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1.
针对二苯并[d,f][1,3]二噁烷传统制备方法中易产生二羟基联苯乙烯副产物的缺点,本文以路易斯酸性胍盐离子液体为催化剂,2,2'-二羟基联苯和端基炔为原料,高区域选择性的合成了二苯并[d,f][1,3]二噁烷,收率39%~84%。 本方法适用于各种端基炔。路易斯酸性胍盐离子液体循环利用5次,活性不变。 相似文献
2.
Russian Journal of Organic Chemistry - New spiro heterocycles, spiro[benzo[h]chromene-4,3′-indoles] and spiro[benzo[f]chromene-1,3′-indoles], have been synthesized in 50–60% yield... 相似文献
3.
P. Haranath V. Sreedhar Kumar C. Suresh Reddy C. Naga Raju C. Devendranath Reddy 《合成通讯》2013,43(10):1697-1708
6‐Substituted‐dibenzo[d, f][1,3,2]dioxaposphepin‐6‐oxides, sulfides, and selenides (5a–i, 6a–d, and 7a–d) were synthesized by reacting 2,2′‐biphenol (1) with phosphorus tribromide in the presence of triethylamine at 0–30°C and subsequent reaction of the monobromide (2) with different Grignard reagents (3) at room temperature. The products (4) were converted to corresponding oxides, sulfides, and selenides (5a–i, 6a–d, and 7a–d) by oxidation with H2O2 at room temperature and refluxing with sulfur and selenium respectively. The chemical structures of all the products were confirmed by analytical, IR, NMR (1H, 13C, and 31P), and mass spectral data. Most of these compounds exhibited moderate antimicrobial activity. 相似文献
4.
HUANG Wei-Yuan LIU Yan-Song LU LongShanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China 《中国化学》1994,(1)
Several polyfluoroalkylated heterocyclic compounds containing methylenedioxy group such as 2-(F-alkyl) substituted 1,3-benzodioxole, piperonal, 4H-1,3-benzodioxin, 1,3-dioxolane and 6-(F-alkyl) substituted dibenzo[d,f][1,3]dioxepin have been prepared through double Michael-addition reactions of 2,2-dihydropolyfluoroalkanoates with the corresponding diphenols or diols in high yields. 相似文献
5.
3′O-silylated derivatives of 5′-O-DMT-2′deoxynucleoside (2) were synthesized in high yield by reaction of 5′-O-DMT-2′-deoxynucleosides (1) with tert-butyl dimethylsilylchloride using sodium hydride, benzyltriethylammonlum chloride [TEBA] and a catalytic amount of dibenzo-[18]-crown-6 [DB-18-C-6] or 15-crown-5 [15-C-51 under mild reaction conditions. 相似文献
6.
Osyanin V. A. Popova Yu. V. Klimochkin Yu. N. 《Russian Journal of Organic Chemistry》2010,46(2):302-303
Russian Journal of Organic Chemistry - 相似文献
7.
É. O. Chukhadzhyan Él. O. Chukhadzhyan K. G. Shakhatuni N. T. Gevorkyan A. T. Babayan 《Chemistry of Heterocyclic Compounds》1996,32(3):280-284
Dialkylpropargyl(3-,-cyclohexenylpropargyl)amrnonium salts are cyclized in the presence of a base catalyst to give dialkyltetrahydrobenzlfliso-indoline salts in high yields. When the 3--cyclohexenylpropargyl and 3 phenylpropargyl groups are both present in the ammonium salt molecule, cyclization proceeds in more than one direction. Salts which contain both the 3-a-naphthylpropargyl and 3-alkenylpropargyl groups are also cyclized in two possible ways.Institute of Organic Chemistry, Republican Academy of Sciences, Armenia, Yerevan. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 328–332, March, 1996. Original article submitted September 30, 1995. 相似文献
8.
2-Thioxo-1,2-dihydrobenzo[d][1,3]thiazin-4-one (TDBTO), a new thiazin-one derivative, was synthesized and investigated. The crystal structure of TDBTO (CsHsNOS2, Mr = 193.8) was determined by single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1 with a = 6.946(3), b = 7.402(3), c = 8.954(4)A, α = 66.931(7)°,β = 89.866(7)°, γ = 72.289(7)°, V = 399.8(3) A^3, Z = 2, Mr = 195.25, Dc = 1.622 g/cm^3,μ = 0.606 mm^-1, F(000) = 200, R = 0.0361 and wR = 0.1032. There exist intermolecular hydrogen bond of N(1)-H(1A)-..O(1) and weak C(6)-H(6A)...O(1) contact in the structure as well as face-to-face π-π stacking interactions between the benzene ring and the thiazin ring of an adjacent benzothiazin unit. The photoinduced proton transfer reaction, transforming the initial thione into thiol form, was found, and the latter form was characterized by UV absorption spectra, fluo-rescence spectra and infrared spectra. 相似文献
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10.
Krystyna Bogdanowicz-Szwed Artur Budzowski Regina Gil Pawe? Serda 《Monatshefte für Chemie / Chemical Monthly》2010,57(7):63-74
Abstract
The new thioamides 2-oxoindane-1-carbothioamides and 2-oxo-1,2,3,4-tetrahydronaphthalene-1-carbothioamides underwent conjugated addition to (E)-β-nitrostyrenes followed by cyclization to give products containing 5-hydroxyimino-2-aryliminothiophene rings spiro-annulated to the 2-indanone or 2-tetralone system. On treatment with hydrochloric acid in boiling methanol the compounds underwent a new rearrangement, involving transformation of the 2-aryliminothiophene ring to a pyrrole and an opening of the alicyclic ring in the proximity of the carbonyl group, affording 2-(1,3-diaryl-2-oxo-5-thioxopyrrol-4-yl)benzeneacetic or 2-(1,3-diaryl-2-oxo-5-thioxopyrrol-4-yl)benzenepropanoic acid methyl esters. The structures of two selected pyrrole derivatives were determined by X-ray crystal analyses. The thioamides derived from 2-indanone showed unexpected reactivity towards primary alcohols and underwent conversion to 2-hydroxy-1H-indene-3-thiocarboxylic acid O-esters. 相似文献11.
A rapid, efficient and benign protocol has been developed for the construction of potentially biologically active furo[2′,3′:4,5]pyrimido[2,1-b][1,3]benzothiazole derivatives as major products along with (3E)-3-[(alkylamino)methylene]-2H-pyrimido[2,1-b][1,3]benzothiazole-2,4(3H)-dione derivatives as minor products using a one-pot, multi-component reaction of isocyanides, aromatic aldehydes and 2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one. The significant features of this protocol are the readily available and low-cost starting materials, short reaction time, mild reaction conditions, high yield of products and avoidance of toxic solvents and catalysts. Structures of compounds 4b and 5a were confirmed from single crystal X-ray studies. 相似文献
12.
Sandra Kolly Hansrudolf Meier Talmo Winkler 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4)
Abstract Besides the common cyclisation reactions between divalent electrophiles such as Soc12, SC12, etc. and 2,2′-alkylidene-bisphenols 1 with selective attack by the two oxygens yielding dibenzo[d,g][1,3,2]dioxathiocines [1] we observed previously an unusual cyclisation of 1 with S2CI2 with a nucleophilic attack by the ortho- and para-carbon atoms (C(2) and C(4)) of bisphenol 1 [2]. We now report a new type of cyclocondensation reaction of 4,4′,6,6′-tetrasubstituted 2,2′-alkylidene-bisphenols 1 with ClSCOCl affording spiro[1,3-benzoxathiepin-4(5H),1′-cyclohexa[2,4]dien]-2,2′-diones 2 together with the cyclic carbonates 3. The structures of the products were elucidated mainly by l3C-NMR- and 1H-NMR-spectroscopy. The mode of formation of the novel spiro thiocarbonates 2 resp. the known carbonates 3 [3] is discussed. 相似文献
13.
Hong Min MA Zhan Zhu LIU Shi Zhi CHEN Xiao Tian LIANGInstitute of Materia Medica Peking Union Medical College & Chinese Academy of MedicalSciences Beijing 《中国化学快报》2004,(7)
A concise and efficient synthesis of the new compounds tetrahydroisoquino [2,1-c] [1,3] benzodiazepine 5 and 7 is reported. 相似文献
14.
Fahmy M. Asaad Nazih Latif Nawal Mishriky Ibrahim Zeid 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-2):17-18
Abstract In the present investigation, the authors could obtain a new series of spiranes (1) through the reaction of the high potential quinone tetrachloro-o-benzoquinone with 2-aryl-3-phenyl-3H-quinazoline-4-thiones. Thus, 2,3-diphenyl- (2a), 2-p-tolyl-3-phenyl- (2b) and 2-p-anisyl-3-phenyl- (2c)-3H-quinazoline-4-thiones react readily with tetrachloro-o-benzoquinone, in boiling toluene, to give the corresponding spiro-1,3-benzodioxole-2,4′-(3′H)-quinazolines (1a-c), respectively. 相似文献
15.
Mohamed A. A. Elneairy Mohamed A. M. Gad-Elkareem Azza M. Abdel-Fattah 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):1451-1466
Pyrdine-2(1H)-thione 1 reacted with ethyl chloroacetate 2 to give 2-S-ethoxy-carbonylmethylpyridine derivative 3, which could be cyclized into thieno[2,3-b]-pyridine-2-carbohydrazide derivative 5 by boiling with hydrazine hydrate. The latter compound reacted with cinnamonitrile derivatives 6a, b, triethylorthoformate, formic acid, dimethylformamide-dimethylacetal, and diethyl carbonate to give the corresponding shiff base 7a, b and pyrido[3′,2′;-4,5]thieno[3,2-d]pyrimidine derivatives 10–13 in respective manner. On the other hand, compound 5 also reacted with carbondisulphide and phenyl isothiocyanate to afford the corresponding 2-(1,3,4-oxadiazolo-2-yl)thieno[2,3-b]pyridine derivatives 18 and 22. Finally, compound 5 reacted with some β-dicarbonyl compounds, such as ethyl acetoacetate, acetylacetone and ethyl β-arylazoacetoacetate, to yield the corresponding 2-(pyrazol-1-yl-carbonyl)thieno[2,3-b]pyridine derivatives 24, 25, and 27 respectively. 相似文献
16.
A. N. Perevoshchikova A. A. Gorbunov Yu. S. Rozhkova P. A. Slepukhin Yu. V. Shklyaev 《Russian Journal of Organic Chemistry》2014,50(4):513-517
The reaction of 1-(4-methoxyphenyl)-1-(1-methylcyclohexyl)ethanol with nitriles in concentrated sulfuric acid afforded 1′-substituted 6′-methoxy-4′,4′-dimethyl-4′H-spiro[cyclohexane-1,3′-isoquinolines] as a result of consecutive Wagner-Meerwein rearrangement and Ritter reaction. 相似文献
17.
18.
L. G. Levkovskaya I. E. Mamaeva L. A. Serochkina T. S. Safonova 《Chemistry of Heterocyclic Compounds》1993,29(4):480-483
Representatives of new heterocyclic systems were obtained — pyrido[3,25,6][1,4]thiazino[3,4-c]- and pyrimido[5,45,6][1,4]thiazino[3,4-c][1,2, 4]triazines. Hydrazides of N-(pyrid-3-yl)- and N-(pyrimid-5-yl)oxamic acids were isolated and characterized. Their acylation products were investigated.For communication 45, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 559–562, April, 1993. 相似文献
19.
V. E. Éman M. S. Sukhanov O. V. Lebedev L. V. Batog L. I. Khmel'nitskii 《Chemistry of Heterocyclic Compounds》1996,32(2):227-228
4,4-Diamino-3,3-azofurazane undergoes intramolecular oxidative cyclization to give 5-[4-amino(1,2,5)oxadiazolyl]-5H-[1,2,3]triazolo[4,5-c][1,2,5]oxadiazole upon heating with Pb(OAc)4 in chlorobenzene oro-dichlorobenzene or with thionyl chloride.Deceased.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 253–254, February, 1996. 相似文献
20.
4,4‐Dialkyl and 4,4‐diaryl‐4H‐benzo[d][1,3]oxathiin‐2‐ones were synthesized by the reaction of 2‐(mercapto‐phenyl)‐dialkyl‐ (or diaryl)‐methanol with CDI in excellent yield. The 2‐(mercaptophenyl)‐dialkyl‐ (or diaryl)‐methanols were prepared by the reaction of commercially available methylthiosalicylate with an appropriate alkyl or aryl Grignard reagent. 相似文献