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1.
An efficient one‐pot synthesis of spiro[indoline‐3,1′‐pyrazolo[1,2‐b]phthalazine] derivatives via three‐component reaction of phthalhydrazide, isatin, and malononitrile (cyanoacetic ester) is described. This new protocol has the advantages of high efficiency, mild reaction conditions, one‐pot procedure, and convenient operation. 相似文献
2.
Saleh M. Al‐Mousawi Mohammad A. Mohammad Mohamad H. Elnagdi 《Journal of heterocyclic chemistry》2001,38(4):989-991
While 3(5)‐aminopyrazole reacts with enaminonitrile to yield pyrazolo[1,5‐a]pyrimidines, 3‐amino‐5‐pyrazolone reacts with the same reagents to yields pyrazolo[3,4‐b]pyridines. 相似文献
3.
Green Synthesis of Spiro[indoline‐3,4′‐pyrazolo[3,4‐b][1,6]naphthyridine]‐2,5′(1′H)‐diones Catalyzed by TsOH in Ionic Liquids 下载免费PDF全文
Bin‐Bin Feng Rong‐Zhang Jin Mei‐Mei Zhang Xiang‐Shan Wang 《Journal of heterocyclic chemistry》2016,53(5):1578-1583
A three‐component reaction of isatin, 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine, and piperidine‐2,4‐dione was treated in ionic liquids catalyzed by TsOH and provided an efficient and green method for the synthesis of spiro[indoline‐3,4′‐pyrazolo[3, 4‐b][1,6]naphthyridine]‐2,5′(1′H)‐dione derivatives in high yields. 相似文献
4.
The three‐component reaction of thiazole (benzothiazole), dialkyl but‐2‐ynedioate, and isatinylidene malononitriles in toluene at 110–120°C in a sealed tube afforded a mixture of cis/trans‐isomers of functionalized diastereoisomeric spiro[indoline‐3,7′‐thiazolo[3,2‐a]pyridines] and spiro[benzo[4,5]thiazolo[3,2‐a]pyridine‐3,3′‐indolines] in good yields. Both cis‐isomers and trans‐isomers were successfully separated out and fully characterized with spectroscopy and single crystal determination. Under similar conditions, the three‐component reaction containing 2‐(1,3‐dioxo‐1H‐inden‐2(3H)‐ylidene)malononitrile resulted in spiro[indene‐2,7′‐thiazolo[3,2‐a]pyridine] derivatives. 相似文献
5.
Mahmoud A. Mohamed 《Journal of heterocyclic chemistry》2012,49(1):200-203
Cyclocondensation of cyanoacetamide and cyanothioacetamide with sodium salt of 3‐hydroxy‐1‐(pyridin‐3‐yl)prop‐2‐en‐1‐one gave 6‐oxo‐[2,3′]bipyridine 5a and 6‐thioxo‐[2,3′]bipyridine 5b derivatives, respectively. Compound 5b upon treatment with different methylenes 8 gave thieno[2,3‐b]pyridines 10 . Treatment of 5b with iodomethane gave bipyridine derivative 7 , which cyclocondensed with hydrazines 11 to give pyrazolo[3,4‐b]pyridines 13 . J. Heterocyclic Chem., (2012). 相似文献
6.
Novel spiro[pyrazolo[3,4‐b]pyridine‐4,3′‐indoline] derivatives were prepared by the three‐component reaction of isatins 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine and Meldrum's acid in the presence of a catalytic amount of melamine trisulfonic acid. This protocol provides a simple one‐step procedure with the advantages of easy work‐up, mild reaction conditions and environmentally benign. 相似文献
7.
An efficient synthetic procedure for the functionalized spiro[indoline‐3,4′‐pyridine] was developed via the four‐component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages of this reaction are using common starting material, mild reaction conditions, broad scope of reactants and operational simplicity. 相似文献
8.
A facile, solvent free, ecofriendly approach for the synthesis of 2‐amino‐3(ethylcarboxy)‐4,6‐disubsti‐tuted pyridine 4 and pyrazolo[3,4‐b]pyridines 6 is herein described employing neat reaction conditions under microwave irradiation. This solventless methodology is environmentally benign as it completely eliminates the use of solvent from the reaction procedure. The observed reaction rate enhancement and high yield of products are due to the neat reaction conditions coupled with microwaves (MWs). 相似文献
9.
Ramin Ghahremanzadeh Mojtaba Mirhosseini Moghaddam Ayoob Bazgir Mohammad Mehdic Akhondi 《中国化学》2012,30(2):321-326
A four‐component reaction in the presence of Alum [KAl(SO4)2·12H2O] as an inexpensive and reusable catalyst using the ionic liquid as an effective green reaction media is reported. 相似文献
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The three‐component reaction of N‐phenacylbenzothiazolium bromides, aromatic aldehydes and indane‐1,3‐dione in ethanol at room temperature in the presence of triethylamine as base afforded functionalized spiro[benzo[d]pyrrolo[2,1‐b]thiazole‐3,2′‐indenes] in good yields and with high diastereoselectivity. The 1H NMR data and single crystal structure clearly indicated that the obtained spiro compounds predominately have one diastereoisomer. 相似文献
12.
《Journal of heterocyclic chemistry》2017,54(5):2922-2928
A highly efficient catalyst‐free1,3‐dipolar cycloaddition reaction of methyleneindolinones and C ,N‐cyclic azomethine imines was realized. The reactions afforded a large variety of spirooxindoles in high yields (up to 99%) and excellent diastereoselectivities (dr > 20:1). Furthermore, the configuration of one of the products was determined on the basis of X‐ray structural analysis. Accordingly, a possible transition‐state model was proposed. 相似文献
13.
《Journal of heterocyclic chemistry》2018,55(4):871-878
An efficient and green reactions of isatins, 3‐amine‐1H‐pyrazole (5‐methyl‐1H‐pyrazol‐3‐amine) and 1,3‐diketone in aqueous medium for the synthesis of novel 1′,7′,8′,9′‐tetrahydrospiro[indoline‐3,4′‐pyrazolo[3,4‐b]quinoline]‐2,5′(6′H)‐dione derivatives were reported in this research. The advantages of this reaction are simple operation, mild‐reaction conditions, wide scope substrate, high yields, and friendly environment. The products were confirmed by IR, 1H NMR, 13C NMR, and HRMS. 相似文献
14.
Microwave‐Assisted Three‐Component Reactions Leading to Pyrano‐Fused Pyrazolo[3,4‐b]pyridines 下载免费PDF全文
Bi‐Hui Xu Man‐Su Tu Yin‐Ping Liu Bo Jiang Xing‐Hang Wang Shu‐Jiang Tu 《Journal of heterocyclic chemistry》2014,51(6):1591-1594
A series of pyrano‐fused pyrazolo[3,4‐b]pyridine derivatives with an aryl group presenting the 2‐position of the pyridine nucleus have been synthesized by microwave‐assisted three‐component reactions of aldehydes, tetrahydropyran‐4‐one, and 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine in HOAc. This method is very efficient because of short reaction times and easy work‐up, and it provides an efficient and promising synthetic strategy for the construction of the tricyclic pyrano‐fused pyrazolo[3,4‐b]pyridine skeleton. 相似文献
15.
Synthesis of Pyrido[2′,3′: 3,4]pyrazolo[1,5‐a]pyrimidine,Pyrido[2′,3′:3,4]pyrazolo[5,1‐c][1,2,4]triazine,and Pyrazolyl Oxadiazolylthieno[2,3‐b]pyridine Derivatives 下载免费PDF全文
Nora M. Rateb 《Journal of heterocyclic chemistry》2014,51(5):1349-1356
6‐(2‐Thienyl)‐4‐(trifluoromethyl)‐1H‐pyrazolo[3,4‐b]pyridine‐3‐amine reacted with different active methylene compounds to afford pyridopyrazolopyrimidine derivatives. On the other hand, it reacted with some halo compounds to give the imidazo[1′,2′:1,5]pyrazolo[3,4‐b]pyridine derivatives. Also, it diazotized to give the corresponding diazonium chloride that is coupled with several active methylene compounds to give the corresponding triazine derivatives. Furthermore, compound 3‐amino‐6‐(2(thienyl)‐4‐(trifluoromethyl)thieno[2,3‐b]pyridine‐2‐carbohydrazide reacted with some β‐dicarbonyl compounds and some sulfur‐containing compounds to afford the corresponding pyrazolyl oxadiazolylthieno[2,3‐b]pyridine derivatives. 相似文献
16.
Dhananjay B. Kendre Raghunath B. Toche Madhukar N. Jachak 《Journal of heterocyclic chemistry》2008,45(5):1281-1286
Synthesis of novel pyrazolo[3,4‐b]pyridines has been achieved successfully by sequence of Gould ‐ Jacobs reaction between 5‐aminopyrazole and diethylethoxymethylenemalonate in good yield. Further the pyrazolo[3,4‐b]pyridines were converted into succinimidoyl active esters which are then replaced by biological samples such as amino acids and carbohydrate in slightly aqueous medium. 相似文献
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18.
2,3‐Dihydro‐1,3,4‐thiadiazoles, pyrazoles, pyrazolo[3,4‐d]pyridazines, thieno[2,3‐b]pyridines, pyrim‐idino[4′,5′:4,5]thieno[2,3‐b]pyridines and pyrrolo[3,4‐d]pyrazoles were obtained in a good yields by treatment of hydrazonoyl halides with each of alkyl carbodithioates, 3‐(dimethylamino)‐1‐naphtho[1,2‐d]furan‐2‐ylprop‐2‐en‐1‐one and N‐arylmalemides. 相似文献
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20.
Khosrow Jadidi Ramin Ghahremanzadeh Peiman Mirzaei Ayoob Bazgir 《Journal of heterocyclic chemistry》2011,48(5):1014-1018
A one‐pot, three‐component method for the efficient and simple synthesis of novel 2′‐amino‐8′,9′‐dihydro‐3′H‐spiro[indoline‐3,5′‐pyrimido[4,5‐b]quinoline]‐2,4′,6′(7′H,10′H)‐trione derivatives in aqueous media is reported. J. Heterocyclic Chem., (2011). 相似文献