Justicidone, a novel p-quinone-lignan derivative from Justicia hyssopifolia

An uncommon, previously unreported p-quinone-lignan compound called justicidone (4-(1,3-benzodioxol-5-yl)-6-methoxynaphtho[2,3-c]furan-1,5,8(3H)-trione) (2), along with the known savinin (1) were isolated from Justicia hyssopifolia (Acanthaceae). Their structures were determined by spectroscopic methods.     

Thuriferic acid. A novel lignan type from juniperus thurifera l

The isolation and structural determination of a novel type of lignan, thuriferic acid, obtained from the hexane extract of the leaves of Juniperus thurifera L (Cupressaceae) are described. Its structure was confirmed by synthesis and the signals of its ¹H and ¹³C NMR spectra were assigned unequivocally by two-dimensional techniques.     

Complete assignments of 1H and 13C NMR data for three new arylnaphthalene lignan from Justicia procumbens

Three new arylnaphthalene lignans, named neojusticin C (1), procumbenoside C (2) and procumbenoside D (3), have been isolated from the whole plant of Justicia procumbens, together with three known ones, justicidinoside B (4), justicidinoside C (5), and diphyllin-1-O-beta-D-apiofuranoside (6). The complete assignments of 1H and 13C NMR data for three new lignans were first obtained by means of 2D NMR techniques, including HSQC and HMBC.     

A novel lignan glycoside with antioxidant activity from Tinospora sagittata var. yunnanensis

A novel lignan glysocide, namely sagitiside A (1), together with two known ones, (+)-lyoniresinol-2α-O-β-D-glucopyranoside (2) and (+)-5'-methoxyisolariciresinol 3α-O-β-D-glucopyranoside (3), was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis. The structure of the new compound (1) was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-3 showed antioxidant activity with EC(50) values 55, 75 and 80?μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.     

A new lignan from Gynostemma pentaphyllum

A new lignan ligballinone 1 with the know ligballinol 2 were isolated from plant Gynostemma pentaphyllum.Their structures were determined through spectroscopic methods including ESI-MS,1D and 2D NMR (1H,13C,DEPT,1H-1H COSY,HMQC,RMBC) and X-ray diffraction experiment for 2.     

A new lignan from Oxytropis myriophylla

The 70% alcohol extract of Oxytropis myriophylla (PALL.) DC. (Leguminosae) exhibited high radical scavenging activity (IC(50) value: 88.0?μg?mL(-1) and 86.7?μg?mL(-1)) on 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays. Further chemical investigation led the isolation of one new lignan, namely myriophylloside G (1), together with three known compounds. Their structural elucidations of all the compounds were based on extensive spectroscopic methods, including HRESIMS and 2D NMR experiments (HSQC, HMBC and (1)H-(1)HCOSY) and by comparison with reference values.     

A new pinoresinol-type lignan from Ligularia kanaitizensis

A new pinoresinol-type Lignan, 9alpha-angloyloxypinoresinol (1), was isolated from the roots and rhizomes of Ligularia kanaitizensis (Franch.) Hand.-Mazz, in addition to a known compound, 9alpha-hydroxypinoresinol (2). The structure of this new lignan (1) was established on the basis of 1D and 2D NMR experiments. Anti-HIV-1 RT biological assay showed that 1 was inhibitory to HIV-1 RT.     

A new aryltetrahydronaphthalene lignan from Epimedium brevicornum

A new aryltetrahydronaphthalene lignan,(+)-cycloolivil formaldehyde condensate(1),was isolated from the whole plants of Epimedium brevicornum(Berberidaceae).Its structure was elucidated on the basis of MS,1D and 2D NMR techniques.     

Larrealignans A and B, novel lignan glycosides from the aerial parts of Larrea tridentata

Two new lignan glycosides, named larrealignans A (1) and B (2), and a known lignan (3) were isolated from the aerial parts of Larrea tridentata (Zygophyllaceae). The structures of 1 and 2 were determined on the basis of spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds (1-3) and aglycones (1a, 2a) of 1 and 2 were evaluated for their cytotoxic activities against HL-60 human leukemia cells.     

A new cyclobutane lignan from Cinnamomum balansae

A new cyclobutane lignan, named cinbalansan (6), was isolated from the leaves of Cinnamomum balansae, along with five known compounds, 1,2-dimethoxy-4-(1-E-propenyl)benzene (1), 1,2-dimethoxy-4-(1-Z-propenyl)benzene (2), 1,2-dimethoxy-4-(2-propenyl)benzene (3), 3,4-dimethoxybenzaldehyde (4), and E-(3,4-dimethoxyphenyl)-2-propenal (5). The structure of cinbalansan was shown to be 1beta,2beta,3alpha,4alpha-1,2-dimethyl-3,4-bis(3,4-dimethoxyphenyl)cyclobutane by a combination of 1H-, 13C-NMR, and NOE- experiments and by direct analysis of the 1H-NMR spectrum by the method of X-application.     

Synthesis and cytotoxicity of novel podophyllotoxin derivatives

In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance,a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents.Seven novel podophyllotoxin derivatives were synthesized by linking 4β-amino-4-deoxypodophyllotoxin with N-substituted 5-methylindol-3- yl-glyoxyl chlorides and tested against K562 and K562/A02 using SRB methods in vitro,KB and KBV using MTT methods in vitro.     

A new furofuran lignan from Piper terminaliflorum Tseng

The chemical investigation of whole plants Piper terminaliflorum Tseng led to the isolation of one new furofuran lignan, 7-methoxyasarinin (1), along with three known amide alkaloids (2–4) as N-3,5-dimethoxy-4-hydroxycinnamoylpyrrole (2), dihydropipercide (3) and 1-[(2E,4E,9E)-10-(3,4-Methylenedioxyphenyl)-2,4,9-undecatrienoyl]pyrrolidine (4). Their structures were elucidated by extensive spectroscopic analyses, including 1D, 2D NMR and HR-ESI-MS, and by comparison with the literature. Compounds (2–4) were isolated from Piper terminaliflorum Tseng for the first time. All isolated compounds (1–4) were evaluated for their cytotoxic activities against five human cancer cell lines (including A-549, SMMC-7721, HL-60, MCF-7 and SW-480).     

Design and synthesis of novel cytotoxic podophyllotoxin derivatives

<正>In order to investigate the effect of different C4 linkage moieties on the cytotoxicity of podophyllotoxin derivatives,novel 4-Nand 4-C-substituted 4'-O-demethylepipodophyllotoxin derivatives were designed and synthesized.All the compounds were tested against A549 and MCF-7 tumor cells in vitro,and six compounds showed significant cytotoxicity.The most active compound 9f was superior to GL-331,and exhibited potent cytotoxicity with IC_(50) value at 10~(-7) mol/L level.     

Synthesis and antitumor activity of novel podophyllotoxin derivatives

In order to find compounds with superior bioactivity and overcoming multidrug resistance,a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as potential antitumor agents.Seven novel podophyllotoxin derivatives were synthesized by linking-4β-amino-4-deoxypodophyllotoxin with alcohols through maleic acid and tested against K562 and K562/A02 using MTT assay in vitro.