共查询到20条相似文献,搜索用时 739 毫秒
1.
K. V. Shvidenko K. G. Nazarenko T. I. Shvidenko A. A. Tolmachev 《Chemistry of Heterocyclic Compounds》2010,46(1):56-60
Acylation of pyrrolidin-2-ylidenemalononitrile with benzoyl chloride leads to the formation of 2-(1-benzoylpyrrolidin-2-ylidene)malononitrile.
The obtained product was used as starting material in the synthesis of γ-aminopropylpyrazoles and pyrimidines. 相似文献
2.
3.
The base-free TiCl4-mediated condensation of 3,5-disubstituted-4H-1,2,6-thiadiazin-4-ones 8 with malononitrile affords 20 difficult to access (3,5-disubstituted-4H-1,2,6-thiadiazin-4-ylidene)malononitriles 7. The reaction tolerates 3,5-diaryl, diphenoxy, dimethoxy and diphenylthio substituted thiadiazinones, but not diamino, monohydroxy or dihalo substituents. Nevertheless, asymmetrically substituted 3-halo-5-phenyl- and 3-chloro-5-methoxy-4H-1,2,6-thiadiazin-4-ones convert into the corresponding ylidenemalononitriles in good yield. Furthermore, the condensation works well with ethyl cyanoacetate and diethyl malonate, but not with Meldrum's acid, dimedone or nitromethane. Finally, 2-(3-chloro-5-phenyl-4H-1,2,6-thiadiazin-4-ylidene)malononitrile (7q) reacts with aniline to give 4,7-diphenyl-6-(phenylimino)-6,7-dihydropyrrolo[2,3-c][1,2,6]thiadiazine-5-carbonitrile (12) in moderate yield demonstrating the potential use of these ylidenes to prepare novel 6–5 fused 4H-1,2,6-thiadiazines. 相似文献
4.
M. Komal Reddy T. Ravinder Reddy K. Raghava Raju 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):313-318
This article describes the reaction of 3,6-diphenyl-thieno[3,2-b]furan-2,5-dione 1 with different amino acids 2a–j in glacial acetic acid which afforded the 2-(2-(3-hydroxy-5-oxo-4-phenylthiophen-2(5H)-ylidene)-2-phenylacetamido)propanoic acid analogues 3a–j and also describes the reaction of 3,6-diphenyl-thieno[3,2-b]thiophene-2,5-dione 4 with different amino acids 5a–e in acidic medium to give 2-(2-(3-mercapto-5-oxo-4-phenylthiophen-2(5H)-ylidene)-2-phenylacetamido)propanoic acid analogues 6a–e. All the compounds have been screened for their anti-inflammatory activity against the carrageenan induced rat paw edema in albino rats. In the primary screening, some of the compounds exhibited appreciable activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
5.
The reaction of 2-(dialkylamino)-7-methoxychromones with malononitrile in the presence of acetic anhydride afforded [2-(dialkylamino)-7-methoxy-4H-chromen-4-ylidene]malononitriles. When these compounds were refluxed with concentrated hydrochloric (or hydroiodic) acid, 2-(dialkylamino)-7-methoxy(or hydroxy)-4-methylchromenylium salts were obtained. The use of concentrated sulfuric acid or polyphosphoric acid in the hydrolysis was also investigated. The preparation of ethyl [2-(dialkylamino)-7-methoxy-4H-chromen-4-ylidene]cyanoacetates and their behavior when treated with acids are also described, as well as the synthesis of some 3-(dialkylamino)-1-methylnaphtho[2,1-b]pyrylium salts. 相似文献
6.
G. A. M. Elhagali G. A. Elsayed R. A. Eliswey A. A. El-Sherif 《Journal of the Iranian Chemical Society》2018,15(6):1243-1254
Diazotization of 2-(4-oxothiazolidine-2-ylidene) acetonitrile 1 with aryl diazonium chloride derivatives afforded 4-thiazolidinones 2a, b, whereas 3a, b derivatives produced through reaction of arylcarbonohydrazonoyl dicyanide with thioglycolic acid. Cyclization of 2a with aromatic aldehydes and malononitrile gave the expected substituted thiazolo [3,2-a] pyridines 4a, b. The reaction of 1 with anthraldehyde (1:1 molar ratio) gave the expected 4,5-dihydro-4-oxothiazole derivatives 5 which condensed with other mole p-chlorobenzaldehyde and gave the corresponding bisarylidine derivative 6. Thiazolo [3,2-a] pyridine enaminonitrile derivative 7 produced through addition of malononitrile to bisarylidine 6. Also, compound 7 reacted with other mole of malononitrile and furnished thiazolo [3,2-a] pyridine 12, furthermore, compound 7 refluxed with phenyl hydrazine, thiourea, and formic acid, to form the corresponding thiazolo [3,2-a] pyridines 13, 15 and 17, respectively. Also, compound 1 reacted with phNCS in presence of KOH and afforded 19. The molecular modeling of the synthesized compounds has been drawn and their molecular parameters were calculated. Also, valuable information is obtained from calculation of the molecular parameters including electronegativity, net dipole moment of the compounds, total energy, electronic energy, binding energy, electrophilicity index, HOMO and LUMO energy. 相似文献
7.
G. V. Baryshnikov B. F. Minaev V. A. Minaeva H. Ågren 《Journal of Structural Chemistry》2010,51(5):817-823
The quantum chemical DFT method with the B3LYP hybrid functional in 6–31++G(d,p) and 6–311+G(d,p) basis sets is used to calculate the equilibrium geometric parameters of different conformations of 5-(4-oxo-1,3-thiazolidine-2-ylidene)-rhodanine
and its substituted form ethyl–5-(4-oxo-1,3-thiazolidine-2-ylidene)-rhodanine-3′-acetic acid applied in the synthesis of indoline
and some other sensitizing dyes for solar cells. The thermodynamic parameters of four conformers and their synthesis reactions
are calculated. The effect of substituents on the thermodynamic stability of the studied isomers is shown. 相似文献
8.
O. V. Khilya T. A. Volovnenko A. V. Turov R. I. Zubatyuk O. V. Shishkin Yu. M. Volovenko 《Chemistry of Heterocyclic Compounds》2011,47(9):1141-1154
The reaction of azolylacetonitriles with γ-chlorobutyryl chlorides gave the corresponding 2-(1-R-1,3-di- hydro-2H-benzimidazol-2-ylidene)-,
2-(1,3-benzothiazol-2-ylidene)-, and 6-chloro-2-(4-methylthiazol-2-ylidene)-3-oxohexanenitriles. A study of the intramolecular
cyclization of 2-(quinazolin-2-ylidene)-3-oxo-6-hexanenitriles and -heptanenitriles has led to the development of an efficient
method for the preparation of 2-(quinazolin-2-yl)-2-(tetrahydrofuran-2-ylidene)acetonitriles. The (Z,E)-isomerism of the synthesized
2-hetaryl-2-(tetrahydrofuran-2-ylidene)acetonitriles was studied. 相似文献
9.
A. M. Magerramov R. A. Alieva V. I. Mardanova F. M. Chyragov A. V. Kurbanov K. A. Potekhin 《Journal of Structural Chemistry》2012,53(1):202-205
Single crystal X-ray diffraction is used to determine the crystal and molecular structure of 4-trifluoro-2-[2-(4-fluorophenyl)hydrazine-1-ylidene]-1-(thiophen-2-yl)butane-1,3-dione.
Crystallographic data for C14H8F4N2O2S are as follows: a = 8.2723(6) ?, b = 9.3009(7) ?, c = 9.9895(7) ?; α = 79.224(2)°, β = 75.851(2)°, γ = 72.337(2)°. Triclinic crystal system, P-1 space group, d
x = 1.622 g/cm3, V = 704.83(9) ?3, μ = 0.286 mm−1, crystal size 0.30×0.20×0.20 mm, R1 = 0.0891, wR2 = 0.1989. 相似文献
10.
Two new 1-substituted 4-(2-phenylquinazolin-4-yl)-and 4-(2-phenylquinazolin-4-ylidene) thio-semicarbazides were formed by
a multistep domino reaction of imidoyl isothiocyanate derivative with 1,1-di-R-hydrazine in acetone solution. Application
of hydrazine hydrate under the same reaction conditions afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(propen-2-yl)-1-(propan-2-ylidene)
thio-semicarbazide via a six-step triple-component domino reaction.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1688–1693, November, 2008. 相似文献
11.
A. V. Lipeeva E. E. Shul’ts M. M. Shakirov G. A. Tolstikov 《Russian Journal of Organic Chemistry》2010,46(12):1858-1868
Palladium-catalyzed amination of 2-(1,3-dibromopropan-2-ylidene)-7H-furo[3,2-g]chromene-3,7(2H)-dione with various amines and amino acid derivatives led to the formation of the corresponding 2-(1,3-diaminopropan-2-ylidene)-substituted
oreoselones. The yields depended on the catalytic system, base, and amine structure. Di- and polyazamacrocyclic furocoumarin
derivatives were obtained by reactions of 2-(1,3-dibromopropan-2-ylidene)-7H-furo[3,2-g]chromene-3,7(2H)-dione with linear di- and polyamines (hexamethylenediamine, spermine, spermidine, and 3,6-dithiaoctane-1,8-diamine), catalyzed
by palladium complexes. 相似文献
12.
Rolf W. Saalfrank Claus-Jürgen Lurz Uwe Wirth Hans Georg Von Schnering Karl Peters 《Journal of heterocyclic chemistry》1991,28(8):1863-1868
Reaction of 3,3-diazido-2-cyanoacrylate 5 with four moles of ammonia gives tetrazolyl-bisammonium salt 7 . The key-intermediate is the amino-vinyl azide 6 which spontaneously undergoes a 1,5′ ring-closure reaction followed by double deprotonation. Treatment of 7 with hydrochloric acid yields the parent of 2-(4,5-dihydro-1H-tetrazol-5-ylidene)-2-cyanoacetate 9 (R = Me, Et) as the only tautomer. Regiospecific monoalkylation of bisammonium salt 7a with dimethyl sulfate and reaction of ammonium salt 12 with hydrochloric acid gives (E)2-(1-methyl-4,5-dihydro-1H-tetrazol-5-ylidene)-2-cyanoacetate ( 13 ) (X-ray structure of derivative 14 ). Compound 13 can also be obtained from vinyl azide 10 and methylamine. This experiment as well as AM1 calculations of 9a, 23 and 24 strongly favour tautomer 9a . 相似文献
13.
Substituted 2-amino-4-aryl-3-cyano-5-oxo-5,6-dihydro-4H-pyrano[2,3-d]pyrido[3",2":4,5]thieno[3,2-b]pyridines were synthesized by the reactions of 4-hydroxy-1H-thieno[2,3-b;4,5-b]dipyridin-2-ones with arylidenemalononitriles or by the three-component reactions of hydroxythienodipyridinones with aldehydes and malononitrile in DMF in the presence of triethylamine. Methods for syntheses of substituted 3-alkoxycarbonyl-6-amino-4-aryl-2-(3-cyanopyridin-2-ylthiomethyl)-4H-pyrans were developed on the basis of the reactions of 4-(3-cyanopyridin-2-ylthio)acetoacetates and arylidenemalononitriles or aldehydes and malononitrile. Ethyl 4-(3-cyanopyridin-2-ylthio)acetoacetate and 4-methoxybenzylidenecyanothioacetamide were used for the synthesis of 6-(pyridin-2-ylthiomethyl)-3-cyanopyridine-2(1H)-thione. 相似文献
14.
AbstractA series of new N′-(11H-indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazonamides 3a–3j was synthesized in excellent yields from the reaction of N3-substituted benzohydrazonamides 1 and 2-(11H-indeno[1,2-b]quinoxalin-11-ylidene)malononitrile 2 in dichloromethane or with 11H-indeno[1,2-b]quinoxalin-11-one 4 in ethyl acetate at ambient temperature. The new compounds have been characterized and screened for biological activity. Some of them showed significant antibacterial and antifungal activities. In particular, compounds 3c and 3e showed interesting activities as antibacterial agents while compounds 3a 3c, 3e, 3g, and 3i showed high antifungal activities. 相似文献
15.
Mariadoss Arockia doss Sambandam Savithiri Venugopal Thanikachalam 《Phosphorus, sulfur, and silicon and the related elements》2017,192(12):1264-1270
A series of new (E)-2-(3-pentyl-2,6-diarylpiperidin-4-ylidene)-N-phenylhydrazinecarbothioamides (1-6) were synthesized from the corresponding 3-pentyl-2,6-diarylpiperidine-4-ones condensation with phenyl thiosemicarbazide. Their chemical structures were confirmed by means of elemental analysis, FT-IR, 1H, and 13C NMR spectral techniques and for compound 3, HOMOCOSY, HSQC, HMBC, NOESY, and DEPT NMR spectral techniques. From the NMR spectral data the compounds (1-6) are shown to exist in normal chair conformation with equatorial orientation of all the phenyl groups at C-2 and C-6 and pentyl group at C-3. The synthesized compounds were screened for their bacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, and Escherichia coli and fungal activity against Candida albicans, Rhizopus sp, Aspergillus niger, and Aspergillus flasvus. 相似文献
16.
V. V. Konovalova Yu. V. Shklyaev P. A. Slepukhin A. N. Maslivets 《Russian Journal of Organic Chemistry》2014,50(9):1357-1360
Aroylketenes generated by thermolysis of 6-aryl-2,2-dimethyl-4H-1,3-dioxin-4-ones reacted with (Z)-2-[4a,7,10-trimethyl-1,3,4,4a,5,10b-hexahydrophenanthridin-6(2H)-ylidene]acetamide to give (Z)-3-aryl-3-hydroxy-N-{(Z)-2-[4a,7,10-trimethyl-1,3,4,4a,5,10b-hexahydrophenanthridin-6(2H)-ylidene]acetyl}acrylamides whose structure was confirmed by X-ray analysis. 相似文献
17.
A. V. Kazakova N. D. Kushch L. I. Buravov E. B. Yagubskii S. V. Simonov L. V. Zorina S. S. Khasanov R. P. Shibaeva E. Canadell J. Yamada M. Umemiya 《Russian Chemical Bulletin》2007,56(1):49-55
New radical cation salts based on 2,5-bis(1,3-dithian-2-ylidene)-1,3,4,6-tetrathiapentalene (BDA-TTP) with copper(II) metal complex anions, β-(BDA-TTP)4Cu2Cl6 and (BDA-TTP)2CuCl4, were synthesized and structurally characterized. Single crystals were prepared by electrochemical oxidation of BDA-TTP under
galvanostatic conditions. X-ray diffraction study demonstrated that the salts have a layered structure, in which the conducting
BDA-TTP layers alternate with the [Cu2Cl6]2− or [CuCl4]2− anions. Both salts show the semiconductor-type temperature dependence of the conductivity.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 48–54, January, 2007. 相似文献
18.
《Journal of Saudi Chemical Society》2022,26(4):101502
The chromophore 2-(3-cyano-4-((2-(4,6-dimethyl-5-nitro-1H-pyrazolo[3,4-b]pyridin-3-yl) hydrazono)methyl)-5,5-dimethylfuran-2(5H)-ylidene)malononitrile (PPHTCF) was synthesized through coupling of diazotized 3-amino-4,6-dimethyl-5-nitropyrazolo[3,4-b]pyridine with 3-cyano-2-(dicyanomethylene)-4,5,5-trimethylfuran (TCF). The absorption solvatochromism behaviour of PPHTCF, in various solvents, presented ΔEmax = +5.40 where the positive sign suggested red shift occurrence, implying that the PPHTCF has more polar lowest excited state than its ground one. While, the PPHTCF fluorescence spectra afforded λem, in 575–633 nm range, and was more dependent on the solvent polarity than the absorption λmax, despite both exhibited red shift by 58 and 42 nm, respectively. To discover the PPHTCF solvatochromism behaviour in term of “Stokes’ shift”, both of Lippert-Mataga and linear solvation-energy relationship (LSER) formulations have been utilized and the outcomes endorsed that the later was better than the former (R2 = 0.9728). Finally, TD-DFT simulated absorption and emission spectra in EtOH revealed that λmax has been resulted mainly from HOMO → LUMO; HOMO-5 → LUMO and HOMO-2 → LUMO transitions, respectively. 相似文献
19.
N-Arylisoindolines 1a-c reacted with (2,4, 7-trinitro-9H-fluoren-9-ylidene)propanedinitrile ( A ) in pyridine with admission of air via a net α-H-atom abstraction and formation of [3-(2-aryl-3-arylimino-2,3-dihydro- 1H-isoindol-1-ylidene)-2-aryl-2,3-dihydro-1H-isoindol-1-ylidene]propanedinitriles 2a-c , N-[2-aryl-3-(2-aryl-3-arylimino-2,3-dihydro-1H-isoindolyl-1-idene)-2,3-dihydro-1H-isoindol-1-ylidene]arenamines 3a, b , N, N'-[2-aryl-1H-isoindole-1,3(2H)-diylidene]bisarenamines 4a, b and N-arylphthalimides 5a-c in moderate yields. 2,4,7-Trinitro-9-fluorenone as well as one reduction product each of the latter and of A, namely compounds 6 and 7 , respectively, are also found. The structure of 2b has been unambiguously confirmed by an X-ray crystal structure analysis. A rationale for the conversions observed is presented. These involve dehydrogenation and oxidative couplings of 1a-c as well as transfer of N-aryl fragment from 1a-c to intermediate products. 相似文献