共查询到20条相似文献,搜索用时 31 毫秒
1.
Ronald E. Hackler Kenneth W. Burow Sylvester V. Kaster David I. Wickiser 《Journal of heterocyclic chemistry》1989,26(6):1575-1578
A general synthesis of 3-amino-3-alkylpropenenitriles is described. These intermediates are further transformed to 5-amino-3-alkylisothiazoles. Also described is the synthesis of the novel isomer, 3-amino-5-t-butyl-isothiazole. 相似文献
2.
A. B. Sheremetev 《Russian Chemical Bulletin》2005,54(4):1057-1059
A “one pot” method for the synthesis of 3-amino-4-aryl- and 3-amino-4-hetarylfurazans from β-aryl- and 4-β-hetaryl-β-oxo acid
esters was developed.
Dedicated to Corresponding Member of the Russian Academy of Sciences E. P. Serebryakov on the occasion of his 70th birthday.
__________
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 1030–1032, April, 2005. 相似文献
3.
A new synthesis of 2-amiuo-3-methoxypyrazine, an intermediate in the synthesis of sulfalene, via 2-carbamido-3-hydroxy pyrazine and subsequent Hofmann rearrangement of 2-carhamido-3-methoxypyrazine, is described. 相似文献
4.
The structure of 2-amino-3-carbamoylchromone has been studied by 1D and 2D NMR spectroscopy. Selective hydrolysis of this compound gives 3-carbamoyl-4-hydroxycoumarin, whereas the reactions with acetic anhydride and hydrazines, 2-methyl-4H-chromeno-[2,3-d]pyrimidine-4,5(3H)-dione and 3-aminochromeno[4,3-c]pyrazol-4-ones, respectively.
相似文献5.
Ippolito Antonini Francesco Claudi Gloria Cristalli Mario Grifantini Sante Martelli 《Journal of heterocyclic chemistry》1981,18(2):399-404
The course of the thermal decomposition of various 2-amino-3-substituted aziridino-1,4-naphthoquinones (Ia-g) was investigated. In all the cases, the thermal decomposition gave variable amounts of 2,3-diamino-1,4-naphthoquinone (II) and of substituted 1,2,3,4,5,10-hexahydrobenzo[g]quinoxaline-5,10-diones (IIIa-g) with complete stereospecificity. The decomposition of the aziridines Ib,f also gave significative amounts of 2-amino-3-allylamino-1,4-naphthoquinones (IVb,f). In the case of 2-amino-3-(2′-phenyl-3′-ethylaziridino)-1,4-naphthoquinone (Ig), the formation of trans-1-phenyl-1-butene (V), 2-(1-phenylpropyl)-1H-naphtho-imidazole-4,9-dione (VI), 2-phenyl-3-ethyl-3,4,5,10-tetrahydrobenzo[g]quinoxaline-5,10-dione (VII), 2-phenyl-3-ethyl-5,10-dihydrobenzo[g]quinoxaline-5,10-dione (VIII), and a mixture of cis- and trans-4H-2,3,5,6-tetra-hydro-2-phenyl-3-ethyl-5-iminonaphtho[1,2-b]oxazin-6-one (IX) also occurred. Hypotheses concerning the mechanism and the steric course of this reaction are given. The reaction is a general method for the stereospecific synthesis of 2,3-disubstituted 1,2,3,4,5,10-hexahydrobenzo[g]quinoxalines. 相似文献
6.
V. V. Lipson T. M. Karnozhitskaya S. V. Shishkina O. V. Shishkin A. V. Turov 《Russian Chemical Bulletin》2009,58(7):1441-1444
The reaction of 3-amino- and 3-amino-5-methylthio-1,2,4-triazoles with cinnamaldehyde takes two directions to form mixtures
of 5-[N-(3-phenylpropenylideneamino)]-1H-1,2,4-triazoles and 5-phenyl-4,5,6,7-tetrahydro[1,2,4]triazolo[1,5-a]pyrimidin-7-ols. 相似文献
7.
3-Amino-1,2,3,4-tetrahydrocarbazoles are easily prepared from the readily available 3-hydroxy-1,2,3,4-tetrahydrocarbazoles by conversion of the latter to the p-toluene- or methanesulfonate ester, followed by nu-cleophilic displacement with azide ion. The resulting 3-azido-1,2,3,4-tetrahydrocarbazoles are then catalytically hydrogenated to their 3-amino counterparts. 相似文献
8.
Acylation of 5-amino-3H-1,3,4-thiadiazolin-2-one (2) was undertaken selectively at either the 3-NH position or at 5-amino group depending on reaction conditions. The 3-NH is highly acidic and acylation takes place with acid anhydrides at this position in high yields in the presence of pyridine or triethylamine. The diacylation of both the 3-position and the 5-amino group was only possible via the 5-amino-3-acyl-1,3,4-thiadiazolin-2-one intermediates 4 . Under neutral conditions, acylation only occurs at the 5-amino group with acyl chlorides forming 5-acylamino-3H-1,3,4-thiadiazolin-2-ones 5 . 5-Acetylamino-3H-1,3,4-thiadiazolin-2-one can also be synthesized by the thermal transformation of 5-amino-3-acetyl-1,3,4-thiadi-azolin-2-one in acetic acid. 相似文献
9.
Enol lactones such as 4-hydroxy-6-methyl-2H-pyran-2-one (triacetic acid lactone, TAL) and 4-hydroxycoumarin when treated with 2-amino-3-formylchromone under basic conditions
afforded 3-acetoacetyl benzopyranopyridones and benzopyranopyridines, respectively. A series of pyrazole derivatives was prepared
by the reaction of 3-acetoacetyl benzopyranopyridones with different hydrazines. All compounds were characterised on the basis
of spectral data and their antibacterial activity evaluated. 相似文献
10.
Several 3-amino-4(3H)-quinazolinones were prepared from o-aminobenzoylhydrazines and triethyl orthoformate or from isatoic anhydrides, hydrazines and triethyl orthoformate. o-Aminobenzoylhydrazine intermediates were obtained by reaction of isatoic anhydrides with hydrazines. Some of the aminoquinazolinones displayed anticonvulsant activity in mice. 相似文献
11.
By the use of the 1H? 1H and 1H? 31P coupling constants in two analogues of aspartic acid i.e. 3-amino-3-phosphonatopropionic and 3-amino-3-(methylphosphinato) propionic acids, it was shown that the six parameter formulation for the evaluation of mole fractions of three staggered ethanic rotamers is not necessarily better than the two parameter formulation in this system. The results allowed the recommendation of the following values for the two vicinal proton parameters i.e. J(HH)g=2.3, J(HH)t=13.9 and for the two vicinal proton-phosphorus parameters i.e. J(HP)g=4.2, J(HP)t=33.0 Hz. 相似文献
12.
Franco Gatta Maria Rosaria Del Giudice Luciano Di Simone Guido Settimj 《Journal of heterocyclic chemistry》1980,17(5):865-868
A new synthesis of 7-chloro-2,3-diamino-5-phenyl-3H-1,4-benzodiazepines is described, which allows for the preparation of compounds bearing the same or different substituents at the 2 and 3 positions, starting from 2-amino-7-chloro-3-hydroxy-5-phenyl-3H-1,4-benzodiazepines. 相似文献
13.
Nam Sook Cho Chan Soo Ra Do Young Ra Jin Soo Song Sung Kwon Kang 《Journal of heterocyclic chemistry》1996,33(4):1201-1206
2-Aroyl-5-aroylamino-1,2,4-thiadiazolin-3-ones ( 2 ) have been synthesized through aroylation of 5-arruno-2H-1,2,4-thiadiazolin-3-one ( 1 ) as an analog of cytosine. The aroylation was carried out with a substituted aroyl chloride in pyridine at 56~58°C. It has been established that the intermediates of the reactions are 2-aroyl-5-amino-1,2,4-thiadiazolin-3-ones ( 3 ) on the basis of the spectral data, additional experimental information and ab initio molecular orbital calculations. 相似文献
14.
Nam Sook Cho Chan Soo Ra Do Young Ra Jin Soo Song Sung Kwon Kang 《Journal of heterocyclic chemistry》1996,33(6):1823-1828
2-Aroyl-5-aroylamino-1,2,4-thiadiazolin-3-ones 2 have been synthesized through aroylation of 5-amino-2H-1,2,4-thiadiazolin-3-one ( 1 ) as an analog of cytosine. The aroylation was carried out with a substituted aroyl chloride in pyridine at 56–58°. It has been established that the intermediates of the reactions are 2-aroyl-5-amino-1,2,4-thiadiazolin-3-ones 3 on the basis of the spectral data, additional experimental information and ab initio molecular orbital calculations. 相似文献
15.
Ronald W. Johnson Ronald J. Matlson J. Walter Sowell 《Journal of heterocyclic chemistry》1977,14(3):383-385
A facile route for the synthesis of substituted 2-amino-3-cyano-4-methylpyrroles from N-acetyl-α-amino ketones and malononitrile is reported. 相似文献
16.
Sergey M. Desenko Victoria V. Lipson Oleg V. Shishkin Sergey A. Komykhov Valery D. Orlov Evgeny E. Lakin Valery P. Kuznetsov Herbert Meier 《Journal of heterocyclic chemistry》1999,36(1):205-208
The reaction of 3-amino-1,2,4-triazole ( 1 ) with substituted methyl cinnamates 2a-h leads selectively to the formation of 7-aryl-6,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones 3a-h . The structure eluci dation of the products is based on ir, 1H and 13C nmr measurements and X-ray diffraction. 相似文献
17.
Ovchinnikova I. G. Valova M. S. Matochkina E. G. Kodess M. I. Tumashov A. A. Slepukhin P. A. Fedorova O. V. Rusinov G. L. Charushin V. N. 《Russian Chemical Bulletin》2011,60(5):965-974
A new type of intramolecular cyclization of 1,5-bis[2-(E-3-oxo-3-phenylprop-1-enyl)-phenoxy]-3-oxapentane with 3-aminotriazole promoted by potassium ions was discovered. A cascade
mechanism for the formation of crownophane with 4,7-dihydro[1,2,4]triazolo[1,5-a]-pyrimidine fragment was suggested. Effects of oligooxyethylene fragment of the chalcone podand and acid-base catalysis on
the selectivity of the cyclocondensation processes and degree of oxidation of triazolopyrimidine fragments were studied. The
product structures were confirmed by IR, 1H and 13C NMR spectroscopy and X-ray diffraction study. 相似文献
18.
Israel Scheinfeld James C. Parham George Bosworth Brown 《Journal of heterocyclic chemistry》1982,19(5):1231-1233
N-Oxidation of 2-amino-6-chloropurine to the 3-oxide provided a convenient intermediate for the synthesis of 2-amino-6-substituted purine 3-oxides, including the previously unavailable 2,6-diaminopurine 3-oxide. Thiation of the 6-halogen was accompanied by reduction of the N-oxide. The properties of the 1- and 3-oxides of 2,6-diaminopurine are compared. 相似文献
19.
V. A. Dorokhov A. V. Komkov A. M. Sakharo V. S. Bogdanov 《Russian Chemical Bulletin》1996,45(1):168-170
A method hxsynthesizing 3-acetyl-2-amino-4-pyyridone has been suggested. The synthesis involves the condensation of dimethylformamide dimethylacetal at the NH2 group of diphenylboron chelate diacetylketene aminal followed by its intramolecular cyclization under the action of NaOMe in MeOH.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 177–179. January, 1996. 相似文献
20.
J
Zsef Reiter Lszl Pong Tams Somorai PTer Dvortsk 《Journal of heterocyclic chemistry》1986,23(2):401-408
The correct isomeric and tautomeric structure of different 1- and 2-R1-3-R2,R3-amino-5-amino-1,2,4-triazole derivatives prepared from the corresponding N-cyano-N'-R2,R3-S-methyl-isothioureas and the corresponding hydrazines was proved with the help of their ir, uv, 1H-nmr and 13C-nmr spectra as well as the uv spectra of the Schiff bases of an isomeric pair. 相似文献