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1.
The reduction of the isomeric 5,6-epoxy-2-carboethoxyisoquinuclidines with lithium aluminum hydride afforded 5- and 6-hydroxy-2-methylisoquinuclidine. Contrary to expectation essentially single epimers were obtained for each alcohol. 相似文献
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Wei ZL Sakamuri S Petukhov PA George C Lewin NE Blumberg PM Kozikowski AP 《Organic letters》2002,4(13):2169-2172
[structures: see text] Both (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy-8-(1-decynyl)benzolactam-V8 were designed and synthesized as PKC modulators. Biological assays reveal the (6R)-ligand to be 20-fold more potent than its (6S)-counterpart in binding to PKC alpha. 相似文献
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8-Phenyl, 8-(p-methoxyphenyl) and 8-(p-chlorophenyl)-7-hydroxyxanthine were synthesized by ring closure of 6-amino-5-nitrosouracil with benzaldehyde, p-methoxybenzaldehyde and p-chlorobenzaldehyde, respectively. The disproportionation of these products to the corresponding 8-phenylxanthines and 6-amino-5-nitrosouracil was studied. The dependence of the rate of the reaction on the various substituents was studied. The disproportionation reaction is inhibited by the polarophilic ethyl acetylenedicarboxylate and enhanced by phosphate. 相似文献
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H. Schwarz 《Fresenius' Journal of Analytical Chemistry》1966,218(4):280-281
Ohne Zusammenfassung 相似文献
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Preparation of 1-aminomethylenemercapto derivatives of 2, 4, 6, 8-tetrathiaadamantane and adamantane
B. M. Lerman L. I. Umanskaya F. Z. Galin G. A. Tolstikov 《Chemistry of Heterocyclic Compounds》1976,12(5):553-555
1-Aminomethylenemercapto derivatives of 3, 5, 7, 9, 9-pentamethyl-2, 4, 6, 8-tetrathiaadamantane and adamantane were obtained by aminomethylation of 3, 5, 7, 9, 9-pentamethyl-2, 4, 6, 8-tetrathiaadamantane-l-thiol and adamantane-1-thiol.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 658–660, May, 1976. 相似文献
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《Polyhedron》1987,6(5):897-905
Homo- and heterodinuclear complexes of composition [M2L2](ClO4)2·4H2O, [CuML2](ClO4)2·nH2O (M = Ni, Co or Mn; L = L1 or L2) and [CuML2Cl2]·2H2O (M = Ni or Co) have been synthesized with the dinucleating ligands 2-hydroxy-5-methyl- benzene-1,3-dicarbaldehyde (HL1) and 1,3-diacetyl-2-hydroxy-5-methylbenzene (HL2). These compounds have been characterized and their chemical reactivities investigated. The electrochemical behaviour of [M2L22](ClO4)2·4H2O and [CuML22](ClO4)2·nH2O complexes have been examined in acetonitrile and dimethyl sulfoxide using Hg and Pt electrodes. The cyclic voltammograms obtained with a Hg electrode show quasi-reversible electron transfers for both metal centres that often get complicated due to decomplexation of metal ions and adsorption phenomena. On a Pt electrode irreversible electron transfers occur at more negative potentials. 相似文献
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《Tetrahedron: Asymmetry》1999,10(14):2739-2747
The synthesis of (+)-(R)-5-hydroxy-6-hydroxymethyl-7-methoxy-8-methylflavanone is described. A new chromylation method of β-ketosulfoxide 9 leading to the Michael acceptor 12 has been developed. Dilithium tetrachlorocuprate was shown to be a very efficient catalyst for the conjugate addition reaction of phenyl magnesium bromide to the α,β-unsaturated sulfoxide 12. The instability of the obtained adducts 10 represents a limitation in terms of yield. It was confirmed that the natural flavanone leridol does not possess the structure of title compound 1. 相似文献
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Paolo Bonomi Paola Cairoli Daniela Ubiali Carlo F. Morelli Marco Filice Ines Nieto Massimo Pregnolato Paolo Manitto Marco Terreni Giovanna Speranza 《Tetrahedron: Asymmetry》2009,20(4):467-472
(R)-2-Tetralol (R)-2a, (R)-5-hydroxy-2-tetralol (R)-2b and (R)-8-hydroxy-2-tetralol (R)-2c, which are key intermediates in the synthesis of pharmacologically active 2-aminotetralins 3, were prepared in moderate to very high enantiomeric excess (up to 99% ee) by enzymatic resolution of the corresponding racemic butyrates rac-1a, rac-1b and rac-1c, respectively, using lipases immobilized on octyl agarose. This methodology is an alternative to the microbial reduction of 2-tetralones. 相似文献
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Oxidation of 5-hydroxy-5, 6-dihydro-4H-1, 2, 5-oxadiazines leads to the formation of 6H-1,2, 5-oxadiazine-5-oxides. Acid treatment of 5, 6-dihydro-4H-1, 2, 5-oxadiazines and 6H-1, 2, 5-oxadiazine-5-oxides results in heterocyclic-ring contraction with the formation of imidazole 3-oxides and 1-hydroxyimidazole 3-oxides. The structures of the products are established by their spectral properties and confirmed by independent synthesis.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1264–1266, September, 1970. 相似文献
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2-(2-Quinolyl)- and 2-(4-phenyl-2-quinolyl)-5,6-benzocinchoninic acids were synthesized, and their derivatives were obtained and decarboxylated. The UV and IR spectra of the compounds were studied, and it was found that all of the new compounds form colored Cu(I) complexes.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 239–241, February, 1973. 相似文献
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S. G. Krivokolysko V. D. Dyachenko E. B. Rusanov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2001,37(8):987-992
4-(2-Chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethylpiperidin-2-thione, which was used for the synthesis of 2-allylthio-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thienoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine, was obtained by the reaction of 2-thienoyltrifluoroacetone with 2-chlorophenylphenylmethylenecyanothioacetamide or with a mixture of 2-chlorobenzaldehyde and cyanothioacetamide in the presence of N-methylmorpholine. The molecular and crystal structure of the piperidinthione have been established by X-ray crystallography. 相似文献
15.
Ryoichi Hirayama Masahiro Kawase Tetsutaro Kimachi Kiyoshi Tanaka Fumio Yoneda 《Journal of heterocyclic chemistry》1989,26(5):1255-1259
Various 8-hydroxy-5-deazaflavin derivatives were synthesized as the model compounds of coenzyme F420-These compounds oxidized benzylamine to benzaldehyde more efficiently than the corresponding 8-unsubstituted 5-deazaflavins. 相似文献
16.
V. I. Troitskaya I. G. Oksengendler S. V. Pazenok M. S. Lyubich S. M. Larina L. M. Yagupol'skii 《Chemistry of Heterocyclic Compounds》1982,18(1):39-43
The synthesis of 2,3-dimethyl-5- and -6-trifluoromethylindoles and 2,3,3-trimethyl-4-, -5-, and -6-trifluoromethylindolenines, from which quaternary salts, as well as indocarbo- and di- and tricarbocyanine dyes were obtained, is described. The effect of the introduction of a trifluoromethyl group in the 4, 5, and 6 positions on the color of the indocyanine dyes is examined.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 47–51, January, 1982. 相似文献
17.
Indolizines. 6. Relative reactivities of isomeric 6-, 7-, and 8-ethoxycarbonylindolizine derivatives
T. S. Loseva M. S. Goizman G. G. Dvoryantseva E. E. Mikhlina L. N. Yakhontov 《Chemistry of Heterocyclic Compounds》1979,15(5):507-514
The kinetics of the alkaline hydrolysis of 2-phenyl-6-, -7-, and -8-ethoxycarbonylindolizines were studied. The rate constants for the hydrolysis of these compounds and the indexes of the dissociation constants of 2-phenylindolizine-6-,-7-, and -8-carboxylic acids were determined by spectrophotometry. The indexes of the electronic structures and reactivities of 2-methyl-6-, -7-, and -8-ethoxycarbonylindolizines were calculated from theory.See [1] for Communication [5].Deceased.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 627–633, May, 1979. 相似文献
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The conversion of 5--D-ribofuranosyl cyanides to the corresponding 2--ribofuranosylbenzothiazoles (under the influence of 2-aminothiophenol) and to 5--glycosyltetrazoles (by reaction with sodium azide and ammonium chloride) is described. It is shown that acylation of the latter structures with acetic anhydride or benzoyl chloride is a convenient method for the synthesis of 5--glycosyl-1,3,4-oxadiazoles.See [1] for communication I.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 893–896, July, 1978. 相似文献