共查询到20条相似文献,搜索用时 93 毫秒
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Ion mobility spectrometers are extremely fast and sensitive sensors for trace gases, which identify these according to their motion through a neutral gas under the influence of an electric field. In this work, the basics of ion mobility are summarized, different areas of application for ion mobility spectrometers are explained and three basic types of ion mobility spectrometers are presented. 相似文献
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Kuan Hu Hao Geng Qingzhou Zhang Qisong Liu Mingsheng Xie Chengjie Sun Wenjun Li Huacan Lin Fan Jiang Tao Wang Yun‐Dong Wu Zigang Li 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2016,128(28):8145-8149
The addition of a precisely positioned chiral center in the tether of a constrained peptide is reported, yielding two separable peptide diastereomers with significantly different helicity, as supported by circular dichroism (CD) and NMR spectroscopy. Single crystal X‐ray diffraction analysis suggests that the absolute configuration of the in‐tether chiral center in helical form is R, which is in agreement with theoretical simulations. The relationship between the secondary structure of the short peptides and their biochemical/biophysical properties remains elusive, largely because of the lack of proper controls. The present strategy provides the only method for investigating the influence of solely conformational differences upon the biochemical/biophysical properties of peptides. The significant differences in permeability and target binding affinity between the peptide diastereomers demonstrate the importance of helical conformation. 相似文献
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