A Convenient One-Pot Synthesis of N-Alkylanilines from Benzanilides

The direct synthesis of secondary amines from the corresponding primary amines by alkylation has been widely used. The major drawback, however, consists of polyalkylation. Several procedures exist for the solution of the problem. Some of the early methods involve reduction³, or alkylative hydrolysis⁴ of Schiff base. Other methods include acid hydrolysis of alkylated formanilides prepared from primary aromatic amine and trialkyl orthoformate⁵, or acid hydrolysis of N-alkylated phosphinamides⁶, or zinc cleavage of N-alkylated phenacylsulfonamides⁷, or reductive deprotection of N-alkylated trifluoromethanesulfonamides⁷. This latter method is analogous to the Gabriel synthesis of     

A Convenient One-Pot Synthesis of Phosphino-Dipeptide Analogs

A general "one-pot" synthetic method is described for the preparation of phosphinodipeptides of type 1 , in 60-80% overall yield, allowing the variation of the substituents in f and/or g position to the phosphorus atom and also in f position to the nitrogen atom.     

A Convenient One-Pot Preparation of Symmetrical Polymethoxyanthracenes

Symmetrical polymethoxyanthracenes are rapidly made and easily isolated in moderate yield by treatment of appropriately substituted (methoxy)_n halobenzenes with lithium 2,2,6,6-tetramethylpiperidide (LTMP) in refluxing THF.     

A Convenient One-Pot Synthesis of Di-t-butylphosphinic Chloride

A convenient one-pot synthesis of (t-Bu)₂P(O)Cl (1) from m-chloroperbenzoic acid and (t-Bu)₂PCl is described. The byproduct m-chlorobenzoic acid is neutralized by addition of Et₃N. Complex 1 crystallizes in the monoclinic space group P2₁/c (No. 14), with a = 5.9637(2) Å, b = 11.4734(4) Å, c = 16.2400(5) Å and β = 107.7160(14).     

A Convenient One-Pot Synthesis of 1,2-Aminoalcohols

We have developed a rapid facile synthesis of 1,2-aminoalcohols from a variety of aldehyde starting materials. This one pot synthesis proceeds via the in situ formation of cyanohydrin trimethylsilyl ethers and the subsequent addition of Grignard reagents. This method is of particular use where the initial aldehyde exhibits water solubility.     

一锅法合成二硫醚的简便制备过程研究

双（三氯甲基）碳酸酯与三苯基膦反应生成的二氯三苯基膦在三乙胺存在下与 硫酚（醇）反应，合成了一系列收率良好的二硫醚化合物。该过程采用“一锅法” ，操作方便，后处理简单，条件温和，提供了一条合成二硫醚的重要路线。     

A Convenient One-Pot Synthesis of Cyclohexenic Primary Amines

The reaction between Grignard reagents prepared from allylic or propargylic halides and the N-phenylsulfenimine derived from the heptane-2,6-dione affords primary 1-alkenyl (or alkynyl)-3-methylcyclohex-2-enamines in good yields.     

A Convenient Two-Step One-Pot Synthesis of Alkylthiophosphoramidates Derivatives

N-thiophosphonylamino groups have been greatly overlooked as potentially potent, transition-state analogues, or tetrahedral--intermediate inhibitors of metalloproteases. Alkylthiophosphoramidates derivatives were synthesized y reaction of O-isopropyl phosphorodichloridothioate with an amino acid este followed by hydrolysis in 2M NH 4 OH. The reaction was monitored by 31 P NMR spectroscopy.     

一锅法制备全乙酰吡喃溴代糖

将未保护的吡喃糖与醋酸酐在分子碘的催化下制得全乙酰吡喃糖 ,随后不经分离直接与溴化氢的冰醋酸溶液( 4 5 %)反应得到全乙酰吡喃溴代糖 .这种一锅法制备全乙酰吡喃溴代糖操作方便 ,收率高 ,经济实用且对环境友好     

A Convenient Route to Substituted Thiocarbamides

A varicty of substituted thioureas result from thiuram disufides by a simple reaction with different amines.     

Convenient, Efficient One-Pot Synthesis of Ferrocenylcyanide

In asymmetric catalysis, chiral (central chiral, planar chiral, axial chiral) ferrocenylligands is one of the most successful class of auxiliaries in recent years, and some ofthem have reached the stage of industrial applications'. But many challenges remain forthe synthesis of the intermediate. One of them is how to get ferrocenylcyanide I directlyfrom ferrocenecarboxyaldehyde 2, which can be easily prepared according to thecorresponding literature2. As far as known, I is an important interm…     

A One-Pot and Convenient Synthesis of Coumarins in Solventless System

An efficient and facile preparation of simple coumarins via in situ Wittig reaction of salicylaldehydes, triphenylphosphine, and chloroethylacetate supported on MgO in satisfactory yields in solvent-free condition.     

A Convenient Syntheses of some New Substituted Guanidines

The cyanamides of 2,6-dimethylaniline, N-methyl-α, β -naphthylamines, 2-methylpiperidine and indoline yielded their respective guanido derivatives on treatment with dry ammonia and their structures have been characterized through spectral studies.     

An Improved Synthesis of 3-Substituted Furans from Substituted Butene-1,4-diols

A two-phase mixture of water and hexanes improves the yields of furans produced by the oxidation of butene-1,4-diols.     

Efficient and Convenient One-Pot Synthesis of Dioxadiazaphophepines

The reaction of vicinal dioxime with sodium hydride in dry THF followed by addition of dichlorophosphates or dichlorothiophosphates yields 2-oxo-1,3,4,7-dioxadiazaphosphepines and 2-thioxo-1,3,4,7-dioxodiazaphosphepines in moderate to good overall yields. The products are characterized by elemental analyses, molecular weights and spectral (IR, ¹H, ¹³C and ³¹P NMR) studies. A salt elimination route is used for the synthesis of titled heterocycles.     

A Convenient One-Pot Synthesis of Symmetric Secondary and Tertiary Vicinal Diamines

A convenient one-pot synthesis of symmetric vicinal diamines utilizing sodium borohydride/trifluoroacetic acid reduction methodology is described .     

One-Pot Synthesis of Substituted Cyclohexanes from Condensation of Aldehyde and Methylketone

Six-carbonringsareusuallypreparedfromDiels-Alder[2rr 4tt]cyclicaddition,DieckmanncondensationorintramolecularMichaelcondensati0n.H0wever,inmostofthecases,thepreparati0nofsubstitUtedcyclohexaneshastounderg0areacti0nsequence.Toreachthisbyaone-stepreaction,sofar,isstillapr0bleminsyntheticorganicchehastry.ThisletterintendstogiveapreliminaryrePortonanewmethodtosynthesizesubstitUtedcyclohexanesthroughsingle-stepintermolecularcondensation0fanaldehydeandamethylketoneinthepresenceofanalkali.Thereact…     

A Convenient One-Pot Synthesis of Dibenzyl Diselenides Under Microwave Irradiation Conditions

A simple, rapid and efficient method for the synthesis of dibenzyl diselenides under microwave irradiation is reported. The effect of microwave irradiation power, times and solvent on the reaction is investigated.