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1.
Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl_2 catalyst 总被引:2,自引:0,他引:2
Albert S.C.Chan 《中国化学快报》2009,20(4):407-410
β-Amino esters were synthesized via ZnCl_2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min.Theβ-amino ester was converted into the corresponding aspartic acid derivatives. 相似文献
2.
Chun Xu Lü 《中国化学快报》2010,21(1):31-34
<正>Cerium trichloride heptahydrate(CeCl_3·7H_2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone.This protocol has advantages of high yield,no environmental pollution,mild condition,and simple work-up procedure. 相似文献
3.
Gassa F Contini A Fontana G Pellegrino S Gelmi ML 《The Journal of organic chemistry》2010,75(21):7099-7106
A very efficient three-component synthesis of a series of syn α-hydroxy-β-amino esters, obtained in high diastereoselection and yield, was realized starting from an aldehyde, benzylamine, and the ketene silyl acetals derived from Ley's lactones. The synthetic protocol was optimized and the above compounds were obtained without the isolation of intermediates. The origin of the observed diastereoselection was investigated through a computational model of the key reaction step. 相似文献
4.
HE Ming PAN ZhaoXi BAI Song LI Pei ZHANG YuPing JIN LinHong HU DeYu YANG Song SONG BaoAn 《中国科学:化学(英文版)》2013,56(3):321-328
The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1,3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety.The adducts were isolated with high enantiomeric excess(up to 99%). 相似文献
5.
A simple and efficient method has been developed for the synthesis ofα-amino nitriles from aldehydes,amines and trimethylsilyl cyanide(Me3SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature. 相似文献
6.
Jaiprakash N. Sangshetti ;Nagnnath D. Kokare ;Sandeep A. Kotharkar ;Devanand B. Shinde 《中国化学快报》2008,19(7):762-766
A simple one-pot synthetic method for the preparation of 2,4,5-triaryl-lH-imidazoles from benzoin or benzil, ammonium acetate, aromatic aldehydes, and ZrOCl2-8H2O catalyst is described. The ZrOCl2-8H2O catalyst was found to be equally effective for aromatic and heteroaromatic aldehydes and also for the preparation of substituted 1,4-di(4,5-diphenylimidazol-yl) benzene. 相似文献
7.
Maasoumeh Jafarpour Abdolreza Rezaeifard Mahdieh Heidari 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1470-1482
Abstract Operationally simple and environmentally benign methods for some organic transformations comprising reductive coupling of sulfonyl chlorides, chemoselective deoxygenation of sulfoxides, and halogenation of alcohols mediated by ZrOCl2·8H2O/MX in water have been developed. GRAPHICAL ABSTRACT 相似文献
8.
Pramod Kulkarni Balaji Totawar Pudukulathan K. Zubaidha 《Monatshefte für Chemie / Chemical Monthly》2012,141(10):625-629
Abstract
Various β-aminoketones were synthesized in a three-component reaction of ketones, aldehydes, and amines in the presence of calcium chloride as catalyst in ethanol in high yields as compared to other synthetic methods. The advantages of this new method are a short reaction time (2 h), high yields, easy workup, convenience, low cost, and eco-friendly protocol. 相似文献9.
10.
Megharaja Holiyachi Samundeeswari L. Shastri Bahubali M. Chougala Vinay A. Sunagar 《合成通讯》2016,46(16):1386-1395
Organocatalyzed direct intermolecular aldol reactions have been developed for substituted 4-formylcoumarins with acetone in water using L-proline and phthalimido-prolinamide catalysts without use of additives. Stereoselective products obtained were in excellent yields (up to 97%) with high purity (up to 99%) and enatioselectivities (up to 95%). The isolated compounds were confirmed by infrared, NMR, high-performance liquid chromatography, and mass spectrometry and some of them by single-crystal x-ray crystallography. 相似文献
11.
Murali Krishna Kolli Palani Elamathi Vishweshwar Rao Katta Gajendrasinh Balvantsinh Raolji 《合成通讯》2018,48(6):638-649
One-pot synthesis of α-aminophosphonates directly from aryl nitro compounds, aldehydes/ketones, and diethyl phosphite using sodium dithionite through reduction and followed by Kabachnik–Fields reaction under metal-free conditions is reported. The major advantages are excellent yield, high chemoselectivity, neutral reaction medium, and simple experimental procedure. This methodology consists of the following steps: 1) amine formation from nitro compound, 2) imine formation from amine and aldehyde/ketone, 3) phosphate addition to imine. 相似文献
12.
A series of insoluble salts of Keggin heteropoly compounds were prepared and used as catalysts for the Mannich-type reaction of benzaldehyde, aniline, and cyclohexanone in water. Among them, Cs2.5H0.5PW12O40 showed excellent catalytic activity. Effects of surfactant, catalyst loading and temperature were studied to introduce the best reaction condition. The optimized reaction conditions were extended to Mannich reaction of various aldehydes, ketones, and amines in water. This rapid procedure afforded structurally divers β-amino ketones with major anti diastereoselectivity. Additionally, four new compounds were reported. The catalyst was recovered and reused for subsequent runs. 相似文献
13.
《Tetrahedron: Asymmetry》2000,11(12):2509-2523
The asymmetric synthesis of N-phenylethyl-2-phenyldecahydroquinolin-4-ones was performed via a Lewis acid catalyzed imino-Diels–Alder reaction between the enantiopure (R)-N-phenylethylbenzylideneimine and the trimethylsilyl enol ether of acetylcyclohexene. The regio- and stereoselective formation of intermediary bicyclic enoxysilanes, followed by their stereoselective protonation was evidenced. The initial stereoselectivity was kept only if the reaction mixture was treated using controlled basic conditions. Three enantiopure title compounds were isolated with a 5–15% yield. 相似文献
14.
15.
Hong-Ying Niu Ling-Yun Su Shi-Xia Bai Jian-Ping Li Xi-Lan Feng Hai-Ming Guo 《中国化学快报》2017,28(1):105-108
C8-Alkyl-substituted purine analogues were synthesized through direct alkylation of 8-H purine with tetrahydrofuran in the presence of Co catalyst in one step. The reactions gave a series of novel C8-oxygen heterocyclic alkyl purine compounds in good yields under mild reaction conditions by the readily available alkylating reagents, providing a complementary route to the classical coupling reactions for the synthesis of C8-alkyl-substituted purine analogues. 相似文献
16.
Nataliia Gorodylova Petra Šulcová Monika Bosacka Elżbieta Filipek 《Journal of Thermal Analysis and Calorimetry》2014,118(2):1095-1100
In this paper, we report results of thermoanalytical investigation on the reaction between ZrOCl2·8H2O and (NH4)2HPO4 in molar ratio 1:2. Differential thermal-thermogravimetric and X-ray diffraction analyses were performed in order to reveal the chemical transformations, which took place during heating of the individual compounds ZrOCl2·8H2O, (NH4)2HPO4 and the mixture ZrOCl2·8H2O:2(NH4)2HPO4. It was shown that the transformations in the mixture below 160 °C were connected with dehydration of ZrOCl2·8H2O and interaction between the components of the mixture, which resulted in the formation of NH4Cl, NH4H2PO4 and a mainly amorphous zirconium phase, most likely t-ZrO2. The zirconium component subsequently reacted with ammonium dihydrophosphate (below 200 °C) or with dehydrated phosphate derivatives (above 200 °C), which in both cases yielded an amorphous product. The interaction between the components of the mixture resulting in the formation of ZrP2O7 was completed by its crystallisation at 610 °C. Our study indicates an alternative low-temperature approach for the synthesis of the technologically important ZrP2O7 material. 相似文献
17.
Zhiguo Zhang Dan Wang Bing Wang Qingfeng Liu Tongxin Liu Wei Zhang Beibei Yuan Zhijia Zhao Dandan Han Guisheng Zhang 《Tetrahedron》2013
This paper presents an alternative route to γ-amino ketones via a SnCl4·5H2O mediated ring-opening reaction of the 4,5-dihydropyrroles with the advantages of readily available reactants, good to excellent yields and applicability to a wide range of substrates. 相似文献
18.
(6-Amino-2-chloro-3-fluorophenyl)methanol is prepared through both traditional methods and palladium catalyzed iterative C–H halogenation reactions.In comparison to traditional approach,the C–H functionalization strategy demonstrated a few advantages including milder reaction conditions higher yields,better selectivity and practicality,and high chemical diversity. 相似文献
19.
Seyed Meysam Baghbanian Maryam Farhang 《Journal of the Iranian Chemical Society》2013,10(5):1033-1037
A simple and efficient method has been developed for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines in the presence of CuFe2O4 nanoparticles as a heterogeneous recyclable catalyst at room temperature in high yields. 相似文献
20.
Hui Yonghai Zhang Yongfei Luo Yongyue Li Jianpeng Wang Yun Gao Tianming Xia Jialiang Wang Sheng Zhang Shiqi 《Research on Chemical Intermediates》2021,47(2):521-532
Research on Chemical Intermediates - Mesoporous MCM-41-supported Schiff base and CuSO4·5H2O (MCM-41@Schiff base-CuSO4·5H2O) catalyzed one-pot three-component condensation of cyclic... 相似文献