共查询到17条相似文献,搜索用时 140 毫秒
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芳香酮与芳香醛及芳香胺的Mannich反应 总被引:6,自引:0,他引:6
醛、酮与芳香醛及芳香胺的 Mannich 反应,文献[1]曾报道在 HCl-EtOH 溶液中苯乙酮及甲醛与芳香胺的 Mannich 反应。本文在此基 相似文献
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苄叉绕丹宁及其类似物的N—Mannich碱合成 总被引:2,自引:0,他引:2
Mannich 反应在有机合成中占有重要地位。通过 Mannich 反应合成的化合物可以具有止痛、杀菌、杀虫、抗癌等多种生物效应。在应用 N-Mannich 反应合成的斑蝥素类似物和绕丹宁衍生物中,有些化合物具有抗癌活性。绕丹宁分子中活泼亚甲基及酰亚胺两个部位均可进行 Mannich 反应,提供新的结构类型 相似文献
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本文报道了以苯甲酰胺,醛(或酮)苯基二氯化膦为原料进行的Mannich反应,其产物经部分水解合成了α-(N-苯甲酰氨基)二取代甲基苯基膦酸(Ⅰ),此化合物脱水关环得2,5-二苯基-3,3-二取代-2,3-二氢-1,4,2-氧氮磷杂环戊烯-2-氧化物(Ⅱ).经1HNMR及元素分析证明了Ⅰ和Ⅱ的结构,并对反应机理进行了探讨。 相似文献
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2-戊酮、芳香醛与芳香胺的Mannich反应邹君华,易林(西南师范大学化学系,重庆630715)关键词Mannich反应,芳香醛,芳香胺,2-戊酮80年代以前,一般认为芳香胺与甲醛及含有α-氢的酮不能发生Mannich反应 ̄[1,2,3],相应的Ma... 相似文献
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2'-羟基查耳酮的Mannich反应及其产物的生物活性 总被引:2,自引:0,他引:2
研究了2'-羟基查耳酮的Mannich反应, 发现该反应区域选择性地发生在查耳酮B环C-3'位, 利用此法共合成了12个新的Mannich碱化合物, 其结构经元素分析、1H NMR和IR得到确证. 该反应制备步骤简单, 条件温和, 产物易纯化, 收率从中等到高(49~72%). 初步的生物活性测定表明其中部分化合物具强效的CDK1/cyclin B抑制活性, 多数化合物对肿瘤细胞具较强的抑制活性. 相似文献
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A series of Mannich base derivatives of 2-hydroxy-chalcones were obtained expediently in good to excellent yields by microwave-assisted Mannich reaction. The regioselectivity of the reaction occurred preferentially at the C-3 position of the 2-hydroxy-chalcone backbone. In comparison with conventional results, results from microwave possesses give better yields in shorter times. Further vasorelaxation assay showed that 2-hydroxy-3-((4-methylpiperazin-1-yl)methyl)-4,6-dimethoxymethoxy-3′-bromo-chalcone 8 significantly decreased maximal PE-induced contraction (Emax = 100 ± 5.97%, EC50 = 10.2 ± 0.51 µM). 相似文献
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2 甲基辛醇和 2 甲基癸醇是合成松树叶蜂Diprionpini性信息素活性组分的关键中间体[1 ] ,可以由相应的 2 甲基辛酸和 2 甲基癸酸还原得到。2 甲基脂肪酸的合成有很多报道 ,Mayers等[2 ] 对手性唑啉阴离子进行烷基化 ,然后酸解 ,得到 2 甲基脂肪酸 ;Bystrom等[3] 以 2 乙基 4 甲氧基 唑啉为起始反应物 ,用碘辛烷对其进行烷基化 ,然后酸解 ,得到 2 甲基癸酸 ,收率 60 %。Evans等[4] 则以N 酰基唑烷酮为起始反应物 ,合成 2 甲基辛酸 ,收率大于 70 %。Hogberg等[5] 对脯氨酸甲酯进行两次烷基化 ,然后酸解 ,得到 2 甲基脂肪酸 … 相似文献
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Li Yuan MOU Zi Yun LIN Li Ya ZHU* Xiao Tian LIANG Institute of Materia Medica Chinese Academy of Medical Sciencesand Peking Union Medical College Beijing Center for Biophysical Science Engineering University of Alabama at Birmingham 《中国化学快报》2001,(6)
Mannich reaction is widely used for the synthesis of many kinds of compounds1. In the synthesis of the derivatives of styryl ketonic Mannich bases, a one-pot method is used, in which ketone, secondary-amine hydrochloride, paraformaldehyde are refluxed together in alcohol2,3. In most cases the normal Mannich product MA is obtained. But when certain amine is used as the reactant, a side-product IM, instead of MA is obtained. MS and 1HNMR data indicate that compound IM is a new type of Man… 相似文献
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An effcient synthetic protocol for the β-amino carbonyl compounds was developed via one-pot three-component Mannich reaction of aromatic aldehydes, aromatic amines and cyclohexanone catalyzed by 2-hydroxylpy-ridine under mild reaction conditions. β-Amino carbonyl compounds were obtained in moderate to good yields and reasonable diastereoselectivities. The effects of different solvents, catalyst amounts and the scope of different substrates on the Mannich reactions were investigated. The plausible reaction mechanism was also discussed. 相似文献
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1,3‐Dimethylbenzimidazolidine reacts with ketones, which can provide activating α hydrogens and primary or secondary amines under acidic conditions, to yield aminomethylation derivatives by a covert Mannich reaction. 相似文献