Microwave Irradiation Promoted Synthesis of Aryloxy Acetic Acids

Several aryloxy acetic acids were synthesized under microwave irradiation. The factors, which affect the reaction, were investigated and optimized. It was revealed that the best yields(92. 7%--97.4%) were obtained when the molar ratio of the reactants was n(ArOH) : n(NaOH) : n(CICH2CO2H) = 1：2.5： 1.2 with microwave irradiation power of 640 W for 65--85 s.     

Convenient Synthesis of Highly Substituted Imidazole Derivatives

A one-pot synthesis of the trisubstituted imidazole derivatives from α-acetoxy-α-chloro-β-keto-esters, aldehydes, and ammonium acetate has been developed.     

One‐Pot Synthesis of 2,4,5‐Triphenyl Imidazoles from 1,2‐Diols as Key Reagents

A simple one‐pot procedure for the preparation of 2,4,5‐triphenyl imidazole derivatives is presented. The procedure involves the lead tetraacetate oxidation of 1,2‐diols to give aldehydes in situ , which then undergo a three‐component reaction with benzil and ammonium acetate to yield the imidazole derivatives.     

Rapid and Convenient Synthesis of N‐Arylmorpholines under Microwave Irradiation

A series of N‐arylmorpholines 1a , 1b , 1c , 1d , 1e , 1f , 1g , 1h , 1i , 1j , 1k , 1l , 1m , 1n was obtained by cyclocondensation of arylamines and diethylene glycol dimesylate under microwave irradiation in an aqueous potassium carbonate medium. The reaction is rapid and convenient, and a variety of functional groups are tolerated in the process.     

微波常压法合成水杨酸酯

在浓硫酸催化下，采用微波常压法由水杨酸分别与正丁醇、异丁醇、正戊醇和异戊醇反应合成相应的水杨酸酯。结果表明：当水杨酸：醇：Ｈ２ＳＯ４＝１：５．５：０．３（摩尔比）时，采用５６０Ｗ微波辐射２２ｍｉｎ，水杨酸酯的产率可达８８．７％￣９６．４％，反应速度至少是常规反应的１４倍。     

Condensation of Meldrum Acids with Carbonyl Compounds in Dry Media under Microwave Irradiation

以冰醋酸－六氢吡啶为催化剂，硅胶或氧化铝为载体，Ｍｅｌｄｒｕｍ酸与一系列醛酮在微波辐射下发生缩合反应，产率为２２～９７％。     

Synthesis of Glucosylguanidinohydrazones under Microwave Promotion and Ultrasound Irradiation

Guanylhydrazone derivatives were obtained by the condensation of glucosylated aminoguanidines with 3‐formylchromones in refluxing THF. Target compounds were synthesized by conventional method, microwave promotion and ultrasound irradiation methods. The structure of all new compounds was confirmed by IR, ¹H NMR, ¹³C NMR spectral data and elemental analyses.     

Rapid Syntheses of Benzyl Acetate Under Microwave Irradiation

ＲａｐｉｄＳｙｎｔｈｅｓｅｓｏｆＢｅｎｚｙｌＡｃｅｔａｔｅＵｎｄｅｒＭｉｃｒｏｗａｖｅＩｒｒａｄｉａｔｉｏｎＪＩＡＮＧＹｕ－Ｉｉｎ;ＹＵＡＮＹｕｎ－ｃｈｅｎｇ;ａｎｄＳＵＮＹｕｅ－ｈｕａ（ＳｃｈｏｏｌｏｆＣｈｅｍｉｃａｌＥｎｇｉｎｅｅｒｉｎｇ,Ｄａｌ...     

A Convenient Synthesis of Pyrazole‐imidazoline Derivatives by Microwave Irradiation

A series of 28 hybrids pyrazole‐imidazolines 1a – n and 2a – n were synthesized by a new methodology using microwave irradiation, in short time (20–30 min), in low power (50–70 W), and in 34–92% yield. Among all methodologies evaluated, no side products were obtained. All derivatives were completely characterized by FT–IR, ¹H and ¹³C NMR, GC–MS, and HRMS.     

Synthesis of Substituted Salicylanilides under Microwave Irradiation

Summary. Salicylanilides were prepared in 70–95% yields in 4–8min from phenyl salicylate or phenyl 4-methoxysalicylate and substituted anilines under microwave irradiation under solvent free conditions.Received October 17, 2002; accepted October 22, 2002 Published online July 3, 2003     

微波辐射下合成芳香硫醚

本文对在微波条件下S－烃基化反应进行了研究，并提供一种硫酚和卤代烃在氧化铝作载体的条件下，不用任何有机溶剂经微波辐射简便、快速、有效合成芳香硫醚的方法。     

Synthesis of 9-Substituted Berberine Derivatives with Microwave Irradiation

Hyperglycemia is frequently accompanying with hyperlipidemia. To explore the potent drugs with dual-activity and dual-site effects that could reduce blood glucose and blood lipid at the same time, fibrate group with lipid-lowering effect on the 9th position of berberine(BBR) was introduced using the drug design combination principle and the multi-target collaborative treatment method. Moreover, the molecular structure of BBR was modified, and six 9-substituted derivatives of BBR were designed and synthesized, among which, five compounds have never been reported before. In addition, the molecular structures of these derivatives were identified using liquid chromatography-mass spectrometry(LC-MS), ¹H nuclear magnetic resonance(¹H NMR) and ¹³C NMR, respectively. Furthermore, the microwave irradiation experimental technique was applied in the synthesis reaction using the novel microwave synthesizer, which accelerated the reaction rate, enhanced the reaction yield, reduced the reaction by-products, and simplified the post-processing steps. In the meantime, the 9-position regioselective demethylation of BBR was explored through quantum chemical calculation during the synthesis of berberrubine. The computations were consistent with the experimental results, which contributed to deducing the mechanism of its selective methylation.     

微波辐射固体酸催化合成马来酸双酯

首次在微波辐射下，用活性炭固载对甲苯磺酸催化合成了马来酸双酯．当微波辐射功率为150W．正辛醇：酸酐＝3：1，催化剂用量为2．5g时，反应20min后，马来酸酐转化率达89．8％，产物的选择性为99．5％．同时，也发现随着醇的炭数增多，反应温度和反应速率增加；在微波辐射条件下，酯化反应速率、产物选择性都高于常规加热方式下的反应结果．     

Synthesis of Guanylhydrazones Under Microwave Irradiation

Abstract

The reaction of aromatic aldehydes and ketones with aminoguanidine hydrochloride under microwave irradiation (MWI) afforded guanylhydrazones in shorter reaction times and improved yield as compared to the conventional methodology.     

A Convenient One-Pot Synthesis of Dibenzyl Diselenides Under Microwave Irradiation Conditions

A simple, rapid and efficient method for the synthesis of dibenzyl diselenides under microwave irradiation is reported. The effect of microwave irradiation power, times and solvent on the reaction is investigated.     

The Use of Microwave Irradiation for the Rapid Organic Synthesis

Introduction With the development of scientific technology, people continuously search for new methods which can accelerate reactions. Nowadays as a new technology, microwave irradiation has gained much practical importance in chemical reactions. Microwave irradiation has been applied successfully to the areas, such as inorganic synthesis, the prepara-     

微波辐射下N-芳基甲酰胺的合成

以甲酸作为甲酰化试剂，通过微波辐射合成的11种N-芳基甲酰胺。产率比传统 方法有所提高，反应时间缩短了20-120倍。     

Synthesis of Some New Tetrahydrobenzo[b]thiophene Derivatives and Tetrahydrobenzothienopyrimidine Derivatives Under Microwave Irradiation

A simple, straightforward method to synthesize 2,9-dicarbanitrile-1, 10-phenanthroline from 2,9-dimethyl-1, 10-phenanthroline via 2,9-dicarbamoyl-1, 10-phenanthroline is described.     

新的手性芳酰胺分子钳的微波干法合成

在微波辐射无溶剂条件下, 以1,3-二苯氧乙酸为隔离基, L-氨基酸甲酯为手臂设计合成了9个新的分子钳人工受体. 所有化合物的结构均经1H NMR, IR, MS及元素分析所确证. 同传统方法相比, 该法具有简单、快速、有效、对环境友好等优点. 初步的实验结果表明, 这类分子钳受体对D/L-氨基酸甲酯具有良好的对映选择性识别性能.     

Synthesis of 1H‐Imidazoles Catalyzed by Cu‐Nanoparticle and Its Physicochemical Properties

Series of 1‐arylmethyl‐4, 5‐dihydro‐2‐aryl‐1H‐imidazole were synthesized expeditiously in good yields from 1,2‐diaminoethane and aromatic aldehydes in the presence of Cu nanoparticle under microwave irradiation in solvent‐free method. Monodisperse spherical Cu nanoparticles with a diameter range of 45 ± 8 nm were synthesized by polyol process. The particle size and elemental structure of copper nanoparticles were confirmed by XRD data and was found to be having a face‐centered cubic structure. The resulting substituted imidazoles have been studied in the achievement of degree of drug absorption enhancement as well as the potential associated toxicity on the basis of hypothetical antibacterial pharmacophores and structures that were designed to interact with both of gram‐positive and gram‐negative bacteria. All the synthesized molecules were characterized on the basis of 1H NMR, 13C NMR, mass spectrometry, and elemental data.