萼果香薷中的五种新化合物

萼果香薷中的五种新化合物沈序维，郑尚珍，尹昨栋，宋占午，王莱（西北师范大学化学系，兰州，７３００７０）（西北师范大学生物系）关键词萼果香薷，唇形科，呋喃黄酮，呋喃香豆素萼果香薷（Ｅｌｓｈｏｆｔｚｉａｄｅｎｓａ）是一种用于消炎和止血的唇形科植物。本文对...     

阿拉善马先蒿中新木脂素甙成分研究

阿拉善马先蒿中新木脂素甙成分研究高建军，刘自民，王继和，贾忠建（兰州大学有机化学研究所应用有机化学国家重点实验室，兰州，７３００００）关键词阿拉善马先蒿，玄参科，新木脂素甙前文［１］报道了从阿拉善马先蒿（ＰｅｄｉｃｕｌａｒｉｓａｌａｓｃｈａｎｉｃａＭ...     

Zn_2Al－PW_（12－n）V_nO_（40）（n＝1～4）的合成与表征

Ｚｎ_２Ａｌ－ＰＷ_（１２－ｎ）Ｖ_ｎＯ_（４０）（ｎ＝１～４）的合成与表征郭军，孙铁，沈剑平，蒋大振闵恩泽（吉林大学化学系，长春，１３００２３）（石油化工科学研究院）关键词Ｐ－Ｗ－Ｖ杂多阴离子，柱撑水滑石，合成同多和杂多阴离子柱撑水滑石（简称ＰＯＭｓ－...     

天然有机化合物的质谱研究 黄酮和黄酮甙与碱金属离子K+和Na+的快原子轰击质谱

在作黄酮和黄酮甙的快原子轰击质谱（ＦＡＢＭＳ）时,如果同时加入氯化钠和氯化钾两种碱金属盐,就会在谱图中同时出现［Ｍ＋Ｋ］＋和［Ｍ＋Ｎａ］＋两个强峰,由于这两个峰相差１６个原子质量单位（ａｍｕ）,很容易辨认,并且发现在其谱图中找不到明显的碎片离子和Ｎａ＋和Ｋ＋的加合离子,而只有其分子和Ｋ＋和Ｎａ＋的加合,所以很容易在ＦＡＢ谱中识别它们,因而就可以快速、准确地确定样品的分子量     

半边苏中黄酮类化合物的研究

半边苏为唇形科香薷属植物,民间主要用于驱风发汗,治疗瘫痪、痨伤吐血和疮毒等症。其挥发油成分的研究已有报道,我们从全草的乙醇提取液中得到的5种黄酮类化合物,通过波谱和理化等方法综合分析鉴定:晶Ⅰ5-羟基-6,7-二甲氧基黄酮,晶Ⅱ5-羟基-7,     

蒽醌及黄酮类化合物与人血清白蛋白的结合反应研究

用荧光光谱法研究了大黄素，黄酮，栎精。柚皮甙，黄芩甙和龙胆苦甙等化合物与人血清白蛋白（ＨＳＡ）的结合反应，发现除龙胆苦甙外，其余化合物对ＨＳＡ的荧光有很强的猝平作用。从荧光猝灭结果求得了它们与ＨＳＡ的结合常数，表明这些化合物与ＨＳＡ的结合能力随其所含极性基团的增多而减弱。根据Ｆｏｒｓｔｅｒ非辐射能量转移机理，求出第一结合部位与ＨＳＡ分子中２１４－色氨酸残基的距离，由此提出了形成复合物的结构模型，并     

中草药溪黄草低极性组份的研究

１前言溪黄草（Ｒａｂｄｏｓｉａ．ｓｅｒｒａ（Ｍａｘｉｍ．）Ｈａｒａ）属于唇形科香茶菜属植物，是一种多年生草本植物。据中华大辞典记载，其具有清热祛湿，凉血散瘀之功效，对急性肝炎，肠炎，痢疾等有较好效果。但是该植物化学组成的研究目前在国外尚未有报道，国内研究报道有４篇卜’１。共分出８个化合物：ＲａｂｄｏｓｅｒｒｉｎＡ，ＲａｂｄｏｓｅｒｒｉｎＢ，ＢｘｃｌｓａｎｌｎＡ，Ｋａｍｅｂａｋａｕｎｎ，Ｚａ一羟基乌索酸，乌索酸，卜谷自醇及一ｐ谷尚醇一Ｄ一葡萄糖贰。该植物的石油醚提取层的化学组分未见报道。我们利用高…     

簇合物SFeCO2（CO）9的合成方法研究

簇合物ＳＦｅＣｏ＿２（ＣＯ）＿９的合成方法研究赵转云，武和平，殷元骐（中国科学院兰州化学物理研究所兰州７３００００）ＳＦｅＣｏ＿２（ＣＯ）＿９是一四面体构型的潜手性簇合物，由此为前体，合成簇合物ＳＦｅＣｏＭ（ＣＯ）＿ｘ（Ｍ＝Ｃｒ，Ｍｏ，Ｗ，Ｒｈ，Ｒｕ...     

CMC d－p π Bond in Solid State（Ⅱ） Band Structure and Metallic Properties in Incommensurate Misfit Layer Compounds（MS）_xTS_2（M＝Sn，Pb and La；T＝V，Nb，Ta and Cr）

ＣＭＣｄ－ｐπＢｏｎｄｉｎＳｏｌｉｄＳｔａｔｅ（Ⅱ）ＢａｎｄＳｔｒｕｃｔｕｒｅａｎｄＭｅｔａｌｌｉｃＰｒｏｐｅｒｔｉｅｓｉｎＩｎｃｏｍｍｅｎｓｕｒａｔｅＭｉｓｆｉｔＬａｙｅｒＣｏｍｐｏｕｎｄｓ（ＭＳ）_ｘＴＳ_２（Ｍ＝Ｓｎ，ＰｂａｎｄＬａ；Ｔ＝Ｖ，Ｎｂ...     

油菜花粉的化学成分分析

从云南草坝采集的油菜（ＢｒａｓｉｃａｃａｍｐｅｓｔｒｉｓＬ）花粉中分离出１２个化合物，鉴定了其中６个：二十九烷（Ａ），β－谷甾醇（Ｂ），蔗糖（Ｃ），十六烷酸（Ｄ），十八烷基甘油醚－１（Ｅ），胡萝卜甙（Ｈ），Ｅ首次从花粉中分离到。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.