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E. E. Mikhlina V. Ya. Vorob'eva M. V. Rubtsov 《Chemistry of Heterocyclic Compounds》1967,2(2):172-176
Various methods of preparing 3-aminoquinuclidine from quinuclid-3-one oxime and hydrazone are developed. Quinuclidine derivatives with a substituted amino group at position 3 are synthesized. 相似文献
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A number of alkylidene esters are synthesized from the corresponding ketones and cyanoacetic ester, and treatment of the esters with sulfur in the presence of a catalytic amount of diethylamine gives 2-amino-3-ethoxycarbonylthiophene derivatives. 相似文献
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A number of alkylidene esters are synthesized from the corresponding ketones and cyanoacetic ester, and treatment of the esters with sulfur in the presence of a catalytic amount of diethylamine gives 2-amino-3-ethoxycarbonylthiophene derivatives. 相似文献
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By treating 3-nitroindazole with hydroxylamine-O-sulfonic acid in basis medium, we have obtained its 1-amino derivative. We have observed that in chloroform solution in the presence of triethylamine, it is slowly converted to 1-ethylideneamino-3-nitroindazole. We discuss a possible mechanism for this unexpected reaction.Scientific-Research Institute of Physical and Organic Chemistry, Rostov State University. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1343–1346, October, 1996. 相似文献
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F. M. Stoyanovich E. P. Zakharov O. V. Lysenko V. N. Yarovenko M. M. Krayushkin 《Russian Chemical Bulletin》1991,40(1):225-227
Preparative syntheses have been developed for 2-amino-5-cyano-1,3,4-oxadiazole from the semicarbazone of methyl glyoxylate and some of its transformations were studied. This product is an important intermediate in the preparation of its derivatives.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1. 243–246, January, 1991. 相似文献
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6-氨基-3-取代吲哚的合成和生物活性研究 总被引:1,自引:0,他引:1
6-氨基-3-取代吲哚及其衍生物是一种重要的医药和有机化工中间体,不仅能合成一些具有生理活性和药理活性的化合物,如:合成一些具有药物活性的色胺类化合物及其衍生物[1,2];合成一些植物生长调节剂,如吲哚-3-乙腈和吲哚-3-乙酸类化合物[3];合成一些具有生物活性的天然化合物Drag 相似文献
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Ethyl sarcosinate adds to 2, ?3- and 4-pyridylmethylidenemalonates to produce the Michael adducts, which can be conveniently cyclized to oxopyrrolidine diesters under Dieckmann conditions. Mild oxidation converted the crude adducts to the isomeric 1-methyl-3-hydroxy-5-pyridylpyrrole-2,4-dicarboxylates. Addition of ethyl glycinate to ethyl picolinoylacetate or ethyl nicotinoylacetate produced the corresponding enaminoesters, but these azadiesters were not cyclized under the usual Dieckmann conditions. 相似文献
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4-Amino-5-aryi-1,2,4-triazole-3-thiones I react with acid chlorides to yield 4-acylamino-5-aryl-1,2,4-triazole-3-thiones II. Compounds I also react with methylene iodide, chloroacetonitrile and methyl bromoacetate to give bis-(4-amino-5-aryl-1,2,4-triazol-3-ylthio)methanes III, 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles IV and 4-amino-5-aryl-3-carbomethoxymethylthio-1,2,4-triazoles V, respectively. Compounds V react with hydrazine hydrate to give the corresponding acid hydrazides VI which in turn condenses with acid chlorides and aldehydes to afford respectively 1-[(4-amino-5-aryl-1,2,4-triazol-3-ylthio)acetyl]-2-aroylhydrazines VII and aryl methylene (4-amino-5-aryl-1,2,4-triazol-3-ylthio)acethydrazones VIII. The antimicrobial activities of the above compounds were screened against different strains of bacteria and fungi. 相似文献
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Reaction of an arylmethyl halide with 3-amino-1,2,4-triazole ( 1 ) allows the preparation of the three N-aryl-methyl derivatives of 1 bearing the substituent on the heterocyclic nitrogen atoms. In basic medium (methoxide anion in DMF or methanol, or in benzene by phase transfer catalysis), the isomers 3 and 5 substituted at N-1 and N-2 respectively are obtained, while the isomer 4 is isolated from neutral medium (DMF). The isomers 3 and 4 may be also prepared by cyclization of appropriate formylguanidinium derivatives. 3-Arylmethylamino-1,2,4-triazoles 2 may be obtained through reaction of 3-chloro-1,2,4-triazole ( 6 ) with arylmethylamines. Photolysis of the N-arylmethyl-3-amino-1,2,4-triazoles 2-5 in methanol or water-methanol mixture, induces homolytic and heterolytic cleavage of the arylmethyl-C-N bond giving rise to 3-amino-1,2,4-triazole ( 1 ). Thus, compounds 2-5 with arylmethyl groups able to absorb solar light may be considered as potential photoactivatable herbicides. 相似文献
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Yu. V. Popov V. M. Mokhov N. A. Tankabekyan O. Yu. Safronova 《Russian Journal of Applied Chemistry》2012,85(9):1387-1394
Synthetic routes to new amino nitriles with the functional groups at the 2-position of the adamantane core, based on reactions of adamantanonimines with acetone cyanohydrin or of adamantanone cyanohydrin with aliphatic amines, are considered. The products can be used for preparing new biologically active substances, unsymmetrical adamantyl-containing diamines or amino acids. 相似文献
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Nath M Sulaxna Song X Eng G 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2006,64(1):148-155
Some tri- and diorganotin(IV) compounds of the general formula, RnSnL4-n (where n=2, R=Me, n-Bu and Ph; n=3, R=Me, n-Bu, n-Pr and Ph; HL=5-amino-3H-1,3,4-thiadiazole-2-thione) have been synthesized by the reaction of RnSnCl4-n (where n=2 or 3, R=Me, n-Bu, n-Pr and Ph) and the sodium salt of the ligand. Oct2SnL2 was obtained by the reaction of Oct2SnO with HL in a 1:2 molar ratio under azeotropic removal of water. The bonding and coordination behavior in these derivatives are discussed on the basis of IR, Far-IR, multinuclear (1H, 13C and 119Sn) NMR and 119Sn M?ssbauer spectroscopic studies. These investigations suggest that in all the compounds the ligand acts as monoanionic bidentate coordinating through ring N(3) and exocyclic S. Thermal studies of five compounds, viz., Ph3SnL, Me2SnL2, n-Bu2SnL2, Oct2SnL2 and Ph2SnL2 have been carried out in the temperature range 25-1000 degrees C using TG, DTG and DTA techniques under an atmosphere of dry nitrogen. 相似文献