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提出了高效液相色谱法测定苯并三氮唑产品以及工业循环冷却水中苯并三氮唑含量的方法。色谱分离采用Kromasil C18(4.6 mm×250 mm,5μm)色谱柱,以乙腈-水(25+75)为流动相,流量为1.0 mL.min-1,检测波长为260 nm。苯并三氮唑的质量浓度在3.84~76.8 mg.L-1范围内与峰面积呈线性关系,平均回收率为96.4%。 相似文献
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邻苯二甲酸在苯并三氮唑银为银源的光敏热显影体系中的作用 总被引:3,自引:1,他引:2
史瑶 《影像科学与光化学》2008,26(1):39-46
本文研究了邻苯二甲酸(H2PA)的用量以及H2PA的阴离子和阳离子对以苯并三氮唑银为银源的光敏热显影体系的影响.结果表明,在苯并三氮唑银体系中,邻苯二甲酸(H2PA)的阳离子(H+)降低了体系的pH值,还原剂的显影活性和H2PA与银离子的络合能力;而其阴离子(PA2-)则与苯并三氮唑银生成中间体,起到传输银离子的作用. 相似文献
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碲氢化钠是一个用途广泛的磁试剂,自作为有用的去溴试剂以来,日益受到化学工作者的关注,不断有文献报道它的合成及应用.例如能有效地还原卤代烃、硝基化合物、叠氮化合物和亚胺等.近年来,Katritzky报道了胺烷基化苯并三氮唑衍生物的合成及应用,此衍生物中的苯并三氮唑基是很好的离去基团,易被各种亲核试剂所取代.我们在前文中对硒氢化钠与胺烷基化苯并三氮唑反应生成二苄基二硒醚的合成进行了报道.本文用碲氢化钠与胺烷基化苯并三氮唑反应,结果生成还原产物N-取代胺. 相似文献
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利用Pd(Ⅱ)配合物为催化剂,使用4,7-二溴-2-十二烷基-1,2,3-苯并三氮唑和1,4-二乙炔基-2,5-二(烷氧基)苯通过Sonogashira反应合成了3个带有不同长度烷氧基侧链,主链中含有1,2,3-苯并三氮唑单元的聚苯乙炔类聚合物。采用FT-IR、1H-NMR对其化学结构进行了表征。结果表明:这类聚合物的数均分子量在0.93×104~1.13×104,苯并三氮唑单元上长链烷基和苯环上长链烷氧基的存在使此类聚合物在CHCl3、THF等溶液中的溶解度较大,其固态薄膜也较容易制备,聚合物在固态薄膜状态下的紫外-可见最大吸收波长比在CHCl3溶液中红移了约45 nm,在固态薄膜状态下的荧光发射峰比在CHCl3溶液中也发生了较大的红移。 相似文献
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苯并三氮唑及其羧酸酯衍生物对铜缓蚀机理的分子动力学模拟研究 总被引:1,自引:0,他引:1
用分子动力学(MD)方法, 模拟计算了5种铜缓蚀剂[苯并三氮唑(BTA)、苯并三氮唑-5-羧酸甲酯(MBTC)、苯并三氮唑-5-羧酸丁酯(BBTC)、苯并三氮唑-5-羧酸己酯(HBTC)、苯并三氮唑-5-羧酸辛酯(OBTC)]与Cu2O晶体的相互作用. 结果发现, 中性条件下缓蚀剂分子与Cu2O晶体的结合能均大于酸性条件下的数值, 但两种条件下结合能的大小排序均为OBTC>HBTC>BBTC>MBTC>BTA. 对体系各种相互作用以及对关联函数g(r)的分析表明, 体系结合能主要由库仑作用提供, Cu2O晶体中的Cu原子与缓蚀剂分子中的N原子之间形成了配位键. 在与Cu2O(001)晶面结合过程中, BTA及其衍生物分子发生了扭曲变形, 但形变能远小于体系的非键相互作用能. 相似文献
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合成了新型离子液体(ILs)1-烷基-3-羧甲基苯并三氮唑双三氟甲磺酰亚胺盐,并对其进行了表征.将其与双氧水组成催化氧化体系,考察了脱除模型油品中硫化物的效果.结果表明,以离子液体1-5基-3-羧甲基苯并三氮唑双三氟甲磺酰亚胺盐[C2O2BBTA][NTf2]为萃取/催化剂,设定n(H2O2)∶n(S)=2.5∶1,m(模型油)∶m(离子液体)=5∶1,在75℃下反应1 h后,模型油中二苯并噻吩(DBT)、苯并噻吩(BT)和4,6-二甲基二苯并噻吩(4,6-DMDBT)的脱硫率分别为98.3%,98.3%和96.6%.所合成离子液体重复使用10次,脱硫率无明显变化.该方法操作简单、反应条件温和,可以实现深度脱硫. 相似文献
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设计合成了三类含1,2,3-三氮唑结构的1,5-苯并硫氮杂[艹卓]化合物3-(1H-1,2,3-三氮唑)-4-芳基-2,5-二氢-1,5-苯并硫氮杂[艹卓](5a^5f)、3-(2H-1,2,3-三氮唑)-4-芳基-2,3-二氢-1,5-苯并硫氮杂[艹卓](6a^6f)和3-(1H-1,2,3-三氮唑)-4-芳基-2,3,4,5-四氢-1,5-苯并硫氮杂[艹卓](7a^7f).研究了中间体及目标产物的合成条件,分离出其中两个副产物并进行了结构确定.目标产物的抑真菌活性测试表明,化合物5a^5f对真菌具有良好的抑制作用,对新生隐球菌的抑制效果尤为突出.初步抑真菌构效关系研究表明, 1H-1,2,3-三氮唑环和C=C双键是化合物5a^5f抑真菌活性的关键官能团. 相似文献
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《Arabian Journal of Chemistry》2019,12(7):1387-1394
Corrosion inhibition effect of 2-mercaptobenzothiazole (MBT) and 2-aminobenzothiazole (ABT) compounds on ST-37 carbon steel in 1 M hydrochloric acid solution was investigated by electrochemical impedance spectroscopy (EIS), and it was observed that both of these compounds have corrosion inhibition effect on carbon steel. Evaluation of electrochemical behavior in test solutions showed that by increasing the immersion time from 15 to 300 min, corrosion resistance of samples is increased and at the same immersion time MBT has a better corrosion inhibition in comparison to ABT. AFM technique was performed for MBT and ABT. The results of calculations showed superior inhibition efficiency of MBT in comparison to ABT. This can cause easier protonation and consequently adsorption on the metal surface occurs. 相似文献
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JIANG Long-Guang ;YU Hai-Yang ;YUAN Cai ;WANG Jun-Dong ;CHEN Li-Qing ;Edward J. Meehan ;HUANG Zi-Xiang ;HUANG Ming-Dong 《结构化学》2009,28(11):1427-1432
Urokinase-type plasminogen activator (uPA) plays a crucial role in the regulation of plasminogen activation, tumor cell adhesion and migration. The inhibition of uPA activity is a promising mechanism for anti-cancer therapy. Most current uPA inhibitors employ a highly basic group (either amidine or guanidine group) to target the S1 pocket of uPA active site, which leads to poor oral bioavailability. Here we study the possibility of using less basic 2-aminobenzothiazole (ABT) as S1 pocket binding group. We report the crystal structures of uPA complexes with ABT or 2-amino-benzothiazole-6-carboxylic acid ethyl ester (ABTCE). The inhibitory constants of these two inhibitors were measured by a chromogenic competitive assay, and it was found that ABTCE is a better inhibitor for uPA (Ki = 656 μM) than ABT (Ki = 5.03 mM). This work shows that 2-amniobenzothiazole can be used as P1 group which may have better oral bioavailability than the commonly used amidine or guanidine group. We also found the ethyl ester group occupies the characteristic oxyanion hole and contacts to uPA 37- and 60-loops. Such work provides structural information for further improvements of potency and selectivity of this new class of uPA inhibitor. 相似文献
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Miao Kan Zhifei Wang Yan Xingtao Wang Jeremy L. Hitt Langqiu Xiao Jeffrey M. McNeill Yong Wang Yixin Zhao Thomas E. Mallouk 《Angewandte Chemie (International ed. in English)》2020,59(28):11462-11469
A molecularly thin layer of 2‐aminobenzenethiol (2‐ABT) was adsorbed onto nanoporous p‐type silicon (b‐Si) photocathodes decorated with Ag nanoparticles (Ag NPs). The addition of 2‐ABT alters the balance of the CO2 reduction and hydrogen evolution reactions, resulting in more selective and efficient reduction of CO2 to CO. The 2‐ABT adsorbate layer was characterized by Fourier transform infrared (FTIR) spectroscopy and modeled by density functional theory calculations. Ex situ X‐ray photoelectron spectroscopy (XPS) of the 2‐ABT modified electrodes suggests that surface Ag atoms are in the +1 oxidation state and coordinated to 2‐ABT via Ag?S bonds. Under visible light illumination, the onset potential for CO2 reduction was ?50 mV vs. RHE, an anodic shift of about 150 mV relative to a sample without 2‐ABT. The adsorption of 2‐ABT lowers the overpotentials for both CO2 reduction and hydrogen evolution. A comparison of electrodes functionalized with different aromatic thiols and amines suggests that the primary role of the thiol group in 2‐ABT is to anchor the NH2 group near the Ag surface, where it serves to bind CO2 and also to assist in proton transfer. 相似文献
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Nuša Hojnik Matjaž Kristl Gregor Ferk Amalija Golobič Matejka Turel Zvonko Jagličić 《Journal of Coordination Chemistry》2016,69(9):1484-1498
A proton transfer compound, (ABTH)+(PydcH)? (1), obtained from 2-aminobenzothiazole (ABT) and 2,6-pyridinedicarboxylic acid (Pydc) as well as its Eu(III), Tb(III), and Cu(II) complexes (ABT)3[Eu(Pydc)3]·5H2O (2), (ABT)3[Tb(Pydc)3]·5H2O (3), and (ABT)[Cu(Pydc)(PydcH)]·3H2O (4) were obtained under ambient conditions and structurally verified by single-crystal X-ray diffraction analyses and further characterized by elemental analyses, powder X-ray diffraction (PXRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and magnetic measurements. Compounds 2–4 are the first known solids containing complex anions with Pydc ligands, 2-aminobenzothiazole cations (ABT), and solvate water molecules. During the synthesis of 3, a secondary phase with the formula ABTCl?H2O was obtained and characterized by elemental analysis and single-crystal X-ray diffraction. The asymmetric unit of 5 consists of six symmetry independent ABT cations, six chlorides, and six water molecules. The two lanthanide complexes showed characteristic emissions of Eu3+ and Tb3+ ions. The good solubilities of these complexes in water and their luminescence properties make them attractive luminescent labels of biological molecules. 相似文献
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Reemtsma T 《Rapid communications in mass spectrometry : RCM》2000,14(17):1612-1618
A method was developed for the analysis of 2-substituted benzothiazoles from wastewaters by reversed-phase liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS). While benzothiazole (BT), 2-amino- (ABT), 2-methyl-, 2-thiocyanomethylthio- and 2-methylthiobenzothiazole were separated with a methanol gradient acidified with formic acid and detected in the positive mode, 2-mercapto- and 2-hydroxybenzothiazole (OHBT) as well as benzothiazole-2-sulfonic acid (BTSA) were separated with the addition of ammonium acetate and detected in the negative ion mode. Detection limits range from 10 ng L(-1) for ABT to 200 ng L(-1) for OHBT after direct injection of 100 μL sample volumes, while BT requires 2.5 μg L(-1). The method is, thus, suitable for direct analysis in wastewaters. Its application to tannery effluent samples revealed, that, besides a 90-95% elimination of total benzothiazoles, the concentration of OHBT and BTSA increased during the biological treatment. Copyright 2000 John Wiley & Sons, Ltd. 相似文献
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S. M. T. Shaikh D. H. Manjunatha K. Harikrishna K. C. Ramesh R. Sudhir Kumar J. Seetharamappa 《Journal of Analytical Chemistry》2008,63(7):637-642
A simple and sensitive spectrophotometric method for the determination of four catecholamines viz., adrenaline bitartarate
(ABT), methyldopa (MDP), dopamine hydrochloride (DPH), and levodopa (LDP), in both pure form and in pharmaceutical formulations
is described. The method is based on the reaction of diazotized sulphanillic acid (DSA) with catecholamines in a basic medium
to yield orange-red colored products having absorption maxima at 507 nm for MDP and at 475 nm for others analytes. The colored
species obeyed Beer’s law in the range of 1–27, 0.5–17, 0.6–15, and 1.5–19.2 μg/mL for ABT, MDP, DPH, and LDP, respectively.
The molar absorptivity values as obtained from Beer’s law data were found to be 0.812 × 104, 0.947 × 104, 0.927 × 104, and 0.709 × 104 L/(mol cm), while Sandell’s sensitivity values were observed to be 412.03, 25.15, 20.44, and 27.81 ng/cm2 for ABT, MDP, DPH, and LDP, respectively. Common excipients did not interfere with the proposed method. The results of the
proposed methods compare favorably with those of official methods. The proposed method offers a simplicity, reliability, rapidity,
and accuracy compared to the existing methods.
The text was submitted by the author in English. 相似文献
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《Journal of Coordination Chemistry》2012,65(24):4255-4262
A crystal of [Na2(ABT)?·?5H2O] (ABT?=?3,3′-azobis(1,2,4-triazole)) (1) was characterized by single-crystal X-ray diffraction. Complex 1 features a 1-D chain and each ABT2? is a µ1,2,6 bridge with three triazole nitrogen atoms coordinating to three different sodium(I). Aqueous solution of 1 (6.0?×?10?5?mol?L?1) shows photochromism. Fluorescence of solid 1 displays green photoluminescence under UV-light or laser irradiation and can be employed to label onion cell. 相似文献
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Park J Park JH Ock KS Ganbold EO Song NW Cho K Lee SY Joo SW 《Journal of colloid and interface science》2011,363(1):105-113
Intracellular uptake of serum-coated gold nanoparticles (AuNPs) in a single mammalian cell was examined in order to investigate the interactions of cell culture media and aromatic thiol-functionalized gold surfaces using micro-spectroscopic tools. The AuNPs modified by the aromatic thiols of para-aminobenzenethiol (ABT), para-hydroxy benzenethiol (HBT), and para-carboxylic benzenethiol (CBT, para-mercaptobenzoic acid) bearing NH(2), OH, and COOH surface functional groups are presumed to adsorb the serum proteins as indicated from the compiled quartz crystal microbalance (QCM) data. The QCM results indicate that among the constituents, fetal bovine serum (FBS) should be the major adsorbate species on AuNPs incubated in Roswell Park Memorial Institute (RPMI) medium. The functionalized AuNPs were found to be internalized as an aggregation state in mammalian cells as evidenced by transmission electron microscopy (TEM) images. We monitored such cellular uptake behaviors of aromatic thiol-modified AuNPs using dark-field microscopy (DFM)-guided confocal surface-enhanced Raman scattering techniques in order to identify the three-dimensional localization inside the single cell. We found that the uptake amounts of ABT, HBT, and CBT were similar by counting up to 70 particles inside the cells incubated in the solution mixture of the aromatic thiol and 1,4-phenylenediisocyanide (PDIC) as a reference. This result indicates for the short aromatic thiol compounds, the AuNPs should enter the cell after the serum-coating regardless of the surface functional groups. Considering that the aromatic thiols have little effect on the serum coating, the DFM/SERS method is an effective tool for monitoring the localization of AuNPs inside a single cell. 相似文献
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Summary The synthesis and coordination behaviour of 1-allylbenzotriazole (ABT), containing both -donating heterocyclic ring nitrogen(s) and a -bonding olefinic group, has been studied by complexation with CoII, NiII, CuII, CuI and AgI salts. The solid complexes M(ABT)2X2 (M=Co, Ni or Cu and X=a counterion) and M(ABT)X (M=Cu or Ag and X=Br, I, or NO3) have been characterised by1H-n.m.r. (representative CuI species) and other physical data. Different modes coordination for the title ligand have been proposed based upon i.r. data which indicate the participation of a -donating ring nitrogen only in complexes with bivalent metal salts, and the involvement of both the ring nitrogen and the allylic olefinic component in bonding to a monovalent metal ion.1H-n.m.r. data are qualitatively commensurate with participation of the allyl group in monovalent metal complexes. 相似文献
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The inhibition effect of three azole compounds, 2-aminobenzimidazole(ABM), 2-aminothiazole(AT) and 2-aminobenzothiazole(ABT), on the corrosion of mild steel in a 1 mol/L HCl solution was investigated by means of potentiodynamic polarization measurement, electrochemical impedance spectroscopy(EIS) and scanning electron mi-croscopy(SEM). The correlation between inhibition efficiency and molecular structure of inhibitor was theoretically studied via quantum chemical calculations. The results show that the inhibition efficiency(η) of the inhibitors follows the order of ηABT >ηAT >ηABM. Moreover, ABM, AT and ABT belong to mixed-type inhibitors. The adsorption of the inhibitors on the steel surface follows the Langmuir adsorption isotherm, with both physisorption and chemisorption. 相似文献