两层耦合可激发介质中螺旋波转变为平面波

采用Br-Eiswirth模型研究了两层耦合可激发介质中螺旋波的动力学,两层介质通过网络连接,即在每一层介质上,每一列选一个可激发单元作为中心点,在一层介质上同一列的可激发单元只与另一层介质上对应的中心点及其8个邻居有耦合.数值模拟结果表明:通过这种局部耦合,在适当小的耦合强度下两耦合螺旋波可实现同步,增大耦合强度会导致螺旋波漫游和漂移,造成螺旋波不同步,观察到螺旋波与静息态、低频平面波和不规则斑图共存现象.在适当强的耦合强度下,还观察到两螺旋波转变成同步的平面波消失现象.对产生这些现象的物理机理做了讨论.     

Development and transition of spiral wave in the coupled Hindmarsh--Rose neurons in two-dimensional space

The dynamics and the transition of spiral waves in the coupled Hindmarsh--Rose (H--R) neurons in two-dimensional space are investigated in the paper. It is found that the spiral wave can be induced and developed in the coupled HR neurons in two-dimensional space, with appropriate initial values and a parameter region given. However, the spiral wave could encounter instability when the intensity of the external current reaches a threshold value of 1.945. The transition of spiral wave is found to be affected by coupling intensity D and bifurcation parameter r. The spiral wave becomes sparse as the coupling intensity increases, while the spiral wave is eliminated and the whole neuronal system becomes homogeneous as the bifurcation parameter increases to a certain threshold value. Then the coupling action of the four sub-adjacent neurons, which is described by coupling coefficient D’, is also considered, and it is found that the spiral wave begins to breakup due to the introduced coupling action from the sub-adjacent neurons (or sites) and together with the coupling action of the nearest-neighbour neurons, which is described by the coupling intensity D.     

Mechanisms of target and spiral wave propagation in single cells

Target and spiral wave propagation have been observed in single cells such as myocites. Moreover, in the same cells, transition from target waves to planar waves or from the latter to spiral waves was also observed. Considering an oscillatory medium described by the Ginzburg-Landau equation we suggest that such phenomena could be explained if cell nuclei and cell organelles are considered as obstacles in a small bounded medium. We discuss the role of cell geometry as well as the phenomenon of reentry at the cellular level.     

Specificity of the phenomenon of acoustoelasticity in a two-dimensional internally structured medium

A two-dimensional model of a microstructured medium is considered in the form of a square lattice consisting of elastically interacting circular particles with translational and rotational degrees of freedom. The interactions between the particles are modeled by a set of elastic springs. Differential equations are derived to describe the propagation and interaction of acoustic waves in such a medium. The relation between the velocities of wave propagation and the small strain arising in the structure under external action is determined. Analytical expressions that determine the difference between the squares of the velocities of both longitudinal and shear waves propagating in two mutually perpendicular directions in a medium with an externally induced anisotropy are derived and analyzed.     

External forcing of spiral waves

The effect of an external rhythm on rotating spiral waves in excitable media is investigated. Parameters of the unperturbed medium were chosen, such that the organizing spiral tip describes meandering (hypocyclic) trajectories, which are the most general shape for the experimentally observed systems. Periodical modulation of excitability in a model of the Belousov-Zhabotinsky (BZ) reaction forces meandering spiral tips to describe trajectories that are not found at corresponding stationary conditions. For different modulation periods, two types of resonance drift, phase-locked tip motion, a spectrum of hypocyclic trajectories, and complex multifrequency patterns were computed. The computational results are complemented by experimental data obtained for periodically changing illumination of the photosensitive BZ reaction. The observed drastic deformation of the tip trajectory is considered as an efficient means to study and to control wave processes in excitable media.     

交替行为对螺旋波影响的数值模拟研究

在离散可激发介质Greenberg-Hasting模型中引入交替(alternans)行为,研究了交替行为对螺旋波的影响.数值结果表明:在适当选择参数下,交替对螺旋波有很大影响,例如交替导致螺旋波的形状振荡,形成呼吸螺旋波,交替使螺旋波漫游、漂移,甚至使螺旋波漫游出系统的边界,交替使螺旋波破碎形成小螺旋波、反靶波和时空混沌等,首次在均匀介质中观察到交替导致传导障碍,使螺旋波破碎和消失,并对发生这些现象的机理进行了分析. 关键词： 离散可激发介质 螺旋波 靶波 漫游     

The inverse excitation-induced abnormal spiral wave

The effects of a local constant forcing on spiral waves in two-dimensional excitable media described by Bär model are investigated. A constant external forcing is imposed on the core of spiral wave, leading to parameter variability of a medium. It is found that the forcing can significantly alter the shape and rotation period of spiral wave when the values of related parameters are properly chosen. The change of wave structure is attributed to the transition from normal excitation to inverse excitation in the forced medium. An abnormal spiral wave with a very thick spiral arm has been observed. The physical mechanism underlying these phenomena is theoretically analyzed.     

Dynamics of Meandering Spiral Waves Driven by Two-Point Feedback

We numerically study the dynamics of meandering spiral waves in theexcitable system subjected to a feedback signal coming from two measuring points located on a straight line together with the initial spiral core. The core location and size radius of the final attractors are computed, and they change with the position of the moving measuring point in a unique way. By the Fourier Spectral analysis, we find the frequency-locked behaviors different from the
driving scheme of the external periodic force. It is also found that the meandering spiral wave can be eliminated when the moving measuring point approaches closely the boundary and its feedback gain is large enough. This offers an effective and convenient method for eliminating meandering spiral waves.     

极化电场对可激发介质中螺旋波的控制

螺旋波在不同的物理、化学和生物系统中普遍存在.周期外场,比如极化电场,尤其是具有旋转对称性的圆极化电场可对螺旋波动力学产生重要影响.本文综述了极化电场对可激发介质中螺旋波的控制,包括共振漂移、同步、手征对称性破缺、多臂螺旋波的稳定、次激发介质中的螺旋波、三维回卷波湍流态的控制、心脏组织中螺旋波的去钉扎、心脏组织中螺旋波湍流态的控制等.     

Mechanisms of defibrillation by standing waves in the bidomain ventricular tissue with voltage applied in an external bath

Standing waves of depolarisation produced by periodic low-voltage driving eliminate propagation activity in the heart, thus providing a defibrillating effect. The phenomenon cannot be reproduced by mono- or bidomain models of cardiac tissue, where voltage perturbations decay exponentially with a space constant λ₁≈1 mm. Extension of the bidomain model taking into account effects of the external bathing medium allows simulation of the standing waves which eliminate spiral wave activity in the tissue. Mechanisms of such a defibrillating effect can be explained by the existence of an additional, unusually long space constant, λ₂≈20 mm, in the bidomain model with a bath, which emerges due to redistribution of the applied voltage by the external conductive medium.     

间接延迟耦合可激发介质中螺旋波的演化

采用Bär 模型研究了通过被动介质间接延迟耦合的两层可激发介质中螺旋波的相互作用. 数值模拟结果表明: 延迟耦合可以促进两个螺旋波的同步, 也可导致从螺旋波到集体振荡、各种靶波、时空混沌态或静息态的转变; 在这个耦合系统中还观察到周期 2和周期3螺旋波以及螺旋波漫游和漂移现象; 对产生这些现象的物理机制做了讨论. 关键词： 螺旋波 被动介质 时间延迟耦合 同步     

Light induced annihilation and shift of spiral waves

The light-induced collapse of a pair of spiral waves was studied in a chemically active medium based on the photosensitive Ru(bpy)(3)-catalyzed Belousov-Zhabotinsky reaction. Spiral waves annihilate only if the light intensity is increased in proper phase relative to the spiral waves' rotation. Otherwise, the distance between spiral wave cores increases and the pair survives. Computer simulations reveal the mechanism which forces the spiral waves to collide and annihilate. It is based on the shift of a single spiral wave upon an instantaneous decrease of excitability of the medium. (c) 1996 American Institute of Physics.     

Applying a global pulse disturbance to eliminate spiral waves in models of cardiac muscle

Removal of spiral waves in cardiac muscle is necessary because of their threat to life. Common methods for this removal are to apply a local disturbance to the media, such as a periodic forcing. However, most of these methods accelerate the beating of the cardiac muscle, resulting in the aggravation of the ventricular tachycardia, which directly threatens life. In the present study, in order to clear off spiral waves, a global pulse-disturbance is applied to the media based on three models of cardiac muscle. It is found that the spiral waves are eliminated and the frequency of the cardiac muscle is decreased in a short time, and finally, the state of the medium reaches the normal oscillation, which supports a target waves. Our method sheds light on the removal of spiral waves in cardiac muscle and can prevent the ventricular tachycardia as well as the ventricular fibrillation.     

Dynamics of Spiral Waves Induced by Periodic Mechanical Deformation with Phase Difference

The dynamics of spiral waves under the influences of periodic mechanical deformation are studied. Here, the mechanical deformation propagating along the medium with phase differences are considered. It is found that weak mechanical deformation may lead to resonant drift of spiral waves. The drift direction and velocity can be changed by the wave length of the deformation. Strong mechanical deformation may result in breakup of spiral waves. The characteristics of breakup are discussed. The critical amplitudes are determined by two factors, i.e. the wave length and frequency of the periodic mechanical deformation. When the wave length of mechanical deformation is comparable to the spiral wave, simulation shows that the critical amplitude is substantially increased. As the frequency of the mechanical deformation is around 1.5 times of the spiral wave, the critical amplitudes are minimal.     

Lévy噪声与周期力共同驱动下的螺旋波动力学

研究加性Lévy噪声与周期外力对FitzHugh-Nagumo可激系统中螺旋波动力学行为的影响.螺旋波波头的运动随外力周期在一定范围内呈规则变化,该规则变化可用相应的傅立叶谱理解,维持该规则变化的是锁频行为.Lévy噪声序列中包含着小概率的大尺度噪声,螺旋波波头运动改变主要来自于它们的影响,本文指出Lévy噪声对波头运动的影响也依赖于外力周期的取值.在适当的参数取值下,Lévy噪声的存在也能导致螺旋波的消失,这为螺旋波的控制、消除提供了一种方法.分析了系统周期与外力周期的锁定行为,给出了不同噪声强度下的Arnold舌,指出随机共振行为的存在.     

无扩散功能的缺陷对螺旋波动力学行为的影响

采用Br 模型,在二维激发介质中引入无扩散功能的缺陷,研究了均匀分布的缺陷对螺旋波动力学行为的影响.研究发现,缺陷导致介质的激发性降低、波传播速度减少,在一定数量的缺陷均匀分布下,缺陷可以使原来稳定的螺旋波发生漫游或破碎,缺陷使原来不稳定的螺旋波稳定或漫游,首次在激发介质中观察到螺旋波因Doppler效应破碎形成小螺旋波和时空混沌共存现象.对产生这些现象的物理机理做了简要的讨论. 关键词： 激发介质 螺旋波 缺陷     

用低通滤波方法终止心脏组织中的螺旋波和时空混沌

通过让心肌细胞钠离子通道的触发门变量延迟打开, 使介质具有激发延迟能力, 介质延迟激发时间随控制电压和刺激频率增加而增加, 当控制电压超过一个阈值时, 延迟激发介质具有低通滤波作用:低频波可以连续通过, 而高频波不能连续通过. 本文用Luo-Rudy相I模型研究了介质延迟激发对螺旋波和时空混沌的影响, 数值模拟结果表明: 当控制电压超过阈值时, 介质的延迟激发可有效消除螺旋波和时空混沌; 从小逐渐增大控制电压, 在钙最大电导率较小情况下, 延迟激发会导致介质激发性降低, 使螺旋波漫游幅度增大, 直至传导障碍导致螺旋波消失; 当钙最大电导率较大时, 延迟激发会导致螺旋波失稳变弱, 这样当控制电压增加到一定值时, 时空混沌可以演化成漫游螺旋波, 当控制参数被适当选取时, 观察到漫游幅度大的螺旋波漫游出系统边界消失现象, 继续增大控制电压将导致时空混沌直接消失.     

Beyond the Kuramoto-Zel’dovich theory: Steadily rotating concave spiral waves and their relation to the echo phenomenon

In numerical experiments with the Fitzhugh-Nagumo set of reaction-diffusion equations describing two-dimensional excitable media, unusual solutions are found that correspond to a concave spiral wave steadily rotating round a circular obstacle in a finite-size medium. Such a wave arises in the region of parameters corresponding to the solitonlike regime (see text); it appears due to the interaction between the peripheral areas of a “seed” spiral wave with a convex front and the echo waves incoming from the outer boundaries of a medium. The solutions obtained are in contradiction with intuition and represent a numerical counterexample to the known theories that forbid steadily moving excitation waves with concave fronts. Nevertheless, a concave spiral wave is a stable object; being transformed to the usual spiral wave with a convex front by suppressing echo at the outer boundaries of the medium, it is again recovered upon restoring the echo conditions. In addition to the single-arm spiral concave wave, solutions are obtained that describe multiarm waves of this type; for this reason, the concave fronts of these waves are a coarse property.     

心脏中的螺旋波和时空混沌的抑制研究

以Luo-Rudy相I心脏模型为基础,研究心脏中螺旋波和时空混沌的控制,提出了两种控制方法: (Ⅰ)通过交替改变细胞外钾离子浓度来产生平面波,再利用弱外电场辅助平面波抑制螺旋波和时空混沌; (Ⅱ)先提高细胞外钾离子浓度,然后利用外电场激发波的方式产生平面波,再用平面波去抑制螺旋波和时空混沌. 研究结果表明,只要适当选择控制参数,这两种方法都能够有效抑制螺旋波和时空混沌. 当心肌出现局部缺血时,在心肌缺血处就会出现高的细胞外钾离子浓度,在这种情况下, 可以采用电场发射波的方法来抑制心脏中的螺旋波和时空混沌.对这些控制方法的优点和控制机制做了解释.