共查询到19条相似文献,搜索用时 171 毫秒
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黄酮类化合物研究(Ⅷ)——7-取代黄酮及2'''',4-二羟基-3-甲氧基-4''''-取代查尔酮的合成 总被引:1,自引:0,他引:1
3,4′,7-三羟基黄酮和3,3′,4′,7-四羟基黄酮是中草药舒冠通糖浆的主要成份,该药对冠心病、心绞痛、胸闷有一定疗效。为系统研究黄酮类化合物的构效关系,我们在前文基础上又合成了5个新的4′-羟基-7-取代黄酮及5个3′-甲氧基-4′-羟基-7-取代黄酮。在此过程中,又合成了4个新的2′,4-二羟基-3-甲氧基-4′-取代查尔酮。其合成路线如下: 相似文献
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2-取代苯并噻唑的合成进展 总被引:2,自引:0,他引:2
综述了近十年来2-取代苯并噻唑合成方法的研究成果. 近年来, 无溶剂合成、固相合成、微波促进合成、离子液体为介质的合成以及Pd, Cu, Mn, Sc等新试剂的催化合成都已成为合成此类化合物的有效新方法. 特别是这些新方法的联合使用引起了人们的广泛关注. 相似文献
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Using modified Baker-Venkataraman reaction a novel class of 3-acyl flavones and chromones have been synthesised. Reaction mechanism for their formation have been elucidated. The properties of 3-acyl flavonoids indicate them to be precursors for the synthesis of flavones. 相似文献
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[Structure: see text] 2-morpholin-4-yl-4-oxo-4H-chromen-8-yl 2,2,2-trifluoromethanesulfonate is a key intermediate for the synthesis of the DNA-dependent protein kinase (DNA-PK) inhibitor 8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one (NU7441). Two improved methods for the synthesis of this triflate have been developed: (A) in 35% overall yield, through modification of the published route, and (B) in 15% overall yield, by a new route employing a Baker-Venkataraman rearrangement to enable generation of the chromenone scaffold. Both syntheses depend on the judicious use of allyl protecting groups. 相似文献
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黄酮是一类具有抗炎,抗菌,抗病毒等作用的化合物.本文综述了黄酮类化合物的重要合成方法及其最新发展. 相似文献
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Kumar S Jain SK Sharma N Rastogi RC 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2001,57(2):299-308
The absorption and fluorescence spectra of some biologically active flavones have been studied as a function of the acidity (pH/H0) of the solution. Dissociation constants have been determined for the ground and first excited singlet states. The results are compared with those obtained from Forster-Weller calculations. The acidity constants obtained by fluorimetric titration method are in complete agreement (in most of the systems) with ground state data indicating a excited state deactivation prior to prototropic equilibration. Compared to umbelliferones, flavones are only weakly fluorescent in alkaline solution. This behaviour is explained by the small energy difference between the singlet excited state and triplet excited state giving rise to more efficient intersystem crossing. Most of the flavones studied here undergo adiabatic photodissociation in the singlet excited state indicating the formation of an exciplex or a phototautomer. 相似文献
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The cation-induced or electrochemical oxidation of flavonols has been reported to yield 2-(hydroxybenzoyl)-2-hydroxy-3(2H)-benzofuranone. Two new gradient reversed phase HPLC methods are presented which allow the determination of those oxidized flavonols simultaneously with flavonols and flavones. UV and electrochemical detection are used because of their high sensitivity. Qualitative detection together with quantification of all compounds is achieved with photodiode-array detection. An electrospray ionization ion trap mass spectrometric method is presented for unique identification of the benzofuranones after HPLC separation. 相似文献
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The cation-induced or electrochemical oxidation of flavonols has been reported to yield 2-(hydroxybenzoyl)-2-hydroxy-3(2H)-benzofuranones. Two new gradient reversed phase HPLC methods are presented which allow the determination of those oxidized flavonols simultaneously with flavonols and flavones. UV and electrochemical detection are used because of their high sensitivity. Qualitative detection together with quantification of all compounds is achieved with photodiode-array detection. An electrospray ionization ion trap mass spectrometric method is presented for unique identification of the benzofuranones after HPLC separation. 相似文献
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The 8-iodo flavones formed by cyclization of benzyl-protected chalcones with iodine in dimethyl sulfoxide have been transformed by a Suzuki coupling reaction into a variety of 8-aryl derivatives. Deprotection with boron tribromide has generated a family of new 8-aryl flavones containing four to eight hydroxyl groups. 相似文献
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《Tetrahedron letters》2017,58(42):3943-3946
An efficient and stereoselective approach for the formal total synthesis of Stigmatellin A has been described. The key steps involved in this synthesis are desymmetrization of the bicyclic olefin to introduce two methyl and two hydroxyl chiral centers, Friedel Crafts acylation, regioselective demethylation, Baker-Venkataraman rearrangement and Grubbs cross metathesis. 相似文献
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Sonia Gattinoni 《Tetrahedron letters》2007,48(6):1049-1051
The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been carried out by Marschalk alkylation of 1-hydroxy-3,6,8-trimethoxyanthraquinone, followed by a Baker-Venkataraman chain elongation and an acid-catalyzed cyclization for the construction of the pyrone ring. 相似文献