Dihydrochalcones from Symplocos vacciniifolia

A new dihydrochalcone glucoside, vacciniifolin, along with confusoside, trilobatin and sieboldin were isolated from the leaves of Symplocos vacciniifolia. By the method of spectral analysis, this new compound was elucidated as 2‘,3,4,4‘-tetrahydroxydihydrochalcone 4‘-O-β-D-glu-copyranoside.     

Cochinchin from Dracaena cochinchinensis

A new compound, Cochinchin (1), together with 7,4‘-dihydroxyflavone (2), 7-hydroxy-4‘-methoxyflavane (3),7-hydroxy-3-(4-hydroxybenzyl)chroman (4), 4‘-hydroxy-2,4-dirnethoxydihydrochalcone (5) and 4‘-hydroxy-2,4,6-trimethoxydihydrochalcone (6) was isolated from the resin (trivial name, “dragon‘s blood“) of Dracaena cochinchinensis (Lour.) S. C. Chert. The structure of 1 was elucidated on the basis of spectroscopic data as (2,3-trans)-6-allyl-2-(3,5-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2,3-dihydrobenzo[1,4]dioxin which is a natural product possessing a new framework.     

Diterpenoids from Rabdosia Nervosa

Six ent-kaurene type diterpenoids were isolated from the leaves of Rabdosia nerwsa. Among them.ganer-vosin A and B are new compounds, the structures of which were elucidated as 1 and 2 respectively by spectral and chemical methods. The other four were identified as odonicin (3), novelrabdosin (4), nodosin (5) and shikokianal acetate (8). Compounds (1), (2), (5) and (8) have not been found in this herb previously.     

Flavonoids from Carthamus tinctorius

Two new flavonoids,(2S)-4′,5-dihydroxyl-6,7-di-O-β-D-glucopyranosyl flavanone(1) and 6-hydroxykaempferol 6,7-di-O-β-D-glucopyranoside(2),were isolated from Carthamus tinctorius.Their structures were elucidated by spectroscopic means including 2D NMR,ESIMS and CD.     

Eremophilenolides from Cacalia Roborowskii

ThegenusCacaliabelongstothetribesenecioneae,facelyCompositae,andcomprisesmorethan60speciesoccurringinChina,'ofwhichca.26specieslacelongbeenusedasChinesetradihonalfolkherb.2SeveralspeciesofthegenusCacahawereinvestigatedduetotheirantioxidantantiradical,andantiltistamineactivities.3Thepresenceofpyrrolizidinealkaloidsandsesquitefpenesinmanyspeciesoftribesenencioneaceiswelldocumented.'"InacontinuahonoftileStudyontilesmictureswiUIbioactivitiesfromtileCacahagenus,wereportheretheisolahonandsmictta…     

Diterpenoids from Isodon sculponeatus

Further investigation on the leaves of Isodon sculponeatus afforded two new ent-kaurane diterpenoids,sculponeatins J and K .Their sturctures were elucidated on the basis of their spectral properties,as well as X-ray crystallographic analysis ,The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested ,and sculponeation J showed significant inhibitory effects with IC50 values less than 1.0 μg/mL。     

Triterpenoids from Fuscoporia obliqua

Fuscoporia obliqua is the birch tree fungus. It had been reported to contain severaltriterpenes of the lanostane type and pigment1-3. In the course of systematic study of itschemical composition, we isolated two novel triterpenoids named 3I3,22 o -dihydroxylanosta-8,24E-diene-25-peroxide (compound I ), 36,22 o,25-trihydroxy-lanosta-8,24Ediene (compound II). The isolation and structure elucidation of these compounds arereported in this paper.Compound i, m.p. 196-198C, [ Q ] '.)' 56.4 (CHCI…     

Alkaloids from Fritillaria Hupehensis

Phytochemical investigation of the bulbs of Fritillaria hupehensis resulted in the isolation and structural elucidation of a new highly conjugated alkaloid of veratramine type identified as 3β,23β-dihydroxy-7,12（14）-dien-5α- veratramin-6-one （1）, together with two known alkaloids, ebeinine （2） and zhebeinine （3）, which were isolated for the first time from F. hupehensis. The structures of alkaloids 1-3 were established by extensive 1D and 2D NMR spectral analyses.     

Oligostilbentes from Vitis DavidII

PreviousinvestigationsrevealedthatsomeVitisspeciesarerichinoligostilbenes'-'.InthecontinuinginvestigationforoligostilbenesfromVitisspp-,wehaveisolatedanoveltetrastilbene,davidolA1,alongwithresveratrol',( )-E-viniferin',ampelopsinC',ampelopsinE',vitisinAl'3andhopeaphenol7-9fromthestemsofVitisdavidiiFoex9.ThedriedpowderedstemsofVdavidiiFoex.wasextractedwithacetone.TheacetoneextractwasthenconcentratedunderreducedpressureandfractionatedbyaseriesofsolventpartitionintoanEtOAc-solublephenolicfr…     

Diterpenoid Alkaloids from Aconitum Pendulum

InthecourseofourcontinulngresearhforthebioaCtivediterpenoidalkaloidswehaveinvestigatedACO~PCntheBusch,aChinesebohonalheth,whichisdistributedinnoAnweStmChina.AnewditerPenoidalkaloidl2-ePiacetyldehydrlucidusculline(l)andanewnorditerPenoidalkaloid2-hydroxydeoxyaconihne(2)wereisolatedfromthisSPeCies,togetherwitheightknownaconihne(3)I1l,dtoxyaconihne(4)l2l,3-aeetylaconihne(5)I3],l2-ePi-acetyldehydronaPelline(6)I4l-dehydrolucidusculline(7)I5],dehydronaPelline(8)I6],l2-epidehydronaPelline(9…     

Biphenyl Ferulate from Glehnia littoralis

From the underground parts of Glehnia littoralis Fr.Schmidt ex Miquel (Umbelliferae), a new compound named glehnilate was obtained. Its structure was determined by analysis of its spectral data.     

New Diterpenoids from Coleus forskohlii

Two new diterpenoids, forskolin G and H were isolated from the chloroform extract of the roots of Coleus forskohlii, and based on spectroscopic data,their structures were identified as 1α-hydroxy-6β,7β-diacetoxy-8,13-epoxylabd-14-ene-11-one(1),and 1α，6β-diacetoxy-8,13-epoxy labd-14-ene-11-one (2),respectively.     

New Xanthones from Polygala crotalarioides

Introduction Xanthonesaresecondarymetabolitescommonly occurringinafewhigherplantfamilies,fungiandli chen.Theirhightaxonomicvalueinsuchfamiliesand theirpharmacologicalproperties,includinginvitrocy totoxicity,invivoantitumouractivity,antifungal,anti bacteri…     

New Isoflavonoside from Bupleurum Scorzonerifolium

BupleurumscorzonerlfoliumwasrecordedinChinesePhannacopiea(1995edihon)andusedasananhinflanunatoryandanhhepatotoxicmedicine'.Besidesmanysaponins,anewisoflavonosidewasobtained.ThispaperdealswiththestrUctUreelucidationofthecomPOund.CompoundTLI,Paleyellowcrystals,mp190-193oC.FAB-MScIn/z597[M NaHZO] .TheUV(MeOH)bandsat242,298,305(sh)nmsuggestedanisofiavonolskeleton.TheiHNMRdataTLI,87.sl(2H,d,J=8.7Hi)and6.99(2H,d.J=8.7Hi)indicatedthatB-hogofTLIonlypossessedasubstitUhonalgroupatPOs…     

New Eudesmenes from Erigeron annus

Chemical investigation of Erigeron annus afforded two new eudesmenes, which were identified as 1β, 5α-dihydroxyeudesma-4(15)-en (1) and 1β, 7α-dihydroxyeudesma-4(15)-en (2).Their structures were established by spectroscopic methods including 2D NMR experiments.     

Eremophilane Sesquiterpenes from Cacalia Roborowskii

Themajorityofphytochemicalstudiesonsenencioneace(compositae)specieshavebeenconcentratedonthepyrrolizidinealkaloidsandsesquiteIPenesbecauseoftheirpotentialbioactivitiesandCytotoalcactivities.lCacaliaroborowskii(maxim)LinginslongbeenusedasfolkremedyinnorthwestemChina.Recently,wehadisolatedseveralneweremophilenolides'fromtherootsofthisplant.Asacontinuahonofourinvestigationontillsspecies,wenowpresenttileisolationandsmicturalelucid.ltionoffouraddihonalneweremophilanesesquiterpenes.Theirsmicturesw…     

New Sesquiterpene from Senecio flammeus

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New Sesquiterpenes from Cacalia ainsliaeflora

Two new eremophilane sesquiterpenes, 3β-angeloyloxy-8-oxo-eremophil-6(7)-en-12-oic acid 1 and 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en-12-oic acid 2, and a novelnor-eremophilane derivative, 3β-angeloyloxy-10β-hydroxy-8-oxo-eremophil-6(7)-en 3 were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods, including 2D NMR.