Cover Picture: Recent Advances in Transition Metal‐Catalyzed Asymmetric Radical Reactions (Chin. J. Chem. 3/2018)

The control of stereoselectivity in radical reactions is of great importance, but remains a formidable challenge. The cover picture shows that the enantiomerically pure compounds can be prepared in radical transformations using chiral transition metal complexes as catalysts. Recent advances are summarized in the review by Kong et al. on page 247–256.

     

Cover Picture: Understanding Zeolites Catalyzed Methanol‐to‐Olefins Conversion from Theoretical Calculations (Chin. J. Chem. 5/2018)

The cover picture shows the complexity of the reaction mechanism of zeolites catalyzed methanol‐to‐olefins (MTO) conversion. The MTO process plays a vital role in the production of light olefins from nonpetroleum resources. Despite of the successful industrialization of the MTO process in China, the detailed reaction mechanism is not yet well understood. The theoretical studies on the MTO hydrocarbon pool mechanism by the Group of Xie are summarized in the Chemistry Author Up Close by Xie et al. on page 381–386.

     

Back Cover: Asymmetric Synthesis of Chiral α‐Substituted Mercaptoglycine Derivatives via α‐Sulfenylation of Ni(II) Complex of Glycine and S‐Substituted 4‐Methylbenzenesulfonothioate (Chin. J. Chem. 9/2017)

The back cover picture shows the asymmetric synthesis of α ‐substituted mercaptoglycine via nickel(II) complex. The α ‐substituted mercaptoglycine is an important framework of various peptide drugs and nickel(II) complex can be utilized to generate single enantiomer of α ‐substituted amino acid efficiently. This work establishes an efficient method to access α ‐substituted mercaptoglycine with good yield and high stereoselectivity, which can promote the design of new peptide drugs in a broad scope. More details are discussed in the article by Wang et al. on page 1383‐1390.

     

Back Cover: Synthesis,Nematicidal Activity,and 3D‐QSAR of Novel 1,3,4‐Oxadiazole/ Thiadiazole Thioether Derivatives (Chin. J. Chem. 10/2018)

The back cover picture shows As two important heterocyclic active groups, oxadiazole and thiadiazole are used to develop new pesticide with high efficiency and broad spectrum of biological activities. On the basis of our previous works, forty one novel 1,3,4‐oxadiazole/thiadiazole thioether derivatives were synthesized and their nematicidal activities against Tylenchulus semipenetrans were evaluated. And compound 33 was designed by using the CoMFA and CoMSIA models, which exhibited excellent nematicidal acivity in vitro. More details are discussed in the article by Song et al. on page 939‐944.

     

Cover Picture: Nickel‐Catalyzed Cross‐Electrophile Coupling of Aryl Bromides with Pyrimidin‐2‐yl Tosylates (Chin. J. Chem. 9/2017)

The cover picture shows a new protocol for the NiCl₂ ‐catalyzed cross‐electrophile coupling of aryl bromides with pyrimidin‐2‐yl tosylates to give the corresponding C2 ‐arylation pyrimidine derivatives. This study provides an improvement over previous methods by using pyrimidin‐2‐yl tosylates instead of halides as coupling partners that are stable and easily available. More details are discussed in the article by Wang et al. on page 1366–1370.

     

Back Cover: Dual Stereocontrol for Enantioselective Hydrogenation of Dihydroisoquinolines Induced by Tuning the Amount of N‐Bromosuccinimide (Chin. J. Chem. 2/2018)

The back cover picture shows an efficient dual enantioselective synthesis of 1‐substituted 1,2,3,4‐tetrahydroisoquinoline, which was realized through iridium‐catalyzed hydrogenation of 1‐substituted 3,4‐dihydroisoquinolines. Only tuning the amount of N‐bromosuccinimide, this reaction promoted by (R)‐BINAP is able to furnish both enantiomers of products up to 89% ee (S) and 98% ee (R), respectively. Dual activation role of N‐bromosuccinimide is proposed to be responsible for the reversal of enantioselectivity under two hydrogenation conditions. More details are discussed in the article by Zhou et al. on page 139–142.

     

Inside Cover: Synthetic Strategies for Constructing Two‐Dimensional Metal‐Organic Layers (MOLs): A Tutorial Review (Chin. J. Chem. 8/2018)

The inside cover picture shows Metal‐organic layer (MOL), the two‐dimensional analog of metal‐organic framework (MOF), is a new member of two‐dimensional materials. This tutorial review summarizes current synthetic approaches for MOL preparation. More details are discussed in the article by Wang et al. on page 754–764.

     

Inside Back Cover: Cu(II)‐Catalyzed Ligand‐Free Oxidation of Diarylmethanes and Second Alcohols in Water (Chin. J. Chem. 9/2017)

The inside back cover picture shows a simple and efficient Cu(II )‐catalyzed ligand‐free oxidation of diarylmethanes and secondary alcohols using 70% TBHP in water. A series of diarylmethanes were directly oxidized into diaryl ketones in 67%–98% yields. Additionally, various secondary alcohols were also transformed into the desired products in 48%–98% yields. Importantly, the catalytic system in the absence of any organic solvent, surfactant, or phase transfer agent, had a wide substrate scope and a high tolerance for various functional groups. More details are discussed in the article by Liu et al. on page 1391–1395.

     

Back Cover: Lactonization of C(sp2)—H Bonds in Enamides with CO2 (Chin. J. Chem. 5/2018)

The back cover picture shows a novel synthesis of 1,3‐oxazin‐6‐ones from enamides with CO₂ through C—H carboxylation and one‐pot cyclization. The concept of “CO₂ = CO + O”, using CO₂ to replace toxic CO and stoichiometric oxidant, guilds the development of this chemistry as well as green and safe synthetic methods in the future. More details are discussed in the article by Yu et al. on page 430–436.

     

Inside Cover: Temperature‐responsive Catalyst for the Coupling Reaction of Carbon Dioxide and Propylene Oxide (Chin. J. Chem. 4/2018)

The inside cover picture shows a temperature controllable porphyrin aluminum catalyst using 5,10,15,20‐tetra(1,2,3,4,5,6,7,8‐octahydro‐1,4:5,8‐dimethanoanthracen‐9‐yl)porphyrin as ligand, which showed significantly temperature‐responsive selectivity in the coupling reaction of CO₂ and PO. Only cycloaddition reaction happened at temperature above 75 °C to produce 100% CPC, whereas copolymerization became dominant to afford PPC with selectivity over 91% at temperature below 50 °C. More details are discussed in the article by Wang et al. on page 299–305.

     

Back Cover: Asymmetric Synthesis of the Ring A Substructure of Genkwadane A (Chin. J. Chem. 9/2018)

The back cover picture shows Genkwadane A was isolated from the flower buds of Daphne genkwa which shows bioactivity against HeLa, HepG2, HT‐1080, MCF‐7, A549, U‐937, K562 and HL60 cell lines. It is the first time that a daphnane diterpenoid bearing a 1,10‐double bond was isolated. In this paper, B. Liu and co‐workers report asymmetric synthesis of the ring A substructure of genkwadane A in 10 steps from D‐tartrate derivative. More details are discussed in the article by Liu et al. on page 831–836.

     

Back Cover: Internally Reuse Waste: Catalytic Asymmetric One‐Pot Strecker Reaction of Fluoroalkyl Ketones,Anilines and TMSCN by Sequential Catalysis (Chin. J. Chem. 4/2018)

A highly enantioselective one‐pot Strecker reaction of α‐fluoroalkyl α‐aryl ketones, anilines, and TMSCN is disclosed, which simultane‐ously reuses water byproduct and catalyst from the ketimine formation step as a promoter and an additive to improve the reactivity and enantioselectivity of the subsequent Strecker reaction, respectively. The picture shows that the chiral bifunctional tertiary amine mediated asymmetric Strecker reaction is irrigated by the water generated in the p‐TsOH catalyzed ketimine formation, and fertilized by the remaining acid catalyst. More details are discussed in the article by Zhou et al. on page 321–328.

     

Inside Cover: Upgrading CO2 by Incorporation into Urethanes through Silver‐Catalyzed One‐Pot Stepwise Amidation Reaction (Chin. J. Chem. 2/2018)

The inside cover picture shows an outline of significant advances on exhaust gas e.g. sustainable CO₂ recycling into urethanes via effective and renewable silver catalysis. Through one‐pot two‐step stepwise reaction of propargylic alcohols, CO₂, and various amines, a wide range of urethanes are obtained in excellent yields and selectivity together with unprecedented high TON and TOF value under mild conditions. Here, robust catalyst is compared to Magician's hand for its versatility in organic synthesis, and the picture indicates the meanings of greenness and transformation. More details are discussed in the article by Zhang et al. on page 147–152.

     

Cover Picture: Palladium‐Catalyzed Intermolecular Oxidative Coupling Reactions of (Z)‐Enamines with Isocyanides through Selective β‐C(sp2)‐H and/or C=C Bond Cleavage (Chin. J. Chem. 8/2018)

The cover picture shows Two efficient intermolecular oxidative coupling reactions of (Z)‐enamines with isocyanides via palladium catalysis have been developed. In these transformations, the β‐C(sp²)‐H and/or C ＝ C bond were cut off selectively by using different anionic ligands, leading to controllable chemodivergent and stereoselective construction of a wide range of (E)β‐carbamoylenamine derivatives with intramolecular hydrogen bonds. More details are discussed in the article by Jiang et al. on page 712–715.

     

Cover Picture: Construction of Crown Ether‐Stoppering [3]Rotaxanes Based on N‐Hetero Crown Ether Host (Chin. J. Chem. 7/2017)

The cover picture shows shows the construction of crown etherstoppering [3]rotaxanes based on N ‐hetero crown ether host. Usually, crown ethers play the role of host macrocycles to combine with the guest molecules in the construction of rotaxanes. Based on the fact that crown ethers have large dimension, two [3]rotaxanes containing four crown ether units were designed and synthesized, of which, two N ‐hetero crown ether components were employed as the macrocyclic hosts to assemble the mechanically interlocked framework by using a template‐directed clipping reaction while bis (metaphenylene‐26‐crown‐8) located on two sides of template diammonium acting as the stoppering groups of [3]rotaxanes. More details are discussed in the article by Yin et al. on page 1050–1056.

     

Cover Picture: Visible Light Accelerated Vinyl C–H Arylation in Pd‐Catalysis: Application in the Synthesis of ortho Tetra‐substituted Vinylarene Atropisomers (Chin. J. Chem. 1/2018)

The cover picture shows a protocol of a palladium‐catalyzed arylation of vinylarenes with diaryliodonium salts with the assistance of visible light. A palladium‐vinylarene complex may be excited via the visible light irradiation, where the kinetic isotope effect (k_H/k_D) was around 1.1. However under darkness, the reaction proceeded very slowly, and the kinetic isotope was found as 3.6, indicating the C—H bond cleavage step is the rate‐determining step. This protocol avoided high reaction temperature and enabled us to access a series of ortho tetra‐substituted vinylarene atropisomers with high enantiospecificity. More details are discussed in the article by Gu et al. on page 11–14.

     

Cover Picture: Electrochemical Synthesis of (Aza)indolines via Dehydrogenative [3+2] Annulation: Application to Total Synthesis of (±)‐Hinckdentine A (Chin. J. Chem. 10/2018)

The cover picture shows an electricity powered dehydrogenative [3+2] annulation reaction of (hetero)arylamines with tethered di‐, tri, and tetra‐substituted alkenes for the preparation of indoline and azaindoline products. The electrochemical reactions proceed through H2 evolution and thus avoid the use of stoichiometric chemical oxidants. This method, which is applicable to the preparation of highly functionalized (aza)indoline scaffold, enables the total synthesis of (±)‐hinckdentine A in 12 steps. More details are discussed in the article by Xu et al. on page 909–915.

     

Inside Cover: General Reductive Amination of Aldehydes and Ketones with Amines and Nitroaromatics under H2 by Recyclable Iridium Catalysts (Chin. J. Chem. 9/2017)

The inside cover picture shows secondary and tertiary amines, which are important intermediates in organic synthesis for the preparation of natural products, pharmaceutical and agronomical compounds. The direct reductive amination of aldehydes and ketones represents a powerful tool for the preparation of secondary and tertiary amines. Here, direct and general reductive amination of aldehydes and ketones with amines and nitroaromatics was presented under H₂ using recyclable iridium catalysts, and lots of secondary and tertiary amines were produced in high yields. Moreover, the heterogeneous iridium catalysts Ir@NC(600‐2h) can be reused several times without evident deactivation. More details are discussed in the article by Huang et al. on page 1371–1377.

     

Inside Cover: Structural Designs for Accommodating Volume Expansion in Sodium Ion Batteries (Chin. J. Chem. 9/2018)

The inside cover picture shows that four effective routes are applied to the anode material to help it keep fit, which is out of shape due to the intake of sodium ions. As a result, the sodium ion batteries (SIBs) with this anode exhibit high electrochemical performances, so that they tend to meet the demand for large‐scale energy storage devices. In this review, four strategies based on structural designs are summarized in order to accommodate volume changes of anode materials in SIBs, including nanoarchitecture configuration, buffer matrix protection, cavity volume reservation, and interlayer spacing regulation. More details are discussed in the review by Fu et al. on page 866–874.

     

Inside Back Cover: Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand (Chin. J. Chem. 8/2017)

The inside back cover picture shows the allosteric modulation of human serum albumin (HSA) induced by the Peptide SA06 ligand. Peptide SA06 is a reported peptide ligand comprising 20 amino acids, and is known to non‐covalently bind with HSA to extend the lifetime and improve the pharmacokinetic performance of drug molecules. The structural evidence on the allosteric interaction between peptide ligand and HSA, and the structure‐affinity relations of the binding mechanism have been revealed in this work, which can also shed light on optimization of therapeutic properties in the affinity‐controlled delivery systems. More details are discussed in the article by Wang et al. on page 1270–1277.