Adducts of tellurium and organotellurium(IV) chlorides with transition metal chelates of tetradentate schiff bases

Summary Coordinative interaction between tellurium tetrachloride or aryltellurium trichloride and transition metal chelates of tetradentate Schiff bases has yielded bimetallic molecular adducts of the general formula R_nTeCl_4–n · ML [n = 0 or 1, R = Ph,p-MeOC₆H₄ orp-EtOC₆H₄, M = nickel(II) or copper(II) and L^2– dianion of the Schiff bases derived from salicylaldehyde oro-hydroxyacetophenone and ethylenediamine]. The i.r. spectral and magnetic measurements on the complexes in the solid state indicate coordination of the metal chelates to tellurium(IV)via two phenolic oxygens. Planarity about the transition metal ion is thus retained.     

Cobalt(II) and nickel(II) chelates of some 5-pyrazolone-based,Schiff-base ligands

The cobalt(II) and nickel(II) chelates of Schiff bases, derived by condensing 4-butyryl-3-methyl-1-phenyl-2-pyrazolin-5-one (BMPP) with o-, m-, p-phenylenediamine, benzidine, and ethylenediamine have been synthesized and characterized by elemental analyses, thermogravimetric analyses (TGA), conductance data, magnetic measurements, IR, ¹H NMR, ¹³C NMR, mass, and electronic spectroscopies. Each of the Schiff bases was an ONNO donor to metal forming chelates formulated as [M(L)(H₂O)₂] _n with M = Ni(II) and Co(II) and L is the di-anion of the Schiff base. The monomeric (n = 1) and dimeric (n = 2) species of these metal chelates, based on available evidence, are suggested.     

Synthesis,spectral, DFT,and antimicrobial studies of tin(II) and lead(II) complexes with semicarbazone and thiosemicarbazones derived from (2-hydroxyphenyl)(pyrrolidin-1-yl)methanone

A new series of metal complexes [M(L)₂] (where M = Sn(II), Pb(II), and HL = semicarbazone, thiosemicarbazone or phenylthiosemicarbazone) have been prepared and characterized by elemental analysis, conductance measurements, molecular weight determinations, UV–visible, infrared, and nuclear magnetic resonance (¹H-, ¹³C-, and ¹¹⁹Sn-NMR) spectral studies. Elemental analysis of the metal complexes suggested 1 : 2 (metal–ligand) stoichiometry. Infrared spectra of the complexes agree with coordination to the metal through the nitrogen of the azomethine (>C=N?) and the oxygen/sulfur of the ketonic/thiolic group. Electronic spectra suggest a distorted tetrahedral geometry for all Schiff base complexes. The bond lengths, bond angles, highest occupied molecular orbital, lowest unoccupied molecular orbital, Mulliken atomic charges, and the lowest energy model structure of the complexes have been determined with DFT calculations. Representative Schiff base and its metal chelates have been screened for their in vitro antibacterial activity against four bacteria, Gram-positive (Bacillus cereus, Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) and four strains of fungus (Penicillium chrysogenum, Aspergillus niger, Rhizopus nigricans, and Alternaria alternata). The metal chelates possess higher antimicrobial activity than the free ligands.     

Study of the chemical structure and their nematicidal activity of N2O2 tetradentate Schiff base metal complexes

Coordination compounds of Cu (II), Y (III), Zr (IV) and La (III) with the tetradentate Schiff base (H₂L) obtained through the condensation of p‐phenylenediamine with salicylaldehyde under reflux conditions. The complexes were characterized by elemental analysis, magnetic susceptibility, molar conductance and also, with various spectroscopic techniques such as ¹H NMR, UV–Vis., IR and XRD techniques. Electrolytic nature of complexes was ascertained by molar conductance values. In these four complexes, the ligand chelates act in a tetradentate manner via azomethine nitrogen and oxygen atoms of phenolic groups. Electronic spectroscopic data are in agreement with an octahedral geometrical structure. Thermal degradation analyses in nitrogen gas were used to investigate the number and location of water molecules. The chemical formulae of metal complexes were confirmed by microanalytical data. The activation thermodynamic parameters, such as, E^*, ΔH^*, ΔS^* and ΔG^* were calculated from the DTG curves using Coats Redfern (CR) and Horowitz–Metzeger (HM) methods at n = 1 or n ≠ 1. Nematicidal activities indicate that the ligand exhibit greater activity when compared to its complexes. In addition metal complexes displayed good moderate nematicidal activities.     

Synthetic,spectroscopic, fluorescence,and biological investigation of Co(II), Ni(II), Cu(II), and Zn(II) complexes of Schiff bases derived from 3-formyl-2-mercaptoquinolines (Quinol-2-thiones)

Co(II), Ni(II), Cu(II), and Zn(II) complexes have been prepared with Schiff bases derived from 3-formyl-2-mercaptoquinoline and substituted anilines. The prepared Schiff bases and chelates have been characterized by elemental analysis, molar conductance, magnetic susceptibilities, electronic, IR, ¹H-NMR, ESR, cyclic voltammetry, FAB-mass, and thermal studies. The complexes have stoichiometry of the type ML₂ · 2H₂O coordinating through azomethine nitrogen and thiolate sulfur of 2-mercapto quinoline. An enhancement in fluorescence has been noticed in the Zn(II) complexes whereas quenching occurred in the other complexes. The ligands and their metal complexes have been screened in vitro for antibacterial and antifungal activities by MIC methods with biological activity increasing on complexation. Cu(II) complexes show greater bacterial than fungicidal activities. The brine shrimp bioassay was also carried out to study the in vitro cytotoxicity properties of the ligands and their corresponding complexes. Only four compounds have exhibited potent cytotoxic activity against Artemia salina; the other compounds were almost inactive for this assay.     

Syntheses,Spectral, and Biological Studies of New Imines Derived From 5-Bromothiophene-2-Carboxaldehyde and Their Si(IV), Sn(IV) Complexes

The Schiff bases (imines) HL¹ and HL² have been synthesized by the reaction of 5-bromothiophene-2-carboxaldehyde with 4-amino-5-mercapto-1,2,4-triazole and 4-amino-3-ethyl-5-mercapto-1,2,4-triazole, respectively. Organosilicon(IV) and organotin(IV) complexes having the general formulae R₂MCl(L¹), R₂MCl(L²), R₂M(L¹)₂, R₂M(L²)₂, (M = Si, Sn; R = CH₃) were synthesized by the reaction of R₂MCl₂ with these Schiff bases in 1:1 and 1:2 molar ratio. The Schiff bases and their metal complexes have been characterized with the aid of elemental analyses, molar conductance, and spectroscopic studies, including UV, IR, ¹H, ¹³C, MS, ²⁹Si, and ¹¹⁹Sn NMR spectroscopy. On the basis of these studies, the resulting complexes have been proposed to have trigonal bipyramidal and octahedral geometries. In vitro activities of the Schiff bases and their metal complexes against some Gram positive and Gram negative bacteria and fungi have been carried out and described.     

Metal complexes of azo coumarin derivative: synthesis,spectroscopic, thermal,and antimicrobial studies

Cu(II), Co(II), Ni(II), Cd(II), and Zn(II) complexes of 6-(2-phenyldiazenyl)-7-hydroxy-4-methyl coumarin (PAHC) are characterized based on elemental analyses, infrared, ¹H NMR, magnetic moment, molar conductance, mass spectra, UV-Vis analysis, thermogravimetric analysis (TGA), and X-ray powder diffraction. From the elemental analyses, it is found that the complexes have formulae [M(L)₂(H₂O) _n ] ? xH₂O (where M = Cu(II), Co(II), Ni(II), Cd(II), and Zn(II), n = 0–2, x = 1–4). The molar conductance data reveal that all the metal chelates are non-electrolytes. From the magnetic and solid reflectance spectra, it is found that the structures of these complexes are octahedral or tetrahedral. The synthesized ligand and metal complexes were screened for antibacterial activity against some Gram-positive and Gram-negative bacteria.     

Synthesis and spectroscopic studies of new Cu(II), Ni(II), VO(IV) and Zn(II) complexes with N,N′-bis(2-hydroxynaphthalin-1-carbaldehydene)-1,2-bis-(o-aminophenoxy)ethane

A novel tetradentate, N₂O₂-type Schiff base, synthesized from 1,2-bis-(o-aminophenoxy)ethane and 2-hydroxynaphthalin-1-carbaldehyde, forms stable complexes with transition metal ions such as Cu(II), Ni(II), VO(IV) and Zn(II) in DMF. Microanalytical data, elemental analyses, magnetic measurements, ¹H NMR, UV, visible and IR-spectra as well as conductance measurements were used to confirm the structures.     

Synthesis,characterization and biological studies of oxovanadium(IV) complexes with triazole‐derived Schiff bases

A series of triazole‐derived Schiff bases (L¹–L⁵) and their oxovanadium(IV) complexes have been synthesized. The chemical structures of Schiff bases were characterized by their analytical (CHN analysis) and spectral (IR, ¹H and ¹³C NMR and mass spectrometry) data, and oxovanadium(IV) complexes were elucidated by their physical (magnetic susceptibility and conductivity), analytical (CHN analysis), conductance measurements and electronic spectral data. The molar conductivity data indicate the oxovanadium(IV) complexes to be non‐electrolyte. The Schiff bases act as bidentate and coordinate with the oxovanadium(IV)‐forming stoichiometry of a complex as [M (L‐H)₂] where M = VO and L = L¹–L⁵ in a square‐pyramidal geometry. The agar well diffusion method was used for in vitro antibacterial screening against E. coli, S. flexenari, P. aeruginosa, S. typhi, S. aureus and B. subtilis and for antifungal activity against T. longifucus, C. albican, A. flavus, M. canis, F. solani and C. glaberata. The biological activity data show the oxovanadium(IV) complexes to be more antibacterial and antifungal than the parent Schiff bases against one or more bacterial and fungal strains. Copyright © 2009 John Wiley & Sons, Ltd.     

Synthesis,spectral, MOE and cytotoxic studies of nano Ru (III), Pr (III) and Gd (III) metal complexes with new Schiff base ligand based on dibenzoyl methane and anthranilic acid

Three metal complexes of Gd (III), Pr (III) and Ru (III) metal ions with Schiff base ligand (H₂L) (prepared through l:2 condensation of dibenzoyl methane and anthranilic acid) were prepared and characterized using various physio-chemical methods like: elemental analyses, IR, mass spectrometry, magnetic moment, ¹H NMR, SEM and TG/DTG thermal analysis. The analytical and spectroscopic tools showed that the complexes had composition of ML type with octahedral geometry. The mass spectra gave the possible molecular ion peaks of the Schiff base ligand and three metal chelates. The ¹H NMR data supported the IR finding that the ligand coordinated to the metal ions via carboxylate proton displacement. Thermal analysis (TG/DTG) was utilized to differentiate between coordinated and hydrated water molecules. The Schiff base (H₂L) and its metal complexes have been screened for their antibacterial activity against Gram (+) bacteria (Streptococcus aureus and Bacillis subtilis), Gram (−) bacteria (Salmonella typhimurium and Escherichia coli) and two fungi (Aspergillus fumigatu and Candida albicans) organisms by agar diffusion method. The anticancer activity was screened against human breast cancer cell line (MCF-7). The H₂L ligand and its metal chelates were docked using MOE 2008 software with crystal structure of Gram (+) bacteria: Staphylococcus aureus (PDB ID: 3Q8U) and Gram (−) bacteria: Salmonella typhimurium (PDB ID: lDZR) to identify the binding orientation or conformation of the complex in the active site of the protein.     

Some Zirconium(IV) Complexes of Sterically Constrained Sulfur-Containing Schiff Bases of Heterocyclic β -Diketones: Synthetic Strategy and Structural Investigation Based Upon Spectroscopic Studies

Zirconium(IV) Schiff base chelates having the general formula ZrL(OPr ⁱ )₂ [where LH ₂ = R CH ₃ , R = –C ₆ H ₅ , –C ₆ H ₄ Cl(p)] were synthesized by the reaction of Zr(OPr ⁱ )₄.Pr ⁱ OH with sterically constrained sulfur-containing Schiff bases of heterocyclic β -diketones in a 1:1 molar ratio in dry refluxing benzene. The complexes ZrL(OPr ⁱ ) ₂ were used as important precursors for the synthesis of the complexes of the type Zr(L) ₂ . The complexes, Zr(L) ₂ , were prepared by the interaction of precursor ZrL(OPr ⁱ ) ₂ with sterically constrained sulfur-containing Schiff bases of heterocyclic β -diketones in a 1:1 molar ratio in dry benzene. The structures of these zirconium(IV) chelates have been discerned with the help of elemental analyses, physicochemical studies, and spectral [IR and NMR ( ¹ H and ¹³ C)] data. A distorted trigonal bipyramidal and a distorted octahedral geometry may be assigned to zirconium(IV) chelates of the types ZrL(OPr ⁱ ) ₂ and Zr(L) ₂ , respectively.     

Synthesis and spectral studies of copper(II), nickel(II), cobalt(II) and vanadyl(II) complexes of tridentate Schiff bases of 1,2,3,5,6,7,8,8a-octahydro-3-oxo-N,1-diphenyl-5-(phenylmethylene)-2-naphthalenecarboxamide

Summary Metal(II) chelates of Schiff bases derived from the condensation of 1,2,3,5,6,7,8,8a-octahydro-3-oxo-N,1-diphenyl-5-(phenylmethylene)-2-naphthalenecarboxamide with o-aminophenol (KAAP), o-aminothiophenol (KAAT) or o-aminobenzoic acid (KAAB) have been prepared and characterized. The complexes are of the type [M(N₂X)]₂ for M = Cu^II and M(NX)₂·nH₂O for M = Ni^II, Co^II and VO^II (X = phenolic oxygen, thiophenolic sulphur or carboxylic oxygen; n = 0 or 2). Conductivity data indicate that the complexes are non-ionic. The Schiff bases behave as dibasic tridentate ligands in their copper(II) complexes and as monobasic bidentate ligands in their nickel(II), cobalt(II) and vanadyl(II) complexes. The subnormal magnetic moments of the copper(II) complexes are ascribed to an antiferromagnetic exchange interaction arising from dimerization. Nickel(II) and cobalt(II) complexes are trans octahedral whereas vanadyl(II) complexes are square pyramidal     

Synthesis,characterization, and biological activity of some transition metal complexes with Schiff base ligands derived from 4-amino-5-phenyl-4<Emphasis Type="Italic">H</Emphasis>-1,2,4-triazole-3-thiol and salicaldehyde

Abstract  

The coordination behaviour of a Schiff base with SNO donation sites, derived from condensation of 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol and salicaldehyde, towards some bi- and trivalent metal ions, namely Cr(III), Mn(II), Fe(III), Co(II) (Cl, ClO₄), Ni(II) (Cl, ClO₄), Cu(II), and Zn(II), is reported. The metal complexes were characterized on the basis of elemental analysis, IR, ¹H NMR, solid reflectance, magnetic moment, molar conductance, and thermal analyses (TG, DTG, and DTA). The ionization constant of the Schiff base under investigation and the stability constants of its metal chelates were calculated pH-metrically at 25 °C and ionic strength μ = 0.1 M in 50% (v/v) ethanol–water mixture. The chelates were found to have octahedral (Mn(II)), trigonal bipyramidal (Co(II), Ni(II), Zn(II)), and tetrahedral (Cr(III), Fe(III), and Cu(II)) structures. The ligand and its binary chelates were subjected to thermal analyses and the different thermodynamic activation parameters were calculated from their corresponding DTG curves to throw more light on the nature of changes accompanying the thermal decomposition process of these compounds. The free Schiff base ligand and its metal complexes were tested in vitro against Aspergillus flavus, Candida albicans, C. tropicalis, and A. niger fungi and Bacillus subtilis and Escherichia coli bacteria in order to assess their antimicrobial potential. The results indicate that the ligand and its metal complexes possess antimicrobial properties.     

Synthesis,characterization and antimicrobial activity of triorganotin(IV) derivatives of some bioactive Schiff base ligands

Triorganotin(IV) complexes of the type Me₃Sn[OC(R¹):CH(CH₃)C:NR²OH] and Ph₃Sn[OC(R′):CH(CH₃)C:NR″OH] (R′ = ─CH₃, ─C₆H₅; R″ = ─(CH₂)₂─, ─(CH₂)₃─) have been synthesized by the reactions of trimethyl/phenyltin(IV) chloride with the sodium salt of corresponding Schiff base ligands in unimolar ratio in refluxing tetrahydrofuran. All these compounds have been characterized using elemental analyses and their probable structures have been proposed on the basis of infrared, ¹H NMR, ¹³C NMR, ¹¹⁹Sn NMR and mass spectroscopic studies. In the trimethyltin(IV) derivatives the central tin atom is tetracoordinated, whereas in the analogous triphenyltin(IV)derivatives the central tin atom is pentacoordinated. All these ligands, metal precursors and corresponding triorganotin(IV) complexes have been screened for antimicrobial activities. A comparison of activities of the ligands and their corresponding triorganotin(IV) derivatives has been made. Attempts have also been made to relate the activity to the structure of these compounds.     

Zirconium (IV), Thorium (IV) and Dioxouranium (VI) Complexes of Dibasic Tridentate Schiff Bases

Dibasic tridentate Schiff bases obtained by the condensation of O -aminobenzoic acid with salicyldehyde and its 5-chloro and 5-bromo derivatives were synthesised and used to pracipitate Zr(IV), Th(IV) and UO₂(VI) metals as complexes. The 1:1 (metal-ligand) stoichiometry of these complexes is shown by elemental analysis, gravimetric estimations and conductometric titrations while the structures of the complexes are proved by i.r. spectra and thermogravimetric analysis. The magnetic susceptibility measurements by Gouy method show, these complexes to be monormeic and diamagnetic. The molar conductance values in nitrobenzene indicate the nonelectrolytic behaviour of the complexes. The results show that the complexes of the type Zr(OH)²L.H²O, Th(OH)²L.H²O and UO²L.H²O are formed having solvent molecule in co-ordination with metal ion.     

Spectroscopic study of molecular structures of novel Schiff base derived from o-phthaldehyde and 2-aminophenol and its coordination compounds together with their biological activity

New Schiff base (H₂L) ligand is prepared via condensation of o-phthaldehyde and 2-aminophenol. The metal complexes of Cr(III), Mn(II), Fe(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) with the ligand are prepared in good yield from the reaction of the ligand with the corresponding metal salts. They are characterized based on elemental analyses, IR, solid reflectance, magnetic moment, electron spin resonance (ESR), molar conductance, ¹H NMR and thermal analysis (TGA). From the elemental analyses data, the complexes are proposed to have the general formulae [M(L)(H₂O)n]·yH₂O (where M = Mn(II) (n = 0, y = 1), Fe(II) (n = y = 0), Co(II) (n = 2, y = 0), Ni(II) (n = y = 2), Cu(II) (n = 0, y = 2) and Zn(II) (n = y = 0), and [MCl(L)(H₂O)]·yH₂O (where M = Cr(III) and Fe(III), y = 1–2). The molar conductance data reveal that all the metal chelates are non-electrolytes. IR spectra show that H₂L is coordinated to the metal ions in a bi-negatively tetradentate manner with ONNO donor sites of the azomethine N and deprotonated phenolic-OH. This is supported by the ¹H NMR and ESR data. From the magnetic and solid reflectance spectra, it is found that the geometrical structures of these complexes are octahedral (Cr(III), Fe(III), Co(II) and Ni(II) complexes), tetrahedral (Mn(II), Fe(II) and Zn(II) complexes) and square planar (Cu(II) complex). The thermal behaviour of these chelates is studied and the activation thermodynamic parameters, such as, E*, ΔH*, ΔS* and ΔG* are calculated from the DrTGA curves using Coats-Redfern method. The parent Schiff base and its eight metal complexes are assayed against two fungal and two bacterial species. With respect to antifungal activity, the parent Schiff base and four metal complexes inhibited the growth of the tested fungi at different rates. Ni(II) complex is the most inhibitory metal complex, followed by Cr(III) complex, parent Schiff base then Co(II) complex. With regard to bacteria, only two of the tested metal complexes (Mn(II) and Fe(II)) weakly inhibit the growth of the two tested bacteria.     

Synthesis,structural, spectroscopic,and thermal studies of some transition-metal complexes of a ligand containing the amino mercapto triazole moiety

A new series of transition-metal complexes of Schiff base ligand containing the amino mercapto triazole moiety ( HL ) was prepared. The Schiff base and its metal complexes were elucidated by different spectroscopic techniques (infrared [IR], ¹H nuclear magnetic resonance, UV–Visible, mass, and electron spin resonance [ESR]), and magnetic moment and thermal studies. Quantum chemical calculations have been carried out to study the structure of the ligand and some of its complexes. The IR spectra showed that the ligand is chelated with the metal ion in a neutral, tridentate, and bidentate manner using NOS and NO donors in complexes 1 – 6 , 10–12 , and 7 and 8 , respectively, whereas it behaves in a monobasic tridentate fashion using NOS donor sites in copper(II) nitrate complex ( 9 ). The magnetic moment and electronic spectra data revealed octahedral and square pyramidal geometries for complexes 2 , 11 , 12 , and 5 – 8 and 10 , respectively. However, the other complexes were found to have tetrahedral ( 4 ), trigonal bipyramidal ( 1 and 3 ), and square planar ( 9 ) structures. Thermal studies revealed that the chelates with different crystallized solvents undergo different types of interactions and the decomposition pathway ended with the formation of metal oxygen (MO) and metal sulfur (MS) as final products. The ESR spectrum of copper(II) complex 10 is axial in nature with hyperfine splitting with ²B_1g as a ground state. By contrast, complexes 7 and 8 undergo distortion around the Cu(II) center, affording rhombic ESR spectra. The HL ligand and some of its complexes were screened against two bacterial species. Data showed that complex 12 demonstrated a better antibacterial activity than HL ligand and other chelates.     

Synthesis,spectral characterization,redox and antimicrobial activity of Schiff base transition metal(II) complexes derived from 4-aminoantipyrine and 3-salicylideneacetylacetone

A novel tetradentate N₂O₂ type Schiff base, synthesized from 1-phenyl-2,3-dimethyl-4-aminopyrazol-5-one(4-aminoantipyrine) and 3-salicylidene-acetylacetone, forms stable complexes with transition metal ions such as Cu ^II , Ni ^II , Co ^II and Zn ^II in ethanol. Microanalytical data, magnetic susceptibility, IR, UV-Vis.,¹H-NMR, ESR and Mass spectral techniques were used to confirm the structures. Electronic absorption spectra of the complexes suggest a square-planar geometry around the central metal ion. These complexes show higher conductance values, supporting their electrolytic nature. The monomeric nature of the complexes was confirmed from their magnetic susceptibility values. Cyclic voltammogram of the copper(II) and nickel(II) complexes in DMSO solution at 300 K were recorded and the results are discussed. The X-band ESR spectra of the copper complex were recorded and the molecular orbital coefficient values were calculated from the spectra. The in vitro antimicrobial activities of the investigated compounds were tested against bacteria such as Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis and Escherichia coli and fungi like Aspergillus niger and Rhizoctonia bataicola. Most of the metal chelates show higher antimicrobial activity for the above microorganisms than that of the free ligand.     

New nanobidentate Schiff base ligand of 2-aminophenol with 2-acetyl ferrocene with some lanthanide metal ions: synthesis,characterization and Hepatitis A,B, C and breast cancer docking studies

Three lanthanide complexes (La(III), Er(III), and Yb(III)) derived from ferrocene-based Schiff base ligand (HL) were synthesized from condensation of 2-aminophenol with 2-acetylferrocene. The ligand and metal complexes were characterized based on elemental analyses, IR, ¹H NMR, molar conductance, SEM and thermal analyses (TG, DTG). The molar conductance revealed that all the metal chelates were electrolytes having the general composition [M(L)(Cl)(H₂O)₃]Cl·4H₂O. HL and its complexes were screened for their antibacterial and antifungal activity by agar diffusion method. The results of these studies showed that the metal complexes are more effective antibacterial and antifungal agents as compared with the free ligand. The anticancer activity was screened against human breast cancer cell line (MCF-7). Results indicated that metal complexes showed an increased cytotoxicity in proliferation to cell lines as compared to free ligand. Molecular docking studies were performed to identify the binding orientation or conformation of a complex in the active site of the protein. HL and its complexes were docked with crystal structure of DDB1 of breast cancer, crystal structure of HCV, RNA-dependent RNA polymerase, receptors of HBV core protein, crystal structure of the Fab fragment of anti-HAV.     

Synthesis,Spectral, and 3D Molecular Modeling of Tin(II) and Organotin(IV) Complexes of Biologically Active Schiff Bases Having Nitrogen and Sulfur Donor Ligands

Reaction of tin(II) chloride and dimethyltin dichloride with Schiff bases derived from S-benzyldithiocarbazate leads to the formation of a new series of tin(II) and organotin(IV) complexes of general formula SnCl ₂ .L and Me ₂ SnCl ₂ .L (where L = Schiff bases are derived from the condensation of S-benzyldithiocarbazate with heterocyclic aldehydes). An attempt has been made to prove the structures of the resulting complexes on the basis of elemental analysis, conductance measurements, molecular weight determinations, infrared, and multinuclear magnetic resonance ( ¹ H, ¹³ C, and ¹¹⁹ Sn NMR) spectral studies. A few representative ligands and their tin complexes have also been screened for their antibacterial and antifungal activities and found to be quite active in this respect.