3-乙酰氨基苯乙酮的合成

苯乙酮经硝化、还原及酰化反应得到新型镇静催眠药佐匹配（Zaleplon)的重要中间体3－乙酰氨基苯乙酮。     

Some lanthanide complexes of N-(2-pyridyl) acetamide

The complexes formed in the reaction between some lanthanide perchlorates and N-(2-pyridyl)acetamide (aapH) have been prepared and characterized. The compounds have the formulae [Ln(aapH)₄] (ClO₄)₃ (where Ln  Pr, Nd, Eu, Gd, Ho, Yb and Lu) and are solid crystalline substances. The new compounds were characterized by means of chemical analyses, molar conductivities, vibrational spectra, thermograviemetry and electronic absorption and emission spectra. The vibrational spectra and molar conductances indicate that the perchlorate groups are ionic and that aapH acts as a bidentate ligand through the carbonyl oxygen and the ring nitrogen. The PMR of La(aapH)₄ (ClO₄)₃ and [Lu(aapH)₄]ClO₄)₃ reveals that the ligands are planar and corroborates the vibrational evidence that they coordinate in a bidentate manner. The oscillator strength (P_exp) of the hypersensitive transition of the Nd(III) complex has been studied and the nephelauxetic effect has been evalauted. The emission of the Eu(III) complex at 77° is very intense and a tentative assignment of its symmetry has been made.     

Reaction of Acylpyruvic Acids and Their Esters with N-(2-Aminophenyl)acetamide

Russian Journal of Organic Chemistry - Acylpyruvic acids and their esters regioselectively reacted with N-(2-aminophenyl)acetamide to give acyclic enamines, substituted...     

Selective Noncatalytic Hydration of N-(1,1-Dimethyl-2-propynyl)-acetamide to N-(1,1-Dimethyl-2-oxopropyl)acetamide

Russian Journal of Organic Chemistry -     

Molecular structure of N-(2-hydroxyethyl)pyridinium bromide

X-ray diffraction, structural analysis was employed to establish the structure of N-(2-hydroxyethyl)pyridinium bromide, C₇H₁₀NO⁺-Br^–. The plane of the pyridinium ring is twisted by 93 relative to the C-C bond of the side-chain. The N-C-C-O torsion angle is 63.6. The OH bond is oriented toward the heteroaromatic ring. The H-O-C-C torsion angle is 84.4. The molecular packing in the crystal lattice is such that the bromide ions are found between the heteroaromatic rings and the hydrogen bonded to the hydroxyl groups.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2617–2619, November, 1990.     

Influence of the N-[methylpyridyl]acetamide ligands on the photoluminescent properties of Eu(III)-perchlorate complexes

This work reports the synthesis, characterization and spectroscopic studies of Eu(III)-perchlorate complexes with amide ligands derived from N-[x-methylpyridyl]acetamide where x=3, 4 and 6. The Eu(ClO₄)₃3(x-mpa) complexes were characterized by elemental analyses, molar conductance, TG analyses and vibrational spectroscopy. Raman and infrared data show that the perchlorate ion, (ClO₄ ⁻), is bonded to Eu(III) as a monodentate ligand and that in these three complexes water molecules are not coordinated to the rare earth ion. The profiles of the emission spectra of the complexes with 3- and 4-mpa ligands are very similar but they differ from the complex containing 6-mpa ligand. This spectroscopic behavior can be rationalized in terms of the Ω_λ (λ=2 and 4) and R₀₂ experimental intensity parameters. The values of Ω₂ (∼6.5×10⁻²⁰ cm²) in these complexes are smaller than in Eu(III)-TTA compounds (Ω₂∼35.0×10⁻²⁰ cm²), indicating that in the former case the rare earth ion is in a chemical environment less polarizable. Lifetime and emission quantum efficiency measurements for the emitting level ⁵D₀ were carried out and the results are discussed.     

Synthesis of 2- [ (4-Hydroxylcarbomylphenyl) -methylamino ] - N- ( 2- aminophenyl ) acetamide

Early studies revealed that the hybrid polar/apolar compound N, N′-hexamethylene bisacetaamide (HMBA) was a very effective inducer of differentiation in a transformed cell lines. [1] The use of this polar/apolar compound to induce murine erythroleukemia cells (MELC) to undergo erythoid differentiation with suppression of oncogenicity has proved a useful model to study inducer-mediated differentiation of transformed cell. [2] To search more effective inducers, we utilized the computer to design a new target compound. Herein, we reported the synthesis of title compound.     

Spectroscopic study of the structure of N-(2-benzimidazolyl)-O-methylcarbamate

X-ray electronic, IR, and electronic spectroscopy were used to determine that N-(2-benzimidazolyl)-O-carbamate in the crystalline state and in organic solvents exists predominantly in the benzimidazole carbamate form. The acid-base characteristics of N-(2-benzimidazolyl)-O-methylcarbamate were evaluated. The spectra of this compound were interpreted using quantum chemical calculations and experimental data.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 68–74, January, 1986.     

Spectroscopic and structural studies on dichlorobis(nicotinamide)zinc(II)

ZnCl₂(C₆H₆N₂O)₂ complex was prepared and investigated. The stoichiometry of this complex was derived from the results of elemental analysis and infrared spectroscopic studies. The crystal and molecular structure of the complex was also crystallographically characterized, to obtain a certain structure. The Zn(II) atom is coordinated by two chloride ligands and two N atoms from the nicotinamide ligands, in a distorted tetrahedral coordination environment, with Zn-N distances 2.058(3) and 2.057(4) Å, Zn-Cl distances of 2.221(1) and 2.209(1) Å and N-Zn-N and Cl-Zn-Cl angles of 101.8(1) and 121.81(5)°, respectively.     

Structure and intramolecular hydrogen bonds in Bis(trifluoromethylsulfonylamino)methane and N-[(trifluoromethylsulfonyl)aminomethyl]acetamide

Bis(trifluoromethylsulfonylamino)methane in an inert medium exists as an equilibrium mixture of monomeric forms with various types of intramolecular hydrogen bonds, whose population depends on the polarity of the medium. The energetically most favorable form is a symmetrical form containing two N-H...O=S bonds. Less stable are the isomer with two N-H...F-C bonds and the unsymmetrical isomer with two different hydrogen bonds. N-[(Trifluoromethylsulfonyl)aminomethyl]acetamide contains one intramolecular intramolecular N-H...O=C hydrogen bond and preserves ability for self-association.