Two-dimensional miscibility studies of alamethicin and selected film-forming molecules

Alamethicin (ALM), a 20-amino acid antibiotic peptide (peptaibol) from fungal sources, was mixed in Langmuir monolayers with six different surfactants: semifluorinated (F6H18, F10H19, F8H10OH, F6H10SH) and hydrogenated (C18SH and DODAC), aimed at finding appropriate molecules for ALM incorporation for nanodevice construction. Alamethicin-containing mixed monolayers were investigated by means of surface manometry (pi-A isotherms) and Brewster angle microscopy (BAM). Our results show that only semifluorinated alkanes can serve as an appropriate material since they form miscible and homogeneous monolayers with ALM within the whole concentration range. All the remaining surfactants, possessing polar groups, were found to demix with ALM. This effect was explained as being due to the existence of strong polar interactions between vertically oriented surfactant molecules, which tend to separate from horizontally oriented alpha-helices of the peptide. On the contrary, semifluorinated alkanes, lacking any polar group in their structure and bearing a large dipole moment, interact with ALM, also possessing a huge cumulative dipole moment. These dipole-dipole interactions between ALM and SFAs are more attractive than those between SFA molecules in their pure monolayers, causing the large ALM molecule, situated parallel to the interface, to be surrounded by SFA molecules in perpendicular orientation, leading to the formation of a highly organized binary mixed monolayer. BAM images of the ALM monolayer indicate that this peptide collapses with the nucleation and growth mechanism, like the majority of surfactants, which contradicts the model of ALM collapse by desorption, previously published in the literature.     

Interactions of a fluoroaryl surfactant with hydrogenated, partially fluorinated, and perfluorinated surfactants at the air/water interface

A novel surfactant containing pentafluorophenyl moiety attached at the terminal position of undecanol (11,11-difluoro-11-(pentafluorophenyl)undecan-1-ol, abbr. PBD) was synthesized and employed for the Langmuir monolayer characterization and miscibility studies with a semifluorinated alkane (perfluorodecyleicosane, abbr. F10H20) and four alcohols differing in the degree of fluorination in their hydrophobic chains: octadecanol (C18OH), perfluorooctyldecanol (F8H10OH), perfluoroisononyldecanol (iF9H10OH) and 1H,1H-perfluorooctadecanol (F18OH). Pure monolayers of all of the investigated surfactants as well as their mixtures were investigated with surface pressure-area isotherms complemented by Brewster angle microscopy (BAM) images. PBD was found to form stable Langmuir monolayers of liquid-expanded character. Characteristic dendritic structures were formed at the very early stage of compression and remained up to the vicinity of collapse, where 3D crystallites appeared. 2D miscibility studies revealed that PBD forms mixed monolayers with the investigated semifluorinated alkane (F10H20) as well as with perfluorinated alcohol (F18OH) within the whole composition range, do not mix with octadecanol to the fully hydrogenated alcohol, whereas it is partially miscible (up to a certain surface pressure value) with the studied semifluorinated alcohols. The analysis of the miscibility derived from the surface pressure-area isotherms (collapse pressure vs composition dependencies) agrees well with BAM images. Molecular interactions in the investigated systems have been quantified with interaction parameter, alpha.     

Two-dimensional miscibility studies--the analysis of interaction between long-chain alcohols and semifluorinated alkanes

This work presents the results of phase behavior studies of two-dimensional (2D) binary systems involving semifluorinated alkanes (SFAs) and fatty alcohols. Four different SFAs were selected for investigations: (i) with a short and branched perfluorinated moiety (iF3H20), (ii) with a short and normal perfluorinated chain (F4H20), (iii) with a long and branched perfluorinated fragment (iF9H20), and (iv) with a long and normal perfluorinated group (F10H20). Two alcohols were selected to mix with the above-mentioned SFAs: tetradecanol and docosanol. The measurements were based on surface pressure/area isotherms in addition to Brewster angle microscope (BAM) imaging. Dependencies of the collapse surface pressure and the compression modulus vs the monolayer composition together with the excess free energy of mixing values, complemented with BAM images, enabled us to draw some general conclusions regarding the phase behavior of the investigated mixed systems. Generally, it has been noticed that the addition of docosanol into an SFA monolayer exerts a condensing effect, contrary to tetradecanol. Moreover, SFAs with a long perfluorinated segment mix to a larger extent with alcohols as compared to their analogues having a short perfluorinated moiety. The resultant phase diagrams for all the investigated eight mixtures are presented and discussed.     

Fluorinated vs hydrogenated surfactants in mixtures with valinomycin—The Langmuir monolayer study

Selected fluorinated and hydrogenated surfactants, namely a semifluorinated alkane (SFA): 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-henicosafluorononacosane (F10H19), two long chain alcohols: 18,18,18,17,17,16,16,15,15,14,14,13,13,12,12,11,11-heptadecafluorooctadecane-1-ol (F8H10OH) and octadecane-1-ol (C18OH) and with two long chain thiols of the analogous apolar part structure to the above-mentioned alcohols, i.e.: 18,18,18,17,17,16,16,15,15,14,14,13,13,12,12,11,11-heptadecafluorooctadecane-1-thiol (F8H10SH) and octadecane-1-thiol (C18SH) have been tested in mixtures with valinomycin as potential artificial matrixes for its immobilization. The thermodynamic analysis (ΔG^exc vs X_val plots) based on surface pressure–area isotherm registration for particular valinomycin/surfactant mixtures, complemented with BAM images of the films structure indicate that only fluorinated surfactants are suitable materials for valinomycin incorporation as they form homogeneous miscible monolayers at X_val below 0.5.     

Iso-branched semifluorinated alkanes in Langmuir monolayers

A series of semifluorinated n-alkanes (SFAs), of the general formula: (CF3)2CF(CF2)6(CH2)nH (in short iF9Hn), n = 11-20 have been synthesized and employed for Langmuir monolayer characterization. Surface pressure and electric surface potential measurements were performed in addition to Brewster angle microscopy results, which enabled both direct visualization of the monolayers structure and estimation of the monolayer thickness at different stages of compression. Our paper was aimed at investigating the influence of the iso-branching of the perfluorinated fragment of the SFA molecule on the surface behavior of these molecules at the air/water interface. It occurred that iF9 SFAs with the number of carbon atoms in the hydrogenated moiety from 11 to 20 are capable of Langmuir monolayer formation. Monolayers from iF9H11 to iF9H13 are instable, whereas those formed by iF9 SFAs with longer hydrogenated chains form stable films at the free surface of water. As compared to SFAs containing perfluorinated chain in a normal arrangement, iso-branched molecules have a greater tendency to aggregate. Lower stability of monolayers formed by iF9 SFAs as compared to F10 SFAs originated from the surface nucleation observed in BAM images, even at the very initial stages of compression. The dipole moment vector for iso-branched SFAs was found to be virtually aligned with the main axis of the molecule, contrary to F10 SFAs, where the dipole moment vector was calculated to be tilted with respect to the main molecular axis. Quantitative Brewster angle microscopy measurements (relative reflectivity experiments) enabled us to monitor the changes of monolayer thickness at different stages of monolayer compression.     

Mixed Langmuir monolayers of gramicidin A and fluorinated alcohols

Mixed monolayers of gramicidin A (GA) and three alcohols, differing in the degree of fluorination, namely C18OH, F18OH, and F8H10OH have been investigated by means of: surface manometry (pi-A isotherms) and Brewster angle microscopy (BAM) aiming at finding appropriate molecules for incorporating gramicidin A for a biosensor design. Our results proved that only the semifluorinated alcohol is appropriate material for this purpose since it forms miscible and homogeneous monolayers with GA within the whole concentration range. The experimental results have been supported by the calculations of van der Waals energy profiles using the Insight II program. Both the hydrogenated and perfluorinated alcohols were found to aggregate at higher surface pressures, which exclude their application for gramicidin-based biosensor construction.     

Giant brainlike aggregates from new fluorocarbon/hydrocarbon hybrid cationic surfactants

A rapid synthetic procedure in two steps from perfluoroalkylethyl iodide derivatives led to 18 novel ammonium type hybrid surfactants of the general formula: R(F)(CH(2))(2)S(CH(2))(2)N(+)(CH(3))(2)R(H)Br(-) (R(F) = C(4)F(9), C(6)F(13), C(8)F(17); R(H) = C(4)H(9), C(6)H(13), C(8)H(17), C(10)H(21), C(12)H(25), C(14)H(29)). These hybrid surfactants exhibited very low surface tension (from 16 to 25 mN/m) as well as low critical micellar concentration until 1.5 × 10(-5) mol/L. A special focus was made on aggregation phenomenon as giant multilamellar "brainlike" vesicles were observed via cryogenic scanning electron microscopy (cryoSEM) and transmission electron microscopy (TEM; with a contrast agent) suggesting a high encapsulation ability and a very important specific surface of these particular organizations.     

Design of ordered bimodal mesoporous silica materials by using a mixed fluorinated-hydrogenated surfactant-based system

Mesoporous silica materials have been prepared using aqueous solutions of hydrogenated-fluorinated surfactant mixtures. The phase behavior of the C18H35(OC2H4)10-C6F15C2H4(OC2H4)11OH [RH18(EO)10-RF6(EO)11] mixture in aqueous solution was first established at the temperature at which the silica source is added, i.e., 20 or 40 degrees C. We have delimited the different phase domains. Concerning the mesostructured silica, whatever the temperature at which the silica source is added, mesoporous material with a hexagonal array of their channel is formed via a cooperative templating mechanism (CTM), if the content of RF6(EO)11 in the surfactant mixture is lower than 50%. Moreover, when the silica source is added at 40 degrees C, the recovered materials exhibit a bimodal pore size distribution. The appearance of this bimodality has been related to the coexistence of hydrogenated micelles with fluorinated wormlike micelles. By contrast, the bimodality is not observed when the silica source is added at 20 degrees C.     

Polyoxometalate-supported transition metal complexes and their charge complementarity: synthesis and characterization of [M(OH)6Mo6O18[Cu(Phen)(H2O)2]2][M(OH)6Mo6O18[Cu(Phen)(H2O)Cl]2].5H2O (M = Al(+, Cr3+)

Two Anderson-type heteropolyanion-supported copper phenanthroline complexes, [Al(OH)6Mo6O18[Cu(phen)(H2O)2]2]1+ (1c) and [Al(OH)6Mo6O18[Cu(phen)(H2O)Cl]2]1- (1a) complement their charges in one of the title compounds [Al(OH)6Mo6O18[Cu(phen)(H2O)2]2][Al(OH)6Mo6O18[Cu(phen)(H2O)Cl]2].5H2O [1c][1a].5 H2O 1. Similar charge complementarity exists in the chromium analogue, [Cr(OH)6Mo6O18[Cu(phen)(H2O)2]2][Cr(OH)6Mo6O18[Cu(phen)(H2O)Cl]2].5 H2O [2c][2a].5 H2O 2. The chloride coordination to copper centers of 1a and 2a makes the charge difference. In both compounds, the geometries around copper centers are distorted square pyramidal and those around aluminum/chromium centers are distorted octahedral. Three lattice waters, from the formation of intermolecular O-H.....O hydrogen bonds, have been shown to self-assemble into an "acyclic water trimer" in the crystals of both 1 and 2. The title compounds have been synthesized in a simple one pot aqueous wet-synthesis consisting of aluminum/chromium chloride, sodium molybdate, copper nitrate, phenanthroline, and hydrochloric acid, and characterized by elemental analyses, EDAX, IR, diffuse reflectance, EPR, TGA, and single-crystal X-ray diffraction. Both compounds crystallize in the triclinic space group P. Crystal data for 1: a = 10.7618(6), b = 15.0238(8), c = 15.6648(8) angstroms, alpha = 65.4570(10), beta = 83.4420(10), gamma = 71.3230(10), V = 2182.1(2) angstroms3. Crystal data for 2: a = 10.8867(5), b = 15.2504(7), c = 15.7022(7) angstroms, alpha = 64.9850(10), beta = 83.0430(10), gamma = 71.1570(10), V = 2235.47(18) angstroms3. In the electronic reflectance spectra, compounds 1 and 2 exhibit a broad d-d band at approximately 700 nm, which is a considerable shift with respect to the value of 650-660 nm for a square-pyramidal [Cu(phen)2L] complex, indicating the coordination of [M(OH)6Mo6O18]3- POM anions (as a ligand) to the monophenanthroline copper complexes to form POM-supported copper complexes 1c, 1a, 2c, and 2a. The ESR spectrum of compound 1 shows a typical axial signal for a Cu2+ (d9) system, and that of compound 2, containing both chromium(III) and copper(II) ions, may reveal a zero-field-splitting of the central Cr3+ ion of the Anderson anion, [Cr(OH)6Mo6O18]3-, with an intense peak for the Cu2+ ion.     

季铵盐型双子表面活性剂与十八醇的混合单分子膜

研究了双子表面活性剂12-2-16和12-2-12分别与十八醇(C18H37OH)在空气-水界面上混合单分子膜的π-A等温线. 在相分离表面压以下, 比较了不同表面压下和不同混合比单分子膜的混合表面过剩自由能ΔGMexo, 分析了双子表面活性剂与脂肪醇在空气-水界面上混合膜中的相容性. 结果表明, 12-2-16与C18H37OH在所有混合摩尔比下随着表面压增高, 自由能增大. 12-2-12与C18H37OH混合膜体系的相容性取决于两者的混合比, ΔGMexo随所加入C18H37OH摩尔分数的增加逐渐增大, 从异种分子间净的吸引作用转变到相互排斥作用体系, 转变点为C18H37OH加入量的摩尔分数0.65. 当混合为热力学自发过程时, 增大表面压将有利于混合; 而对相互排斥体系, 增加表面压将使体系内异种分子之间的相互排斥作用更大.     

Miscibility behavior of dipalmitoylphosphatidylcholine with a single-chain partially fluorinated amphiphile in Langmuir monolayers

Surface pressure-area, surface potential-area, and dipole moment-area isotherms were obtained for monolayers made from a partially fluorinated surfactant, (perfluorooctyl)undecyldimorpholinophosphate (F8H11DMP), dipalmitoylphosphatidylcholine (DPPC), and their combinations. Monolayers, spread on a 0.15 M NaCl subphase, were investigated at the air/water interface by the Wilhelmy method, ionizing electrode method, and fluorescence microscopy. Surface potentials were analyzed using the three-layer model proposed by Demchak and Fort. The contribution of the dimorpholinophosphate polar head group of F8H11DMP to the vertical component of the dipole moment was estimated to be 4.99 D. The linear variation of the phase transition pressure as a function of F8H11DMP molar fraction (X(F8H11DMP)) demonstrated that DPPC and F8H11DMP are miscible in the monolayer. This result was confirmed by deviations from the additivity rule observed when plotting the molecular areas and the surface potentials as a function of X(F8H11DMP) over the whole range of surface pressures investigated. Assuming a regular surface mixture, the Joos equation, which was used for the analysis of the collapse pressure of mixed monolayers, allowed calculation of the interaction parameter (xi=-1.3) and the energy of interaction (Delta epsilon =537 Jmol(-1)) between DPPC and F8H11DMP. The miscibility of DPPC and F8H11DMP within the monolayer was also supported by fluorescence microscopy. Examination of the observed flower-like patterns showed that F8H11DMP favors dissolution of the ordered LC phase domains of DPPC, a feature that may be key to the use of phospholipid preparations as lung surfactants.     

Synthesis and Surface Properties of N-Alkyl-N-methylgluconamides and N-Alkyl-N-methyllactobionamides

Three series of nonionic N-alkylaldonamides, N-alkyl-N-methylgluconamides (Cn-MGA, Cn: n-C(10)H(21), n-C(12)H(25), n-C(14)H(29), n-C(16)H(33), and n-C(18)H(37)), N-alkyl-N-methyllactobionamides (Cn-MLA, alkyl as above-mentioned), and N-oleyl-N-methylglucon/lactobionamide, were synthesized in the reaction of an appropriate N-alkyl-N-methylamine with delta-D-glucolactone and lactobionic acid, respectively. Krafft temperatures of aqueous solutions and surface properties of these surfactants at 20 degrees C, i.e., surface excess concentration, Gamma(cmc), surface area demand per molecule, A(min), efficiency in surface tension reduction, pC(20), effectiveness in surface tension reduction, Pi(cmc), critical micelle concentration, CMC, and CMC/C(20) parameter as well as standard free energies of adsorption, DeltaG degrees (ads), and of micellization, DeltaG degrees (mic), were determined. It was shown that introduction of the methyl group to the amide nitrogen increased the solubility of the surfactants, which was confirmed by their Krafft temperatures. Lactobionamides are more water soluble than gluconamides. On the other hand, the Cn-MGA surfactants are more surface active than the respective Cn-MLA ones. This observation is based on the determined adsorption and micellization parameters. The presence of one double bond in a hydrocarbon chain as in oleyl-amides increases their hydrophilic character compared with that of saturated C18 derivatives. No distinct differences were observed between the A(min) values obtained for both series studied, although they differ markedly in the size of the hydrophilic groups. Copyright 2001 Academic Press.     

Function and performance of silicone copolymer (VI). Synthesis and novel solution behavior of water-soluble polysiloxanes with different hydrophiles

Silicone surfactants containing different pendant hydrophilic groups such as diethanol tertiary amine (SHE, nonionic), diethanol methyl quaternary amine (cationic) and triethyl quaternary amine (cationic) have been synthesized and characterized by ¹H and ¹³C NMR and gel permeation chromatography. The solution behavior of these novel surfactants has also been investigated by surface tension measurement and a fluorescence method. It has been observed that the surface tension of these surfactants decreases as a function of time at a very low polymer concentration (1 × 10⁻⁴ wt%). At higher concentration (0.1 wt%), the equilibrium surface tensions reached very low values compared to that of typical polymer surfactants, for example, poly(ethylene oxide–propylene oxide) block copolymer (EPE0.8). In addition, the low I ₁/I ₃ values of these silicone surfactants indicate the formation of polymer aggregates in aqueous solution, and an extremely low I ₁/I ₃ value of SHE (1.06) compared to other polymeric surfactants (EPE0.8) and conventional surfactants [poly(ethylene glycol n-nonyl phenyl ethers), cetyltrimethylammonium bromide, and sodium dodecyl sulfate] indicates its stronger hydrophobicity. Received: 15 May 2000 Accepted: 18 October 2000     

Thermal decomposition of CF3 and the reaction of CF2 + OH --> CF2O + H

The reflected shock tube technique with multipass absorption spectrometric detection (at a total path length of approximately 1.75 m) of OH-radicals at 308 nm has been used to study the dissociation of CF3-radicals [CF3 + Kr --> CF2 + F + Kr (a)] between 1,803 and 2,204 K at three pressures between approximately 230 and 680 Torr. The OH-radical concentration buildup resulted from the fast reaction F + H2O --> OH + HF (b). Hence, OH is a marker for F-atoms. To extract rate constants for reaction (a), the [OH] profiles were modeled with a chemical mechanism. The initial rise in [OH] was mostly sensitive to reactions (a) and (b), but the long time values were additionally affected by CF2 + OH --> CF2O + H (c). Over the experimental temperature range, rate constants for (a) and (c) were determined from the mechanistic fits to be kCF3+Kr = 4.61 x 10-9 exp(-30,020 K/T) and kCF2+OH = (1.6 +/- 0.6) x 10-10, both in units of cm3 molecule-1 s-1. Reaction (a), its reverse recombination reaction reaction (-a), and reaction (c) are also studied theoretically. Reactions (c) and (-a) are studied with direct CASPT2 variable reaction coordinate transition state theory. A master equation analysis for reaction (a) incorporating the ab initio determined reactive flux for reaction (-a) suggests that this reaction is close to but not quite in the low-pressure limit for the pressures studied experimentally. In contrast, reaction (c) is predicted to be in the high-pressure limit due to the high exothermicity of the products. A comparison with past and present experimental results demonstrates good agreement between the theoretical predictions and the present data for both (a) and (c).     

氧杂氟表面活性剂及其与同电性碳氢表面活性剂混合溶液的表面吸附和胶团形成

研究了四种氧杂氟表面活性及其与同电性直链碳氢表面活性剂混合体系的表面活性;考察了混合体系中的表面吸附和胶团形成现象.在吸附层中分子间有明显的互疏作用,在溶液中倾向于各自形成胶团.还讨论了反离子结合度不同对理想混合胶团的组成CMC的计算的影响,提出了一般的计算式,实验测得这些氧杂氟表面活性剂有较低的胶团反离子结合度.     

Mixed fluorinated-hydrogenated surfactant-based system: preparation of ordered mesoporous materials

We have investigated a mixed fluorinated-hydrogenated surfactant-based system [C8F17C2H4(OC2H4)9-C12H25(OC2H4)8] in water. The phase diagram exhibits that the micellar domain can be divided into three parts: above 80 wt% of water both hydrogenated and fluorinated surfactants are completely miscible and they formed mixed micelles in all proportion. When the water concentration is decreased from 80 to 60 wt% a gap of miscibility appears and two micellar zones, one fluorocarbon-rich micelles and one hydrocarbon-rich micelles are observed. The liquid crystal domain is composed of one fluorocarbon-rich (H(F)(1)) and one hydrocarbon-rich (H(H)(1)) hexagonal phase. The hydrophobic radius and the cross-sectional area remain constant in the H(H)(1) and in the H(F)(1) domains. Moreover, SAXS measurements proved that the hydrophobic chains in the liquid crystal phases adopt rather an extended conformation. Then the mixture of surfactants was used as template for the preparation of mesoporous materials. Mesostructured silicas with a well hexagonal array of their channels were prepared via a cooperative templating mechanism (CTM), if the loading of fluorinated surfactant is larger than 50%. Decreasing the proportion of the fluorinated amphiphile in the mixture leads to the formation of mesoporous silica with a disordered structure. In this case the channel arrangement is no longer governed by the fluorinated surfactant but by the hydrogenated one.     

A novel flow reactor for studying reactions on liquid surfaces coated by organic monolayers: methods, validation, and initial results

A new flow reactor has been developed that allows the study of heterogeneous kinetics on an aqueous surface coated by an organic monolayer. Computational fluid dynamics simulations have been used to determine the flow characteristics for various experimental conditions. In addition a mathematical framework has been developed to derive the true first-order wall loss rate coefficient, k(1st)(w), from the experimentally observed wall loss rate, k(obs). Validation of the new flow reactor is performed by measuring the uptake of O(3) by canola oil as a function of pressure and flow velocity and the reactive uptake coefficients of N(2)O(5) by aqueous 60 wt % and 80 wt % H(2)SO(4). Using this new flow reactor, we also determined the reactive uptake coefficient of N(2)O(5) on aqueous 80 wt % H(2)SO(4) solution coated with an 1-octadecanol (C(18)H(37)OH) monolayer. The uptake coefficient was determined as (8.1 +/- 3.2) x 10-4, which is about 2 orders of magnitude lower compared to the reactive uptake coefficient on a pure aqueous 80 wt % H(2)SO(4) solution. Our measured reactive uptake coefficient can be considered as a lower limit for the reactive uptake coefficient of aqueous aerosols coated with organic monolayers in the atmosphere, because in the atmosphere organic monolayers will likely also consist of surfactants with shorter lengths and branched structures which will have a smaller overall effect.     

Synthesis and Crystal Structure of a Novel Bimetallic Porphyrin Complex Salt {[MnTPP(CH3OH)2]3Fe(CN)6}·13H2O

A novel bimetallic porphyrin complex salt, {[MnTPP(CH3OH)2]3Fe(CN)6}·13H2O (TPP = tetraphenylporphyrin), has been synthesized and structurally characterized by X-ray diffraction analysis. The crystal is of trigonal, space group R-3 with a = b = 31.0618(10), c = 11.8366(8) (A), Z = 3, V = 9890.3(8) (A)3, C144H134FeMn3N18O19, Mr = 2641.36, Dc = 1.330 g/cm3, μ(MoΚα) = 0.463 mm-1, F(000) = 4131, R = 0.0525 and wR = 0.1382 for 3045 observed reflections (I ＞ 2((I)). The title complex is composed of one [Fe(CN)6]3- anion, three [MnTPP(CH3OH)2] cations and thirteen water molecules, which are connected by multiform hydrogen bonds leading to a 3D supramolecular network structure.     

Synthesis and Crystal Structure of a Novel Bimetallic Porphyrin Complex Salt {[MnTPP(CH_3OH)_2]_3Fe(CN)_6}·13H_2O

A novel bimetallic porphyrin complex salt, {[MnTPP(CH3OH)2]3Fe(CN)6}13H2O (TPP = tetraphenylporphyrin), has been synthesized and structurally characterized by X-ray diffraction analysis. The crystal is of trigonal, space group R-3 with a = b = 31.0618(10), c = 11.8366(8) A, Z = 3, V = 9890.3(8) A3, C144H134FeMn3N18O19, Mr = 2641.36, Dc = 1.330 g/cm3, μ(MoΚα) = 0.463 mm-1, F(000) = 4131, R = 0.0525 and wR = 0.1382 for 3045 observed reflections (I > 2σ(I)). The title complex is composed of one [Fe(CN)6]3- anion, three [MnTPP(CH3OH)2]+ cations and thirteen water molecules, which are connected by multiform hydrogen bonds leading to a 3D supramolecular network structure.