幼儿头发锌、铅含量与身高、体重关系的研究

测定了深圳市南山区486名3岁儿童的身高，体重及其发锌，铅的含量。并对儿童头发锌，铅含量与身高。体重之间的关系进行了分析。结果显示，儿童的身高，体重与发锌含量呈显著的正相关。而与发铅呈显著负相关。证实锌具有促进儿童体格发育的作用。而铅则对体格发育具有妨碍作用。     

厌食与反复呼吸道感染小儿的发锌.铜分析

测定了７５例厌食小儿、１０１例呼吸道感染小儿和１２０例健康儿童发锌、铜，结果表明：厌食儿及易感儿平均发锌值分别为８０．９０×１０－６和７５．７６×１０－６，均极显著低于健康儿（Ｐ＜０．０１）；发铜则无显著差异。发锌值在７０×１０－６以下者有６０％以上身高、体重低于正常标准。说明微量元素锌与小儿食欲、免疫功能和生长发育有密切关系。     

儿童发锌含量差异对血红蛋白及铜代谢的影响

分析测定了３４６名儿童的发锌（Ｚｎ）、发铜（Ｃｕ）含量，从中抽出发锌含量大于１００×１０－６和小于６０×１０－６的两组儿童进行比较，发现高锌儿童的血红蛋白（Ｈｂ）含量显著高于低锌儿童；身高、体重等代表体格发育的指标明显不同，高锌组儿童发育明显优于低锌组．说明发锌含量高低直接影响到儿童造血功能及发育水平．另外高锌组的发铜含量比低锌组低，两组μｕ／Ｚｎ比值有显著性差异，锌的高含量对铜的代谢有一定影响，锌对铜具有拮抗作用．     

微量元素锌促进儿童生长发育临床研究

报道以微量元素锌治疗缺锌患儿１１８例并与１１４例作对照观察．结果发现，衡量生长发育与营养的敏感指标：身高、体重、血清白蛋白及血色素等参数，治疗组比对照组都显著提高（Ｐ值＜０．０１）．证明锌制剂对缺锌儿童有显著的促进生长发育及改善营养状态作用，作者并对锌的作用机理作了论述．     

营养不良儿童与发锌关系的研究

报告７１例６个月至７岁营养不良儿童与对照组１３７例健康儿童的发锌含量研究结果。调查结果表明，营养不良儿童发锌含量差异极其显著．Ｐ＜０．０１，表明微量元素锌对小儿的生长发育有明显的影响，符合文献报道的关于体辞水平与儿童营养不良的身体发育障碍显著相关．为临床应用锌剂综合治疗营养不良疾病提供科学依据。     

铅在人体中的允许量及其与锌的相关性

236名健康人按年龄分6组统计，发铅值（x±S）为8．98×10－6±4．95×10－6~25.66×10－6±14．16×10-6；高锌及低锌儿童共69例的发铅、发锌相关系数r＝-0．2849，呈负相关，P＜0．01。     

含锌冲剂治疗小儿缺锌的临床观察

本文通过含锌冲剂治疗小儿血锌低下２４例．对患儿临床症状改善情况进行比较，发现改善厌食症状有效率达８６．３６％，反应呼吸道感染有效率达９５．２４％．对缺锌组治疗前与正常儿童血铸进行比较．治疗组血锌比正常组明显偏低，Ｐ＜０．００１，其差异有极显著意义．对治疗组治疗前后的血锌等元素进行测定与比较，口服含锌冲剂治疗后，血锌大部分升高，经ｌ检验，Ｐ＜０．００５，其差别有显著意义。而Ｚｎ／Ｃｕ比值在治疗后明显升高，Ｐ＜０．００１，更说明含锌冲剂对调整微量元素有肯定的效果。     

对211例类风湿关节炎患者微量元素的测定

用同位素激发Ｘ射线荧光分析对２１１例类风湿关节炎患者发中１０种常量及微量元素测定，以探索类风湿关节病与微量元素之间的关系．结果表明：全部女性患者发锌含量明显降低，除３０～３９岁及５０～５９岁年龄组Ｐ＜０．０５外，其余各组均Ｐ＜０．０１。而２０～２９岁男性组患者发锌含量也低，Ｐ＜０．０１。男女患者各组发锶含量较对照组均低，且有明显差异（除男性２０～２９岁组及５０￣５９岁组Ｐ＜０．０５，其余各组均ｐ＜０．０１）。提示类风湿关节病患者发中锌、锶含量较正常人低。因此，如临床上补充锌和锶元素，可能是有效治疗类风湿关节病的新途径．     

缺锌对儿童体格发育影响的研究

调查了广州地区１４５例儿童的发锌及体格发育情况。结果表明，１０３例发锌明显低于正常值，占７１％。发锌低者体格发育落后，并有９．８％缺锌者营养不良。揭示了本地区儿童缺锌的普遍性，分析了缺锌的原因，为今后做好防治工作提供依据。     

补锌剂与小儿厌食症的临床研究

从锌是保证小儿生长发育的必需微量元素,与机体生长、发育有密切关系着手,经临床和实验室研究,应用中西药和营养滋补品组方,经科学加工制成适合儿童口味的补锌剂,对148例发锌在100×10－6以下、食量每餐50g以下儿童进行治疗。服用本剂后食量、身高、体重、发锌、血红蛋白均有显著增加,血清免疫球蛋白水平提高,显效137例,有效9例,总有效率达98.60o％。本制剂具有作用快、疗效高、安全等特点,可作小儿厌食症的首选药物。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.