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1.
Introduction(+)-α-Cyperone(1)and(-)-α-10-epicyperone(2)arewidelyusedaschiraltemplatesforthesynthesisofothersesquiterpenederiv... 相似文献
2.
WeiShuoFANG HongYanLIU QiChengFANG 《中国化学快报》2005,16(1):38-40
Four 10-propionyl docetaxel analogues (lla-d) with 2α-amido substituents were prepared, and their antitumor activity against three solid tumor cell lines and their drug-resistant counterparts were determined. 相似文献
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MengZHANG DaLiYIN JiYuGUO XiaoTianLIANG 《中国化学快报》2004,15(9):1033-1035
An unusual formation of cyclic sulfite at C-4 and C-5 positions of taxane was accomplished by treatment of compound 1 with excess MeSOEC1/Et3N and a possible mechanism was proposed. 相似文献
5.
L. G. Shagun I. A. Dorofeev N. O. Yarosh L. V. Zhilitskaya L. I. Larina M. G. Voronkov 《Russian Journal of Organic Chemistry》2013,49(11):1676-1679
C- and N-Amino-1,2,4-triazoles react with 1-iodopropan-2-one in the absence of bases and phasetransfer catalysts (40°C, 9-12 h) to furnish 3-amino-1,4-bis(2-oxo-propyl)-4H-1,2,4-triazolium triiodide and 4-amino-1-(2-oxopropyl)-4H-1,2,4-triazolium iodide. The alkylation of 1,2,4-triazol-4-amine with 1-iodopropan-2-one and 1,3-diiodopropan-2-one in the presence of elemental iodine led to the formation of 4-amino-1-(2-oxopropyl)-4H-1,2,4-triazolium triiodide and 2-oxopropane-1,3-diylbis(4-amino-4H-1,2,4-triazolium) bis(triiodide). Triiodides are oily fluids possessing electric conductivity of 1.1 × 10?3 Ω m?1 opening the route to new types of electroconducting ionic liquids. 相似文献
6.
Oxidation of various cyclic and acyclic ketones under mild conditions with chlorocatecholborane, a bulky pyridine base, and TEMPO to the corresponding α-aminoxylated products in good to excellent yields (52-99%) is described. For enones as substrates, products of a β-chloro-α-aminoxylation are obtained (70-89%). 相似文献
7.
Dr. Hidde Elferink Wouter A. Remmerswaal Kas J. Houthuijs Oscar Jansen Dr. Thomas Hansen Prof. Dr. Anouk M. Rijs Dr. Giel Berden Dr. Jonathan Martens Prof. Dr. Jos Oomens Prof. Dr. Jeroen D. C. Codée Dr. Thomas J. Boltje 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(63):e202201724
Uronic acids are carbohydrates carrying a terminal carboxylic acid and have a unique reactivity in stereoselective glycosylation reactions. Herein, the competing intramolecular stabilization of uronic acid cations by the C-5 carboxylic acid or the C-4 acetyl group was studied with infrared ion spectroscopy (IRIS). IRIS reveals that a mixture of bridged ions is formed, in which the mixture is driven towards the C-1,C-5 dioxolanium ion when the C-5,C-2-relationship is cis, and towards the formation of the C-1,C-4 dioxepanium ion when this relation is trans. Isomer-population analysis and interconversion barrier computations show that the two bridged structures are not in dynamic equilibrium and that their ratio parallels the density functional theory computed stability of the structures. These studies reveal how the intrinsic interplay of the different functional groups influences the formation of the different regioisomeric products. 相似文献
8.
Yu. B. Salamonov O. A. Luk'yanov A. G. Bass Yu. A. Strelenko 《Russian Chemical Bulletin》1994,43(11):1860-1863
Previously unknownN-dinitroalkyl-NNO-azoxybenzenes have been prepared (by nitration ofN-(-hydroximino) alkyl-NNO-azoxybenzenes) and transformed to some derivatives.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 1972–1975, November, 1994 相似文献
9.
A. A. Danilin P. P. Purygin N. V. Makarova M. N. Zemtsova I. K. Moiseev 《Russian Journal of Organic Chemistry》2001,37(1):56-61
Reactions of 1-adamantyl bromomethyl ketone and 1-(1-adamantyl)-3-bromo-2-propanone with acetylacetone and ethyl acetoacetate in a mixture of dry diethyl ether with anhydrous methanol in the presence of sodium methoxide afforded 3-(1-adamantylcarbonylmethyl)-2,4-pentanedione, ethyl 2-(1-adamantylcarbonylmethyl)-3-oxobutanoate, 4-acetyl-1-(1-adamantyl)-2,5-hexanedione, and ethyl 2-acetyl-5-(1-adamantyl)-4-oxopentanoate. The Knoevenagel-Cope reactions of 1-adamantyl bromomethyl ketone and 1-(1-adamantyl)-3-bromo-2-propanone with diethyl malonate yielded, respectively, diethyl 1-(1-adamantyl)-2-bromoethylidenemalonate and diethyl 1-(1-adamantylmethyl)-2-bromoethylidenemalonate. O-Alkylation of ethyl acetoacetate with 1-adamantyl bromomethyl ketone gave ethyl 3-(1-adamantylcarbonylmethoxy)-2-butenoate. Carboxylic acids reacted with 1-adamantyl bromomethyl ketone to form the corresponding 2-(1-adamantyl)-2-oxoethyl carboxylates. 相似文献
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Russian Chemical Bulletin - 相似文献
11.
Phenolic derivatives of-santonin have been synthesized and their antioxidant effect has been studied.Institute of Phytochemistry, National Academy of Sciences of the Republic of Kazakhstan, Karaganda. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 247–249, March–April, 1997. 相似文献
12.
β-Amino-α-phenyl-α-ferrocenylethanol, FcC(OH)(Ph)CH2NH2 was prepared by the reduction of cyanohydrin trimethylsilyl ether of benzoylferrocene with lithium aluminum hydride. This new compound was characterized by elemental analysis, IR and 1H NMR spectroscopy. The structure was also confirmed by a single crystal X-ray study. The compound crystallizes in monoclinic P21/c space group with unit cell dimensions: a = 12.5906(17), b = 5.9636(8), c = 19.8320(3) Å, β = 102.047(2)∘, V = 1456.3(3) Å3, Z = 4. The structure exhibits intra- and inter-molecular hydrogen bonding of the type N—H⋅ < eqid1 > ⋅O and O—H⋅ < eqid2 > ⋅N, respectively. The pattern of the inter-molecular hydrogen bonding interaction contains a 10-atom ring with two donors and two acceptors, showing a dimeric crystal packing. 相似文献
13.
R. I. Baichurin L. V. Baichurina N. I. Aboskalova V. M. Berestovitskaya 《Russian Journal of General Chemistry》2013,83(9):1764-1770
The method for preparation of ethyl α-nitrocinnamates by nitroacetic acid ester alkenylation with aromatic aldehydes in the presence of acetic acid and β-alanine has been modified. Structures of the prepared compounds have been proved by electronic, IR, 1H, and 13C-{1H} NMR spectroscopy (including heteronuclear correlation experiments 1H-13C HMQC and 1H-13C HMBC). In solution these compounds exist in the form of Z-isomer; the Z?E isomerization is observed in the case of the compound containing strong electron-donor group [N(CH3)2] at benzene ring. 相似文献
14.
G. A. Gazieva M. I. Struchkova N. G. Kolotyrkina 《Chemistry of Heterocyclic Compounds》2011,47(2):210-214
Previously unknown 1,3-dialkyl-4,5-bis[4-alkyl(phenyl)thiosemicarbazido]imidazolidine-2-thiones and 4,5,7-trialkylperhydroimidazo[4,5-e]-1,2,4-triazine-3,6-dithiones have been synthesized by the α-thio-ureidoalkylation of 4-alkyl(phenyl)thiosemicarbazides using
1,3-dialkyl-4,5-dihydroxyimidazolidine-2-thiones. 相似文献
15.
Moiseev I. K. Makarova N. V. Zemtsova M. N. 《Russian Journal of Organic Chemistry》2003,39(12):1685-1701
The review summarizes and analyzes both theoretical aspects and practical applications of C-, N-, O-, and S-alkylation with -halo ketones of aliphatic, alicyclic, aromatic, and heterocyclic compounds. Some reactions of -halo ketones with difunctional nucleophiles are also discussed. 相似文献
16.
《中国化学快报》1997,(12)
SinenxanA(1)isabioSynheticallyavailallletaxoidI'1ComParedwiththehaousanticanceragentPaClitaxel(taxol',2)[2],themOStconSPicuouschrencebebenthesetW0co~dsinthelocallonOfOxygnnfunchonsisl4P-0AcinthefOrmerandl3a-0C0Rinthelatter.Wththeaimof~ningnewanhcanceragents,wewereinterestedinInakingchendcalmedCationsonsinenxanAincluding,amongothers,theconSructon0ftheoxetanering'],andtheattaChmentOfanisoserine-twsidechainatl4-positionasadricryOf2.InthecourseOfitSforcturaJm~CatioftweboserVedthaitSC-… 相似文献
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The kinetics and mechanisms of condensation of pyridoxal with L-α-glutamic acid and L-glutamine were studied by UV spectroscopy and polarimetry. L-α-Glutamic acid reacts with pyridoxal to form a Schiff base whose subsequent hydrolysis gives rise to pyridoxamine and α-ketoglutaric acid. The reaction of Lglutamine with pyridoxal involves the Γ-NH2 group and affords a Schiff base whose subsequent hydrolysis gives rise to pyridoxamine and L-α-glutamic acid. 相似文献
19.
Yu-Fen Zhao Pei-Sheng Cao 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1):757-760
N-phospho-α -amino acids obtainable from aqueous condition were different from their corresponding β -analogues intrinsically. As the self-reproduction unites, N-phospho-α -amino acids were capable to produce non-random oligopeptides. As the phosphoryl donor, they were able to phosphorylate the nucleosides much faster than the deoxynucleosides. 相似文献
20.
Jean-Luc Pirat Jean Marc Lambert Henri-Jean Cristau 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1)
Abstract A procedure for the preparation of N-protected 1 or unprotected Ca,a-disubstituted (diarylaminomethyl)-phosphonic acids and their esters is reported.1 This method is a generalisation of the Kabachnik-Fields method described in the literature.2 相似文献