共查询到20条相似文献,搜索用时 15 毫秒
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Jairo Quiroga Mario Alvarado Braulio Insuasty Manuel Nogueras Adolfo Snchez Justo Cobo 《Journal of heterocyclic chemistry》1998,35(6):1309-1311
This paper describes the synthesis of a new series of 7-amino-5-aryl-6-cyano-5,8-dihydropyrido-[2,3-d]pyrimidin-4(3H)-ones 3 from the reaction of 6-amino-4-pyrimidinones 1 with arylidene derivatives of malonodinitrile 2 . The structure of the final compounds was determined on the basis of nmr measurements, especially by 1H, 1H-, 1H, 13C COSY, DEPT, HMBC and HMQC experiments. 相似文献
3.
Krishna C. Joshi Vijai N. Pathak Urmila Garg 《Journal of heterocyclic chemistry》1979,16(6):1141-1145
Nine new fluorine containing 5-amino-1,3-disubstituted pyrazoles have been synthesized and characterized by spectral studies. Condensation reactions of these 5-amino-1,3-disubstituted pyrazoles with fluorinated 1,3-diketones in the presence of glacial acetic acid have been studied and the structures of the resulting 1H-pyrazolo[3,4-b]pyridines have been confirmed by ir, pmr and 19F nmr spectral studies. 相似文献
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Shuntaro Mataka Kazufumi Takahashi Masashi Tashiro 《Journal of heterocyclic chemistry》1981,18(6):1073-1075
The reaction of 3,4-dibenzoyl-1-methyl-2,5-diphenylpyrrole ( 1 ) and -1-phenylpyrazole ( 2 ) with methylamines ( 3a-c ) afforded pyrrolo[3,4-c]pyridine ( 4 ), and isomeric 2H-pyrazolo[3,4-c]pyridines ( 5a-c ) and [4,3-c]pyridines ( 6a-c ), respectively. 相似文献
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A. A. Krauze é. é. Liepin'sh Yu. é. Pelcher G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1987,23(1):102-106
The alkylation of piperidinium salts of substituted 1,4-dihydropyridine-2-thiols with chloroacetonitrile or iodoacetamide gave 2-cyanomethylthio- and 2-carbamoylmethylthio-substituted 6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridines, which undergo intramolecular cyclization in basic media to give 3-amino-6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-2-cyano(carbamoyl)-4,7-dihydrothieno[2,3-b]pyridines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 124–128, January, 1987. 相似文献
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The synthesis of a number of new 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid derivatives is described. Most of these compounds have either an alkoxy or a basic substituent in position 4. 相似文献
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The synthesis and characterization of a number of 3-aryl-6H-isoxazolo[3,4-d]pyrazolo[3,4-b]pyridines and 3-aryl-6H-isoxazolo[5,4-d]pyrazolo[3,4–6]pyridines from common precursors, 5-benzoyl-4-chloro-1H-pyrazolo-[3,4-b]pyridines, has been described. The structures were determined by unambiguous chemical synthesis and by isolation and 13C nmr analysis of some key, isolated, intermediates. The ability of these compounds to displace [3H]flunitrazepam from CNS binding sites was also observed. 相似文献
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Ana Donaire-Arias Ana Maria Montagut Raimon Puig de la Bellacasa Roger Estrada-Tejedor Jordi Teixid Jos I. Borrell 《Molecules (Basel, Switzerland)》2022,27(7)
Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds. 相似文献
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Pyrazolo[3,4-b]pyridines (4) and (5) have been obtained by the condensation of 3-(alkyl/aryl)-5-amino-1-phenyl-1H-pyrazole-4-carboxaldehydes (3) with active methylene compounds viz: diethyl malonate and malononitrile. 相似文献
11.
A. Monge J. A. Palop P. Parrado C. Perez-Ilzarbe E. Fernndez-Alvarez 《Journal of heterocyclic chemistry》1987,24(2):437-439
Starting with ethyl 3-aminoindole-2-carboxylate, the synthesis of 3-amino-5H-pyrimido[5,4-b]indole-2,4-dione 5 , 3-amino-5H-pyrimido[5,4-b]indol-4-one 10 and some related compounds is described. Preliminary results about the inhibition of platelet aggregation by these compounds is reported. 相似文献
12.
Theodore C. Miller 《Journal of heterocyclic chemistry》1966,3(3):338-344
A new synthesis of 5α-androstano[3,2-b]pyridin-17β-ol acetate (VIa) and 17-methyl-5α-androstano[3,2-b]pyridin-17β-ol (VIb), first reported by Shimizu, Ohta, Ueno, and Takegoshi, was achieved. The analogous 5α - androstano[17,16-b]pyridin-3β-ol (XII), 5α-androstano[17,16-b]pyridin-3-one (XIVa), and androst-4-eno[17,16-b]pyridin-3-one (XIVb) were also prepared. An illustration of the method follows. Condensation of 3β-hydroxy-5α-androstan-17-one (VIIa) with 3-(2-furyl)acrolein afforded 16-[3-(2-furyl)-2-propenylidene]-3β-hydroxy-5α-androstan-17-one (VIIIa), the oxime (IXa) of which was thermally cyclized to 5α-androstano[17,16-b]-6′-(2-furyl)pyridin-3β-ol (Xa). 3β-Hydroxy-5α-androstano[17,16-b]pyridine-6′-carboxylic acid (XI) was obtained by ozonolysis of Xa. Thermal decarboxylation of XI gave XII. Cinnamaldehyde was used in place of 3-(2-furyl)acrolein to give the corresponding phenylpyridines. 相似文献
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Jairo Quiroga Angelina Hormaza Braulio Insuasty Manuel Mrquez 《Journal of heterocyclic chemistry》1998,35(2):409-412
A series of dihydropyrazolo[3,4-b]pyridin-6-ones 3 was prepared by cyclization of 5-amino-1-aryl-3-methylpyrazoles 1 and Meldrum's acid benzylidene derivatives 2 in nitrobenzene. The structure of 4,5-dihydropyrazolo[3,4-b]pyridin-6-ones and reaction orientation were determined by nmr measurements. 相似文献
15.
Braulio Insuasty O Henry Insuasty I Jairo Quiroga P Claudio Saitz Carolina Jullian 《Journal of heterocyclic chemistry》1999,36(3):635-638
New 4-Aryl-6-methyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines and 4-aryl-8-methyl-6-phenyl-2,3-dihydropyrazolo[4,3-b]diazepines were obtained from the reaction of 4,5-diamino-3-methyl-1-phenylpyrazole 1 with one equivalent of the 3-dimethylaminopropiophenones 2 in absolute ethanol. The structures of 4-aryl-6-methyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines 3 and 4-aryl-8-methyl-6-phenyl-2,3-dihydropyrazolo[4,3-b]diazepines 4 were determined by detailed nmr measurements. 相似文献
16.
A. V. Eremeev V. G. Andrianov I. P. Piskunova 《Chemistry of Heterocyclic Compounds》1978,14(5):500-502
Various furazano [3, 4-b] pyrazine derivatives were synthesized by condensation of 3, 4-diaminofurazan with substituted phenylglyoxals, cyclic di- and triketones, and diethyl acetylenedicarboxylate.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 613–615, May, 1978. 相似文献
17.
É. A. Bisenieks Ya. R. Uldrikis I. É. Kirule G. D. Tirzit G. Ya. Dubur 《Chemistry of Heterocyclic Compounds》1982,18(11):1187-1189
Cycloalkyl esters of 4-aryl- and 4-cinnamyl-2-methyl-5-oxo-1,4-dihydroindeno[1,2-b]pyridine-3-carboxylic acids were synthesized. Their antioxidant activities, which are most pronounced for the 4-(2-nitrophenyl) derivatives, were determined with respect to the inhibition of the autooxidation of methyl oleate.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1528–1531, November, 1982. 相似文献
18.
An efficient method has been developed for the synthesis of a novel β-keto ester-containing pyranoquinoline compound, i.e., ethyl 4-oxo-3,4-dihydro-1H-pyrano[3,4-b]quinoline-3-carboxylate. The method entails a two-step synthesis. The first step involves the Williamson-type reaction of ethyl 2-bromomethyl-3-quinoline-3-carboxylate with ethyl hydroxyacetate in anhydrous benzene to afford the intermediate ethyl 2-[(2-ethoxy-2-oxoethoxy)methyl]quinoline-3-carboxylate. The second step includes the Dieckmann condensation reaction of the resulting intermediate in the presence of sodium ethoxide in anhydrous toluene to afford the desired pyranoquinoline containing β-keto ester moiety. Keto-enol tautomerism of the compound thus obtained was investigated by spectroscopic methods. 相似文献
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3-Aminocoumarin undergoes the Skraup reaction to give a new ring system, 5H[l]benzo-pyrano[3,4-b]pyridin-5-one (IVa). When 3-aminocoumarin was condensed with the ethoxy methylene derivatives of active methylene compounds, ethyl acetoacetate, and dimethyl acetylenedicarboxylate, the intermediates Vla-VIf were formed which on thermal cyclizations afforded other derivatives of 5H[l ]benzopyrano[3,4-b]pyridin-5-one (IVb-IVf). The nitration of IVa gave IVg. 相似文献
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The preparation of 3-amino- and 3-dialkylamino-4-cyanoazepino[3,4-fc]indoles bearing substituents on the aromatic nucleus and N10 is outlined. Starting from suitable substituted ethyl 3-formylindole-2-carboxy-latcs 2 , condensation with malononitrile ( 3 ) and subsequent sodium borohydride-reduction yielded ethyl 3-(2,2-dicyanoethyl)indole-2-carboxylates 5 and 19 , respectively, which were cyclized in boiling alkoxides to 3-alkoxy-4-cyanoazepino[3,4-b]indoles 10,11,20 and 21 . This sequence constitutes a novel and flexible route to functional azepino[3,4-b>]indoles. The aminolysis of 10,11,20 and 21 with different amines and ammonia yielded the title compounds which were screened for their possible biological activity. 相似文献