Laryngeal electromyographic responses to perturbations in voice pitch auditory feedback

The present study was conducted to test the hypothesis that intrinsic laryngeal muscles are involved in producing voice fundamental frequency (F(0)) responses to perturbations in voice pitch auditory feedback. Electromyography (EMG) recordings of the cricothyroid and thyroarytenoid muscles were made with hooked-wire electrodes, while subjects sustained vowel phonations at three different voice F(0) levels (conversational, high pitch in head register, and falsetto register) and received randomized pitch shifts (±100 or ±300 cents) in their voice auditory feedback. The median latencies from stimulus onset to the peak in the EMG and voice F(0) responses were 167 and 224 ms, respectively. Among the three different F(0) levels, the falsetto register produced compensatory EMG responses that occurred prior to vocal responses and increased along with rising voice F(0) responses and decreased for falling F(0) responses. For the conversational and high voice levels, the EMG response timing was more variable than in the falsetto voice, and changes in EMG activity with relevance to the vocal responses did not follow the consistent trend observed in the falsetto condition. The data from the falsetto condition suggest that both the cricothyroid and thyroarytenoid muscles are involved in generating the compensatory vocal responses to pitch-shifted voice feedback.     

Voice F0 responses to pitch-shifted voice feedback during English speech

Previous studies have demonstrated that motor control of segmental features of speech rely to some extent on sensory feedback. Control of voice fundamental frequency (F0) has been shown to be modulated by perturbations in voice pitch feedback during various phonatory tasks and in Mandarin speech. The present study was designed to determine if voice Fo is modulated in a task-dependent manner during production of suprasegmental features of English speech. English speakers received pitch-modulated voice feedback (+/-50, 100, and 200 cents, 200 ms duration) during a sustained vowel task and a speech task. Response magnitudes during speech (mean 31.5 cents) were larger than during the vowels (mean 21.6 cents), response magnitudes increased as a function of stimulus magnitude during speech but not vowels, and responses to downward pitch-shift stimuli were larger than those to upward stimuli. Response latencies were shorter in speech (mean 122 ms) compared to vowels (mean 154 ms). These findings support previous research suggesting the audio vocal system is involved in the control of suprasegmental features of English speech by correcting for errors between voice pitch feedback and the desired F0.     

Noise tolerance in human frequency-following responses to voice pitch

Speech communication usually occurs in the presence of background noise. This study examined noise tolerance in the brainstem's processing of voice pitch, as reflected by the scalp-recorded frequency-following response (FFR) from 12 normal-hearing adults. By systematically manipulating signal-to-noise ratio (SNR) across three different stimulus intensities, the results indicated that Frequency Error, Slope Error, and Tracking Accuracy remained relatively stable until SNR was degraded to 0 dB or lower (i.e., a turning point). This turning point not only provided physiological evidence supporting pitch tolerance of noise but also allowed recommendation of a minimal SNR when evaluating pitch processing in difficult-to-test patients.     

Effect of tonal native language on voice fundamental frequency responses to pitch feedback perturbations during sustained vocalizations

The purpose of this cross-language study was to examine whether the online control of voice fundamental frequency (F(0)) during vowel phonation is influenced by language experience. Native speakers of Cantonese and Mandarin, both tonal languages spoken in China, participated in the experiments. Subjects were asked to vocalize a vowel sound /u/at their comfortable habitual F(0), during which their voice pitch was unexpectedly shifted (± 50, ± 100, ± 200, or ± 500 cents, 200 ms duration) and fed back instantaneously to them over headphones. The results showed that Cantonese speakers produced significantly smaller responses than Mandarin speakers when the stimulus magnitude varied from 200 to 500 cents. Further, response magnitudes decreased along with the increase in stimulus magnitude in Cantonese speakers, which was not observed in Mandarin speakers. These findings suggest that online control of voice F(0) during vocalization is sensitive to language experience. Further, systematic modulations of vocal responses across stimulus magnitude were observed in Cantonese speakers but not in Mandarin speakers, which indicates that this highly automatic feedback mechanism is sensitive to the specific tonal system of each language.     

Relationship between changes in voice pitch and loudness

Changes in mean fundamental frequency accompanying changes in loudness of phonation are analyzed in 9 professional singers, 9 nonsingers, and 10 male and 10 female patients suffering from vocal functional dysfunction. The subjects read discursive texts with noise in earphones, and some also at voluntarily varied vocal loudness. The healthy subjects phonated as softly and as loudly as possible at various fundamental frequencies throughout their pitch ranges, and the resulting mean phonetograms are compared. Mean pitch was found to increase by about half-semitones per decibel sound level. Grossly, the subject groups gave similar results, although the singers changed voice pitch more than the nonsingers. The voice pitch changes may be explained as passive results of changes of subglottal pressure required for the sound level variation.     

Voice F0 responses to pitch-shifted auditory feedback: a preliminary study

Auditory feedback has been suggested to be important for voice fundamental frequency (F₀) control. The present study featured a new technique for testing this hypothesis by which the pitch of a subject's voice was modulated, fed back over earphones, and the resultant change in the emitted voice F₀ was measured. The responses of 67 normal, healthy young adults were recorded as they attempted to ignore intermittent upward or downward shifts in pitch feedback while they sustained steady vowel sounds (/a/) or sang musical scales. Ninety-six percent of subjects increased their F₀ when the feedback pitch was decreased, and 78% of subjects decreased their F₀ when the pitch feedback was increased. Latencies of responses ranged from 104 to 223 ms. Results indicate people normally rely on pitch feedback to control voice F₀.     

Sex-related differences in vocal responses to pitch feedback perturbations during sustained vocalization

The present study assessed the effect of sex on voice fundamental frequency (F(0)) responses to pitch feedback perturbations during sustained vocalization. Sixty-four native-Mandarin speakers heard their voice pitch feedback shifted at ± 50, ± 100, or ± 200 cents for 200 ms, five times during each vocalization. The results showed that, as compared to female speakers, male speakers produced significantly larger but slower vocal responses to the pitch-shifted stimuli. These findings reveal a modulation of vocal response as a function of sex, and suggest that there may be a differential processing of vocal pitch feedback perturbations between men and women.     

Compensatory responses to loudness-shifted voice feedback during production of Mandarin speech

Previous studies have demonstrated that perturbations in voice pitch or loudness feedback lead to compensatory changes in voice F(0) or amplitude during production of sustained vowels. Responses to pitch-shifted auditory feedback have also been observed during English and Mandarin speech. The present study investigated whether Mandarin speakers would respond to amplitude-shifted feedback during meaningful speech production. Native speakers of Mandarin produced two-syllable utterances with focus on the first syllable, the second syllable, or none of the syllables, as prompted by corresponding questions. Their acoustic speech signal was fed back to them with loudness shifted by +/-3 dB for 200 ms durations. The responses to the feedback perturbations had mean latencies of approximately 142 ms and magnitudes of approximately 0.86 dB. Response magnitudes were greater and latencies were longer when emphasis was placed on the first syllable than when there was no emphasis. Since amplitude is not known for being highly effective in encoding linguistic contrasts, the fact that subjects reacted to amplitude perturbation just as fast as they reacted to F(0) perturbations in previous studies provides clear evidence that a highly automatic feedback mechanism is active in controlling both F(0) and amplitude of speech production.     

Vocal responses to unanticipated perturbations in voice loudness feedback: an automatic mechanism for stabilizing voice amplitude

The present study tested whether subjects respond to unanticipated short perturbations in voice loudness feedback with compensatory responses in voice amplitude. The role of stimulus magnitude (+/- 1,3 vs 6 dB SPL), stimulus direction (up vs down), and the ongoing voice amplitude level (normal vs soft) were compared across compensations. Subjects responded to perturbations in voice loudness feedback with a compensatory change in voice amplitude 76% of the time. Mean latency of amplitude compensation was 157 ms. Mean response magnitudes were smallest for 1-dB stimulus perturbations (0.75 dB) and greatest for 6-dB conditions (0.98 dB). However, expressed as gain, responses for 1-dB perturbations were largest and almost approached 1.0. Response magnitudes were larger for the soft voice amplitude condition compared to the normal voice amplitude condition. A mathematical model of the audio-vocal system captured the main features of the compensations. Previous research has demonstrated that subjects can respond to an unanticipated perturbation in voice pitch feedback with an automatic compensatory response in voice fundamental frequency. Data from the present study suggest that voice loudness feedback can be used in a similar manner to monitor and stabilize voice amplitude around a desired loudness level.     

Compensation for pitch-shifted auditory feedback during the production of Mandarin tone sequences

Recent research has found that while speaking, subjects react to perturbations in pitch of voice auditory feedback by changing their voice fundamental frequency (F0) to compensate for the perceived pitch-shift. The long response latencies (150-200 ms) suggest they may be too slow to assist in on-line control of the local pitch contour patterns associated with lexical tones on a syllable-to-syllable basis. In the present study, we introduced pitch-shifted auditory feedback to native speakers of Mandarin Chinese while they produced disyllabic sequences /ma ma/ with different tonal combinations at a natural speaking rate. Voice F0 response latencies (100-150 ms) to the pitch perturbations were shorter than syllable durations reported elsewhere. Response magnitudes increased from 50 cents during static tone to 85 cents during dynamic tone productions. Response latencies and peak times decreased in phrases involving a dynamic change in F0. The larger response magnitudes and shorter latency and peak times in tasks requiring accurate, dynamic control of F0, indicate this automatic system for regulation of voice F0 may be task-dependent. These findings suggest that auditory feedback may be used to help regulate voice F0 during production of bi-tonal Mandarin phrases.     

Repetition rate and signal level effects on neuronal responses to brief tone pulses in cat auditory cortex

This study describes the effects on the spike count, spike timing, and entrainment of cat auditory cortex neurons of parametric variations in the repetition rate and amplitude of a brief, characteristic frequency tone pulse. Data were obtained from single neurons in barbiturate-anesthetized cats to which signals were presented monaurally to the ear contralateral to the recording electrode. All neurons showed low-pass sensitivity to tone repetition rate. In cells with a monotonic rate response, the effect of an increasing stimulus level was to elevate the response rate and to extend performance to higher repetition rates. In nonmonotonic cells, cutoff frequencies (for repetition rate) varied with overall spike count. Latent periods increased with increases in repetition rate. This effect developed over the first few stimulus trials at any given repetition rate. Spike entrainment to the tone pulses varied with both repetition rate and signal level. Increases in signal level improved entrainment for responses to stimuli presented at low repetition rates, but entrainment at high repetition rates always saturated at significantly imperfect levels.     

The role of pitch in the discrimination of voice quality

Pitch is an important attribute of a musical sound. With it the melody of a song is established. With it the beauty of a voice is showcased. But how does pitch affect the perception of voice? Is it used to help to distinguish among voices or does it merely exist in the background, affecting the fine details of a voice but not radically altering the voice? The purpose of this paper is to review some of the evidence on the role of pitch in the perception of voice quality; specifically for the discrimination of one voice quality from another. The objective of the discussion is to understand how pitch affects our perception of voice quality and its importance to the perception of musical sound.     

Relating binaural pitch perception to the individual listener's auditory profile

The ability of eight normal-hearing listeners and fourteen listeners with sensorineural hearing loss to detect and identify pitch contours was measured for binaural-pitch stimuli and salience-matched monaurally detectable pitches. In an effort to determine whether impaired binaural pitch perception was linked to a specific deficit, the auditory profiles of the individual listeners were characterized using measures of loudness perception, cognitive ability, binaural processing, temporal fine structure processing, and frequency selectivity, in addition to common audiometric measures. Two of the listeners were found not to perceive binaural pitch at all, despite a clear detection of monaural pitch. While both binaural and monaural pitches were detectable by all other listeners, identification scores were significantly lower for binaural than for monaural pitch. A total absence of binaural pitch sensation coexisted with a loss of a binaural signal-detection advantage in noise, without implying reduced cognitive function. Auditory filter bandwidths did not correlate with the difference in pitch identification scores between binaural and monaural pitches. However, subjects with impaired binaural pitch perception showed deficits in temporal fine structure processing. Whether the observed deficits stemmed from peripheral or central mechanisms could not be resolved here, but the present findings may be useful for hearing loss characterization.     

Modulation of auditory evoked responses to spectral and temporal changes by behavioral discrimination training

Background  

Due to auditory experience, musicians have better auditory expertise than non-musicians. An increased neocortical activity during auditory oddball stimulation was observed in different studies for musicians and for non-musicians after discrimination training. This suggests a modification of synaptic strength among simultaneously active neurons due to the training. We used amplitude-modulated tones (AM) presented in an oddball sequence and manipulated their carrier or modulation frequencies. We investigated non-musicians in order to see if behavioral discrimination training could modify the neocortical activity generated by change detection of AM tone attributes (carrier or modulation frequency). Cortical evoked responses like N1 and mismatch negativity (MMN) triggered by sound changes were recorded by a whole head magnetoencephalographic system (MEG). We investigated (i) how the auditory cortex reacts to pitch difference (in carrier frequency) and changes in temporal features (modulation frequency) of AM tones and (ii) how discrimination training modulates the neuronal activity reflecting the transient auditory responses generated in the auditory cortex.     

Hybrid measurement of auditory steady-state responses and distortion product otoacoustic emissions using an amplitude-modulated primary tone

A maximum auditory steady-state response (ASSR) amplitude is yielded when the ASSR is elicited by an amplitude-modulated tone (f(c)) with a fixed modulation frequency (f(m) = 40 Hz), whereas the maximum distortion product otoacoustic emission (DPOAE) level is yielded when the DPOAE is elicited using a fixed frequency ratio of the primary tones (f2/f1 = 1.2). When eliciting the DPOAE and ASSR by the same tone pair, optimal stimulation is present for either DPOAE or ASSR and thus adequate simultaneous DPOAE/ASSR measurement is not possible across test frequency f2 or f(c), respectively. The purpose of the present study was to determine whether the ASSR and DPOAE can be measured simultaneously without notable restrictions using a DPOAE stimulus setting in which one primary tone is amplitude modulated. A DPOAE of frequency 2f1-f2 and ASSR of modulation frequency 41 Hz were measured in ten normal hearing subjects at a test frequency between 0.5 and 8 kHz (f2 = f(c)). The decrease in the DPOAE level and the loss in ASSR amplitude during hybrid mode stimulation amounted, on average, to only 2.60 dB [standard deviation (SD) = 1.38 dB] and 1.83 dB (SD = 2.38 dB), respectively. These findings suggest simultaneous DPOAE and ASSR measurements to be feasible across all test frequencies when using a DPOAE stimulus setting where the primary tone f2 is amplitude modulated.     

Dissociation of pitch from timbre in auditory short-term memory

In three experiments, untrained listeners made same/different judgments on pairs of pure or complex tones with periods that eventually differed by +/- 4%. On each trial, the two test tones were separated by 4.3 s, during which other tones (I) were heard but had to be ignored. The period (p) of the first test tone was randomly selected between 1/600 and 1/300 s. The period of each I tone was randomly selected among four possible values, close to p (+/- 3% or 6% apart) in some conditions, and remote from p in other conditions. In addition, from condition to condition, the spectral content of the I tones was varied independently of their periods: The I tones could have the same harmonic content as the test tones, or a very different harmonic content. Subjects' performances were much better when the periods of the I tones were remote from p than when they were close to p, as expected from previous findings by D. Deutsch [e.g., Science 175, 1020-1022 (1972)]. But, more importantly, the relation between the spectral contents of the I tones and the test tones had, by itself, practically no effect on performance. Thus performance was affected by the pitches of the I tones, but not by their timbres. These results suggest that pitch is processed independently of timbre in auditory short-term memory.     

Human brain-stem auditory evoked responses obtained by cross correlation to trains of clicks, noise bursts, and tone bursts

Brain-stem auditory evoked responses (BAERs) were obtained in eight normal-hearing young adults. Stimuli included clicks, noise bursts, and tone bursts. Tone bursts included carrier frequencies of 1, 2, 4, and 8 kHz. All stimuli were presented at 60 dB nHL. BAERs were obtained by presenting stimuli in pseudorandom trains, called maximum length sequences (MLSs). BAERs were recovered by cross correlating the responses with a recovery sequence. MLS-BAERs were obtained with minimum pulse intervals (MPIs) of 6, 4, and 2 ms. Conventional BAERs were also obtained for stimuli presented at a rate of 30 Hz. BAERs were obtained for all stimuli, for both the conventional averaging technique and for the cross-correlation technique. BAERs were observed for MPIs as short as 2 ms for all stimuli. Wave V was the only peak consistently identifiable for these stimuli. For all stimuli, wave V latency increased and wave V amplitude decreased with decreasing MPI. This is the first demonstration of the use of maximum length sequences combined with cross correlation to obtain BAERs to noise burst and tone burst stimuli.     

Neuromagnetic steady-state responses to auditory stimuli

Steady-state magnetic responses to clicks presented at rates between 10 and 70 Hz have been recorded in healthy humans. The responses were highest in amplitude around 40 Hz. This amplitude enhancement is satisfactorily explained by summation of responses evoked by single clicks. The field maps suggest activation of the auditory cortex at all stimulus frequencies. Similar responses were obtained with gated noise bursts and by pauses in a series of clicks. The mean "apparent latency," determined from the phase lag at rates 30-70 Hz, was 54 ms. The physiological relevance of this quantity is shown to be questionable.     

Neural responses to auditory temporal patterns

Sets of regularly repeating auditory stimuli elicit unique perceptions; listeners are able to identify specific temporal patterns. Some temporal patterns are unambiguous (only one pattern can be perceived), while others are ambiguous (numerous patterns can be detected). While the psychophysical properties of such percepts have been well studied, little is known about the underlying neurological bases of temporal pattern perception. In this experiment, the role of adaptation in temporal pattern perception is examined by studying neural responses in four cats to a temporal pattern that is perceptually unambiguous and one that is perceptually ambiguous. Measurements were made of the whole-nerve action potential, the auditory brainstem response, and potentials from the surface of the primary auditory cortex. The adaptation patterns corresponded with the perceptual organization of temporal patterns in humans at all levels of the nervous system studied.