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合成了3种BINOL双酰胺(Ⅰ~Ⅲ),其结构经1H NMR, 13C NMR, HR-MS(ESI)和元素分析确证。研究了I~III对取代吲哚和硝基烯烃的Friedel-Crafts烷基化反应的催化性能,并对反应条件进行了优化。结果表明:在最优条件(CH2Cl2为溶剂,Ⅰ为催化剂,于40 ℃反应12 h)下,吲哚及取代吲哚与硝基烯烃均能有效的进行Friedel-Crafts烷基化反应,收率和ee值最高可达88%和90%。 相似文献
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苯并呋喃衍生物和吲哚衍生物广泛存在于天然产物中,普遍具有生物活性.缩醛是被频繁使用的羰基保护基团.在TMSOTf和三甲基吡啶作用下,芳香基和烷基缩醛都可以直接与苯并呋喃或者吲哚发生烷基化反应;缩醛的两个烷氧基被苯并呋喃或者吲哚取代生成双苯并呋喃或双吲哚甲烷衍生物,与苯并呋喃相比,吲哚烷基化反应的得率较高.环状缩醛、含有氨基的缩醛和丙酮缩二甲醇也可以直接发生烷基化反应,反应条件温和.缩醛的一个烷氧基被吲哚取代的产物及其被转化为双取代产物的实验结果为反应机理提供了证据. 相似文献
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由于手性3-取代吲哚化合物是许多具有生物活性天然产物和药物分子的核心骨架,其合成方法的研究就格外令人注目.尤其是近二十年来,利用手性金属配合物和有机小分子催化剂实现吲哚的C(3)位不对称傅-克烷基化反应已成为有机界广泛研究的热点.按照促进不对称傅-克烷基化反应的手性催化剂进行分类,就近年来其在3-取代吲哚化合物合成中的应用加以综述,并对今后的发展方向进行了展望. 相似文献
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A few kinds of novel Schiff base complexes have been prepared by three component reaction of the substituted hydroxyacetophenone with several aliphatic diamines and transition metals such as; Ni(II), Zn(II) and UO2(II) under mild reaction conditions. The products have been afforded with excellent yields and appropriate reaction times. The structure of these ligands has been characterized by their IR, 1H NMR, 13C NMR and MS spectral and physical data. 相似文献
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通过异丙氧基铝和邻苯二甲酸酐、乙酰乙酸乙酯及丙烯酸反应,合成了螯合物单体邻苯二甲酸异丙酯酰氧基-丙烯酰氧基-乙酰乙酸乙酯络铝,由自由基聚合法合成了聚合物,用元素分析仪、VPO、IR、1HNMR和27AlNMR证实了它们的结构,并研究了它们在DMF中的荧光性质。 相似文献
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Horseradishperoxidase(HRP)canstronglycatalyzethereactionofH2O2oxidizingophenylenediamine(OPD),thechromaticproductofwhichcanbedetectedinenzymelinkedimmunosorbentassay(ELISA)withspectrophotometry[1].Involtammetricenzymelinkedimmunoassay[2—4],OPDH2O2HRPsystemhasf… 相似文献
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Schröder H 《Combinatorial chemistry & high throughput screening》2003,6(7):741-753
Solid phase synthesis has become a routine technique in combinatorial chemistry. The need in analytical methods to characterize nondestructively resin bound molecules has been fulfilled by the introduction of High Resolution Magic Angle Spinning (HR MAS) NMR of solvent swollen beads. HR MAS NMR can give solution like proton NMR spectra and one- and two-dimensional NMR techniques are amenable, allowing detailed structure analysis. Recent developments are the application of a diffusion filter to suppress solvent signals and dipolar recoupling techniques to gain spatial information. HR MAS NMR has been applied to monitor reactions and elucidate reaction products. 相似文献
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D. A. Surovtseva D. A. Orlov T. A. Morozova A. V. Krylov A. P. Belov 《Kinetics and Catalysis》2006,47(6):855-857
The allyl complex di-μ-chloro-bis[(1,2,3-η)-1-carboxy-3-(1-hydroxyethyl)allyl]dipalladium (which is a hydroxyl-containing palladium η3-allyl complex based on sorbic acid) has been synthesized from trans,trans-2,4-hexadienic (sorbic) acid and Na2PdCl4 in an aqueous solution. The complex has been isolated from the reaction solution and has been characterized by IR, 1H NMR, and 13C NMR spectroscopy. Its composition has been determined by elemental analysis. The protodemetalation kinetics of the complex in aqueous solutions has been studied. The rate of this reaction obeys a second-order equation, first-order with respect to each reactant. A reaction mechanism has been derived from protodemetalation kinetics and data characterizing the state of the reactants. 相似文献
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M. A. Madre É. É. Liepin'sh R. A. Zhuk O. V. Sakhartova M. Yu. Lidak 《Chemistry of Heterocyclic Compounds》1986,22(4):425-431
The reaction of bis(trimethylsilyl)hypoxanthine with methyl trichloromethyl ether has been investigated. 1-Methoxymethyl-, 7-methoxymethyl-, and 9-methoxymethyl-hypoxanthine, as well as 1,7-, 1,9-, and 3,7-bismethoxymethylhypoxanthine, have been isolated from the reaction mixture. The structures of the isomers have been established on the basis of an analysis of their UV, IR, 1H NMR, 13C NMR, and 15N NMR spectra. The influence of the conditions under which the reaction is carried out on the yield of the alkylation products and the isomeric composition of the reaction mixture has been studied.For report 2, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 518–524, April, 1986. 相似文献
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The DABCO-catalyzed (DABCO = 1,4-diazabicyclo[2.2.2]octane) reaction of but-3-yn-2-one and methyl propiolate with salicyl N-tosylimines yields highly functionalized chromenes and has been thoroughly investigated; the rational mechanism for the reaction has been demonstrated on the basis of 1H NMR spectroscopic investigation. 相似文献
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通过乙酸1-(2-二苯膦基二茂铁基)-乙基酯和二甘醇反应,制得新的醚基化的二茂铁基膦配体2-二苯膦基二茂铁基-乙基-5-羟基-3-氧杂戊醚(产率77%),其结构经1H NMR、13C NMR、31P NMR及MS鉴定。 初步研究发现,该醚基化的二茂铁基膦可作为支持配体应用于钯催化的Suzuki反应中,可催化溴代芳烃及带吸电子基的氯代芳烃与苯基硼酸偶联反应制得相应的联芳烃。 催化反应数据表明,配体中的醚氧与Pd中心的配位作用对提高该Pd催化剂的催化性能有一定贡献。 相似文献