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N. P. Gambaryan E. M. Rokhlin Yu. V. Zeifman Chen Ching-yun I. L. Knunyants 《Angewandte Chemie (International ed. in English)》1966,5(11):947-956
The chemistry of polyfluorinated ketones has recently received a great deal of attention. 1 A. Ya. Yakoubovich, Usp. Chim. 25, 3 (1956). 2 H. P. Braendlin and E. T. McBee in: Advances in Fluorine Chemistry. Butterworths, London 1963, Vol. 3, p. 1. 3 The review by Braendlin and McBee [2] does not deal only with perfluorinated ketones; moreover, though published in 1963, it is already outdated. The papers discussed in [1,2] will not be reviewed in the present article. . The carbonyl and imino groups of the fluorinated ketones and their imines react in many different ways. In particular, the electron-attracting perfluoroalkyl groups intensify the electrophilic properties and weaken the nucleophilic properties of the carbonyl group. The perfluoroalkyl group also hinders the heterolytic removal of the hydroxyl group from adducts by reducing the stability of the carbonium ion . The increased electrophilicity of the carbonyl group and the increased stability of the addition products leads not only to a change in reactivity in the characteristic ketone reactions, but also to numerous new reactions which are not observed with non-fluorinated ketones. Thus it is possible to synthesize a wide variety of fluoroorganic compounds from perfluorinated ketones. 4 We have been concerned mainly with hexafluoroacetone, since in addition to being the most readily available and simplest perfluorinated ketone, this is also a typical representative of this class of compounds. . 相似文献
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The synthesis of novel N-acetyl-N,N-dipyrid-2-yl complexes of RhI and IrI, i.e. [RhCl(CH3CONPy2)(COD)] (1) and [IrCl(CH3CONPy2)(COD)] (2), respectively, is described. Upon prolonged treatment in CH2Cl2 at room temperature, complex 1 is transformed into a cationic Rh-complex, i.e. [Rh(CH3CONPy2)(COD)+RhCl2(COD)−] (1a). Compound 1a crystallizes in the monoclinic space group P21/c, complex 2 crystallizes in the triclinic space group . Compound 1 was investigated for its catalytic activity in the hydroformylation of cyclooctene as well as of 1-octene. In addition, 1 was used in various carbonyl hydrosilylation reactions of both aldehydes and ketones. There, turn-over numbers up to 50 000 and yields in the range of 85-100% were observed. Finally, compound 1 was successfully used for the polymerization of N2CHCOOEt yielding highly stereoregular poly(ethoxycarbonylcarbene) with Mw = 67 000 g/mol and a polydispersity index (PDI) of 2.59. 相似文献
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Generation and Trapping Reactions of a Formal 1:1 Complex between Singlet Carbon and 2,2′-Bipyridine
Robert Weiss Silvia Reichel Matthias Handke Frank Hampel 《Angewandte Chemie (International ed. in English)》1998,37(3):344-347
The structural element of a protonated imidazolium system was realized for the first time in the synthesis of 1 from 2,2′-bipyridine and a novel methylenating agent. Reversible deprotonations proceed via 2 to lead to carbene 3 , a formal 1:1 complex between singlet carbon and 2,2′-bipyridine which is stable in solution and can be trapped. For 1 and 2 , unusual hybridizations of the bridging C atom were found experimentally. 相似文献
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The [Cu(acac)2]‐catalyzed reactions of several tertiary enaminones with three diazocarbonyl compounds, i.e., dimethyl diazomalonate, ethyl diazoacetoacetate, and ethyl diazoacetate, yielded amino‐ and additionally carbonyl‐substituted dihydrofurans, together with further furan derivatives. Due to the conjugation of α‐carbonyl/α‐Ph groups, reactions proceeded only via 1,5‐electrocyclization of corresponding keto‐ylides. On the other hand, in the absence of any α‐substituent, tertiary enaminone and ethyl diazoacetate, reacted via an accompanying mechanism by a push‐pull cyclopropane intermediate, to yield a 2,4‐dicarbonyl‐substituted furan in one step with moderate yield. 相似文献
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二卤卡宾与羰基化合物反应的研究进展 总被引:6,自引:1,他引:6
对近年来二卤卡宾与羰基化合物的反应机理研究进行了总结,指出二卤羰基Yilde为反应的中间体,并对影响二卤羰基Ylide的稳定性及后续反应的因素如底物的立体效应,取代基的电子效应,Captodative效应以卤原子半径大小进行了讨论。 相似文献
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Albert Padwa David J. Austin 《Angewandte Chemie (International ed. in English)》1994,33(18):1797-1815
The transition metal catalyzed reaction of α-diazo carbonyl compounds has found numerous applications in organic synthesis, and its use in either heterocyclic or carbocyclic ring formation is well precedented. Early work in this area made use of insoluble copper catalysts. Although these catalysts are still employed today, their use has decreased significantly with the advent of homogeneous copper catalysts and catalysts based on other metals. The discovery that RhII carboxylates facilitate nitrogen loss from diazo compounds rekindled significant interest in the field of diazo/carbenoid chemistry. Since the realization that RhII carboxylates are superior catalysts for the generation of transient electrophilic metal carbenoids from α-diazo carbonyl compounds, intramolecular carbenoid addition and insertion reactions have assumed strategic importance in C? C bond-forming reactions in organic synthesis. In contrast to other catalysts that are suitable for carbenoid reactions of diazo compounds, those constructed with the dirhodium(II ) framework are most amenable to ligand modifications that, in turn, can influence reaction selectivity. This article will emphasize the chemical behavior of transition metal carbenoid complexes that are greatly affected by the nature of the ligand groups attached to the metal center. Much of the discussion will center on the ability of the dirhodium(II ) ligands to determine reaction preference toward different functional groups on the same molecule. 相似文献
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Sincetheearlyl980sinterestin0rganicpoIyvalentiodinec0mp0undshasexperiencedaresurgence'.Afewexamplesofhomo-couplingreacti0nsviathesec0mpoundshavebeenrep0rted-.Wef0undthatl-aIkyneswereeasytoc0upleinthepresenceofPhI(OAc)=orPhI(OH)OTs,catalyticCulandbase,t0aff0rdc0njugateddiynes.l,3-Diyneplaysanimportantr0leinstudiesofm0lecularrec0ngnition',innaturalpr0ducts',andinsynthesis.AlthoughEglintonreaction',Cadi0t-Chalkiewiczc0upling'andGlaserreaction5haveprovidedc0nvenientmeth0dst0synthesizeconjug… 相似文献
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The reactions of several thioketones containing a conjugated C?C bond with diazo compounds were investigated. All of the selected compounds reacted via a 1,3‐dipolar cycloaddition with the C?S group and subsequent N2 elimination to yield thiocarbonyl ylides as intermediates, which underwent a 1,3‐dipolar electrocyclization to give the corresponding thiirane 25 , or, by a subsequent desulfurization, to give the olefins 33a and 33b . None of the intermediate thiocarbonyl ylides reacted via 1,5‐dipolar electrocyclization. If the α,β‐unsaturated thiocarbonyl compound bears an amino group in the β‐position, the reactions with diazo compounds led to the 2,5‐dihydrothiophenes 40a – 40d . In these cases, the proposed mechanism of the reactions led once more to the thiocarbonyl ylides 36 and thiiranes 38 , respectively. The thiiranes reacted via an SNi′‐like mechanism to give the corresponding thiolate/ammonium zwitterion 39 , which underwent a ring closure to yield the 2,5‐dihydrothiophenes 40 . Also in these cases, no 1,5‐dipolar electrocyclization could be observed. The structures of several key products were established by X‐ray crystallography. 相似文献
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Metal carbonyl clusters possess a complicated chemistry that is only beginning to be understood. One of the main current goals in this area is thus an understanding of their reactivity. This article describes the syntheses and reactions of clusters that contain metal carbonyl fragments bridged by a main-group element. But what is the sense of making such clusters still more complicated by the incorporation of main-group elements? The example of μ3-bridged carbonyl clusters will serve to show that the main-group element plays an important role in the study of reaction paths; it holds the metal carbonyl fragments together even when the bonds between them are broken in the course of a reaction. Trinuclear μ3-bridged clusters prove to be small enough to allow the analysis of typical cluster reactions (such as the reversible breaking of metal-metal bonds) in terms of single reaction steps. They are also large enough to provide surprises by their multifaceted reactivity. It will be shown that a detailed study of trinuclear RX-bridged metal carbonyl clusters (X ? N, P, As, Sb, Bi)—a very small part of carbonyl cluster chemistry—can lead to a better understanding of the general reaction principles involved. 相似文献
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Berthold Hoge Dr. Boris Kurscheid Sebastian Peuker Wieland Tyrra Hendrik T. M. Fischer 《无机化学与普通化学杂志》2007,633(10):1679-1685
The reaction of the sterically shielded phosphane derivative, dichlorodiethylaminophosphane, Cl2PNEt2, with an excess of a mixture of 2,6‐bis(trifluoromethyl) and 2,4‐bis(trifluoromethyl)phenyl lithium gives bis[2,4‐bis(trifluoromethyl)phenyl]diethylaminophosphane, [2,4‐(CF3)2C6H3]2PNEt2, in 72 % yield as a colourless solid, while 2,6‐bis(trifluoromethyl)phenyl lithium remains unchanged in solution. The amino derivative crystallizes in the monoclinic space group P21/c (a 869.2(1), b 1857.4(1), c 1357.6(1) pm, β 100.57(4)°, Z = 4). Treatment of [2,4‐(CF3)2C6H3]2PNEt2 in CHCl3 solution with conc. HCl allows the synthesis of [2,4‐(CF3)2C6H3)]2PCl. [2,4‐(CF3)2C6H3]2PCl reacts with H2O in THF solution with quantitative formation of the corresponding secondary phosphane oxide. To obtain bis[2,4‐bis(trifluoromethyl)phenyl]phosphinic acid, [2,4‐(CF3)2C6H3]2P(O)OH, quantitatively, a CHCl3 solution of [2,4‐(CF3)2C6H3]2P(O)H, has to be stirred in an NO2 atmosphere. The phosphinic acid crystallizes is the triclinic space group (a 754.2(1), b 927.6(2), c 1305.5(2) pm, α 85.11(2)°, β 75.45(1)°, γ 79.99(2)°, Z = 2). From the reaction of the phosphinic acid with either elemental sodium or with cyanide salts, the corresponding phosphinate salts are obtained in an almost quantitatively yield. 相似文献
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The Cu(acac)2 catalyzed reactions of dimethyl diazomalonate with enaminones yielded 1,5-cyclization and α-CH insertion products. In the case of anilino derivatives (R1 or R2 = Ph), products resulting from an unusual insertion to the benzoyl ring dominated the reaction. 相似文献
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M. Regitz 《Angewandte Chemie (International ed. in English)》1967,6(9):733-749
When an arenesulfonyl azide, particularly p-toluenesulfonyl azide, reacts, in the presence of a base, with a compound containing an active methylene group, the two hydrogen atoms of the active methylene group are replaced by a diazo group to form a diazo compound and an arenesulfonamide. The method may be used for the synthesis of the diazo derivatives of cyclopentadienes, cyclohexadienes, 1,3-dicarbonyl, 1,3-disulfonyl, and 1,3-ketosulfonyl compounds, ketones, carbonic acid esters, and β-iminoketones. Secondary reactions can lead to azo compounds and heterocycles such as 1,2,3-triazoles, 1,2,3-thiadiazoles, and pyrazolin-4-ones. Azidinium salts react in the same way, but in this case an acidic reaction medium is necessary, a fact that is sometimes advantageous. 相似文献
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Carbene transfer to appropriate substrates is a highly versatile tool for the construction of carbon frameworks with increased functional and structural complexity. In this study, some novel cyclopropane derivatives were synthesized via carbenoid reactions and their further reactivities were investigated. (1E)‐Buta‐1,3‐dien‐1‐yl acetate was reacted with four different diazocarbonyl compounds, ethyl diazoacetate, dimethyl diazomalonate, 1‐diazo‐1‐phenylpropan‐2‐one, and methyl (3E)‐2‐diazo‐4‐phenylbut‐3‐enoate, in the presence of two catalysts. All synthesized substituted cyclopropanes were obtained chemoselectively with respect to less‐hindered C?C bonds. Under the applied conditions, while cyclopropanes 7a and 7d underwent further reactions, cyclopropanes 7b and 7c were stable enough. Cyclopropanes 7a and an additional equivalent of ethyl diazoacetate yielded polyfunctionalized cyclohexenes. Cyclopropanes from methyl (3E)‐2‐diazo‐4‐phenylbut‐3‐enoate yielded polyfunctionalyzed cycloheptadiene isomers by Cope rearrangement. 相似文献
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铜催化C—S偶联反应是有机合成中的重要手段,近年来一直是有机化学和催化化学的研究热点之一.按照反应中所使用的配体的不同对铜催化C—S偶联反应的研究新进展进行了综述. 相似文献