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1.
Katalin Csukonyi János Lázár Gábor Bernáth István Hermecz Zoltán Mészáros 《Monatshefte für Chemie / Chemical Monthly》1986,117(11):1295-1303
The following tetracyclic ring systems and their derivatives have been synthesized for pharmacological investigations: Trimethylenethieno[2,3—d]dihydropyrrolo[1,2—a]pyrimidin-4-one and -4-thione (1 a, 5 a); Tetramethylenethieno[2,3—d]dihydropyrrolo[1,2—a]pyrimidin-4-one and -4-thione (1 b, 1 j, 5 b); Pentamethylenethieno[2,3—d]dihydropyrrolo[1,2—a]pyrimidin-4-one and-4-thione (1 c, 5 c); Trimethylenethieno[2,3—d]tetrahydropyrido[1,2—a]pyrimidin-4-one and -4-thione (1 d, 5 d); Tetramethylenethieno[2,3—d]tetrahydropyrido[1,2,—a]pyrimidin-4-one and -4-thione (1 e, 5 e); Pentamethylenethieno[2,3—d]tetrahydropyrido[1,2—a]pyrimidin-4-one and -4-thione (1 f, 5 f); Trimethylenethieno[2,3—d]tetrahydroazepino[1,2—a]pyrimidin-4-one and -4-thione (1 g, 5 g); Tetramethylenethieno[2,3—d]tetrahydroazepino[1,2—a]pyrimidin-4-on and -4-thione (1 h, 5 h); Pentamethylenethieno[2,3—d]tetrahydroazepino[1,2—a]pyrimidin-4-one and -4-thione (1 i, 5 i); Tentamethylenethieno[2,3—d]tetrahydroazepino[1,2—a]pyrimidin-4-one (7 b); Pentamethylenethieno-[2,3—d]tetrahydropyrido[1,2—a]pyrimidin-4-one (7 c).Compounds1 a–i were synthesized from 2-amino-3-ethoxycarbonyl-4,5-polymethylenethiophene2 a–c with the corresponding lactim ethers (3 a–c) in chlorobenzene in the presence of polyphosphoric acid (PPA). Compounds7 b and7 c were obtained in the reaction of -amino acid esters2 b and2 c with 2-bromopyridine (6). The thione derivatives (5 a–i) were prepared from compounds1 a–i with phosphorus(V) sulphide.Part 74:Szabó J, Fodor L, Szcs E, Bernáth G, Sohár P (1984) Pharmazie 39: 347. 相似文献
2.
H. Junek Brigitte Hornischer H. Sterk 《Monatshefte für Chemie / Chemical Monthly》1968,99(5):2121-2125
Zusammenfassung Malonitril und Acenaphthenchinon reagieren bei Anwesenheit von Basen zum blau gefärbten 6b-Hydroxy-8-imino-7,8-dihydro-6bH-cyclopenta [a]acenaphthylen-7,7,9-tricarbonsäurenitril (5). Kondensation mit Acenaphthenon führt zum 1-Dicyanmethylen-acenaphthen (7) bzw. zum 8-Amino-acenaphtho-[2,1—j]fluoranthen-7-carbonsäurenitril (9).
The reaction of malononitrile and acenaphthenequinone in the presence of bases yields a blue compound, 6b-hydroxy-8-imino-7, 8-dihydro-6bH-cyclopenta[a]acenaphthylene-7,7,9-tricarbonitrile (5). Condensation with acenaphtenone gives 1-dicyanomethyleneacenaphtene (7) and 8-aminoacenaphtho[2,1—j]fluoranthene-7-carbonitrile (9), resp.相似文献
3.
V. Bobošík A. Krutošíková U. Jordis 《Monatshefte für Chemie / Chemical Monthly》1995,126(6-7):747-752
Summary A number of substituted 2,3-dimethylfuro[3,2-c]pyridines was synthesized. 3-(4,5-Dimethyl-2-furyl)propenoic acid (1) was converted to the acid azide2, which in turn was cyclized to give 2,3-dimethyl-5H-furo[3,2-c]pyridine-4-one (3) by heating at 240°C in Dowtherm. The pyridone3 was chlorinated with phosphorus oxychloride to give4, which was reduced with zinc and acetic acid to 2,3-dimethylfuro[3,2-c]pyridine (5). Treatment of4 with several secondary heterocyclic amines led to compounds6a–6c. Reaction of pyridone3 with phosphorus pentasulfide rendered the thione7, which was methylated to8a. The 4-methoxy derivative8b was obtained from4 with sodium methoxide. 2,3,5-Trimethylfuro[3,2-c]pyridine-4-one (9) was obtained by reaction of3 with methyl iodide.Dedicated to Professor Dr.Fritz Sauter on the occasion of his 65th birthday 相似文献
4.
Summary Acetylation of the indazolquinones1a (6-anilino-),b (6-p-toluidino-),c (6-N-methylanilino-),g (6- or 5-methylthio-), andk (benz[f]-) by heating with acetic anhydride yields the 2-acetylindazolquinones4a, b, c, g, andk. Reductive acetylation of the quinones1c, g, h/h
1(6/5-methyl),k and — for structure elucidation — their 1-N- (2c) and 2-N- (3c, 3e)-methyl derivatives with acetic anhydride, zink powder, and sodium acetate gives the 1-acetyl-(7c, g, h/h
1,k), resp. 1-methyl- (8c), and 2-methyl- (9c, e) diacetoxyindazoles. In case of1k, two diacetyl derivatives were isolated in addition to the already known triacetyl derivative7k, regardless of the conditions chosen. Acetylation of the intermediate product of the reaction from phenylthio-benzoquinone with diazomethane also yields a triacetyl-hydroquinone (7f). UV/Vis, IR, and1H NMR spectroscopy were used for structure determination. Comparison of the UV/Vis spectra of the acetyl derivatives4 with those of1, 2, 3, and of compounds7 with those of analog substituted indazols shows that the acetyl group is located in position 2 with compounds4 and in position 1 with compounds7. By means of1H NMR spectra the position of the acetyl group can be determined by the effect of the carbonyl group on the proton in position3. 相似文献
5.
W. Klötzer S. Teitel J. Blount A. Brossi 《Monatshefte für Chemie / Chemical Monthly》1972,103(2):435-441
Zusammenfassung Als Modell für die geplante Umformung von Phthalidisochinolinalkaloiden in natürliche Benzazepinalkaloide (Rhoeadinalkaloide) wird das aus (–)-Narcotin zugängliche Nornarcein2a oder dessen Äthylester2b
2 in das Rheadan8b
1 übergeführt. Ein Rheadan mit dem aromatischen Substitutionsmuster von8b wurde bisher in der Natur noch nicht aufgefunden.
Herrn Prof. Dr.O. Kratky zum 70. Geburtstag gewidmet. 相似文献
Conversion of Phthalideisoquinolines into Benzazepine Alkaloids
As a model for the planned conversion of phthalideisoquinoline alkaloids into natural benzazepine alkaloids (rhoeadine type), nornarceine2a or its ethyl ester2b [obtained from (–)-narcotine,1]2 have been transformed into the rheadane8b 1. The aromatic substitution pattern of8b has not yet been observed in nature.
Herrn Prof. Dr.O. Kratky zum 70. Geburtstag gewidmet. 相似文献
6.
A. Chatterjee A. Sahu M. Saha J. Banerji 《Monatshefte für Chemie / Chemical Monthly》1996,127(12):1259-1262
Summary Sempervirine (2,3,4,13-tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium,1) the pentacyclic anhydronium indole alkaloid ofGelsemium sempervirens Ait. f. (Loganiaceae), has been synthesized in three steps from hexahydroisochroman-3-one (6) and N-2-(3-indolyl)-ethylamine (tryptamine,7). The condensation product, N-2-(3-indolyl)-ethyl-2-(hydroxymethyl)-trans-hexahydrophenylacetamide (8) arising from6 and7 on double cyclization with phosphoryl chloride yielded the 3,4-dehydroyohimbane derivative9. Aromatization of rings C and D of compound9 with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in glacial acetic acid, followed by basification, generated sempervirine (1).
Synthese von Sempervirin, einem pentacyclischen Anhydronium-Indolalkaloid
Zusammenfassung Sempervirin (2,3,4,13-Tetrahydro-1H-benz[g]indolo[2,3-a]chinolizin-6-ium,1), das pentacyclische Anhydronium-Indolalkaloid vonGelsemium sempervirens Ait f. (Loganiceae) wurde ausgehend von Hexahydroisochroman-3-on (6) und N-2-(3-Indolyl)-ethylamin (Tryptamin,7) in 3 Stufen synthetisiert. Das durch doppelte Cyclisierung von6 und7 mit Phosphorylchlorid entstehende Kondensationsprodukt N-2-(3-Indolyl)-ethyl-2-(hydroxymethyl)-trans-hexahydrophenylacetamid (8) ergab das 3,4-Dehydroyohimbanderivat9. Aromatisierung der Ringe C und D von9 mit 2,3-Dichlor-5,6-dicyanobenzochinon (DDQ) in Eisessig und anschließende Einstellung eines basischenpH-Werts lieferte Sempervirin (1).相似文献
7.
Zusammenfassung 4-O-Methyl-7,8-dehydro-metathebainon-methin (1) geht in alkalischer Lösung in das Naphthalin-Derivat3 über, das unter Abspaltung von Formiat7 liefert. Das Auftreten von3 kann durch Isolierung von13a nach Reduktion mit NaBH4 nachgewiesen werden. Die aus3 und7 durch Reduktion erhaltenen Alkohole8a und13a werden in saurer Lösung unter Methanol-Abspaltung zu den 2,3-Dihydro-naphtho[1,8-bc]pyranen9 und14 cyclisiert.
Mit 2 Abbildungen 相似文献
A new rearrangement of a metathebainone derivative with a cyclohexa-2,5-dienone groupment
4-O-Methyl-7.8-dehydrometathebainonemethine (1) in alkaline solution rearranges to the naphthalene derivative3, which eliminates formiate to give7. The occurrence of3 was confirmed by isolation of13a after reduction with NaBH4. The hydroxy compounds8a and13a, obtained by reduction, eliminate methanol and cyclize to the 2.3-dihydronaphtho[1.8-bc]pyrans9 and14.
Mit 2 Abbildungen 相似文献
8.
Repetition of the work ofSugino andTamaka
1 showed that acrylonitrile and guanidine react inDMF to yield not only 3,4,6,7-tetrahydro-2H-pyrimido[1,2—a]pyrimidine-2,8(1H)-diimine (1), but a mixture (F) of1 (as a main product) and 2-amino-4-imino-1,4,5,6-tetrahydropyrimidine-1-propionitrile (7) besides one or two bases not identified so far.1 and7 were isolated as picrates. For the prove of their structures,1- and7-picrate were also prepared by an unequivocal synthesis starting from iminodipropionitrile hydrochloride8 · HCl: The latter on reaction with cyanamide gave9 which cyclized to afford a mixture of1,7 and 2-amino-4-oxo-1,4,5,6-tetrahydropyrimidine-1-propionitrile (10). The picrates of1 and7 were identical with those prepared from the acrylonitrileguanidine-condensateF. This result supports the prior proposed1 structures of pyrimidopyrimidine1 and of4,5 and6, obtained by hydrolysis of1. Nmr-, ir-and some of the mass spectra of1,4,7–10 (and their salts) are reported. 相似文献
9.
Helga Wittmann V. Illi H. Sterk E. Ziegler 《Monatshefte für Chemie / Chemical Monthly》1968,99(5):1982-1989
Zusammenfassung Bei der Einwirkung vonAc
2O auf Phenylmalonsäure entsteht über die Dimerisationsprodukte7 bzw.8, welche aus Phenylketen bzw. Phenylketencarbonsäure gebildet werden, 1,6-Diacetoxy-2,5-diphenyl-3H-naphtho[2,1—b]pyran-3-on (1). Diese komplex verlaufende und unerwartete Reaktion ist in allen Einzelheiten aufgekläurt worden.
The reaction of acetic anhydride with phenylmalonic acid via phenylketene, carboxy phenylketene and the dimeric compounds7 and8 yields 1.6-diacetoxy-2.5-diphenyl-3H-naphtho-[2.1—b]pyran-3-one (1). This complex and unexpected result has been studied in detail.相似文献
10.
G. Kollenz 《Monatshefte für Chemie / Chemical Monthly》1971,102(1):108-113
Zusammenfassung Von den Pyrrol-2,3-dion-3-hydrazonen5–8 läßt sich lediglich7 in das Pyrrolo[2,3–b]indol-3-hydrazon (10) umlagern. Die analogen Heterocyclen9, 11 und12 sind durch direkte Einwirkung der entsprechenden Hydrazine auf die Pyrrolo[2,3–b]indole3 bzw.4 synthetisierbar.
Herrn Dr. techn. Dr. rer. nat. h. c. Dr. phil. h. c.W. G. Stoll, Forschungsdirektor der Ciba-Geigy-AG, Basel, zum 60. Geburtstag gewidmet. 相似文献
Syntheses of Heterocycles, CL: Reactions of Cyclic Oxalyl compounds, IV
Of the pyrrol-2,3-dione-3-hydrazones5–8 only7 can be rearranged to give the pyrrolo[2,3–b]indole-3-hydrazone10. The heterocyclic compounds9, 11, and12 are synthesized by the action of the corresponding hydrazines upon the pyrrolo[2,3–b]indoles3 and4, respectively.
Herrn Dr. techn. Dr. rer. nat. h. c. Dr. phil. h. c.W. G. Stoll, Forschungsdirektor der Ciba-Geigy-AG, Basel, zum 60. Geburtstag gewidmet. 相似文献
11.
Zusammenfassung 2,3,6,7,8-Pentachlorimidazo[1,2—b]pyridazin und 3,6,7,8-Tetrachlor-s-triazolo[4,3—b]pyridazin wurden aus unsubstituierten Verbindungen und einigen Chlor-Derivaten synthetisiert. Die Reihenfolge der Substitution von Wasserstoffatomen durch Chloratome konnte beim Imidazo[1,2—b]pyridazin als 3>2, 7>8>6 ermittelt werden, während beis-Triazolo-[4,3—b]pyridazin der Verlauf als 3>8>7>6 sichergestellt wurde. Nukleophile Substitutionen an diesen perchlorierten Systemen verlaufen am leichtesten in Stellung 8.
Pyridazines. XLVIII: Syntheses and Reactivity of 2,3,6,7,8-Pentachloroimidazo[1,2—b]pyridazine and 3,6,7,8-Tetrachloro-s-triazolo[4,3—b]pyridazine
2,3,6,7,8-Pentachloroimidazo[1,2—b]pyridazine and 3,6,7,8-Tetrachloro-s-triazolo[4,3—b]pyridazine were synthesized from the parent compounds and some of their chloro derivatives. It could be established that in the case of the first condensed system the stepwise introduction of chlorine atoms followed the order of 3>2, 7>8>6 and in the case of the second system this appears to be 3>8>7>6. Nucleophilic substitutions on these perchloro compounds proceed most easily at position 8.相似文献
12.
The HeI photoelectron (PE) spectra of indole ( 1 ), benzimidazole ( 2 ), indazole ( 3 ), 3-chloro-indazole ( 4 ), imidazo[1,2-b]pyridazine ( 5 ), 6-chloroimidazo[1,2-b]pyridazine ( 6 ), 2-phenyl-imidazo[1,2-b]pyridazine ( 7 ), 2-phenyl-6-chloroimidazo[1,2-b]pyridazine ( 8 ), tetrazolo[1,2-a]-pyridine ( 9 ) and 8-cyanotetrazolo[1,5-a]pyridine ( 10 ) have been recorded. The spectra of 2–10 are of special interest for studying lone pair interactions. The assignment of the PE spectra submitted here, conjointly with the electronic structure of the studied compounds is discussed on the basis of molecular orbital calculations. 相似文献
13.
Erich Zbiral Hannelore H. Brandstetter Erwin P. Schreiner 《Monatshefte für Chemie / Chemical Monthly》1988,119(1):127-141
The 7- and 8-Iodnonulosonic acid derivatives1 and2 react with tributyltinhydride-AIBN to the 7- and 8-deoxy-N-acetylneuraminic acid derivatives3 a and4 a which after hydrolysis give the 7-deoxy-N-acetylneuraminic acid3 b (5-N-acetamido-3,5,7-trideoxy--D-galacto-2-nonulopyranosidonic acid=7-Deoxy-Neu5Ac) and 8-deoxy-N-acetylneuraminic acid4 b (5-N-acetamido-3,5,8-trideoxy--D-galacto-2-nonulopyranosidonic acid=8-Deoxy-Neu5Ac). The 4,8,9-tris-(t-butyldimethylsilyl)-N-acetylneuraminic acid derivative5 a yields after transformation to the 7-O-acetyl compound5 b and partial removing of the protecting groups the derivative5 c. Further reaction with theMitsunobu-reagent and methyliodide affords the 9-Iodocompound6 a which turned to the 8-O-acetylderivative6 b. Subsequent reduction by means of tributyltinhydride yields first the 9-deoxyderivative7 a and after hydrolysis the 9-deoxy-N-acetylneuraminic acid7 b (5-N-acetyl amido-3,5,9-trideoxy-D-glycero--d-galacto-2-nonulopy-ranosidonic acid=9-Deoxy-Neu5Ac). Another synthesis of7 b follows the route8 f 8 g 7 c. The Deoxy-N-acetylneuraminic acid3 b could be prepared also by an alternative procedure using the methyl--8,9-methylethylen-4-O-t-butyldimethylsilyl-N-acetylneuraminic acid methylester8 a via the intermediate compounds8 d and8 e. Application of the 8,9-O-methylethyliden-N-acetylneuraminic acid derivative8 opens an approach to the xanthogenates8 a and8 b which could be reduced to the deoxy-N-acetylneuraminic acid derivatives9 a and10 a. Hydrolysis of10 a yields the 4,7-dideoxy-N-acetylneuraminic acid10 b (5-N-acetamido-3,4,5,7-tetradeoxy--D-lyxo-2-nonulopyranosidonic acid=4,7-Dideoxy-Neu5Ac). 相似文献
14.
Summary Reduction of 6-azidouracils2 with hydrogen palladium or sodium dithionite afforded the corresponding 6-aminouracils5 which could also be obtained by reaction of2 with triphenylphosphanevia phosphazenes and subsequent hydrolysis (Staudinger reaction). The use of trimethylphosphite instead of phosphanes yields with2b the expected trimethoxyphosphazene3c, whereas2a reacts to the phosphonoaminopyrimidine4. The syntheses of 5-hydroxy pyrido[2,3-d]pryimidine-2,4,7-triones6, pyrido[2,3-d]pyrimidine-2,4,5-triones8, cyclopenta[e]pyrido[2,3-d]pyrimidin-2,4,5-triones7a,c, and tetrahydro-pyrimido[4,5-b]quinolin-2,4,5-triones7b,d by condensation of 6-aminouracils5 with malonates, ethylaceto/benzoylacetate, ethyl 2-oxocyclopentanecarboxylate and ethyl 2-oxocyclohexanecarboxylate, respectively, are described.
Pyrido[2,3-d]pyrimidine, 2. Mitt. Einstufige Synthese von Pyrido[2,3-d]pyrimidinen und Pyrimido[4,5-b]chinolinen aus 6-Aminouracilen
Zusammenfassung Reduktion der 6-Azidouracile2 mit Wasserstoff/Palladium oder Natriumdithionit ergibt die entsprechenden 6-Aminouracile5, die auch durch Reaktion von2 mit Triphenylphosphin und anschließende Hydrolyse erhalten werden können (Staudinger-Reaktion). Die Verwendung von Trimethylphosphit anstelle von von Trimethylphosphin ergibt mit2b das erwartete Trimethoxyphosphazin3c, während2a zum Phosphonoaminopyrimidin4 reagiert. Die Synthesen der 5-Hydroxy-pyrido[2,3-d]pyrimidin-2,4,7-trione6, der Pyrido[2,3-d]pyrimidin-2,4,5-trione8, der Cyclopenta[e]pyrido[2,3-d]pyrimidin-2,4,5-trione7a,c und der Tetrahydro-pyrimido[4,5-b]chinolin-2,4,5-trione7b,d durch Kondensation der 6-Aminouracile5 mit Malonat, Acetat, Ethyl-2-oxocyclopentancarboxylat und Ethylcyclohexancarboxylat werden beschrieben.相似文献
15.
Judit Kosáry Gyula Jerkovich Katalin Pólos Endre Kasztreiner 《Monatshefte für Chemie / Chemical Monthly》1986,117(6-7):867-874
The novel ring system, 6H-1,2,4-triazino[4,3—b]1,2,4-triazolo[3,4—f]-pyridazine was prepared either by ring closure of1-(1-ethoxycarbonylethylene)-2-(1,2,4-triazolo[4,3—b]pyridazinyl-6)-hydrazine derivatives (4, 5, 7) in polyphosphoric acid or of a hydrazine15 derived from pyridazino-1,2,4-triazine under the action of triethyl orthoformate. Compound8 showed a positive inotropic effect.
Über Pyridazinring enthaltende Verbindungen, 20. 6H-1,2,4-Triazino[4,3—b]1,2,4-triazolo[3,4—f]pyridazin, ein neues angulares Ringsystem
Zusammenfassung Das neue Ringsystem 6H-1,2,4-Triazino[4,3—b]1,2,4-triazolo[3,4—f]-pyridazin wurde entweder durch Ringschluß der1-(1-Ethoxycarbonylethylen)-2-(1,2,4-triazolo[4,3—b]pyridazinyl-6)-hydrazin-Derivate(4, 5, 7) 4, 5, 7 in Polyphosphorsäure, oder aus einem von Pyridazino-1,2,4-triazin abgeleiteten Hydrazin15 durch Ringschluß mit Orthoameisensäuretriethylester hergestellt. Verbindung8 zeigte einen positiven inotropen Effekt.相似文献
16.
Ewald Terpetschnig Walter Ott Gert Kollenz Karl Peters Eva-Maria Peters Hans Georg von Schnering 《Monatshefte für Chemie / Chemical Monthly》1988,119(3):367-378
4-Benzoyl-5-phenylthiophene-2,3-dione (1) reacts witho-phenylendiamine to give the quinoxaline derivative2 which cyclizes either to the furo[2,3-b]quinoxaline4 or to the thieno[2,3-b]quinoxaline5 depending on the reaction conditions. On the other hand, the pyrrol-2,3-diones6 ando-phenylendiamine combine yielding the pyrrolidino[2,3-b][1,5]benzodiazepine derivatives7. The structures of all compounds were confirmed by IR and13C NMR spectroscopic measurements based on X-ray structure determinations of4/5 (mixed crystal) as well as7 b.4/5 crystallize triclinically in the space group P1 (Nr. 2) with two molecules per cell, while7 b crystallizes monoclinically in space group P21/a (Nr. 14) with four molecules7 b and four moleculesDMSO per cell. The reaction pathways leading to the compounds2,4,5, and7 are briefly discussed.
Herrn em. Univ.-Prof. Dr.E. Ziegler zur Vollendung des 75. Lebensjahres mit besten Wünschen gewidmet. 相似文献
17.
Mag. pharm. Dr. Herbert Bartsch 《Monatshefte für Chemie / Chemical Monthly》1977,108(3):559-566
The reactivity of naphth[1,2-d]indoles1a, 3a and6 towards sodium in ethanol was studied.1a yields2, 3a the nor-product3b and dihydrothebainone-dihydromethine (4). Bt reaction of6, octahydrophenanthrenes7a and7b are obtained, the structures of which were elucidated byHofmann degradation to8a and8b. 相似文献
18.
Zusammenfassung In mehrstufiger Synthese werden 1-Methyl-benzo[a]furo[3,2-h]xanthon (II) und 8-Acetyl-10-methyl-benzo[a]furo[2,3-i]-xanthon (III) aus 8-Acetyl-9-hydroxy-benzo[a]xanthon dargestellt.
Diese Veröffentlichung ist ein Teil der Arbeiten für die Dissertation zur Erlangung des Ph. D. an der Karnatak University vonA. Nagana Goud. 相似文献
Starting with 8-acetyl-9-hydroxy-benzo[a]xanthone, 1-methyl-benzo[a]furo[3,2-h]xanthone and 8-acetyl-10-methyl-benzo[a]-furo[2,3-i]xanthone have been synthesized and the results recorded.
Diese Veröffentlichung ist ein Teil der Arbeiten für die Dissertation zur Erlangung des Ph. D. an der Karnatak University vonA. Nagana Goud. 相似文献
19.
Zusammenfassung Es wird über die Synthese von verschiedenen methylsubstituiertens-Triazolo[4,3—b]pyridazinen berichtet. Außerdem wurdens-Triazolo[4,3—b]pyridazin und seine 7-Methyl- und 6-Chlor-Derivate der homolytischen Methylierung unterworfen, die Reaktionsgemische gaschromatographisch auf einzelne Methyl-s-triazolo[4,3—b]pyridazine aufgetrennt und die Verbindungen identifiziert.
Syntheses of pyridazines, XXVI: Synthesis and homolytic methylation of s-triazolo[4.3—b]pyridazines
The syntheses of some methyl substituteds-triazolo[4,3—b]-pyridazines are reported.s-Triazolo[4.3—b]pyridazine and its 7-methyl and 6-chloro analogs were submitted to homolytic methylations and the obtained reaction mixtures were separated by gas chromatography into particular components which were then identified.相似文献
20.
O. B. Smirnova T. V. Golovko L. M. Alekseeva V. V. Chernyshev V. G. Granik 《Russian Chemical Bulletin》2010,59(1):177-185
The reactions of 2-dicyanomethylidene-3-ethoxymethylidene-2,3-dihydroindole with hydrazine hydrate and phenylhydrazine afforded
2,3-diamino-4-cyanopyrido[4,3-b]indole and 3-amino-2-anilino-4-cyanopyrido[4,3-b]indole, respectively, and the reactions of the latter compounds with dimethylformamide diethyl acetal were studied. The reactions
of 2,3-diamino-4-cyanopyrido[4,3-b]indole with benzaldehyde, ethyl acetoacetate, and acetylacetone were investigated. First representatives of new heterocyclic
systems, viz., [1,2,4]triazolo[1’,5’:1,6]-pyrido[4,3-b]indole and pyrazolo[1’,5’:1,2]pyrido[4,3-b]indole, were synthesized. The structure of ethyl 6-cyano-5-[(E)-(dimethylamino)methylideneamino]-2-methyl-7H-pyrazolo-[1’,5’:1,2]pyrido[4,3-b]indole-1-carboxylate was established by X-ray diffraction. 相似文献