共查询到18条相似文献,搜索用时 46 毫秒
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概述了低价钛诱导的羰基还原偶合反应作为环化关键步骤在西松烷型二萜天然产物全合成中的应用。参考文献26篇。 相似文献
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综述了不对称Heck反应的在天然产物合成的中的应用,按照分子内和分子间的不对称Heck反应分两个方面加以介绍和总结,参考文献26篇。 相似文献
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西松烷型二萜类化合物是一大类广泛分布于松脂、烟草、陆地动物及海洋生物体中的具有十四元碳环骨架的化合物.其结构新颖复杂,且大多具有显著和广谱的生物活性.近几十年来,有关这类化合物的研究已引起了人们的极大兴趣.因此,开展这类天然产物及其类似物的全合成及构效关系的研究不仅具有重要的学术价值,而且具有潜在的应用前景. 相似文献
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以香叶醇为起始原料,经多步反应完成了西松烷型大环二萜类天然产物(±)-Sinulariol-A的全合成.合成的关键步骤是醛5与丙烯酸甲酯经改进的Morita-Baylis-Hillman加成以及二价铬诱导的烯丙基氯化物与醛的分子内加成环化 相似文献
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西松烷型二萜内酯的研究进展 总被引:5,自引:0,他引:5
从海洋生物中分离到的西松烷型二萜内酯,大多具有明显的生理活性,引起了广泛的注意。本文综述西松烷型二萜内酯的研究进展,包括分离、结构鉴定和全合成研究。 相似文献
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Youn-Jung Yoon 《Tetrahedron letters》2005,46(5):739-741
A concise, stereocontrolled synthesis of (+)-L-733,060 was achieved. Key features involve diastereoselective oxazoline formation catalyzed by palladium(0) and intramolecular cyclization by catalytic hydrogenation of an oxazoline. 相似文献
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This paper describes our efforts toward the asymmetric synthesis of sarain A which led to efficient preparation of a functionalized azabicyclo[3.3.1]nonane moiety. The key to the synthesis relied on a base-catalyzed asymmetric Diels-Alder cycloaddition to establish multiple stereocenters of a highly substituted cyclohexenone unit and a facile intramolecular aza-Michael addition to form the desired bicyclic system. 相似文献
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Manat Pohmakotr Chutima Kuhakarn Vichai Reutrakul Darunee Soorukram 《Tetrahedron letters》2017,58(51):4740-4746
Furofurans are one of the largest sub-types of classical lignans which have been found to possess a broad range of important biological activities. Tremendous efforts have been directed to develop synthetic methodologies for the synthesis of furofurans, especially in a stereoselective manner, due to their interesting bioactivities associated with the structural and stereochemical complexity. This article summarizes the reports on asymmetric synthesis of furofurans disclosed during the period of 2004–2017. 相似文献
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有机锡化合物在天然产物合成中的应用 总被引:5,自引:0,他引:5
综述了有机锡化合物在不同对称合成天然产物中的应用。有机锡化合物应用于天然产物的不对称合成,反应条件温和、活性高,有很高的立体选择性和区域选择性,有广阔的应用前景。 相似文献
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(+)-Boronolide and (+)-deacetylboronolide were synthesized using Pd-catalyzed CO insertion and lactonization as the key step. As to the 13C NMR data of (+)-deacetylboronolide, the assignment at C-6 position should be revised. 相似文献
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以间异丙基溴苯1为起始原料,通过进攻环氧乙烷及溴代两步制得溴化物3.溴化物3与Hagemann′s酯发生偶联反应,水解后生成偶联产物5.再以路易斯酸BF3·Et2O催化化合物5进行分子内环化为关键步骤得到反式稠合中间体6,最后通过与三苯基膦碘甲烷季盐发生Wittig反应及氧化,合成了(±)-19-去甲基-4(18),8,11,13-四烯-松香烷-7-酮[19-nor-abieta-4(18),8,11,13-tetraen-7-one](8). 相似文献
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Yasuyuki Kita Kazuhiro Higuchi Yutaka Yoshida Kiyosei Iio Shinji Kitagaki Shuji Akai Hiromichi Fujioka 《Angewandte Chemie (International ed. in English)》1999,38(5):683-686
Seventeen years after the isolation of the promising antitumor antibiotic fredericamycin A, the first asymmetric total synthesis of this compound has been accomplished and thereby its absolute configuration established. The key feature is the regiocontrolled [4+2] cycloaddition of 3 to 2 , which was obtained by the stereospecific rearrangement of 1 . Cp = (−)‐camphanoyl. 相似文献