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1.
Mass spectrometric study of the decomposition pathways of canonical amino acids and α‐lactones in the gas phase
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The dissociation pathways of a gas‐phase amino acid with a canonical (non‐zwitterionic) α‐amino acid moiety are studied by using mass spectrometry. Investigation of the canonical amino acid moiety is possible because the ionized amino acid, a sulfonated phenylalanine, has a charge center that is separated from the amino acid, and dissociation occurs by charge‐remote fragmentation. The amino acid is found to dissociate only by loss of NH3 upon collision‐induced dissociation to form a substituted α‐lactone. The dissociation is consistent with what has been observed previously upon pyrolysis of other α‐substituted carboxylic acids. Decarboxylation, which has also been reported previously for amino acid pyrolysis, is not observed, likely because the product would be a high‐energy, ammonium ylide. The resulting α‐lactone is found to undergo dissociation by decarbonylation to give an aldehyde, and by loss of CO2. Decarboxylation is calculated to occur through a transition state involving hydride shift coupled with lactone ring‐opening. The transition state is found to be stabilized by the negative charge, and therefore, decarboxylation is more favorable for anions. The results show that remote ionic groups can be used as mostly inert charge carriers to enable mass spectrometry to be used to investigate the gas‐phase physical and chemical properties of different types of functional groups, including amino acids. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
2.
Javad Jamali‐Paghaleh Ali Reza Harifi‐Mood Mohammad Reza Gholami 《Journal of Physical Organic Chemistry》2011,24(11):1095-1100
Aromatic nucleophilic substitution reaction of 1‐fluoro‐2,4‐dinitrobenzene with para‐substituted and meta‐substituted anilines was kinetically investigated in the mixtures of ethyl acetate and methanol at room temperature. The correlation of second‐order rate coefficients with Hammett's substituent constants yields a fairly linear straight line with negative slope in different mole fractions of ethyl acetate–methanol mixtures. The measured rate coefficients of the reaction demonstrated a dramatic variation in ethyl acetate–methanol mixtures with the increasing mole fraction of ethyl acetate. Linear free energy relationship (LFER) investigations confirm that polarity has a major effect on the reaction rate whereas the hydrogen‐bonding ability of the media has a slight effect on it. Nonlinear free energy relationship based on preferential solvation hypothesis showed differences between the microsphere solvation of the solute and the bulk composition of the solvents, and non‐ideal behavior is observed in the trend of the rate coefficients, which cover the LFER results. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
3.
Atom-dipole interaction model has been used to calculate the molecular polarizabilities, refractive indices along the direction
of principal polarizabilities of glycine and L-alanine and the molar optical rotation of L-alanine. The results of the calculation
have been compared with experimentally observed data from Kerr effect and polarimetric measurements. 相似文献
4.
Apparent molar adiabatic compressibilities (K?, s) of glycine, L-alanine, L-valine, and L-leucine have been determined in aqueous and mixed aqueous solutions of lactose (2 to 6 mass%) at T = (293.15, 298.15, 303.15, and 308.15) K. From these data partial molar adiabatic compressibilities at infinite dilution (K?, s0) have been evaluated to calculate corresponding transfer function. The transfer partial molar adiabatic compressibilities at infinite dilution (ΔK?, s0) are found to be positive. The decrease in the magnitude of transfer partial molar adiabatic compressibilities from glycine to L-leucine indicates the dominance of hydrophobic-hydrophobic interactions between the increasing side chains of amino acids. Also, the contributions of NH3+COO− , and CH2 groups have been calculated by the linear correlation of K?, s0 with number of carbon atoms in the alkyl chain of amino acids. 相似文献
5.
The critical micelle concentration (CMC) of sodium dodecyl sulphate (SDS) in pure water and in the presence of amino acids (0.01, 0.02 and 0.03 mol kg?1), L-valine (Val) and L-leucine (Leu) was determined from conductometric and fluorometric methods using pyrene as luminescence probe. Depression in the CMC at low concentration of amino acids is attributed to the increased hydrophobic–hydrophobic interaction between the non-polar groups of the surfactant, while, at high concentration, amino acids bind strongly with the anion, DS?, head groups of SDS, thereby, delaying the micelle formation, resulting in increased CMC. A pronounced decrease in the CMC, while a marked increase in λ0+, with decrease in the solvated radius (rather than crystal radius) of the counterions is observed. Negative values of ΔG0m and ΔH0m indicate that micellisation of SDS in the presence of amino acids is thermodynamically spontaneous and exothermic. Highest negative value of ΔH0m in 0.01 m Val, with lowest CMC value, shows that 0.01 m aqueous Val is the most suitable medium favouring the micellisation of SDS. Decrease in I1/I3 from Val to Leu confirms the relative hydrophobicity of two amino acids. The observed values of the packing parameter, P, of SDS in water and in aqueous amino acids suggest that micelles formed are spherical in nature. 相似文献
6.
Nikolay O. Mchedlov‐Petrossyan Dmitriy Yu. Filatov Sergey T. Goga Alexander V. Lebed 《Journal of Physical Organic Chemistry》2010,23(5):418-430
Properties of a protophobic polar non‐HBD solvent can be strongly modified by introduction of a small amount of a protophilic polar non‐HBD solvent. In this paper, acetone (AC) with 5 mol% additive of DMSO, a solvent with , was considered as a media for acid–base reactions. Conductance was used for determination of dissociation constants of a set of salts, hydrogen chloride, and picric acid. The last‐named was also studied by UV‐vis spectroscopy. The introduction of 5 mol% of DMSO results in suppressing, to some extent, the homoconjugation processes in AC media as well as of proton hydration by (possible) traces of water. The dissociation of salicylic acid and 2,4‐dinitrophenol was examined utilizing quinhydrone electrodes in a cell with liquid junction. The pKa values of buffer acids and values of buffer solutions were calculated by taking into account the incomplete dissociation of salts. The response of the glass electrode appeared to be satisfactory, which allowed the estimation of the pKa value of benzoic acid. The apparent ionization constants of 22 acid–base indicators in buffer mixtures and perchloric acid solutions were determined in (AC + 5 mol% DMSO) using the spectrophotometric procedure. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
7.
Equations for the solubility of gases and vapours into dry alcohols from methanol to decan‐1‐ol and into water‐saturated alcohols from butan‐1‐ol to decan‐1‐ol have been compared through the use of the Abraham solvation equation. It is shown that there are noticeable differences in solvation into the dry and wet alcohols, and that these differences become larger as the alcohols become smaller and take up more water. The two main factors that lead to the differences in solvation are the solute hydrogen‐bond basicity, B, and solute size, L. Increase in solute hydrogen‐bond basicity favours the wet alcohols and increase in solute size favours the dry alcohols. Solute hydrogen‐bond acidity plays no part, because the hydrogen‐bond basicity of water, wet alcohols and dry alcohols is almost the same. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
8.
Nguyen Thi Minh Hien Joo Hee Chung Xiang‐Bai Chen Woo Jun Kwon Chul Sung Kim In‐Sang Yang 《Journal of Raman spectroscopy : JRS》2015,46(11):1161-1165
LiFe1 − xMnxPO4 olivines are promising material for improved performance of Li‐ion batteries. Spin–phonon coupling of LiFe1 − xMnxPO4 (x = 0, 0.3, 0.5) olivines is studied through temperature‐dependent Raman spectroscopy. Among the observed phonon modes, the external mode at ~263 cm−1 is directly correlated with the motions of magnetic Fe2+/Mn2+ ions. This mode displays anomalous temperature‐dependent behavior near the Néel temperature, indicating a coupling of this mode with spin ordering. As Mn doping increases, the anomalous behavior becomes clearly weaker, indicating the spin–phonon coupling quickly decreases. Our analyses show that the quick decrease of spin–phonon coupling is due to decrease of the strength of spin–phonon coupling, but not change of spin‐ordering feature with Mn doping. Importantly, we suggest that the low electrochemical activity of LiMnPO4 is correlated with the weak spin–phonon coupling strength, but not with the weak ferromagnetic ground state. Our work would play an important role as a guide in improving the performances of future Li‐ion batteries. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
9.
Bogdan A. Marekha Volodymyr A. Koverga Myriam Moreau Mikhail Kiselev Toshiyuki Takamuku Oleg N. Kalugin Abdenacer Idrissi 《Journal of Raman spectroscopy : JRS》2015,46(3):339-352
By means of Raman spectroscopy coupled with density functional theory (DFT) calculations and perturbation correlation moving window two‐dimensional correlation spectroscopy intermolecular interactions were assessed in mixtures of ionic liquid (IL) 1‐n‐butyl‐3‐methylimidazolium hexafluorophosphate (BmimPF6) with polar aprotic solvent γ‐butyrolactone (γ‐BL) over the entire range of compositions. The symmetrical P―F stretching vibration of the IL anion was found to be insensitive to the changes in mixture concentration in contrast to the CO stretching vibration of the γ‐BL and the imidazolium ring C―H stretching vibrations of the IL cation. Each of these vibrational profiles was decomposed in various spectral contributions, and their number was rationalized by the results of quantum‐chemical calculations and/or previous controversial published data. Progressive redshift of the ring C―H stretching wavenumbers was referred to pronounced solvation of the cation at the imidazolium ring site accompanied with H‐bond formation. This was especially pronounced at IL mole fraction less than 0.18. Complicated variations in the intensities of the individual contributions of the CO profile were treated as a manifestation of the changing with concentration pattern of the intermolecular interactions. The self‐association of γ‐BL molecules and distinct cation solvation as dominant intermolecular interactions at low IL content are replaced with weaker cation solvation and ion association at high concentrations of IL. Possible representative molecular structures were proposed on the basis of DFT calculations. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
10.
Solute–solvent hydrogen bonding affects reactivity and other properties of dissolved species. In self‐associated media, because of cooperativity and solvent reorganization, the thermodynamic functions of solute bonding with bulk solvent can be different from those of bimolecular solute–solvent complexes. Using available experimental data on the Gibbs free energies of solvation in aliphatic alcohols and water, we have determined the energies of solute–solvent hydrogen bonding for various proton accepting solutes. We show that the increase in the strength of hydrogen bonds because of the cooperative effect is strong for bonding with bulk water and significantly less so with bulk aliphatic alcohols. The hydrogen bonding Gibbs free energies for the same solute with bulk water and alcohol are correlated, but they correlate poorly with the energies of formation of the corresponding bimolecular solute–solvent complexes. Thus, the traditional hydrogen bond basicity scales, based on data for bimolecular complexes, do not correctly describe the thermodynamics of hydrogen bonding with self‐associated solvents. Our results may help to define a separate solute basicity scale for associated media. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
11.
Molecular mechanics(MM) calculations for interfacial behaviour of sodium n-butyl benzene sulfonate (NaNBBS), sodium iso-butyl benzene sulfonate (NaIBBS) and sodium tert-butyl benzene sulfonate (NaTBBS) show a significant effect of the butyl group geometry on the surface area occupied by these molecules at the air–water interface. NaNBBS, in comparison with NaIBBS and NaTBBS, shows a closer molecular packing at the interface. The simulation predicts minimum hydrotrope concentration of each hydrotrope to reach surface saturation and molecular surface area at the interface match with good accuracy. The shape, size and charge of the hydrotrope aggregates obtained by molecular dynamics simulation also match well with the results of small angle neutron scattering experiments on the same hydrotrope. The simulation shows non-regular and ellipsoidal hydrotropes aggregates with substantial charge on the surface. The aggregates are also more open structures as compared to surfactant micelles. The water accessible surface area of a NaNBBS aggregate was 25% lower in comparison to that of NaTBBS aggregate, indicating closer packing of NaNBBS molecules. The fractional charge on the NaNBBS aggregate decreases with the increase in the number of NaNBBS molecules in the aggregate indicating more counter-ion association. 相似文献
12.
Paulpandian Muthu Mareeswaran Muthuramalingam Prakash Venkatesan Subramanian Seenivasan Rajagopal 《Journal of Physical Organic Chemistry》2012,25(12):1217-1227
The host–guest interaction of p‐sulfonatocalix[4]arene (p‐SC4) with aromatic amino acids (AAs) and two proteins has been studied using UV–Vis absorption, fluorescence, and theoretical methods. Spectral studies supported by binding constant and calculated binding energy (BE) values show that p‐SC4 binds more strongly with tyrosine compared with other AAs. The application of Bader's theory of atoms in molecule shows the involvement of various types of noncovalent interactions in the formation of the host–guest complexes. Both tyrosine and histidine have strong electrostatic interaction with the sulfonato group and other two AAs have dominant π?π interaction with the aromatic rings of calixarene. In addition, the role of C?H···O, C?H···π and lone pair···π (lp···π) interactions in the stabilization of p‐SC4‐AA complexes has also been realized from the atoms in molecule analysis. The electron density at the bond critical points varies with the calculated BEs and trend in BEs is in good agreement with the experimental binding constant values. The work has been extended to the binding of p‐SC4 with proteins, bovine serum albumin and ovalbumin. Ovalbumin exhibits stronger binding with p‐SC4 than bovine serum albumin. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
13.
The temperature‐dependence of radiation damage in macromolecular X‐ray crystallography is currently much debated. Most protein crystallographic studies are based on data collected at 100 K. Data collection at temperatures below 100 K has been proposed to reduce radiation damage and above 100 K to be useful for kinetic crystallography that is aimed at the generation and trapping of protein intermediate states. Here the global and specific synchrotron‐radiation sensitivity of crystalline thermolysin at 100 and 160 K are compared. Both types of damage are higher at 160 K than at 100 K. At 160 K more residue types are affected (Lys, Asp, Gln, Pro, Thr, Met, Asn) than at 100 K (Met, Asp, Glu, Lys). The X‐ray‐induced relative atomic B‐factor increase is shown to correlate with the proximity of the atom to the nearest solvent channel at 160 K. Two models may explain the observed correlation: either an increase in static disorder or an increased attack of hydroxyl radicals from the solvent area of the crystal. 相似文献
14.
Christopher A. Paddon Sarah E. Ward Jones Farrah L. Bhatti Timothy J. Donohoe Richard G. Compton 《Journal of Physical Organic Chemistry》2007,20(9):677-684
Kinetic and thermodynamic (formal potential) data relating to the synthetically useful Li/Li+ couple in tetrahydrofuran (THF) solvent at a range of temperatures (196–295 K) are reported. Formal potentials, have been measured versus the standard reference electrode, in THF. At 295 K the following data have been obtained using a mathematical model to simulate the electro‐deposition (metal deposition and growth kinetics) processes of lithium (Li) on a platinum microelectrode; a of ?3.48 ± 0.005 V, = ?9.2 (±0.5) × 10?4 V K?1, the standard electrochemical rate constant, k0 = 1 (± 0.1) × 10?4 cm s?1, transfer coefficient, α = 0.57 ± 0.03 and diffusion coefficient, D = 8.7 ± 0.1 × 10?6 cm2 s?1. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
15.
P. M. Mancini G. G. Fortunato C. G. Adam L. R. Vottero 《Journal of Physical Organic Chemistry》2008,21(2):87-95
The purpose of this work was to analyze the microscopic feature of binary solvent systems formed by a molecular solvent (acetonitrile or dimethylformamide or methanol) and an ionic liquid (IL) cosolvent [1‐(1‐butyl)‐3‐methylimidazolium tetrafluoroborate or 1‐(1‐butyl)‐3‐methylimidazolium hexafluorophosphate]. The empirical solvatochromic solvent parameters ET(30), π*, α, and β were determined from the solvatochromic shifts of adequate indicators. The behavior of the solvent systems was analyzed according to their deviation from ideality. The study focused on the identification of solvent mixtures with relevant solvating properties in order to select mixed solvents with particular characteristics. The comparison of the molecular–microscopic solvent parameters corresponding to the selected binary mixtures with both ILs considered at similar mixed‐solvent composition revealed that the difference is centered on the basic character of them. A kinetic study of a nucleophilic aromatic substitution reaction between 1‐fluoro‐2,4‐dinitrobenzene (FDNB) and 1‐butylamine (BU) developed in (acetonitrile or dimethylformamide + IL) solvent mixtures is presented in order to investigate and compare the solvent effects on a chemical process. For the explored reactive systems the solvation behavior is dominated by both the dipolarity/polarizability and the basicity of the media, contributing these solvent properties to accelerating the chemical process. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
16.
M. Kurt 《Journal of Raman spectroscopy : JRS》2009,40(1):67-75
The experimental and theoretical vibrational spectra of 4‐chloro‐ and 4‐bromophenylboronic acids (abbreviated as 4Clpba and 4Brpba) were studied. The Fourier transform Raman and Fourier transform infrared (FTIR) spectra of 4Clpba and 4Brpba molecules were recorded in the solid phase. The structural and spectroscopic analyses of the molecules were made by using Hartree–Fock and density functional harmonic calculations. In both 4Clpba and 4Brpba only one form was most stable using B3LYP level with the 6–311 + + G(d,p) basis set. Selected experimental bands were assigned and characterized on the basis of the scaled theoretical wavenumbers by their total energy distribution (TED). Finally, geometric parameters as well as infrared (IR) and Raman bands were compared with the experimental data of the molecules. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
17.
A. Anis Fathima M. Umadevi M. S. Ramachandran V. Ramakrishnan 《Journal of Raman spectroscopy : JRS》2007,38(12):1639-1645
A vibrational spectroscopic study of binary mixtures of salicylaldehyde (SA) in three different solvents (polar and nonpolar) is presented. The vibrational modes ν(CO), hydroxyl stretching mode (C OH) and aldehydic (C H) stretching vibration were analyzed. Changes in wavenumber position and full width half maximum have been explained for neat as well as binary mixtures with different volume fractions of the reference system, SA, in terms of inter‐ and intramolecular hydrogen bonding. The IR spectra of these mixtures have also been taken and compared with the Raman data. The spectral changes have been well explained using the concentration fluctuation model and solute–solvent interaction. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
18.
Sasirekha V Vanelle P Terme T Meenakshi C Umadevi M Ramakrishnan V 《Journal of fluorescence》2007,17(5):528-539
Optical absorption and fluorescence emission spectra of 2,3-bis(chloromethyl)-1,4-anthraquinone (DCMAQ) in single solvents
namely, carbon tetrachloride, acetonitrile, chloroform, propan-2-ol and its binary mixtures [carbon tetrachloride/chloroform,
chloroform/acetonitrile, chloroform/propan-2-ol] have been investigated. The preferential solvation of DCMAQ in above mixtures
has been studied by monitoring the absorption and fluorescence spectra of DCMAQ. The spectral features indicate that DCMAQ
is preferentially solvated by CHCl3 in the above mixtures. This can be elucidated from the local mole fraction, non-linearity in transition energy plot, preferential
solvation index (δ
s2) and (f
2/f
1) values. Molecular recognition properties of p-tert-butylcalix[4]arene (tBC) to DCMAQ via hydrogen bonding and π–π interaction were sensed successfully on the basis of
absorption and fluorescence emission spectroscopies, by which the stoichiometry ratio and the binding constant of the tBC–DCMAQ
complex were determined. 相似文献
19.
Claudia G. Adam M. Virginia Bravo Pedro M. E. Mancini Graciela G. Fortunato 《Journal of Physical Organic Chemistry》2014,27(11):841-849
The type of specific intermolecular and interionic interactions that are established when an ionic liquid is dissolved in water was here analysed. The study of the solvatochromic response of dipolarity micro‐sensors based on Reichardt ET(30) and Kamlet–Abboud–Taft solvent scales and the application of the solvent exchange model confirmed the formation of different intersolvent complexes in binary mixtures of (water + [C4mim] [BF4]/[Br]) type. These complexes provide H‐bond or electron pairs to the polar network, respectively. Moreover, for 4‐methoxybenzenesulfonyl chloride hydrolysis reaction in the (water + [C4mim] [BF4]) system, a higher inhibition (13 times) on the kobs values was observed. Multiple linear regression analysis that allows confirming the solvent effect upon the reactive system is due to the hydrogen‐bond donor properties of intersolvent complex formed. Then, the correlation between two different solvent‐dependent processes proved to be successful. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
20.
E.A. Galaktionov A.K. Savchenko D.A. Ritchie 《Physica E: Low-dimensional Systems and Nanostructures》2006,34(1-2):264
We have studied the effect of electron–electron interaction in the presence of mixed disorder on the conductivity and Hall effect of a high-mobility two-dimensional electron gas in a GaAs/AlGaAs heterostructure. A parabolic, negative, temperature-dependent magnetoresistance (MR) and temperature-dependent Hall effect are observed. We show that these effects can be explained in terms of the interaction theory. In addition, a temperature independent, positive MR is observed. This classical MR is also shown to be a consequence of the mixed disorder. 相似文献