共查询到20条相似文献,搜索用时 0 毫秒
1.
2.
3.
4.
5.
6.
Hanessian S Huang G Chenel C Machaalani R Loiseleur O 《The Journal of organic chemistry》2005,70(17):6721-6734
Methods are described for the total synthesis of bicyclic perhydrofuropyran nucleosides as N-analogues of the naturally occurring malayamycin A. Formation of the N-nucleosides relied on the activation of thioglycosides, proceeding via sulfonium intermediates. Ring closure metathesis was used in two approaches to build the bicyclic dioxa heterocycle. Another approach relied on the use of a sugar precursor and cyclization to the bicyclic thioglycoside. 相似文献
7.
Song H Li X Long Y Schatte G Kraatz HB 《Dalton transactions (Cambridge, England : 2003)》2006,(39):4696-4701
This paper reports syntheses, crystal structures and electrochemical results for two ferrocene(Fc)-modified pyrimidine nucleosides that could potentially be used for investigating electron transfer in DNA. Fc was directly attached to the 5-position of deoxyuridine and deoxycytidine via the Stille coupling reaction. Fc-modified uridine was incorporated into DNA trinucleotides with standard solid-phase synthesis. The structures of corresponding detritylated compounds were determined by single-crystal X-ray analysis. Electrochemical investigations of all compounds by cyclic voltammetry revealed reversible redox processes. 相似文献
8.
R. A. Zhuk A. E. Berzinya G. G. Volynkina S. A. Hiller 《Chemistry of Heterocyclic Compounds》1970,6(4):509-512
The kinetics of the hydrolysis of the pseudoglycosidic C-N bond in the N1-derivatives of uracil, thymine, and 5-fluorouracil at various pH values of the medium have been studied. The dependence of the rate of hydrolysis of N1-(tetrahydrofuran 2-yl)-5-fluorouracil on the temperature has been investigated. The influence of substituants at C5 and N1 of the pyrimidine ring on the stability of the pseudoglycosidic C-N bond has been evaluated.For part V, see [10]. 相似文献
9.
Mitsuji Yamashita Valluru Krishna ReddyPutta Mallikarjuna Reddy Yukihiro KatoBuchammagari Haritha Kazumitsu SuzukiMasaki Takahashi Tatsuo Oshikawa 《Tetrahedron letters》2003,44(17):3455-3458
An efficient method is described in the synthesis of several novel deoxy phospha sugar pyrimidine nucleosides in racemic form, analogs of normal sugar nucleosides, in high yields by treatment of (±)-2-aminophospholane 1-oxide with several, α-cyano-, -acetyl-, -ethoxycarbonyl-β-ethoxy-N-ethoxycarbonylacrylamides. 相似文献
10.
The UV absorption spectra of 5-substituted N1-(tetrahydrofuran-2-yl)- and N1-(2oxotetrahydrofuran-3-yl)uracils have been studied and their protolysis constants have been determined by the spectrophotometric method. A comparison is given with the spectra and pKa values of the corresponding N1-methyl derivatives and ribosides and deoxyribosides.For part IV see [11].The work was carried out with analytical samples of compounds obtained by us previously [9–12]. 相似文献
11.
12.
《Tetrahedron letters》2019,60(43):151183
An efficient method to construct chiral cyclopropyl pyrimidine carbocyclic nucleoside analogues bearing a quaternary center was developed via asymmetric Michael-initiated cyclopropanation. The axis chirality was observed in cyclopropyl pyrimidine carbocyclic nucleoside analogues for the first time, which was caused by the rotationally restricted NC bond in N-COPh moiety. Using (DHQD)2AQN as the organocatalyst, diverse cyclopropyl pyrimidine carbocyclic nucleoside analogues were generated in 76–93% yields and 73–96% ee. 相似文献
13.
14.
S. A. Hiller M. Yu. Lidak R. A. Zhuk A. E. Berzinya K. Ya. Pets I. N. Getsova E. I. Bruk 《Chemistry of Heterocyclic Compounds》1969,5(2):283-285
N1-(-Tetrahydrofuranyl)- and N1-(-tetrahydropyranyl)uracils and the corresponding 6-azauracils have been obtained by the condensation of bistrimethylsilyl derivatives of uracils and 6-azauracils with-chlorotetrahydrofuran and-chlorotetrahydropyran. The superiority of the silyl method over the mercury method used previously has been demonstrated.For part III, see [9]. 相似文献
15.
R. A. Zhuk A. É. Berzinya L. A. Sherin' L. T. Kaulinya S. A. Giller 《Chemistry of Heterocyclic Compounds》1977,13(9):1015-1016
A new method was developed for the synthesis of 1-(2-tetrahydrofuryl) derivatives of uracil, 5-substituted uracils, 6-azauracil, and cytosine by alkylation of 2,4-bis(trimethylsilyl) derivatives of pyrimidine bases with 2-acetoxytetrahydrofuran in the presence of Lewis acids. In contrast to 2-chlorotetrahydrofuran, which is used in a previously described method, 2-acetoxytetrahydrofuran is stable at room temperature and reacts under these conditions with silyl derivatives of uracils in the presence of SnCl4 to give 1-(2-tetrahydrofuryl) derivatives of pyrimidine bases in 80–85% yields.See [1] for communication X.Deceased.Translated from Khimiya Geterotsiklicheskikh Soedineaii, No. 9, pp. 1258–1259. September, 1977. 相似文献
16.
R. A. Zhuk L. A. Sherin' é. é. Liepin'sh S. A. Giller 《Chemistry of Heterocyclic Compounds》1974,10(12):1461-1463
A new method for the synthesis ofN1-(dihydroxyalkyl)uracils by reduction of substituted α- (1-uracilyl)- and γ-[(1-uracilyl)methyl]-γ-butyrolactones with sodium borohydride was found. 相似文献
17.
S. A. Giller R. A. Zhuk A. É. Berzinya L. T. Kaulinya 《Chemistry of Heterocyclic Compounds》1975,11(5):603-606
α-(1-Cytosinyl)-γ-butyrolactone was obtained by condensation of bis(trimethylsilyl)cytosine with α-bromobutyrolactone. The reduction of α-(1-cytosinyl)-γ-butyrolactone with sodium borohydride gave N1-(1,4-dihydroxy-2-butyl)cytosine, the acylation of which with benzoyl chloride and subsequent partial hydrolysis gave N1-(1,4-dihydroxy-2-butyl)-N4-benzoylcytosine. 相似文献
18.
D. Ya. Sniker R. A. Zhuk E. I. Stankevich G. Ya. Dubur S. A. Hiller 《Chemistry of Heterocyclic Compounds》1969,5(1):130-131
The reaction of alkoxy bromides with N1-(-tetrahydrofuryl) derivatives of pyrimidine bases has given a series of 6-alkoxy-5-bromo-1-(-tetrahydrofuryl)-5, 6-dihydrouracils. The hydrogenation of the 1-(-tetrahydrofuryl) derivatives of uracil and of 5-fluorouracil has been studied. It has been shown that in both cases 1-(-tetrahydrofuryl)-5, 6-dihydrouracil is formed. 相似文献
19.
A number of N1-(-butyrolactono) derivatives of 5-substituted uracils have been synthesized by condensing the sodium derivatives of the corresponding bases with -bromobutyrolactone or by the halogenation of N1-(-butyrolactono)uracil.For part I, see [1]. 相似文献
20.
Lagoja IM Pochet S Boudou V Little R Lescrinier E Rozenski J Herdewijn P 《The Journal of organic chemistry》2003,68(5):1867-1871
The synthesis of fully [13C/15N] labeled pyrimidine nucleosides has been achieved from 13C-glucose and labeled nucleobases. The reaction scheme leads directly to the protected nucleosides without the need for the inversion of configuration of C-3 of 13C-glucose. This was achieved by an oxitative ring-opening reaction removing the carbon with the wrong configuration. 相似文献