共查询到20条相似文献,搜索用时 15 毫秒
1.
A novel adamantane acyl amide derivative containing two phthalimido pendant groups(C31H31N3O5) has been synthesized,and its structure was characterized by elemental analysis,IR,1 H NMR spectra,and single-crystal X-ray diffraction.The crystal belongs to triclinic,space group P1 with a=7.3158(10),b=13.2405(18),c=14.378(2),α=72.419(2),β=84.496(2),γ=81.799(2)o,V=1312.0(3)3,Z=2,Dc=1.330 g/cm 3,μ=0.09 mm-1,Mr=525.59,F(000)=556,S=1.001,R=0.0523 and wR=0.0707 for 5901 unique reflections with 2363 observed ones(I>2σ(I)).π-π stacking interactions(offset face-to-face) exist between the two rings of phthalimides from the neighboring molecules in the title crystal structure.The intermolecular dihedral angle between the two rings of neighboring phthalic amides is 6.26° and the distance is 4.008. 相似文献
2.
Wen-Wen Zhang Su-Lei Zhang Bi-Jie Li 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(17):6941-6947
Chiral propargyl amines are valuable synthetic intermediates for the preparation of biologically active compounds and functionalized amines. Catalytic methods to access propargyl amines containing vicinal stereocenters with high diastereoselectivity are particularly rare. We report an unprecedented strategy for the synthesis of enantioenriched propargyl amines with two stereogenic centres. An iridium complex, ligated by a phosphoramidite ligand, catalyzes the hydroalkynylation of β,β-disubstituted enamides to afford propargyl amides in a highly regio-, diastereo-, and enantioselective fashion. Stereodivergent synthesis of all four possible stereoisomers was achieved using this strategy. 相似文献
3.
Wen‐Wen Zhang Su‐Lei Zhang Bi‐Jie Li 《Angewandte Chemie (International ed. in English)》2020,59(17):6874-6880
Chiral propargyl amines are valuable synthetic intermediates for the preparation of biologically active compounds and functionalized amines. Catalytic methods to access propargyl amines containing vicinal stereocenters with high diastereoselectivity are particularly rare. We report an unprecedented strategy for the synthesis of enantioenriched propargyl amines with two stereogenic centres. An iridium complex, ligated by a phosphoramidite ligand, catalyzes the hydroalkynylation of β,β‐disubstituted enamides to afford propargyl amides in a highly regio‐, diastereo‐, and enantioselective fashion. Stereodivergent synthesis of all four possible stereoisomers was achieved using this strategy. 相似文献
4.
5.
以4,4’-二羟基二苯甲酮为原料, 通过McMurry反应合成了三种环芬尼类化合物. 优化条件实现两个酚羟基选择性生成单ω-溴代烷基醚, 通过亲核取代反应连接三齿螯合剂, 得到了一系列雌激素受体β分子探针前体. 用[Et4N]2[Re(CO)3Br3]与之配位合成了其冷标记配合物, 为SPECT (single photon emission computed tomography)显像雌激素受体β从而评估乳腺癌的恶化程度奠定了基础. 产物通过IR, 1H NMR, 13C NMR, HRMS或元素分析进行了表征. 相似文献
6.
S. M. Adekenov O. V. Alebastrov V. A. Raldugin I. Yu. Bagryanskaya Yu. V. Gatilov M. M. Shakirov A. T. Kulyyasov G. A. Tolstikov 《Chemistry of Natural Compounds》2001,37(3):228-233
Bubbling gaseous nitrosylchloride through a chloroform solution of the guaianolide achillin produces very slowly but selectively 1,10-dihydro-1,10-dinitroachillin. This product rapidly, quantitatively, and irreversibly isomerizes into the dinitrocarboxylic acid with retention of the guaian carbon skeleton upon dissolution in pyridine. The structures of the new compounds were found by x-ray structural analysis 相似文献
7.
Vicinal tricarbonyl systems are readily formed by reacting β-dicarbonyl precursors with DMF acetal to form enamines which are then cleaved by photooxidation. This procedure may be applied to the formation of carbacephams. 相似文献
8.
9.
10.
11.
12.
Lithium amide is shown to give better retention of chirality over sodium amide in the nucleophilic addition of acetonitrile to N,N-dibenzyl L-phenylalanine benzyl ester. Solvent effect is obvious in the case of sodium amide. 相似文献
13.
14.
15.
16.
17.
以2-[2-(2-甲氧基乙氧基)乙氧基]乙基-4-甲基苯磺酸为原料,经2步反应制得中间体2,2′-【2,5-二{2-[2-(2-甲氧基乙氧基)乙氧基]}1,4-二(4,4,5,5-四甲基)-1,3,2-二氧硼基】苯(6); 3-溴-1,10-邻菲啰啉和6经Suzuki偶联反应合成了一个新型的邻菲啰啉衍生物--3,3′-【2,5-二{2-[2-(2-甲氧基乙氧基)乙氧基]}-1,4-二(1,10-菲啰啉基)】苯,其结构经1H NMR和MALDI-TOF-MS表征。 相似文献
18.
19.