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1.
Preparation of Stilbenyl Derivatives of Isoxazoles Schiff's bases derived from 3- and 5-(p-formylphenyl)-phenylisoxazoles and o- or p-chloroaniline are reacted with various p-tolyl substituted aromatic heterocycles in the presence of dimethylformamide and potassium hydroxide or potassium t-but-oxide to yield the corresponding heterocyclic substituted stilbenes (‘Anil synthesis’). 5-[4-(Chlorphenylimino-methyl)phenyl]-phenylisoxazoles react less readily than the corresponding 3-isomers. 相似文献
2.
Preparation of Stilbenyl Derivatives of Pyrazoles Schiffs bases derived from 1-, 3- and 5-(p-formylphenyl)phenylpyrazoles and p-chloroaniline are reacted with various p-tolyl substituted aromatic heterocycles in the presence of dimethylformamide and potassium hydroxide or potassium t-butoxide to yield the corresponding heterocyclic substituted stilbenes (anil synthesis). Introduction of a chloro substituent in the 4- and 4,5-positions of the pyrazole system causes a decrease in yield and a hypsochromic shift in the absorption and fluorescence maxima of the title compounds. 相似文献
3.
Kurt Burdeska Hermann Fuhrer Guglielmo Kabas Adolf Emil Siegrist 《Helvetica chimica acta》1981,64(1):113-152
Preparation of Styryl and Stilbenyl Derivatives of Pyrimidines 2- and 4-(p-Tolyl)-substituted pyrimidines react with anils of hetero-aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide or potassium t-butoxide to yield the corresponding 2- and 4-[4″-(heteroaryl)stilben-4′-yl]pyrimidines or the 2- and 4-[a-(heteroaryl)-4′-styryl]pyrimidines respectively (‘Anil synthesis’). Furthermore, the Schiff′s bases derived from p-chloroaniline and 4-(pyrimidine-2-yl and 4-yl)benzaldehydes give, with methyl- and with p-tolyl-substituted heterocycles, the corresponding heterocyclic substituted styryl and stilbenyl derivatives. Alkyl-, alkoxy- or phenyl-substituted pyrimidines undergo also the ‘Anil synthesis’. 相似文献
4.
Adolf Emil Siegrist Gza Kormny Guglielmo Kabas Hans Schlpfer 《Helvetica chimica acta》1977,60(7):2334-2370
Preparation of heterocyclic substituted stilbenyl derivatives of 2H-1,2,3-triazole Schiff's bases derived from 2- and 4-(p-formylphenyl)-2H-1,2,3-triazoles and o- or p-chloroaniline are reacted with various p-tolyl substitued aromatic heterocycles in the presence of dimethylformamide and potassium hydroxide or potassium t-butoxide to yield the corresponding heterocyclic substituted stilbenes (“Anilsynthesis”). In order to avoid opening of the 2H-1,2,3-triazole ring, the reaction is carried out without external heating. In many cases an improvement in yield is obtained by irradiation with UV. light at the beginning of the reaction. 相似文献
5.
Preparation of Stilbenyl Derivatives of 1,2,4-Oxadiazoles Schiffs bases derived from 3- and 5-(p-formylphenyl)-phenyl-1,2,4-oxadiazoles and chloroanilines are reacted with various p-tolyl substituted aromatic heterocycles in the presence of dimethylformamide and potassium hydroxide to yield the corresponding heterocyclic substituted stilbenes (‘Anil synthesis’). The reactivity of 5-[4-(chlorophenylimino-methyl)phenyl]-3-phenyl-1,2,4-oxadiazoles is very low and side reactions will predominate. 相似文献
6.
Hiroyoshi Kamogawa Kunimichi Kitahora Hidehito Hanawa Masato Nanasawa 《Journal of polymer science. Part A, Polymer chemistry》1976,14(5):1235-1240
Several polymerizable hydroquinone derivatives were prepared by the Williamson synthesis. Thus, hydroquinone mono(p-vinylbenzyl) ether (III-1), hydroquinone methyl p-vinylbenzyl ether (III-4), and hydroquinone benzyl p-vinylbenzyl ether (III-5), tert-butylhydroquinone mono(p-vinylbenzyl) ether (III-2), and 2,5-di-tert-butylhydroquinone mono(p-vinylbenzyl) ether (III-3) were synthesized by the reactions of p-chloromethylstyrene with the corresponding hydroquinone derivatives in alcoholic potassium hydroxide or with their potassium salts in dipolar aprotic solvents. All monomers were found to polymerize by free-radical initiation except III-3, which required a cationic initiator. 相似文献
7.
Preparation of styryl derivatives of 2-phenyl-imidazo [1, 2-a]pyridine 2-(p-Tolyl)-imidazo [1, 2-a]pyridines and 7-methyl-2-phenyl-imidazo [1,2-a]-pyridines can be converted, in dimethylformamide, on reaction with anils of aromatic aldehydes in the presence of potassium hydroxide or potassium t-butoxide, into the corresponding 2-(stilben-4-yl)- and 2-phenyl-7-styry1-imidazo [1, 2-a]-pyridines (‘Anil-Synthesis’). The 2-(p-tolyl)-imidazo [1,2-a]pyridines react far less readily than the 7-methyl-2-phenyl-imidazo[1,2-a]pyridines. 相似文献
8.
Adolf Emil Siegrist 《Helvetica chimica acta》1981,64(3):662-680
Preparation of Styryl and Stilbenyl Derivatives of 1H-Benzotriazoles 1-(p-Tolyl)-substituted 1H-benzotriazoles react with anils of aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide to yield the corresponding 1-(styr-4′-yl)-1H-benzotriazoles and 1-(stilben-4′-yl)-1H-benzotriazoles, respectively (‘anil synthesis’). Further, under the same reaction conditions, the Schiff's bases derived from p-chloroaniline and 4-(1′H-benzotriazol-1′-yl)benzaldehydes give, with p-tolyl-substituted heterocycles, the corresponding heterocyclic substituted stilbenyl derivatives. 相似文献
9.
Preparation of styryl derivatives of 3-phenyl-benzisoxazole 3-(p-Tolyl)-1,2-or 2, 1-benzisoxazoles and 6-methyl-3-phenyl-1,2-benzisoxazoles react with anils of aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide or potassium t-butoxide to yield the corresponding 3-(stilben-4-yl)-1,2- or 2,1-benzisoxazoles and the 3-phenyl-6-styryl-1,2-benzisoxazoles respectively (‘Anil Synthesis’). Further, the Schiff's bases derived form chloroanilines and 3-(p-formylphenyl)-1,2-benzisoxazoles yield, with methyl-and p-tolyl substituted heterocyles the corresponding heterocyclic substitued styryl and stilbenyl derivatives. 相似文献
10.
A series of 4-spiro-cyclohexadienonyl-β-lactam-3-carbonitriles, 2,7-dioxo-1-azaspiro[3.5]nona-5,8-diene-3-carbonitriles, was synthesized in satisfactory to excellent yields via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)cyanoacetamides with iodobenzene diacetate (IBD) as oxidant and potassium hydroxide as base. Acetic 4-spiro-cyclohexadienonyl-β-lactam-3-carbimidic anhydrides were obtained when organic base triethylamine was applied instead of potassium hydroxide. The mechanisms of the intramolecular nucleophilic cyclization and formation of acetic β-lactam-3-carbimidic anhydrides were proposed. The cyclization is a sequence of nucleophilic ipso addition and oxidative dearomatization. The formation of acetic carbimidic anhydrides is an acid-catalyzed acetate addition to the nitriles. 相似文献
11.
Tadatomi Nishikubo Takashi Iizawa Kazuo Kobayashi Makoto Okawara 《Tetrahedron letters》1981,22(39):3873-3874
Phase transfer catalyzed elimination reactions of -(2-bromoethyl)-benzylchloride with potassium hydroxide gave -chloromethylated styrene in high yield. 相似文献
12.
Adolf Emil Siegrist Hans Rudolf Meyer Peter Gassmann Serge Moss 《Helvetica chimica acta》1980,63(5):1311-1334
Preparation of Styryl and Distyryl Derivatives of Pyridine 2,4-, 2,5- and 2,6-Dimethylpyridines react with anils of aromatic aldehydes in the presence of dimethylformamide and potassium hydroxide to yield the corresponding distyrylpyridines (‘anil synthesis’). Under the same reaction conditions (4-methylstyryl)pyridines are converted to (stilbenylvinyl)pyridines. Similarly, the Schiff's base derived from pyridine-3-carbaldehyde and p-chloroaniline on treatment with methyl- and p-tolyl-substituted aromatic heterocycles gives the corresponding (heteroaryl-styryl)pyridines, whereas with the Schiff's bases derived from pyridine-2- and -4-carbaldehyde side reactions, such as dimerization followed by disproportionation predominate. 相似文献
13.
In order to study the relationship between structure and activity of chalcones, several now 4-phenyl and 4′-phenyl chalcones are synthesized by condensation of p-phenylbenzaldehyde with, various acetophenones and of p-phenylacetophenone with various aldehydes, respectively, in ethanol under the presence of sodium hydroxide or potassium hydroxide as catalyst. 相似文献
14.
G. Pifferi P. Consonni R. Monguzzi A. Omodei-Sal 《Journal of heterocyclic chemistry》1971,8(6):911-918
Condensation of o-bromomethylphenethyl bromide with potassium salt of N-hydroxyurethan afforded 3-earbethoxy-1,3,4,5-tetrahydro-2,3-benzoxazepine, which was hydrolyzed to 1,3,4,5-tetrahydro-2,3-benxoxazepine (III). The reaction of o-aeetoxymethylphenethyl bromide (VIb) with potassium salt of N-hydroxyurethan in DMF, gave a complex mixture, from which O-[2-(o-acetoxymethylphenyl)(ethyl]-N-earbethoxyhydroxylamine (VIIa) was separated. Subsequent desacetylation to VIIb and halogenation yielded O-[2-(o-bromomethylphenyl)ethyl]-N-carbethoxyhydroxylamine (VIIc). By treatment of VIIc with potassium hydroxide, 2-carbethoxy-1,2,4,5-tetrahydro-3,2-benzoxazepine (X) was obtained together with small amounts of 6,15-diearbethoxy-5,6,8,9,14,15,17, 18-octahy drodibe nzo[d,I]-1,8-dioxa-2,9-diazaeyclotetradec in e (XI). Hydrolysis of X with potassium hydroxide gave 1,2,4,5-tetrahydro-3,2-benzoxazepine (XII). N-Alkyl and N-acyl derivatives of III and XII were also prepared. 相似文献
15.
Wan N. R. W. Isahak Manal Ismail Jamaliah M. Jahim Jumat Salimon Mohd A. Yarmo 《Chemical Papers》2012,66(3):178-187
In this work, the performance of three heterogeneous catalysts, namely potassium hydroxide/γ-alumina, bulk calcium oxide, and nano-calcium oxide, in comparison with the homogeneous potassium hydroxide was studied in
the transesterification of palm oil to produce methyl esters and glycerol. The physical and chemical properties of the heterogeneous
catalysts were thoroughly characterised and determined using a number of analytical methods to assess their catalytic activities
prior to transesterification. The reaction products were analysed using liquid chromatography and their properties were quantified
based on the American Society of Testing and Materials and United State Pharmacopoeia standard methods. At the 65°C reaction
temperature, the oil-to-methanol mole ratio of 1: 15, 2.5 h of the reaction time, and catalyst (φ
r = 1: 40), potassium hydroxide, potassium hydroxide/γ-alumina, nano-calcium oxide, and bulk calcium oxide gave methyl ester yields of 97 %, 96 %, 94 %, and 90 %, respectively.
The impregnation of γ-alumina with potassium hydroxide displayed a catalytic performance comparable with the performance of potassium hydroxide
where the former could be physically separated via filtration resulting in a relatively greater purity of products. Other
advantages included the longer reusability of the catalyst and more active sites with lower by-product formation. 相似文献
16.
Tadatomi Nishikubo Atsushi Kameyama Youji Yamada Yuichi Yoshida 《Journal of polymer science. Part A, Polymer chemistry》1996,34(17):3531-3537
A convenient esterification reaction of poly(methacrylic acid) (PMAA) with certain alkyl halides was performed using 1,8-diazabicyclo-[5.4.0]-7-undecene (DBU) as a base in aqueous solution or in water. The esterification reaction of PMAA with propargyl bromide (PB) proceeded very smoothly and quantitatively at 30°C to give corresponding poly(propargyl methacrylate), although the rate of the reaction decreased with increasing water. The reaction of PMAA with benzyl bromide, o-nitrobenzyl bromide, and p-nitrobenzyl bromide gave corresponding poly(methacrylic ester) using DBU under suitable reaction conditions in water. The esterification reactions of PMAA with PB were carried out using certain organic bases such as triethylamine, 4(N,N-dimethylamino)pyridine and pyridine. Inorganic bases such as sodium carbonate, sodium hydroxide, potassium carbonate, and potassium hydroxide were also tried under the same conditions as with DBU. However, the degrees of estrification with all these bases was much lower than that with DBU. © 1996 John Wiley & Sons, Inc. 相似文献
17.
Kazuhiko Hashimoto Ryo Ohsawa Naohiro Imai Masahiko Okada 《Journal of polymer science. Part A, Polymer chemistry》1999,37(3):303-312
Two kinds of novel vinyl monomers having D ‐glucaric moieties leading to a new type of glycopolymeric inhibitors of β‐glucuronidase, N‐p‐vinylbenzyl‐6‐D ‐glucaramide (6 ) and potassium N‐p‐vinylbenzyl‐6‐D ‐glucaramid‐1‐ate (8 ), were synthesized by the reaction of D ‐glucaro‐6,3‐lactone (3 ) with p‐vinylbenzylamine (5 ) with no catalyst, and the subsequent treatment of the reaction mixture with acetic anhydride and potassium hydroxide aqueous solution, respectively. The radical copolymerization of 8 with acrylamide in various feed ratios at 60°C in 0.1 N potassium chloride aqueous solution gave water‐soluble copolymers (9 ) composed of a synthetic polymeric main chain and many pendant D ‐glucaric chains. The resulting glycopolymers (9 ) were found to inhibit the activity of β‐glucuronidase strongly through a model reaction with p‐nitrophenyl β‐D ‐glucuronide (10 ) in acetic buffer solution (pH 4.7). © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 303–312, 1999 相似文献
18.
H. G. Gilch W. L. Wheelwright 《Journal of polymer science. Part A, Polymer chemistry》1966,4(6):1337-1349
Various α-halo-p-xylenes have been polymerized with base yielding p-xylylene polymers. The reaction involves a 1,6-dehydrohalogenation to give a xylylene which then polymerizes. α,α′-Dichloro-p-xylene forms poly-α-chloro-p-xylylene and polymers containing stilbene units; α,α,α′,α′-tetrachloro-p-xylene gives poly-α,α,α′-trichloro-p-xylylene; alkyl, aryl, and halogen ring-substituted α-chloro-p-xylenes give the corresponding ring-substituted poly-p-xylylenes. The more halogens in the α positions (up to five), the weaker the base necessary for dehydrohalogenation. Sodium hydroxide in methanol will polymerize tetrachloro-p-xylene, while potassium tert-butoxide in refluxing p-xylene is necessary to polymerize α-chloro-p-xylenes. Stilbenes are formed when α-halo-p-xylenes are reacted with potassium tert-butoxide in polar solvents such as dimethyl sulfoxide. 相似文献
19.
The reactions of N-methylsulfonyl-and N-(p-tolylsulfonyl)-2-(cyclopent-1-en-1-yl)-6-methylaniline with molecular bromine in the presence of potassium thiocyanate gave N-methylsulfonyl-and N-(ptolylsulfonyl)-2-(5-isothiocyanatocyclopent-1-en-1-yl)-6-methylanilines. N-Methylsulfonyl-2-(cyclopent-1-en-1-yl)-6-methylaniline reacted with bromine in methanol in the presence of NaHCO3 or with CuBr2 in MeOH to afford N-methylsulfonyl-2-(5-methoxycyclopent-1-en-1-yl)-6-methylaniline. The reaction of N-methylsulfonyl-2-(5-isothiocyanatocyclopent-1-en-1-yl)-6-methylaniline with diethylamine led to the formation of N-methylsulfonyl-2-{5-[diethylamino(thioxo)methyl]aminocyclopent-1-en-1-yl}-6-methylaniline which was converted into 5-methyl-4-methylsulfonyl-2,3,3a,4-tetrahydrocyclopenta[b]indole by heating with potassium hydroxide. 相似文献
20.
Preparation of styryl derivatives of 2-phenyl-4H-1,2,4-triazolo [1,5-a]pyridine 7-Methyl-2-phenyl- and 2-(3-chloro-4-methylphenyl)-4H-1,2,4-triazolo[1,5-a]-pyridines react with anils of aromatic aldehydes in the presence of dimethyl-formamide and potassium hydroxide at 20–45° to yield the 2-phenyl-7-styryl- and 2-(2-chloro-stilben-4-yl)-4H-1,2,4-triazolo [1,5-a]pyridines respectively (‘Anil Synthesis’). Further, the Schiff's bases derived from o-chloroaniline and 2-(p-formyl-phenyl)- and 7-formyl-2-phenyl-4H-1,2,4-triazolo [1,5-a]pyridine yield, with methyl- and with p-tolyl-substituted heterocycles, the corresponding heterocyclic substituted styryl and stilbenyl derivatives. 相似文献