Factors influencing contrast in fast spin-echo MR imaging.

Multi-echo pulse sequences for producing T2-weighted images in much reduced imaging times have recently been developed for routine clinical use. A number of recent articles have described the contrast obtained with fast spin-echo (FSE) sequences and have generally indicated that they depict tissues very similarly to conventional spin-echo (SE) imaging. There are, however, some important differences in contrast between some tissues in FSE images. This work presents a detailed study of the contrast obtained with FSE imaging sequences and examines the image sequence and tissue parameters which influence contrast. The use of multiple refocusing pulses produces several subtle effects not seen in conventional SE imaging sequences, and in this study the precise nature and extent of such effects are described. The relative contributions to image contrast of magnetization transfer, the decoupling of J-modulation effects, the production of stimulated echoes and direct saturation effects, of diffusion and of the effects of the differential attenuation of different spatial frequencies, are each quantified. The mechanisms responsible for the brighter fat signal seen in FSE images, as well as the loss of signal from some other tissues, are explained. Computer simulations, phantom experiments, and clinical images are all used to support the conclusions.     

Frequency-domain photoacoustic phased array probe for biomedical imaging applications

We report the development of a frequency-domain biomedical photoacoustic imaging system that utilizes a continuous-wave laser source with a custom intensity modulation pattern, ultrasonic phased array for signal detection, and processing coupled with a beam-forming algorithm for reconstruction of photoacoustic correlation images. Sensitivity to optical contrast was demonstrated using tissue-mimicking phantoms and in-vivo tissue samples.     

MR knee imaging: axial 3DFT GRASS pulse sequence versus spin-echo imaging for detecting meniscal tears.

The knees of 17 patients (34 menisci) referred for magnetic resonance (MR) imaging to evaluate knee pain were examined using thin axial three-dimensional Fourier transform (3DFT) gradient-refocused acquisition in a steady state (GRASS) images through the menisci, to determine if this method is sensitive and specific for detecting meniscal tears. Results were compared with spin-echo images with long TR and double-echo TE in both coronal and sagittal planes. Arthroscopy results, available in each case, were used as the "gold standard." Twelve meniscal tears were identified at arthroscopy. Axial 3DFT GRASS technique detected 10 of the 12 meniscal tears compared to 9 or 12 using spin-echo technique. With axial 3DFT GRASS technique one false-positive meniscal tear was reported, compared with two false-positive tears on spin-echo images. Axial 3DFT GRASS images were very useful in detecting peripheral tears, showing displaced meniscal fragments, and evaluating complex tears. In this small study, thin axial 3DFT GRASS images were comparable to spin-echo images for detecting meniscal tears, and were helpful in complicated cases in which they provided complementary information to that obtained from spin-echo images.     

In vivo MRI using liquid nitrogen cooled phased array coil at 3.0 T

A liquid nitrogen (LN2) cooled dual-channel array coil was designed and built for use on a 3.0-T whole-body scanner. In vivo imaging of a volunteer's fingers and imaging of a deceased mouse and oil phantom were performed using the LN2 cooled array and a similar room-temperature coil. Imaging results showed that the LN2 cooled array provides a signal-to-noise ratio gain of up to 240% as compared with its room-temperature counterpart. LN2 cooled arrays may be useful for high-resolution clinical imaging of joints, skin, eyes and peripheral vessels as well as for biomedical imaging of small animals in human disease modeling.     

Magnetization prepared rapid gradient-echo (MP-RAGE) MR imaging of the liver: comparison with spin-echo imaging.

We have implemented an MR technique that employs a rapid gradient echo sequence, preceded by magnetization preparation pulses to provide T1- and T2-weighted tissue contrast. With this technique, which can be identified as a member of a new family of pulse sequences, generically named Magnetization Prepared RApid Gradient Echo (MP-RAGE), very short repetition times are used, allowing acquisition times of less than one second and images virtually free of motion-induced artifacts during quiet respiration. Fifteen patients with known liver lesions (metastases, hemangiomas, and cysts) were examined using T1- and T2-weighted 2-dimensional MP-RAGE sequences, and the images were compared with conventional T1- and multi-echo T2-weighted spin-echo (SE) sequences. Signal difference-to-noise ratios (SD/Ns) of the lesions were calculated for all pulse sequences using corresponding axial images and were normalized for voxel volume. The mean normalized SD/Ns of the MP-RAGE sequences were generally comparable to those for the SE sequences. In addition, there were no noticeable respiratory artifacts on the MP-RAGE images whereas these were clearly present on the T2-weighted SE images and to a lesser degree on the T1-weighted SE images. It is concluded that the MP-RAGE technique could become an important method for evaluating the liver for focal disease.     

Improvement of image quality using BLADE sequences in brain MR imaging

The purpose of this study is to compare two types of sequences in brain magnetic resonance (MR) examinations of uncooperative and cooperative patients. For each group of patients, the pairs of sequences that were compared were two T2-weighted (T2-W) fluid attenuated inversion recovery sequences with different k-space trajectories (conventional Cartesian and BLADE) and two T2-TSE weighted with different k-space trajectories (conventional Cartesian and BLADE). Twenty-three consecutive uncooperative patients and 44 cooperative patients, who routinely underwent brain MR imaging examination, participated in the study. Both qualitative and quantitative analyses were performed based on the signal-to-noise ratio, contrast-to-noise ratio (CNR), and relative contrast (ReCon) measures of normal anatomic structures. The qualitative analysis was performed by experienced radiologists. Also, the presence of motion, other (e.g., Gibbs, susceptibility artifacts, phase encoding from vessels) artifacts and pulsatile flow artifacts was evaluated.     

Partial angle inversion recovery (PAIR) MR imaging: spin-echo and snapshot implementation.

The effects of varying the inversion or excitation RF pulse flip angles on image contrast and imaging time have been investigated in IR imaging theoretically, with phantoms and with normal volunteers. Signal intensity in an IR pulse sequence as a function of excitation, inversion and refocusing pulse flip angles was calculated from the solution to the Bloch equations and was utilized to determine the contrast behavior of a lesion/liver model. Theoretical and experimental results were consistent with each other. With the TI chosen to suppress the fat signal, optimization of the excitation pulse flip angle results in an increase in lesion/liver contrast or allows reduction in imaging time which, in turn, can be traded for an increased number of averages. This, in normal volunteers, improved spleen/liver contrast-to-noise ratio (9.0 vs. 5.7, n = 8, p less than 0.01) and suppressed respiratory ghosts by 33% (p less than 0.01). Reducing or increasing the inversion pulse from 180 degrees results in shorter TI needed to null the signal from the tissue of interest. Although this decreases the contrast-to-noise ratio, it can substantially increase the number of sections which can be imaged per given TR in conventional IR imaging or during breathold in the snapshot IR (turboFLASH) technique. Thus, the optimization of RF pulses is useful in obtaining faster IR images, increasing the contrast and/or increasing the number of imaging planes.     

Sequential CW-EPR image acquisition with 760-MHz surface coil array

This paper describes the development of a surface coil array that consists of two inductively coupled surface-coil resonators, for use in continuous-wave electron paramagnetic resonance (CW-EPR) imaging at 760 MHz. To make sequential EPR image acquisition possible, we decoupled the surface coils using PIN-diode switches, to enable the shifting of the resonators resonance frequency by more than 200 MHz. To assess the effectiveness of the surface coil array in CW-EPR imaging, two-dimensional images of a solution of nitroxyl radicals were measured with the developed coil array. Compared to equivalent single coil acquired images, we found the visualized area to be extended approximately 2-fold when using the surface coil array. The ability to visualize larger regions of interest through the use of a surface coil array, may offer great potential in future EPR imaging studies.     

MR imaging of benign prostatic hypertrophy using a Helmholtz-type surface coil.

MR examinations of the prostate were performed on six healthy volunteers and 18 patients with well-documented symptomatic benign prostatic hypertrophy, using an organ-encompassing Helmholtz-type surface coil at 1.5 T. The healthy volunteers were also imaged with a standard circumferential body coil. The morphologic features and signal intensity characteristics of the prostate and adjacent structures were analyzed in the patient group. Several recognizable patterns of benign prostate hypertrophy were identified including bilaterally symmetrical nodules in the central gland, multiple central gland nodules, and a diffusely heterogeneous central gland without appreciable nodules. The peripheral zone was of moderate to high signal intensity on T2-weighted images, and was diffusely heterogeneous in 78% of patients. The false prostatic capsule, peripheral venous plexus, and seminal vesicles were also characterized. A good correlation was shown between prostatic glandular volume and prostate-specific antigen. Calculated signal-to-noise ratios (S/N) were significantly greater on images acquired with the Helmholtz-type receiver coil than on those acquired with the body coil. We conclude that the hyperplastic prostate gland has a variety of MR appearances, but that recognizable patterns are frequently seen. High resolution imaging with a Helmholtz-type surface coil provides excellent anatomical depiction of the prostate and adjacent structures.     

Ultrasonic phased array controller for hyperthermia applications

Multiple and mechanically scanned ultrasound transducer systems have demonstrated the efficacy of using ultrasound to produce deep localized hyperthermia. The use of ultrasonic phased arrays has been proposed as an alternative to these systems. A phased array offers a more flexible approach to heating tumours in that the size, shape, and position of its focal region can be altered during the course of treatment in order to achieve the desired temperature distribution. This added flexibility comes at the cost of increased complexity of the hardware necessary to drive the transducer because each element requires its own amplifer with both phase and amplitude control. In order for phased arrays with large numbers of elements to be feasible for hyperthermia applications, the complexity of this circuitry must be minimized. This paper describes a circuit design which simplifies the electronics required to control a phased array transducer system for hyperthermia applications. The design is capable of controlling virtually any type of phased array transducer operating at frequencies less than 2 MHz. The system performance was verified through beam profile measurements using a 48-element tapered phased array transducer.     

A new-style phased array transducer for HIFU

Considering the complexity of common phased array, and relatively slow mechanical scanning of the single transducer, a new-style transducer that has a changeable focus and a simple control system is needed. The sector phased array transducer, which has many advantages including easy fabrication, movable focus, and a simple control system, can reach the desired requirements. This paper has demonstrated its feasibility by the computation of acoustic field in (y, z) plane. The 24-element phased array, of which the length of the focal region is about 10 mm, and the maximum lateral diameter is about 1.5 mm, can accomplish the adjustment of the focus position. The maximum lateral displacement is 1.5 mm, and the treatment area is about 9 multiples of the single transducer, and only six power amplifiers are needed.     

应用在相控阵雷达上的光学实时延迟线

相控阵天线是雷达技术的重要发展方向之一。电子相控阵雷达所遇到的问题是天线阵列孔径效应限制了雷达信号的瞬时带宽,使其不能满足通信和雷达技术的发展需要。光学实时延迟技术,可以解决这一问题。介绍了相控阵天线光实时延迟控制原理。并对几种典型的光实时延迟线的工作原理和技术特点作了简要的分析。     

Optical beam forming techniques for phased array antennas

Three optical beam forming techniques are identified as applicable to large spaceborne phased array antennas. They are 1) the fiber replacement of conventional RF phased array distribution and control components, 2) spatial beam forming, and 3) optical beam splitting techniques. Two novel optical beam forming approaches, i.e., the spatial beam forming with a smart pixel spatial light modulator (SLM) and the optical beam splitting approaches are conceived with integrated quasi-optical components. Also presented are the transmit and receive array architectures with the new SLM.     

An extended-length coil design for peripheral MR angiography.

Magnetic resonance angiography of the peripheral vascular system has been hampered by the limited view provided by available imaging coils. We have constructed an extended-length, split-saddle design radiofrequency (rf) coil for peripheral angiography. The two coil halves are inductively coupled, to each other and to the rf source. Details regarding the construction of the coil and comparison of the performance with the knee coil are described here. This coil provides the benefit of a larger field of view but with image quality comparable to that of a commercial knee coil.     

Speckle pattern quality assessment for digital image correlation

To perform digital image correlation (DIC), each image is divided into groups of pixels known as subsets or interrogation cells. Larger interrogation cells allow greater strain precision but reduce the spatial resolution of the data field. As such the spatial resolution and measurement precision of DIC are limited by the resolution of the image. In the paper the relationship between the size and density of speckles within a pattern is presented, identifying that the physical properties of a pattern have a large influence on the measurement precision which can be obtained. These physical properties are often overlooked by pattern assessment criteria which focus on the global image information content. To address this, a robust morphological methodology using edge detection is devised to evaluate the physical properties of different speckle patterns with image resolutions from 23 to 705 pixels/mm. Trends predicted from the pattern property analysis are assessed against simulated deformations identifying how small changes to the application method can result in large changes in measurement precision. An example of the methodology is included to demonstrate that the pattern properties derived from the analysis can be used to indicate pattern quality and hence minimise DIC measurement errors. Experiments are described that were conducted to validate the findings of morphological assessment and the error analysis.     

Polarized neutron imaging: A spin-echo approach

Polarized neutron imaging has recently been introduced as an efficient method to three-dimensionally visualize and measure magnetic fields even in the bulk of massive objects. Here we introduce a spin-echo approach for polarized neutron imaging, which has the potential to overcome some drawbacks of the first attempts, namely to deal with strong fields, arbitrary field directions and quantification. Furthermore our novel approach increases the efficiency of quantitative studies due to relaxed monochromatisation requirements for spin-echo neutron imaging and with respect to additional information available in the recorded images, which allows for straightforward quantification in many cases.     

A microstrip transmission line volume coil for human head MR imaging at 4T

A high-frequency RF volume coil based on the use of microstrip transmission line (MTL) has been developed for in vivo 1H MR applications on the human head at 4T. This coil is characterized by major advantages: (i) completely distributed coil circuit, (ii) high-quality factor (Q), (iii) simple coil structure, and (iv) better sensitivity and less signal-intensity variation in the MR image of the human head compared with an RF shielded birdcage coil of similar coil size. The proposed MTL volume coil does not require additional RF shielding for preventing Q degradation from radiation losses due to the unique MTL structure; thus, it provides a maximal useable space inside the volume coil when compared with most volume coils available at high fields with the same overall coil size. The intrinsic B(1) distribution of the MTL volume coil effectively compensates for the dielectric resonance effect at 4T and improves the signal homogeneity in human head MR images in the transaxial planes. The results of this study demonstrate that the MTL volume coil design provides an efficient and simple solution to RF volume coil design for human MR studies at high fields.     

Simulation and data reconstruction for NDT phased array techniques

Phased array techniques are now widely employed for industrial NDT applications in various contexts. Indeed, phased array present a great adaptability to the inspection configuration and the application of suitable delay laws allows to optimize the detection and characterization performances by taking into account the component geometry, the material characteristics, and the aim of the inspection. In addition, the amount of potential information issued from the inspection is in general greatly enhanced. It is the case when the employed method involve sequences of shots (sectorial scanning, multiple depth focusing etc) or when signals received on the different channels are stored. At last, application of electronic commutation make possible higher acquisition rates. Accompanying these advantages, it is clear that an optimal use of such techniques require the application of simulation-based algorithms at the different stages of the inspection process: When designing the probe by optimizing number and characteristics of element; When conceiving the inspection method by selecting suitable sequences of shots, computing optimized delay laws and evaluating the performances of the control in terms of zone coverage or flaw detection capabilities; When analysing the results by applying simulation-helped visualization and data reconstruction algorithms. For many years the CEA (French Atomic Energy Commission) has been being greatly involved in the development of such phased arrays simulation-based tools. In this paper, we will present recent advances of this activity and show different examples of application carried out on complex situations.