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1.
Douglas X. West Imporn Thientanavanich Anthony E. Liberta 《Transition Metal Chemistry》1995,20(3):303-308
Summary Copper(II) complexes of 6-methyl-2-acetylpyridine N(4)-substituted thiosemicarbazones, coordinated either as a neutral or a monoanionic ligand, have been prepared and characterized. I.r., electronic and e.p.r. spectra of the complexes, as well as1H- and13C-n.m.r. spectra of the thiosemicarbazones, have been recorded. Both the thiosemicarbazones and their copper(II) complexes show either modest or no growth inhibitory activity againstAspergillus niger, but theN(4)-dialkyl- and 3-azacyclo-derivatives, and particularly their copper(II) complexes, have considerable activity againstPaecilomyces variotii. 相似文献
2.
《Polyhedron》1999,18(21):2759-2767
Pyruvaldehyde mixed bis(thiosemicarbazones) have been prepared in which the two thiosemicarbazone moieties have different N(4)-substituents. The mixed bis(thiosemicarbazones) and their copper(II) and nickel(II) complexes have been characterized with IR, electronic, mass, 1H NMR (Ni) and EPR (Cu) spectra. Representative crystal structures have been solved of nickel(II) complexes with either a pyruvaldehyde mixed bis(thiosemicarbazone) or a bis(thiosemicarbazone) with identical N(4)-substituents acting as a tetradentate ligand. [Ni(Pu4M4DE)] has an N(4)-methylthiosemicarbazone substituent on the keto “arm” and N(4)-diethylthiosemicarbazone substituent on the aldehyde arm. [Ni(Pu4M)] contains two N(4)-methylthiosemicarbazone moieties. Both bis(thiosemicarbazones) form square-planar N2S2 complexes with nickel(II) and copper(II). 相似文献
3.
Douglas X. West Haileselassie Gebremedhin Timothy J. Romack Anthony E. Liberta 《Transition Metal Chemistry》1994,19(4):426-431
Summary Copper(II) complexes of a large number of 2-acetylpyridine 4N-alkyl thiosemicarbazones were prepared and characterized. I.r., electronic and e.s.r. spectra of the complexes, as well as 1H and 13C n.m.r. spectra of the thiosemicarbazones, were obtained. Both the thiosemicarbazones and their complexes show either modest or no growth inhibitory activity against Aspergillus niger, but many have considerable activity against Paecilomyces variotii. There is a relationship between the antifungal activity and size of the 4N-substituent for both the thiosemicarbazones and their copper(II) complexes. 相似文献
4.
Douglas X. West Michelle M. Salberg Gordon A. Bain Anthony E. Liberta Jesús Valdés-Martínez Simón Hernández-Ortega 《Transition Metal Chemistry》1996,21(3):206-212
Summary Binuclear copper(II) complexes with six 5-nitrosalicylaldehyde N(3)-substituted thiosemicarbazones have been prepared and characterized. I.r., electronic and e.s.r. spectra of the complexes, as well as i.r., electronic, and 1H-and 13C-n.m.r. spectra of the thiosemicarbazones, have been obtained. The crystal structure of a monomeric copper(II) complex of 5-nitrosalicylaldehyde piperidyl-thiosemicarbazone, H25NO2Sapip, grown from DMF solution, has been solved. Neither the thiosemicarbazones or their binuclear copper(II) complexes show growth inhibitory activity against Aspergillus niger, but the copper(II) complexes show some activity against the fungus Paecilomyces variotii. 相似文献
5.
Douglas X. West Mark A. Lockwood Anthony E. Liberta Xin Chen Roger D. Willett 《Transition Metal Chemistry》1993,18(2):221-227
Summary Nickel(II) and copper(II) complexes of acetylpyrazine 3-azabicyclo[3.2.2]-nonylthiosemicarbazone and nickel(II) complexes of acetylpyrazine 4N-methyl-, 4N-dimethyl-, and 3-hexamethyleneiminylthiosemicarbazone have been synthesized and characterized by their spectral and physical properties. Crystal structures for the nickel(II) complexes of the 4N-methyl- and 4N-dimethyl-derivatives, with a chloro ligand in the fourth coordination position, are included. The growth inhibition by the four thiosemicarbazones and their metal complexes against two human pathogenic fungi, Aspergillus niger and Paecilomyces variotii, have been evaluated. 相似文献
6.
West Douglas X. Nassar Amal A. El-Saied Fathy A. Ayad Mohamed I. 《Transition Metal Chemistry》1998,23(4):321-325
Mononuclear copper(II) complexes with 2-aminoacetophenone thiosemicarbazone and three N(4)-substituted thiosemicarbazones have been prepared in ethanolic solution and characterized by physical and spectral methods. I.r., electronic and e.s.r. spectra of the complexes, as well as i.r., electronic, and 1H- and 13C-n.m.r. spectra of the thiosemicarbazones, have been obtained. The 2-aminoacetophenone thiosemicarbazones coordinate as neutral ligands via the thiosemicarbazone moiety's azomethine nitrogen and thione sulfur, except for the piperidylthiosemicarbazone, which undergoes deprotonation and coordinates via the thiolato sulfur, as well as through the azomethine nitrogen. Complexes formed in the presence of triethylamine also form complexes with the anionic form of these thiosemicarbazones. 相似文献
7.
Isolda C. Mendes Juliana P. Moreira Antonio S. Mangrich Solange P. Balena Bernardo L. Rodrigues Heloisa Beraldo 《Polyhedron》2007
Five copper(II) complexes with N(4)-ortho, N(4)-meta and N(4)-para-tolyl thiosemicarbazones derived from 2-formyl and 2-acetylpyridine were obtained and thoroughly characterized. The crystal structure of N(4)-meta-tolyl-2-acetylpyridine thiosemicarbazone (H2Ac4mT) was determined, as well as that of its copper(II) complex [Cu(2Ac4mT)Cl], which contains an anionic ligand and a chloride in the coordination sphere of the metal. The in vitro antimicrobial activities of all thiosemicarbazones and their copper(II) complexes were tested against Salmonella typhimurium and Candida albicans. Upon coordination a substantial decrease in the minimum inhibitory concentration, from 225 to 1478 μmol L−1 for the thiosemicarbazones to 5–30 μmol L−1 for the complexes was observe against the growth of Salmonella typhimurium and from 0.7–26 to 0.3–7 μmol L−1 against the growth of C. albicans, suggesting that complexation to copper(II) could be an interesting strategy of dose reduction. 相似文献
8.
Douglas X. West Cinda S. Carlson Anthony E. Liberta John P. Scovill 《Transition Metal Chemistry》1990,15(5):383-387
Summary Copper(II) complexes of 2-acetylpyrazine2
N-methyl-,4
N-dimethyl- and 3-hexamethyleneiminylthiosemicarbazone have been prepared and characterized. Inhibition of the growth ofAspergillus niger andPaecilomyces bariotii by both the thiosemicarbazones and their copper(II) complexes is included. 相似文献
9.
Songül ELENCE-BAKIR 《Turkish Journal of Chemistry》2021,45(3):835
Six nickel(II) complexes of the N2O2 chelating thiosemicarbazones were synthesized using N1-4-benzyloxysalicylidene-S-methyl/propyl thiosemicarbazone and methoxy-substitute-salicylaldehydes in the presence of Ni(II) ion by template reaction. The structures of thiosemicarbazones and nickel(II) complexes were characterized by elemental analysis, UV-Vis, IR, and 1H-NMR spectroscopies. The structure of the N1-4-benzyloxysalicylidene-S-propyl thiosemicarbazone ( 2 ) was determined by X-ray single-crystal diffraction method. The total antioxidant capacities of synthesized compounds were evaluated by using cupric reducing antioxidant capacity (CUPRAC) method. The thiosemicarbazones exhibited more potent antioxidant capacity than Ni(II) complexes. Trolox equivalent antioxidant capacity (TEAC) of 1c was found highest in tested nickel(II) complexes. In addition, antioxidant activities of tested compounds were evaluated by using the hydroxyl radical, DPPH radical, and ABTS radical scavenging abilities of these compounds. 相似文献
10.
Maria Gil Elena Bermejo Alfonso Castieiras Heloisa Beraldo Douglas X. West 《无机化学与普通化学杂志》2000,626(11):2353-2360
Pyridyl bis(N(4)‐substituted thiosemicarbazones), in which the substituents replacing the NH2 group on the thiosemicarbazone moieties are piperidyl, H2Plpip; hexamethyleneiminyl, H2Plhexim; diethylamino, H2Pl4DE; and dipropylamino, H2Pl4DP, have been synthesized. These bis(thiosemicarbazones) and their nickel(II) complexes have been characterized with IR, electronic, mass, and 1H and 13C NMR spectra. Crystal structures have been solved for H2Plpip and all four nickel(II) complexes. H2Plpip does not possess hydrogen bonding between the thiosemicarbazone moieties, but is in the Z isomeric form with intramolecular hydrogen bonding from both thiosemicarbazone moieties to pyridine nitrogen atoms. The nickel(II) complexes possess square‐planar N2S2 (i. e., imine nitrogen and thiolato sulfur atoms) centers and the two pyridine ring nitrogen atoms are not coordinated. 相似文献
11.
Mostafa Sahar I. El-Asmy Ahmed A. El-Shahawi Mohamed S. 《Transition Metal Chemistry》2000,25(4):470-473
New ruthenium(II) complexes with 2-hydroxybenzophenone N(4)-substituted (Me, Ph and/or piperidyl) thiosemicarbazones have
been prepared and characterised by elemental analysis, molar conductivity, thermal analysis, spectroscopy (i.r., 1H-n.m.r. and u.v.–vis.) and by cyclic voltammetry. The thiosemicarbazones coordinate to ruthenium(II) as mononegative tridentate
ligands via the deprotonated hydroxyl group, N1 nitrogen and thione sulphur centres. The redox properties, nature of the electrode processes and the stability of the complexes
towards oxidation in CH2Cl2 are discussed. The change in the E
1/2 values of the complexes can be related to the basicity of the N(4)-substituents. All the complexes display an irreversible
one-electron charge-transfer couple in the potential range studied.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
12.
El-Saied Fathy A. El-Asmy Ahmed A. Kaminsky Werner West Douglas X. 《Transition Metal Chemistry》2003,28(8):954-960
CoII,III, NiII, and CuII complexes of new dehydroacetic acid N4-substituted thiosemicarbazones have been studied. The substituted thiosemicarbazones, N4-dimethyl-(DA4DM), N4-diethyl-(DA4DE), 3-piperidyl-(DApip) and 3-hexamethyleneiminyl-(DAhexim), when reacted with the metal chlorides, produced two CoII complexes, [Co(DA4DE)Cl2] and [Co(DAhexim)2Cl2]; two CoIII complexes, [Co(DA4DM-H)2Cl] and [Co(DApip-H)(DApip-2H)]; a paramagnetic NiII complex, [Ni(DAhexim)(DAhexim-H)Cl]; three diamagnetic NiII complexes, [Ni(DA4DM-H)Cl], [Ni(DA4DE-H)Cl] and [Ni(DApip-H)Cl]; and four CuII complexes with the analogous stoichiometry of the latter three NiII complexes. These new thiosemicarbazones have been characterized by their melting points, as well as i.r., electronic and 1H-n.m.r. spectra. The metal complexes have been characterized by i.r. and electronic spectra, and when possible, n.m.r. and e.s.r. spectra, as well as elemental analyses, molar conductivities, and magnetic susceptibilities. The crystal and molecular structure of the four-coordinate CuII complex, [Cu(DAhexim-H)Cl] has been determined by single crystal X-ray diffraction and the anionic ligand coordinates via an oxygen of the dehydroacetic acid and the thiosemicarbazone moiety's imine nitrogen and thione sulfur. 相似文献
13.
Mendes Isolda C. Teixeira Letícia R. Lima Rejane Carneiro Tânia G. Beraldo Heloisa 《Transition Metal Chemistry》1999,24(6):655-658
Seven platinum(II) complexes isolated from thiosemicarbazones derived from 2-, 3- and 4-formylpyridine and 2-, 3-, and 4-acetylpyridine have been characterised by microanalyses, molar conductivities and by their i.r. and 1H-n.m.r. spectra. 相似文献
14.
《Polyhedron》1986,5(3):739-742
The synthesis and characterization of tricoordinated tin(II) complexes with semicarbazones and thiosemicarbazones of the type, Sn · L (where L = the semicarbazone or thiosemicarbazone of salicylaldehyde, o-hydroxyacetophenone, 2-hydroxy-1-naphthaldehyde and benzoin) are reported. On the basis of electronic, IR, 1H NMR and Mössbauer spectral studies, some tentative structures have been proposed for these new compounds. 相似文献
15.
Douglas X. West Shari L. Dietrich Imporn Thientanavanich Christine A. Brown A. E. Liberta 《Transition Metal Chemistry》1994,19(2):195-200
Summary Copper(II) complexes of 6-methyl-2-formylpyridine thiosemicarbazone, and its 4N-methyl-, 4N-ethyl-, 4N-phenyl-,4 N-dimethyl-, 4N-diethyl-, 4N-dipropyl-, 3-pyrrolidinyl, 3-piperidinyl- and 3-hexamethyleneiminylthiosemicarbazone derivatives were prepared and characterized.
I.r., electronic and e.s.r. spectra of the complexes, as well as 1H and 13C n.m.r. spectra of the thiosemicarbazones, were obtained. The thiosemicarbazones and their copper(II) complexes show either
modest or no growth inhibitory activity against Aspergillus niger, but the 4N-dialkyl- and 3-azacyclo-derivatives exhibit considerable activity against Paecilomyces variotii. 相似文献
16.
Jerry P. Jasinski Jason R. Bianchani Juan Cueva Fathy A. El‐Saied Ahmed A. El‐Asmy Douglas X. West 《无机化学与普通化学杂志》2003,629(2):202-206
Copper(II) complexes of 3, 4‐hexanedione bis(piperidyl‐ and bis(hexamethyleneiminylthiosemicarbazone), H2Hxpip and H2Hxhexim, respectively, have been prepared and studied spectroscopically. The bis(thiosemicarbazones) have been characterized by their melting points, as well as IR, electronic and 1H NMR spectra. Upon formation of their copper(II) complexes, loss of the hydrazinic hydrogen atoms occurs, and the ligands coordinate as dianionic, tetradentate N2S2 ligands. The crystal structures of H2Hxpip, its 4‐coordinate copper(II) complex, [Cu(Hxpip)], and the related [Cu(Hxhexim)] have been determined by single crystal x‐ray diffraction. The nature of the four‐coordinate copper(II) complexes have also been characterized by ESR, IR, and electronic spectroscopy, as well as magnetic moments and elemental analyses. 相似文献
17.
Summary CuII complexes of 2-formyl, 2-acetyl- and 2-benzoylpyridine N(4)-o-, N(4)-m- and N(4)-p-chlorophenylthiosemicarbazones, coordinated either as a neutral or monoanionic ligand, have been prepared and characterized. I.r., electronic and e.s.r. spectra of the complexes, as well as 1H- and 13C-n.m.r. spectra of the thiosemicarbazones, have been obtained. Both the thiosemicarbazones and their CuII complexes show either modest or no growth inhibitory activity against Paecilomyces variotii. Some of the thiosemicarbazones demonstrated significant activity against tumour cell strains. 相似文献
18.
Douglas X. West David L. Huffman Jill S. Saleda Anthony E. Liberta 《Transition Metal Chemistry》1991,16(6):565-570
Summary Two series of copper(II) complexes. [Cu(HL)X2] and [Cu(L)Cl], where HL is a 2-formylpyridine4
N-substituted thiosemicarbazone, L is an anion formed by loss of the2N hydrogen and X=Cl or Br, have been prepared and spectrally characterised. Their growth inhibition ofAspergillus niger andPaecilomyces variotii has been measured and compared with analogous complexes formed from 2-acetylpyridine thiosemicarbazones. 相似文献
19.
Douglas X. West Christopher E. Ooms Jill S. Saleda H. Gebremedhin Anthony E. Liberta 《Transition Metal Chemistry》1994,19(5):553-558
Summary Copper(II) and nickel(II) complexes of 2-formylpyridine 3-piperidinyl-, 3-hexamethyleneiminyl- and 3-azabicyclo-[3.2.2]nonylthiosemicarbazones were prepared and characterized spectroscopically. 1H and 13C n.m.r. spectra of the thiosemicarbazones and a diamagnetic nickel(II) complex are reported, together with i.r., electronic and e.s.r. spectra of the metal complexes. The thiosemicarbazones and their copper(II) and nickel(II) complexes exhibit considerable growth inhibitory activity against Paecilomyces variotii, but show minimal activity against Aspergillus niger. 相似文献
20.
Douglas X. West Cinda S. Carlson Anthony E. Liberta Julyan N. Albert Christina R. Daniel 《Transition Metal Chemistry》1990,15(5):341-344
Summary Nickel(II) complexes of 2-acetylpyridine4
N-diethyl- and4
N-dipropylthiosemicarbazone show less activity againstAspercallus niger than the free thiosemicarbazones. However, againstPaecilomyces variotii the nickel(II) complexes possess comparable activity at high concentrations and are more active at lower concentrations. Spectral and thermal information about the nickel(II) complexes, which coordinate the anionic thiosemicarbazone ligands in a tridentate manner, is included. 相似文献