified ultrasound wave. For low pressure the expansion and compression is linear to the pressure, for medium acoustic pressure nonlinear behavior starts to occur and for high pressures, but still in the diagnostic range transient scattering can be noticed, resulting in an enhanced scattering followed by a disappearance of the bubble. The nonlinear and transient regime can be utilized for imaging of the contrast agent in or nearby tissue. The magnitude of the nonlinear signal from the contrast has to compete with the nonlinear component of the ultrasound wave, which is generated during propagation. It is shown that contrast is superior to tissue when using low frequencies and imaging the third or fourth harmonic of the transmitted frequency.     

Second Harmonic Generation of Lamb Wave in Numerical Perspective

The influences of phase and group velocity matching on cumulative second harmonic generation of Lamb waves are investigated in numerical perspective.Finite element simulations of nonlinear Lamb wave propagation are performed for Lamb wave mode pairs with exact and approximate phase velocity matching,with and without group velocity matching,respectively.The evolution of time-domain second harmonic Lamb waves is analyzed with the propagation distance.The amplitudes of primary and second harmonic waves are calculated to characterize the acoustic nonlinearity.The results verify that phase velocity matching is necessary for generation of the cumulative second harmonic Lamb wave in numerical perspective,while group velocity matching is demonstrated to not be a necessary condition.     

Second harmonic wave generation from Joule heating in layered organic conductors

The amplitude of a second harmonic wave (SHW) generated from Joule heating as a heat source in organic conductor β-(BEDT-TTF)₂IBr₂ is analyzed as a function of the magnetic field strength and its orientation with respect to the plane of the layers. Angular oscillations of the SHW amplitude are correlated with the angular changes of in-plane conductivity that arise from the periodic dependence of charge carriers velocity on the field orientation. It was found that the nonlinear effect of wave generation leads to a shift between the position of the peaks of the wave amplitude and in-plane conductivity. This allows an important information on the parameter values of organic conductors as well as wave velocity to be obtained. Magnetic field dependence shows that the wave is not strongly attenuated with increasing field and might give insights on the interactions between the electromagnetic, temperature and acoustic oscillations. We found that these observations are completely different compared to those of linear acoustic wave generation. It has been shown that the necessary conditions for observing the nonlinear acoustic wave generation are fulfilled in a wide range of fields and angles that allow the acoustic properties of organic conductors to be studied in detail.     

Experimental and theoretical study of harmonic generation at contacting interface

The second harmonic generation behavior of a contacting interface has been evaluated experimentally and discussed theoretically in the light of a nonlinear interface model. Two aluminum blocks were mated together to constitute a contact interface and subjected to normal compressive loading. A 5 MHz longitudinal toneburst wave was sent to the interface in the normal direction and the transmitted wave was recorded, from which the fundamental and the second harmonic components were extracted. A nonlinearity parameter was obtained as the ratio of the second harmonic amplitude to the squared fundamental amplitude. From the measured contact pressure dependence of the transmitted fundamental amplitude, the linear and the second-order interfacial stiffness parameters were identified, which enabled the evaluation of the nonlinearity parameter based on the theoretical model. The theoretical contact pressure dependence of the nonlinearity parameter was found to be in good qualitative agreement with the experimental results.     

Propagation of acoustic wave in viscoelastic medium permeated with air bubbles

Based on the modification of the radial pulsation equation of an individual bubble, an effective medium method (EMM) is presented for studying propagation of linear and nonlinear longitudinal acoustic waves in viscoelastic medium permeated with air bubbles. A classical theory developed previously by Gaunaurd (Gaunaurd GC and \"{U}berall H, {\em J. Acoust. Soc. Am}., 1978; 63: 1699--1711) is employed to verify the EMM under linear approximation by comparing the dynamic (i.e. frequency-dependent) effective parameters, and an excellent agreement is obtained. The propagation of longitudinal waves is hereby studied in detail. The results illustrate that the nonlinear pulsation of bubbles serves as the source of second harmonic wave and the sound energy has the tendency to be transferred to second harmonic wave. Therefore the sound attenuation and acoustic nonlinearity of the viscoelastic matrix are remarkably enhanced due to the system's resonance induced by the existence of bubbles.     

Intravascular ultrasound tissue harmonic imaging: a simulation study

Recently, the in vivo feasibility of tissue harmonic imaging (THI) with a mechanically-rotated intravascular ultrasound (IVUS) catheter was experimentally demonstrated. To isolate the second harmonic signal content, both pulse inversion (PI) and analog filtering were used. In the present paper, we report the development of a simulation tool to investigate nonlinear IVUS beams and the influence of rotation on the efficiency of PI signal processing. Nonlinear 20 MHz beams were simulated in a homogeneous tissue-mimicking medium, resulting in second harmonic pressure fields at 40 MHz. The acoustic response from tissue was simulated by summing radio-frequency (RF) pulse-echo responses from many point-scatterers. When the transducer was rotated with respect to the point-scatterers, the fundamental frequency suppression using PI degraded rapidly with increasing inter-pulse angles. The results of this study will aid in the optimization of harmonic IVUS imaging systems.     

光学微腔中倍频光场演化和光谱特性

在考虑光学微腔中二阶和三阶非线性效应的情况下,引入了可同时描述腔内基频和倍频光场的演化过程的Lugiato-Lefeve方程,分析了SiN微腔中二次谐波的产生,并讨论了各参数对腔内基频和倍频光场的影响.理论分析结果表明,失谐参量为0时,稳定后的基频光场为平顶脉冲的形式,而倍频光场呈正弦分布;失谐参量增加,将导致腔内基频和倍频光功率在演化过程中出现振荡,且最终稳定的光功率变弱,稳定后的光场分布为周期性变化;失谐参量的值过大,会使得微腔光场处于混沌状态.抽运光强较弱时,腔内可形成稳定的光场分布;抽运光强较强时,会导致腔内色散以及非线性效应过强,最终稳定的光场仍然呈周期性变化,且抽运光功率越强,光功率的演化曲线振荡越强.此外,选取特定的微腔尺寸,微腔可工作于"图灵环"状态.理论分析结果对研究光学微腔中二次谐波的产生有重要意义.     

High-order approximate solution of nonlinear acoustic equation:development and validation

For the nonlinear acoustic wave equation,the commonly used second harmonic solution is not accurate enough,which causes a big error in measuring the material no...