共查询到20条相似文献,搜索用时 15 毫秒
1.
S. M. Ramsh A. V. Smirnova S. Yu. Solovyova Song Minyan 《Chemistry of Heterocyclic Compounds》2008,44(1):92-95
Mechanisms are given for reactions taking place upon heating 2-amino-5-benzylidene-1,3-thiazol-4(5H)-one in a medium consisting
of a secondary amine.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 111–114, January, 2008. 相似文献
2.
Patrizia Diana Antonina StagnoPaola Barraja Alessandra MontalbanoAnna Carbone Barbara ParrinoGirolamo Cirrincione 《Tetrahedron》2011,67(19):3374-3379
Derivatives of the new ring system pyrrolizino[2,3-b]indol-4(5H)-one were prepared in four steps starting from substituted benzonitriles bearing a functionalized amino group in the adjacent position. The unsubstituted- and the dimethoxy-pyrrolizinoindolones 5a and 5b exhibited modest activity against the HL-60(TB) human leukemia cell line, whereas the N-methylated dimethoxy-pyrrolizinoindolone 6b showed to be selective against MOLT-4 leukemia, A549/ATCC, HOP-92, and NCI-H460 non-small cell lung cancer, and CAKI-1 renal cancer cell lines. 相似文献
3.
O. B. Ryabova V. A. Makarov L. M. Alekseeva A. S. Shashkov V. V. Chernyshev V. G. Granik 《Russian Chemical Bulletin》2005,54(8):1907-1914
ortho-Chloroaryl(hetaryl)carboxamides containing one or two nitro groups at positions 3 and/or 5 of the ring undergo condensation
accompanied by the pyrimidine ring closure on refluxing in an excess of sodium methoxide to form bicyclic products, viz., quinazolin-4-one, pyrido[2,3-d]pyrimidin-4-one, and pyrido[4,3-d]pyrimidin-4-one derivatives. The scheme of cyclization processes was proposed. The structures of the reaction products were
confirmed by a number of physicochemical data, including X-ray diffraction analysis.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1851–1858, August, 2005. 相似文献
4.
Jin Luo Shu Li Qiongwen Kang Yi Sun 《Phosphorus, sulfur, and silicon and the related elements》2013,188(12):1180-1186
AbstractSixteen novel 3-methylthio-5-substituted benzamido-6-arylamino-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4 (5H)-one derivatives (4a–p) were successfully synthesized from iminophosphoranes, aryl isocyanate, and substituted benzoylhydrazine. The structures of the title compounds were elucidated by FT-IR, 1H NMR, 13C NMR, and HRMS. Herbicidal activity of the compounds 4a–p against Brassica napus (rape), Echinochloa crusgalli (barnyard grass), Cucumis sativus (cucumber), and Triticum aestivum (wheat) were determined. The results showed that 5-(2-chlorobenzamido)-6-phenylamino-3-methylthio-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4 (5H)-one (4c) displayed remarkable inhibition activity against the stalk and root of rape with 100% inhibition rate at the dosages of 10?mg/L and 100?mg/L, and 5-(4-nitrobenzamido)-6-phenylamino-3-methylthio-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4 (5H) -one (4d) exhibited excellent activity against the stalk and root of barnyard grass with 100% inhibition rate at the same dosages. 相似文献
5.
6.
A simple and convenient synthetic approach to access of 3H-pyrrolo[2,3-c]quinolin-4(5H)-one derivatives by the reaction of (Z)-3-(2-oxo-2-ethylidene)indolin-2-one derivatives 1 with functionalized TosMICs under basic conditions has been reported. The desired products were obtained in good to excellent yields (82–94%). The easy accessibility of the starting materials, simple and mild reaction conditions, short reaction time, and good to excellent chemical yields make this methodology highly efficient. 相似文献
7.
V. A. Dorokhov A. V. Komkov E. M. Shashkova V. S. Bogdanov M. N. Bochkareva 《Russian Chemical Bulletin》1993,42(11):1848-1854
Monoacylketene aminals containing an unsubstituted NH2 group react as C-nucleophiles with benzoyl isothiocyanate to give the corresponding thioamides which undergo cyclization by sodium methoxide in methanol to afford 6-R-amino-5-acetyl-2-phenyl-3H-pyrimidine-4-thiones. A scheme for constructing the pyrido[2,3-d]pyrimidine system from keteneaminals is offered. The reaction of 6-R-amino-5-acetyl-2-phenyl-3H-pyrimidine-4-thiones with dimethylformamide dimethylacetal leads to 8-R-N-4-methylthio-8H-pyrido-[2,3-d]pyrimidine-5-ones. Cyclization of 5-acetyl-6-benzoylamino-4-methylthio-2-phenylpyrimidine by sodium methoxide yields N-unsubstituted 4-methylthio-8H-pyrido-[2,3-d]pyrimidine-5-one.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 1932–1937, November, 1993 相似文献
8.
Two novel schemes have been developed for the synthesis of pyrrolocoumarin derivatives. A series of previously unknown 4,9-dimethylpyrano[3,2-e]indol-7(3H)-ones have been prepared.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No 10, pp. 1524–1532, October, 2004. 相似文献
9.
10.
A. V. Komkov B. I. Ugrak V. S. Bogdanov V. A. Dorokhov 《Russian Chemical Bulletin》1994,43(8):1392-1397
New methods for annelation of a pyridine ring to a pyrimidine ring were suggested. Substituted 8H-pyrido[2,3-d]pyrimidin-5-ones (8a-f) were synthesized by the interaction of 2,6-disubstituted 4-amino-5-acetylpyrimidines (1–4) with formamide or acetamide acetals followed by cyclization under the action of sodium methoxide in methanol. 2,4-Disubstituted 7-phenyl-8H-pyrido[2,3-d]pyrimidin-5-ones (11a-c) were prepared by the reaction of 2,6-disubstituted 5-acetyl-4-benzoylaminopyrimidines (10a-c) with MeONa in boiling BuOH.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1469–1474, August, 1994. 相似文献
11.
V. V. Bakharev A. A. Ghidaspov D. B. Krivolapov E. V. Mironova I. A. Litvinov 《Chemistry of Heterocyclic Compounds》2006,42(8):1051-1058
2-Amino-4-azido-1,3,5-triazin-6(1H)-ones were synthesized by successive substitution of the trinitromethyl groups in 2-amino-4,6-bis(trinitromethyl)-1,3,5-triazines
under the influence of azide and nitrite ions. Interaction of 2-amino-4-azido-1,3,5-triazin-6(1H)-ones with bases led to the
azido-tetrazole tautomeric conversion give salts of 5-aminotetrazolo[1,5-a]-1,3,5-triazin-7-one.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1211–1219, August, 2006. 相似文献
12.
Condensation of 1-alkyl-, 1-allyl-, and 1-benzyl-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-ones with benzaldehydes in acetic acid and subsequent treatment of the reaction mixture with potassium hydroxide afforded 1-substituted 9a-(2-phenylethenyl)-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-one derivatives. 1-Methyl- and 1-ethyl-9a-[2-(4-dimethylaminophenyl)ethenyl]-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-ones were synthesized by alkylation of 9a-[2-(4-dimethylaminophenyl)ethenyl]-1,2,3,9a-tetrahydro-9H-imidazo[1,2-a]indol-2-one with methyl- and ethyl iodides in DMF in the presence of a strong base. 相似文献
13.
M. Musawwer Khan Biswas Saigal Sumbulunnisan Shareef Sarfaraz Khan Subash C. Sahoo 《合成通讯》2013,43(20):2683-2694
AbstractA facile and practical method was described for the synthesis of 4H-chromen-5-ones under catalyst- and solvent-free conditions by one-pot stirring of starting materials at 110?°C. The products were obtained by the reaction between cyclic 1,3-dicarbonyl compounds, aromatic aldehydes and (E)-N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) in short duration with good to excellent yields. This simple and environmentally benign method eliminates the use of expensive, metallic and corrosive catalysts, hazardous organic solvents, and chromatographic separation. 相似文献
14.
We have obtained 4-alkyl-6-amino-5-cyano-3-methyl(propyl, phenyl)-2H,4H-pyrano[2,3-c]pyrazoles by reaction of 4-alkylmethylene-3-substituted 5-pyrazolones with malononitrile or cyanothioacetamide. We have used X-ray diffraction to study the structure of 6-amino-5-cyano-4-isopropyl(hexyl)-3-phenyl-2H,4H-pyrano[2,3-c]pyrazoles. 相似文献
15.
T. A. Kuz’menko V. V. Kuz’menko A. S. Morkovnik L. N. Divaeva 《Chemistry of Heterocyclic Compounds》2006,42(5):648-656
Condensation of 2-alkylamino-1-aminobenzimidazoles and quaternary 1,2-diamino-3R-benzimidazolium salts with pyruvate and α-ketoglutaric
acid has given 4-and 5-substituted 2-methyl-and 2-(2-carboxyethyl)-1,2,4-triazino[2,3-a]benzimidazol-4(5)H-3-ones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 738–747, May, 2006. 相似文献
16.
Jan Kalembkiewicz Jean-Pierre Brunette Maurice J. F. Leroy 《Monatshefte für Chemie / Chemical Monthly》1989,120(8-9):691-698
Summary The effect of aniline derivatives [4-methylaniline=4-toluidine, 3,4-dimethylaniline=3,4-xylidine, N,N-dimethylaniline and tribenzylamine (Am)] on the extraction of cobalt from sulphate, nitrate and perchlorate aqueous media of 1.0M ionic strength with 1-phenyl-3-methyl-4-benzoylpyrazol-5-one (HL) in toluene, has been quantitatively studied. With both primary amines a synergic effect was found owing to theAmH·CoL
3 ion pair extraction. TheAmH·CoL
3 average formation constant, from CoL
2 andAmH·CoL, was logK
s
=3.7 and 3.8 forAm=4-toluidine and 3,4-xylidine respectively. With N,N-dimethylaniline and tribenzylamine which are poorly protonated in the cobalt extractionpH range (4–6), no noticeable synergism was observed.On leave from: Department of Inorganic Chemistry, Chemical Faculty, Ignacy Lukasiewicz Technical University, PL-35-959 Rzeszow, Poland 相似文献
17.
A method for the synthesis of methyl and ethyl 2-R1-4-R2-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-7-carboxylates was proposed. The method is based on condensation of 2-R1-6-R2-5-acetyl-4-aminopyrimidines with ethyl oxalate in the presence of MeONa or EtONa. Products of the Friedländer self-condensation of the starting pyrimidines were also obtained. 相似文献
18.
Summary 5H-Indolo[3,2-a]-6H-phenothiazin-6-one and its regioisomer 1H-Indolo[2,3-a]-6H-phenothiazin-6-one were prepared by the condensation of 2-aminobenzenethiol with carbazole-1, 4-dione or with isomeric mixture of bromo-carbazole-1,4-diones.
Synthese von Indolo-Phenothiazin-6-on-Derivaten (Kurze Mitteilung)
Zusammenfassung 5H-Indolo[3,2-a]-6H-phenothiazin-6-on und sein Regioisomer 1H-Indolo[2,3-a]-6H-phenothiazin-6-on wurden mittels Kondensation von 2-Aminobenzolthiol mit Carbazol-1,4-dion oder mit einer isomeren Mischung von Bromcarbazol-1,4-dionen hergestellt.相似文献
19.
杂环化合物1 苯基 3 甲基 4 吡唑啉 5 酮(HPMP)为β 二酮,不仅可用作金属离子的萃取剂,还可用于核磁共振的位移试剂,也可用于激光、催化、生化、医学等领域[1-4]。我们从PMP出发,合成了它的Co(Ⅱ),Ni(Ⅱ),Cu(Ⅱ)和Zn(Ⅱ)的络合物[5,6]。利用单晶X 射线衍射分析方法报道了标题化合物的晶体结构。1 实验部分在合成PMP席夫碱化合物的过程中,得到标题化合物的单晶体。元素分析结果(括号内为计算值)C%:69 87(69 98),H%:5 62(5 59),N:15 61(15 55)。红外光谱(KBr):1645和1637cm-1的强吸收峰归属为羰基的伸缩振动,… 相似文献
20.
Sunil Vibhute Dattatraya Jamale Santosh Undare Navanath Valekar Kirti Patil Govind Kolekar 《合成通讯》2017,47(19):1747-1757
An environmental friendly synthetic route has been investigated for the synthesis of quinazolin-8 (4H)-one derivatives in the presence of anthranilic acid as a catalyst. The zwitter ion formed in course of reaction may a play key role in the desired transformations leading good to excellent yields. Evaluation of the present protocol by green chemistry metrics demonstrated that it is highly efficient and eco-compatible. 相似文献