A New Abietane Diterpenoid from the Barks of Taxus yunnanensis

Along with the major constituents taxoids, some non-taxane diterpenoids have also been isolated1. During the course of our phytochemical investigation on the bark of Taxus yunnanensis. Cheng et L. K. Fu, a new abietane diterpenoid, taxayunnin (1), and the known taxamairin C (2)2, were isolated. The structure elucidation of taxayunnin 1 was established by spectral analysis.Taxayunnin 1, pale yellow needles, mp 215oC, showed a molecular ion peak at m/z 346 [M+] in its EI mass spectrum, which…     

Abietane Quinones from Rabdosia serra

Rabdosiu Serra (M4-YId Hara is a chinese traditional medicine for the treatment ofhepatitis. enteritis. acute cholecystitis and dysentery'. The present communicationdescribes the first isolation of three abietane quinone diterpenoids from the herb (Figure1 ). The new abietane quinone, 16-acetoxy-7Q-ethoxyroyleanone I was elucidated. Inaddition. two known abietane quinones, horminone 2, 16-acetoxy-7-0-acetylhorminone 3and 6-sitosterol. stigmasterol. ursolic acid. palmitic acid were identifie…     

Flavonoids and iridoids from Stachys corsica

Two flavonoid glycosides containing acetylated allose, and two iridoid glucosides were obtained from a EtOH extract of Stachys corsica, an endemic plant of Sardinia and Corsica. All the compounds have previously been isolated from other species of Stachys.     

Two New Abietane Diterpenoids from Plectranthus barbatus

Chemistry of Natural Compounds - Plectranthus barbatus Andrews is one of the traditional herbs growing in the Okinawa region, Japan. This plant has high nutritional value and is well known...     

New iridoids from Gelsemium species

Four new iridoids structurally related to gelsemide (5) were isolated from two Loganiaceous plants, Gelsemium elegans and G. rankinii. Among them, GEIR-1 (1) has a novel tetracyclic caged structure.     

Two New Abietane Diterpenoids from Coleus xanthanthus

In our previous paper1, we reported a novel sesquiterpenoid from the EtOAc part of Coleus xanthanthus. The continuous work for the investigation of the petroleum part of C. xanthanthus led to the isolation of two new abietane diterpenoids which were identified as 11-acetoxy-coleon U(1) and 11,16-diacetoxy-coleon U(2) by spectral methods. Figure 1 The structures of 1 and 2 1 2 R= H OAcCompound 1 was obtained as pale yellow cubic crystals, mp:190.5-1920C; [(]+ 20.50 (c=0.875, CHCl3). Its…     

Abietane diterpenoids from the barks of Cryptomeria japonica

From the bark of Cryptomeria japonica were isolated sugikurojins I (1) and J (2), and an abietane derivative (3) was obtained for the first time as a natural product. These structures were elucidated primarily through extensive NMR experiments. Sugikurojin I (1) has a unique skeleton incorporating an abietane diterpene and a 1,10-secocadinane sesquiterpene. Sugikurojin J (2) is a peroxyester of hydroxyabietane diterpene and isopimarane acid diterpene. Compound 3 was p-quinone acid, which occurred by cleavage between C-7 and C-8 of sugiol; it was deduced to [4'-isopropyl-1(S),3,3-trimethyl-3',6'-dioxo-bicyclohexyl-1',4'-dien-2(R)-yl]-acetic acid. Also obtained in this investigation were three known diterpenes (4-6).     

A New Abietane Diterpenoid from Orthosiphon wulfenioides

A new abietane diterpenoid,orthosiphonol (11-methoxy-12,14-dihydroxy-8,11,13-abieta trien-7-one)(1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were determined on the basis of spectroscopic evidence.     

Monoterpenoid glucoindole alkaloids and iridoids from Pterocephalus pinardii

A new secondary metabolite, pterocephaline, along with the known cantleyoside, 7α‐morroniside, 3β,5α‐tetrahydrodesoxycordifoline lactam, 5S‐5‐carboxyvincoside, sweroside, and loganin have been isolated from the aerial parts of P. pinardii (Dipsacaceae). Moreover, cantleyoside‐methyl‐hemiacetal and cantleyoside‐dimethyl‐acetal were obtained as seco‐iridoid artifacts. The structures were elucidated by extensive spectroscopic methods including 1D‐(¹H, ¹³C and TOCSY) and 2D‐NMR (DQF‐COSY, HSQC and HMBC). Monoterpenoid glucoindole alkaloids were encountered for the first time in Dipsacaceae family. Copyright © 2010 John Wiley & Sons, Ltd.     

An Abietane Diterpene and a Sterol from Fungus Phellinus igniarius

A new abietane diterpene 12-hydroxy-7-oxo-5, 8, 11, 13-tetraene-18, 6-abietanolide, together with a new natural sterol stigmasta-7, 22-diene-3β, 5α 6α-triol have been isolated from the fruiting body of the fungus Phellinus igniarius. Their structures were elucidated by spectroscopic methods including 2D NMR techniques.     

An Abietane Diterpene and a Sterol from Fungus Phettinus igniarius

A new abietane diterpene 12-hydroxy-7-oxo-5, 8, 11, 13-tetraene-18, 6-abietanolide, together with a new natural sterol stigmasta-7, 22-diene-3β, 5α, 6α-triol have been isolated from the fruiting body of the fungus Phellinus igniarius. Their structures were elucidated by spectroscopic methods including 2D NMR techniques.     

Abietane Diterpenoids from the Hairy Roots of Salvia corrugata

Salvia corrugata Vahl. is an interesting source of abietane and abeo-abietane compounds that showed antibacterial, antitumor, and cytotoxic activities. The aim of the study was to obtain transformed roots of S. corrugata and to evaluate the production of terpenoids in comparison with in vivo root production. Hairy roots were initiated from leaf explants by infection with ATCC 15834 Agrobacterium rhizogenes onto hormone-free Murashige and Skoog (MS) solid medium. Transformation was confirmed by polymerase chain reaction analysis of rolC and virC1 genes. The biomass production was obtained in hormone-free liquid MS medium using Temporary Immersion System bioreactor RITA^®. The chromatographic separation of the methanolic extract of the untransformed roots afforded horminone, ferruginol, 7-O-acetylhorminone and 7-O-methylhorminone. Agastol and ferruginol were isolated and quantified from the hairy roots. The amount of these metabolites indicated that the hairy roots of S. corrugata can be considered a source of these compounds.     

A New Abietane Diterpenoid from Plectranthus bishopianus Benth.

Chemical examination of the MeOH extract of Plectranthus bishopianus Benth ., a rare and endangered plant, resulted in isolation of a new abietane diterpene, 6β‐hydroxy‐7α‐methoxyroyleanone ( 1 ), along with two more diterpenoids, 6,7‐dehydroroyleanone, and 6β,7α‐dihydroxyroyleanone, a triterpene oleanolic acid, and two sterols, β‐sistosterol and stigmasterol. The structures of the isolated compounds were elucidated on the basis of spectroscopic data and also by comparison with authentic samples.     

Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides

Nineteen diterpenoids, including saldigitin A(1) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes(2, 3), and two new nor-abietanes(5, 6) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data,X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal...     

Compounds from Lagotis yunnanensis

The genus Lagotis (Scrophulariaceae) is represented with 17 species in China, mostly growing in the south western part of the country on mountains of 3000 meters above sea level or higher. [1] Several species such as L.glauca, L. integra, L. brachystachya, and L. yunnanensis are used in Tibetan folkloric medicine for the treatment of fever, high blood pressure, and acute and chronic hepatitis. [2,3] As part of our studies of medicinal plants growing on the Yunnan-Tibet Plateau, L. yunnanensis W. W. Smith has been examined. To the best of our knowledge, no scientific study on this plant has hitherto been reported.     

Two New Abietane Quinones from Isodon lophanthoides var.Micranthus

The structures of two new abietane quinones,named micranthins A and B,were determined to be 7α-methoxy-14,16-epoxy-8,13-abietabiene-11,12-dione(1) and 16-acetoxy-6,7-dehydroroyleanone (2) respectively,which were isolated from Isodon lophanthoides var.micranthus.     

Abietane Diterpenoids Isolated from Clerodendrum bracteatum and Their Antioxidant and Cytotoxic Activities

Two new abietane diterpenoids (1,2), along with five known diterpenoids (3–7), were first isolated and purified from the stems of Clerodendrum bracteatum. The structures of the new compounds were established by extensive analysis of mass spectrometric and 1-D, 2-D NMR spectroscopic data. Their antioxidant activities were determined on DPPH radical scavenging and ABTS. The in vitro cytotoxic activities of the compounds were evaluated against the HL-60 and A549 cell lines by the MTT method.     

Four guaianolides from Sinodielsia yunnanensis

Four new guaianolides, sinodielides A-D (1-4), were isolated from Sinodielsia yunnanensis WOLFF together with a known polyacetylene, falcarindiol, and two known coumarins, bergapten and scopoletin. Their structures were established by spectral and X-ray analyses.