共查询到20条相似文献,搜索用时 15 毫秒
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Russian Journal of Organic Chemistry - 相似文献
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L. A. Kayukova K. M. Beketov A. L. Akhelova K. D. Praliev 《Chemistry of Heterocyclic Compounds》2006,42(7):914-917
Cyclization of O-benzoyl-2-(benzimidazol-1-yl)propioamidoxime under different temperature conditions gave 2-[2-(5-phenyl-1,2,4-oxadiazol-3-yl)ethyl]benzimidazole
whose structure has been determined by X-ray analysis.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1057–1061, July, 2006. 相似文献
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Russian Journal of Organic Chemistry - 相似文献
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Russian Journal of Organic Chemistry - 相似文献
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A. A. Chesnyuk S. N. Mikhaylichenko L. D. Konyushkin S. I. Firgang V. N. Zaplishnyi 《Russian Chemical Bulletin》2005,54(8):1900-1906
New 1,2,4-oxadiazolyl-1,3,5-triazines were synthesized from amidoximes derived from sym-triazine mononitriles. The structure of one of the resulting compounds was studied in detail by X-ray diffraction.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1845–1850, August, 2005. 相似文献
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Al-Hazmy SM Kassab KN El-Daly SA Ebeid EZ 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2000,56(9):1773-1780
The electronic absorption, emission and excitation spectra of POHC were measured in different solvents and are affected by solvent polarity. The fluorescence quantum yield of POHC decreases with increasing Richardt and Dimorth solvent parameter (E(T)) value of the solvent. In dilute solutions POHC is almost totally present in its protonated nitrogen tautomer form. The deprotonation is a reversible process. A shoulder in the absorption spectra at approximately 473 nm indicates the presence of a portion of the tautomer (s) that disappears on lowering the temperature. Molecular oxygen acts as a quencher with quenching rate constant of 1.8 x 10(10) M(-1) s(-1) in DMF. Energy transfer from POHC to rhodamine 6G in ethanol was also studied. POHC is relatively photostable in ethanol (phic approximately 1.7 x 10(-4)). Quantum chemical calculations were carried out and correlated to experimental observations. 相似文献
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The 13C NMR spectra of twelve 3-aryl-4-(5-aryl-Δ2-l,2,4-oxadiazolin-3-yl)sydnones and twelve 3-aryl-4-(5-aryl-l,2,4-oxadiazol-3-yl)sydnones have been measured and assigned by means of proton-noise decoupling and DEPT-experiments. The coupling constants were determined by means of gated decoupling, and NOE effects were observed by comparison of proton-decoupled and inverse-gated decoupled spectra. Differences shown by the oxadiazoline and the oxadiazole rings and the substitution effects are discussed. 相似文献
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Rajendra Mohan Srivastava Maria Benedita De Assunl̂t́o Borges Viana Lothar Bieber 《Journal of heterocyclic chemistry》1984,21(4):1193-1195
Seven 3,5-disubstituted oxadiazole derivatives, 3a-g , have been prepared by direct condensation of appropriate benzamidoxime with succinic anhydride. Spectroscopic properties, especially uv, ir and mass spectra confirmed the cyclic 1,2,4-oxadiazole structure. No ring-opened intermediate or side product could be observed. The 1H-nmr assignments of the two CH2 groups were unequivocally made by acid- and base-induced shifts. 相似文献
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设计合成了18个以吡唑桥连1,3,4-噁二唑和1,3,5-三嗪的新型多杂环分子[7A(a~f),7B(a~f)和7C(a~f)];通过红外光谱(IR)、核磁共振波谱(NMR)和高分辨质谱(HRMS)等对目标分子进行了结构表征;评价了目标分子对蛋白酪氨酸磷酸酯酶1B(PTP1B)和细胞分裂周期25磷酸酯酶B(Cdc25B)的抑制活性.结果表明,所有目标分子对PTP1B和Cdc25B均有较好的抑制活性,其中,9个目标分子表现出优异的PTP1B和Cdc25B抑制效果,IC50值低于齐墩果酸(PTP1B抑制活性测试参照物)和正钒酸钠(Cdc25B抑制活性测试阳性参照物),有望成为潜在的PTP1B和Cdc25B抑制剂. 相似文献
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A general method was proposed for the synthesis of 3-(5-aryl-1,3,4-oxadiazol-2-yl)chromones starting from 3-formylchromone. This aldehyde yields acylhydrazones, from which the corresponding unstable nitrile imines are generated. These intermediates undergo intramolecular 1,3-dipolar cycloaddition. 相似文献
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A general procedure was proposed for the synthesis of 3-(5-aryl-1,3,4-oxadiazol-2-yl)chromones by reaction of 3-formylchromone with aroylhydrazines, transformation of the corresponding acylhydrazones into 1,3-dipoles by the action of bromine in the presence of sodium acetate, and intramolecular ring closure. 相似文献
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Nitrile oxide cycloaddition routes to 2-(isoxazolyl)-benzoates and 2-(1,2,4-oxadiazol-3-yl)benzoates
Cycloaddition of aromatic nitrile oxides to methyl o-vinylbenzoate produced methyl 2-(3-aryl-2-isoxazolin-5-yl)benzoates; the isoxazolines were converted to methyl 2-(3-arylisoxazol-5-yl)benzoates. Reaction of the nitrile oxide from o-methoxycarbonylbenzohydroximinoyl chloride ( 11 ) with phenylacetylene, styrenes, and aromatic nitriles resulted in methyl 2-(5-phenylisoxazol-3-yl)benzoate, methyl 2-(5-aryl-2-isoxazolin-3-yl)-benzoates ( 15 ), and methyl 2-(5-aryl-1,2,4-oxadiazol-3-yl)benzoates, respectively. The isoxazolines 15 were converted to the corresponding isoxazoles 16 . 相似文献
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The reaction of 6-methyl-2-methylthio-3-(2-thioxo-1,3,4-oxadiazol-5-yl)methyl-4(3H)-pyrimidinone with butyland benzylamine and also with piperidine and morpholine has been studied. It was found that the primary amines not only open the 1,3,4-oxadiazole ring to form the corresponding thiosemicarbazides but also substitute the methylthio group at position 2 in the pyrimidine ring. Morpholine can only open the 1,3,4-oxadiazole ring but piperidine can also substitute the methythio group to give an oxadiazolethione piperidinium salt.Vilnius University, Vilnius 2734, Lithuania. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1125–1129, August, 1998. 相似文献
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A. V. Sergievskii T. V. Romanova S. F. Mel’nikova I. V. Tselinskii 《Russian Journal of Organic Chemistry》2005,41(2):261-267
Alkylation of 3,5-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-triazole with haloalkanes afforded N-CH2R derivatives, and nitration furnished the corresponding bis-N-nitramine isolated as a trisodium salt. Treatment of the latter with CH3I resulted in denitration. Diazotization and oxidation of 3,5-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4- triazole, its N-methyl and N-carboxy derivatives gave rise to the corresponding azido and nitro derivatives. Salts of 3,5-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-triazol-5-acetic acid with nitrogen-containing bases were synthesized. It was established that the character of reaction products of 3,5-bis(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-triazole with formaldehyde depended on the acid-base properties of the medium.__________Translated from Zhurnal Organicheskoi Khirmii, Vol. 41, No. 2, 2005, pp. 270–276.Original Russian Text Copyright © 2005 by Sergievskii, Romanova, Mel’nikova, Tselinskii. 相似文献
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Nesterova O. M. Zarubina O. S. Tolstyakov V. V. Danagulyan G. G. Trifonov R. E. Smirnov S. N. Slepukhin P. A. Ignatenko N. K. Ostrovskii V. A. 《Russian Journal of Organic Chemistry》2017,53(11):1766-1768
Russian Journal of Organic Chemistry - New tetrazolyl derivatives of pyrimidine were synthesized containing various linker groups. The structure of these compounds was established by NMR... 相似文献
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V. V. Bakharev A. A. Gidaspov E. V. Selezneva V. E. Parfenov I. V. Ulˈyankina I. S. Nazarova Yu. T. Palatova O. S. Elˈtsov 《Chemistry of Heterocyclic Compounds》2012,47(10):1258-1267
Heating 4-R-methoxy-1,3,5-triazin-2-ylnitroformaldoximes with nitriles leads not to the formation of 1,2,4-oxadiazoles but
rather to dimerization of the intermediate 1,3,5-triazinylnitrile oxides to give furoxanes. The reaction of 4-R-6-methoxy-1,3,5-triazin-2-ylnitroformaldoximes
with ammonia and amines gives 1,3,5-triazinylamidoximes, which upon acylation and subsequent intramolecular cyclization yield
(5-R-1,2,4-oxadiazol-3-yl)-1,3,5-triazines. 相似文献