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以O~6-苄基鸟嘌呤(O~6-BG)为起始原料,经4步反应合成了一个新型的O~6-BG衍生物——4-硝基苄基-[6-(苄氧基)-9H-嘌呤-2]氨基甲酸酯(4),其结构经1H NMR和HR-ESI-MS表征。用CCK-8法研究了4对人脑神经胶质细胞(SF126,SF763和SF767)的细胞毒性。结果表明:在低氧环境下,4与ACUN的协同作用对SF126,SF763和SF767均有较好的抑制活性,其IC50分别为0.04 m M,0.1 m M和0.03 m M,优于阳性对照药O~6-BG。 相似文献
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3,5-二氟苄基氯和邻氯基苄基氯在适当的溶剂中与锡粉反应,合成了三(3,5-二氟苄基)氯化锡(1)和四(邻氯苄基)锡(2),经X射线衍射方法测定了新化合物的晶体结构。化合物1属单斜晶系,空间群为C2/c,晶体学参数:a=1.858 33(11)nm,b=1.140 98(7)nm,c=2.690 06(16)nm,β=109.288(10)°,V=5.383 6(6)nm3,Z=8,Dc=1.532 g·cm-3,μ(Mo Kα)=13.61 cm-1,F(000)=2 480,R1=0.085 1,wR2=0.168 1。化合物2属单斜晶系,空间群为P21/m,晶体学参数:a=0.585 54(5)nm,b=1.969 74(18)nm,c=0.857 86(8)nm,β=95.204 0(10)°,V=0.985 34(15)nm3,Z=2,Dc=1.805 g·cm-3,μ(Mo Kα)=14.91 cm-1,F(000)=524,R1=0.054 0,wR2=0.163 9;中心锡原子为畸变四面体构型。对其结构进行量子化学从头计算,探讨了化合物的稳定性、分子轨道能量以及部分前沿分子轨道的组成特征。测定了化合物的热稳定性。 相似文献
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3,5-二氟苄基氯和邻氯基苄基氯在适当的溶剂中与锡粉反应,合成了三(3,5-二氟苄基)氯化锡(1)和四(邻氯苄基)锡(2),经X射线衍射方法测定了新化合物的晶体结构。化合物1属单斜晶系,空间群为C2/c,晶体学参数:a=1.858 33(11)nm,b=1.140 98(7)nm,c=2.690 06(16)nm,β=109.288(10)°,V=5.383 6(6)nm3,Z=8,Dc=1.532 g·cm~(-3),μ(Mo Kα)=13.61 cm~(-1),F(000)=2 480,R1=0.085 1,wR~2=0.168 1。化合物2属单斜晶系,空间群为P21/m,晶体学参数:a=0.585 54(5)nm,b=1.969 74(18)nm,c=0.857 86(8)nm,β=95.204 0(10)°,V=0.985 34(15)nm3,Z=2,Dc=1.805 g·cm~(-3),μ(Mo Kα)=14.91 cm-1,F(000)=524,R1=0.054 0,wR_2=0.163 9;中心锡原子为畸变四面体构型。对其结构进行量子化学从头计算,探讨了化合物的稳定性、分子轨道能量以及部分前沿分子轨道的组成特征。测定了化合物的热稳定性。 相似文献
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以腺苷(2)为原料,经丙酮叉保护2',3'-位羟基得2',3'-O-异丙叉腺苷(3);3经叔丁基二甲硅氯保护5'-羟基得5'-O-叔丁二甲基硅基-2',3'-O-异丙叉腺苷(4);4经二碳酸二叔丁酯保护氨基得到N~6,N~6-二(叔丁氧羰基)-2',3'-O-异丙叉基-5'-O-叔丁二甲基硅基腺苷(5);5用四丁基氟化铵脱去叔丁二甲基硅基合成了新化合物N`6,N~6-二(叔丁氧羰基)-2',3'-O-异丙叉腺苷,总收率54.3%,其结构经~1H NMR,~(13)C NMR,IR和HR-MS表征. 相似文献
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HongYanZHENG ShaoBaiLI 《中国化学快报》2005,16(1):20-22
6, 9, 11-Trihydroxy-6a, 12a-dehydrorotenoid 1 (coccineone B) was synthesized from 2-hydroxybenzaldehyde 2 and phloroglucinol. 相似文献
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1 INTRODUCTION Many crown ethers have been synthesized[1, 2] and widely used[3~5]. The amide-type acyclic poly- ethers with versatile molecular structures offer many advantages over the traditional crown ethers, such as their potential activity for ion-selective electrodes[6] and the extraction of metal ions[7], so they have attracted much scientific attention[8~10]. In an effort to investigate the effect of skeleton of acyclic polyether on the extractability of metal ions, and to find … 相似文献
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The synthesis of fluorine-containing small molecules has had numerous benefits of improving the quality and efficiency of many applications of these compounds. For example, fluorine adds promising functionalities in various areas of imaging (MRI, PET, and NIR); gives cell-targeting properties; and has demonstrated improvements in cell permeability, solubility, and other pharmacologic properties. For these and other numerous reasons, fluorination of molecules has grown in popularity in various fields of chemistry. Many reports show the effects observed from increasing the number of fluorine atoms on a fluorophore scaffold. This report will cover the most significant applications and improvements that fluorine has contributed to in various dye scaffolds such as BODIPY, rhodamine, phthalocyanine, and cyanine in the recent decade. 相似文献
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新型含氟姜黄素类似物的合成、晶体结构及抗肿瘤活性 总被引:7,自引:0,他引:7
采用活性基团拼接法将含氟苯甲醛与酮反应, 合成了5个含氟单羰基姜黄素类似物, 结构经IR, 1H NMR及ESI-MS确认. 对所合成的化合物进行了抗肿瘤活性测试(MTT法), 结果表明, 部分化合物对肿瘤细胞有较强的选择性抑制活性, 其中2,6-二(4-氟亚苯基)环己酮(3a)和2,6-二(2-氟亚苯基)环己酮(3b)的抗肿瘤谱广, 活性较好, 就此对化合物3b作了单晶培养, 并就晶体结构进行了X衍射分析. 结构表明化合物3b属三斜晶系, 空间群 P-1. 晶胞参数 a=0.9222(2) nm, b=0.9732(2) nm, c=1.0127(2) nm, α=88.920(4)°, β=75.672(3)°, γ=62.404(3)°, V=0.7755(3) nm3, Z=2, Dc=1.329 Mg•m-3, μ=0.097 mm-1, F(000)=324, 最终偏离因子R=0.0590, wR=0.1841. 相似文献
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新型含氟α-氨基膦酸酯的合成和晶体结构 总被引:6,自引:2,他引:4
利用含氟苯基亚胺与亚磷酸酯反应,合成了新型含氟α-氨基膦酸酯,通过元素分析、红外光谱、质谱、核磁共振氢谱对其结构进行了表征.X射线单晶衍射测试结果表明:化合物为三斜晶系,空间群P1,a=1.0178(6)nm,b=1.0354(6)nm,c=2.2534(13)nm,α=77.413(10)°,β=78.340(10)°,y=77.540(10)°,V=2.233(2)nm3,Z=4,Dc=1.289 Mg·m-3,μ=O.175 mm-1,F(000)=904.0,最终偏离因子R=0.0728,wR=0.1724. 相似文献
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A novel aqueous fluorine-containing polyurethane was prepared with a hydrophobic macromonomer of a perfluoroalkyl group. Two representative properties of the polyurethane, initial particle diameter dispersed in water and surface free energy of coating films, were investigated. The macromonomer was synthesized by radical copolymerization of perfluoroalkylethyl acrylate and methyl methacrylate with a diol of chain-transfer agent in order to attenuate solubility and hydrophobic property. Anionic aqueous polyurethane was obtained with a good hydrophobic film property by one-step condensation polymerization of the macromonomer with hydrophilic comonomers and successive ionization. The polyurethane showed an initial average diameter of less than 1100 nm in water and surface free energies of less than 19 dyn/cm. The water dispersion property and hydrophobic surface property of the polyurethane can be controlled by controlling the content and hydrophobic property of the macromonomer. The incorporation of the macromonomer in the polyurethane backbone did not show a significant effect on the glass transition temperature, or the softness, of the polyurethane. Copyright 2001 Academic Press. 相似文献
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含氟聚氨酯-丙烯酸酯核壳乳液的制备及性能 总被引:4,自引:0,他引:4
以甲基丙烯酸羟乙酯封端的水性聚氨酯作为大分子单体,与甲基丙烯酸甲酯及甲基丙烯酸全氟烷基乙基酯在乳液中进行自由基共聚合,制得具有核壳结构的水性含氟聚氨酯-丙烯酸酯乳液。通过激光粒度分析、FT-IR、DSC、TGA、表面性能测试、力学性能测试等表征手段,对乳液及其乳胶膜的结构和性能进行了检测,另外,还着重探讨了甲基丙烯酸全氟烷基乙基酯的含量对乳胶膜性能的影响。结果表明:所制得的材料具有预期结构,并且表面能及吸水率低,力学性能优异。氟单体的引入使乳胶膜的表面能大大降低,而力学性能明显提高。 相似文献