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1.
A facile and rapid synthesis of the title compounds via one‐pot reaction of 2‐aminobenzonitrile, orthoesters and ammonium acetate under solvent‐free and microwave condition is described. 相似文献
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《应用有机金属化学》2017,31(12)
A series of N ‐heterocyclic carbene (NHC)/Ag systems were developed for the carboxylative assembly of propargylic alcohols and carbon dioxide (CO2). With the catalysis of these catalytic systems, a variety of target α‐alkylidene cyclic carbonates could be obtained smoothly under atmospheric CO2 pressure in straightforward one‐pot processes. Particularly, these reactions could be performed without any stoichiometric addition of bases or additives. Further mechanistic investigation reveals that the excellent activities are attributed to the effective activations of CO2 accomplished by the NHCs via the formation of the NHC‐CO2 adducts. 相似文献
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A simple and highly efficient method for the preparation of fully substituted pyrroles, from readily accessible secondary propargylic alcohols, 1,3-dicarbonyl compounds and primary amines, has been developed. The one-pot multicomponent reaction, which is catalysed by the system [Ru(eta(3)-2-C(3)H(4)Me)(CO)(dppf)][SbF(6)]/CF(3)CO(2)H (dppf: 1,1'-bis(diphenylphosphanyl)ferrocene), involves initial propargylation of the 1,3-dicarbonyl compound promoted by CF(3)CO(2)H and subsequent condensation between the resulting gamma-keto alkyne and the primary amine to afford a propargylated beta-enamino ester or ketone, which undergoes a ruthenium-catalysed 5-exo-dig annulation to form the final pyrrole. 相似文献
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Daqing Shi Shunjun Ji Lihui Niu Jingwen Shi Xiangshan Wang 《Journal of heterocyclic chemistry》2007,44(5):1083-1090
A short and facile synthesis of pyrido[2,3‐d]pyrimidine derivatives was accomplished in good yields via the three‐component reaction of aldehydes, alkyl nitriles and aminopyrimidines in water in the presence of triethylbenzylammonium chloride (TEBAC). The structures of these compounds were characterized by elemental analysis, IR and 1H NMR spectra and further confirmed by single crystal X‐ray diffraction analysis. 相似文献
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Gazaleh Imani Shakibaei Hamid Reza Khavasi Peiman Mirzaei Ayoob Bazgir 《Journal of heterocyclic chemistry》2008,45(5):1481-1484
Oxazino[5,6‐f]quinolin‐3‐one derivatives have been synthesized in a one‐pot, and efficient process by condensation of 6‐quinolinol, aromatic aldehydes and urea under microwave‐assisted and thermal solvent‐free conditions. 相似文献
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《Journal of heterocyclic chemistry》2017,54(2):1660-1664
N‐phenoxyacetyl‐1,3‐oxazolidine derivatives were synthesized by the cyclization and acylation with β‐amino alcohol, ketone, and phenoxyacetyl chloride as the starting materials. All compounds were characterized by IR, 1H NMR, 13C NMR, ESI‐MS, and elemental analysis. The configuration of 4a was determined by X‐ray crystallography. The preliminary biological tests showed that all products could protect soybean against injury caused by 2,4‐D butylate to some extent. 相似文献
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Dervis Gok 《Journal of heterocyclic chemistry》2019,56(12):3343-3353
A simple and easy synthesis of 2‐(3‐nitro‐phenyl)‐quinazoline‐4‐carboxylic acid ( 3 ) has been successfully developed through a one‐pot three‐component condensation reaction of (2‐amino‐phenyl)‐oxo‐acetic acid sodium salt ( 1 ) obtained from the hydrolysis of isatin with ammonium acetate and 3‐nitrobenzaldehyde. Some novel quinazoline‐ester derivatives 4‐7 were then obtained by the reaction between the new compound 3 and various alcohols. Then, quinazoline‐amide derivatives 10‐14 were synthesized from the reaction of various amines and 2‐(3‐nitro‐phenyl)‐quinazoline‐4‐carbonyl chloride ( 8 ), obtained by the reaction of compound 3 with SOCl2. Finally, some novel quinazoline‐azo derivatives 17‐19 were synthesized by the coupling reaction between β‐dicarbonyl compounds and the novel amino‐quinazoline derivative compound 15 , obtained by reduction of nitro‐quinazoline derivative compound 11 . Thus, a new series of quinazoline‐4‐carboxylic acid, ester, amide, and azo derivatives was synthesized and fully characterized by 1H NMR, 13C NMR, IR, and mass spectrometry analysis. 相似文献
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Manisha R. Bhosle Jyotirling R. Mali Aparna A. Mulay Ramrao A. Mane 《Heteroatom Chemistry》2012,23(2):166-170
An efficient one‐pot three‐component cyclocondensation of 4‐(p‐toulyl sulfonoxy) benzaldehyde, aryl amines, and mercaptoacetic acid in polyethylene glycol 400 (PEG‐400) was conducted to obtain new 2,3‐disubstituted‐4‐thiazolidinones. This route is economical and ecofriendly. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:166–170, 2012; View this article online at wileyonlinelibrary.com . DOI 10.1002/hc.20766 相似文献
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Shujiang Tu Xiaojing Zhang Feng Shi Tuanjie Li Qian Wang Xiaotong Zhu Jinpeng Zhang Jianing Xu 《Journal of heterocyclic chemistry》2005,42(6):1155-1159
A series of new N‐cyclopropyldecahydroacridine‐1,8‐dione derivatives were synthesized by one‐pot reaction of aromatic aldehyde, dimedone (or 1,3‐cyclohexanedione) and cyclopropanamine in solution of glycol and water under microwave irradiation with excellent yields (78‐94%) and short reaction time (5‐10 min). 相似文献
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One‐pot three‐component cyclocondensation of aldehydes, 1,3‐indanedione and enaminones proceeds in the presence of acetic acid to afford Indeno[1,2‐b]quinolin‐9,11(6H,10H)‐dione derivatives, The method has the advantage of excellent yields(85‐94%) and simple workup procedure. 相似文献
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Paresh Nath ChatterjeeSujit Roy 《Tetrahedron》2011,67(25):4569-4577
The heterobimetallic complex [Ir(COD)(SnCl3)Cl(μ-Cl)]2 catalyzes the direct substitution of hydroxyl groups in benzylic and propargylic alcohols by 1,3-dicarbonyl moiety. In 4-hydroxycoumarin, benzylation and propargylation occurs at the 3-position. Selective propargylation or allenylation takes place depending on the nature of propargylic alcohol. By applying the methodology, multi-substituted furans and pyrroles have been synthesized in good yields. 相似文献
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Stoichiometric reaction of 2‐aminopyrimidine with formaldehyde in the presence of formic acid catalyst in water gave N,N′‐bis(2‐pyrimidinyl)methanediamine ( 5 ). Subsequent cyclocondensation of 5 with glyoxal in alcohol (MeOH, EtOH, PrOH and i‐PrOH) under reflux conditions led to the formation of the corresponding 4,5‐dialkoxy‐1,3‐bis(2‐pyrimidinyl)imidazolidines ( 6a‐d ). 4,5‐Dihydroxy‐1,3‐bis(2‐pyrimidinyl) imidazolidine ( 6e ) was obtained when the reaction was carried out in acetonitrile. Based on 1H NMR analysis, it was found that the trans‐dialkoxyimidazolidines ( 6 ) were selectively obtained in these cyclocondensation reactions. 相似文献
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Xi Cun Wang Fang Wang Zheng Jun Quan Zhang Zhang Man Gang Wang 《Journal of heterocyclic chemistry》2006,43(6):1473-1477
The one‐pot two‐step synthesis for acyliminothiazolines by treatment of N,N'‐substituted thioureas with α‐bromocarbonyl compounds under aqueous media was described. Compared to classical reaction in organic solvents, this method consistently has the advantages of short reaction time and being environmentally friendly. 相似文献
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Gowravaram Sabitha M. Bhikshapathi Sambit Nayak R. Srinivas J. S. Yadav 《Journal of heterocyclic chemistry》2011,48(2):267-271
A one‐pot, three‐component synthesis of 2‐amino‐2‐chromenes is described at ambient temperature by the reaction of an aldehyde and malononitrile or ethyl cyanoacetate with α‐naphthol or β‐naphthol in ethanol in presence of a catalytic amount of Triton B. J. Heterocyclic Chem., (2011). 相似文献
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Ali Reza Kazemizadeh Nahid Shajari Reza Shapouri Neda Adibpour Reza Teimuri‐Mofrad Parisa Dinmohammadi 《应用有机金属化学》2016,30(3):148-153
A four‐component reaction between aromatic carboxylic acids, (N‐isocyanimino)triphenylphosphorane, ferrocenecarbaldehyde and dibenzylamine is reported. This approach is an efficient, simple and high‐yield procedure for the synthesis of 1,3,4‐oxadiazole derivatives containing a ferrocene unit. The antimicrobial activities of the products were investigated against Staphylococcus aureus and Pseudomonas aeruginosa in in vitro and in vivo assays. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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This paper compared the performance of β‐zeolite and Amberlyst‐15 catalysts on a liquid phase synthesis of ethyl tert‐butyl ether (ETBE) from ethanol (EtOH) and tert‐butyl alcohol (TBA) β‐Zeolite was synthesized and deposited on monolith support. Its structure was confirmed by an XRD measurement and its composition was analyzed by an XRF measurement. It was found that even though the catalytic activity of β‐zeolite was lower than that of Amberlyst‐15, the selectivity of ETBE was much higher than that of Amberlyst‐15, resulting in almost the same level of ETBE yield. The dehydration of TBA to isobutene (IB) was the major side reaction. The kinetic study of the reaction catalyzed by β‐zeolite supported on monolith was carried out by using a semibatch reactor. The effect of external mass transfer was investigated by varying stirring speeds. The activity‐based rate expressions were developed taking into account of water inhibition. Three temperature levels of 323, 333, and 343 K were performed in the study to obtain the parameters in the Arrhenius's equation and the Van't Hoff's equation. © 2002 Wiley Periodicals, Inc. Int J Chem Kinet 34: 292–299, 2002 相似文献