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铜催化下,以CH3CN和HOAc为混合溶剂,α,β-不饱和羧酸与1,1,1-三氟-2-碘乙烷(ICH2CF3)发生脱羧偶联反应合成了一系列三氟乙基取代烯烃,其结构经1H NMR、13C NMR和HR-MS确证。19F NMR分析显示该反应具有优良的立体选择性(E/Z最高为99/1),分离收率最高达82%。 相似文献
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为了证实过渡金属催化碳碳键交叉偶联反应的双金属效应,首次研究蒙脱土负载纳米钯铜双金属微粒催化Sonogahira交叉偶联反应.结合蒙脱土重金属吸附特性与DMF溶剂热羰化还原,发展了一种新的双金属纳米微粒合成方法,制备了钯铜比例为1∶1的双金属纳米微粒.催化条件优化实验发现,乙二醇二甲醚/水(V∶V=1∶4)混合体系为最佳溶剂.碳酸钾与三苯基膦存在下,MMT@Pd/Cu高效催化芳基碘与系列端炔的交叉偶联反应,以较好产率分离得到15个炔烃衍生物.动力学研究表明,水对蒙脱土片层的溶胀作用与Pd/Cu双金属协同效应是该催化剂高活性的关键. 相似文献
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钯配合物促进的Suzuki-Miyaura交叉偶联反应为构建碳-碳骨架的重要方法,主要用于药物化学、天然产物、材料学及超分子配体等领域。以2-噻吩甲醛、脂肪族/芳香族伯胺、取代肼及羟胺等为原料,合成了9种2-噻吩甲醛亚胺类N,S-双齿配体(3a~3i),其结构经1H NMR, 13C NMR和HR-MS(APCI)表征。并以N-环己基-2-噻吩甲亚胺(3b)为例,研究了配体对钯促进的Suzuki-Miyaura交叉偶联反应的催化性能。结果表明:在反应体系Pd(OAc)2/3b/Cs2CO3/DMF中,苯硼酸与芳溴的交叉偶联反应的分离产率达到95%。 相似文献
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过渡金属催化的偶联反应是构筑C-C键的高效方法,在有机合成中得到了广泛的应用.然而,相对于Heck反应、Negishi偶联与Suzuki偶联等构筑C(sp2)-C(sp2)键的反应,过渡金属催化的构筑C(sp3)-C(sp3)键的偶联反应较难进行,发展较晚.近年来,烷基-烷基C-C键偶联反应受到广泛的重视,一些高效催化剂被开发出来,其中镍催化剂展示出独特的催化活性和选择性.本文将综述镍催化烷基-烷基C-C键偶联反应最新研究进展,主要包括烷基亲电试剂与金属有机试剂交叉偶联反应、导向基参与的C(sp3)-H键活化的偶联反应、镍-光反应催化剂协同催化偶联反应、烷基亲电试剂与亲电试剂的还原偶联反应和镍催化烯烃加成反应等. 相似文献
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A novel 4-anilinoquinazoline dimer linked by a carbon-carbon bond in the C-7 position was synthesized via a one step Suzuki cross-coupling reaction. All structures of new compounds were characterized by 1H NMR, 13C NMR, and HRMS. The inhibition rate of the synthetic 4-anilinoquinazoline dimer 8 against epidermal growth factor receptor-tyrosine kinase enzymes (EGFR) in vitro was 44.4% at the concentration of 5.5 μmol/L. 相似文献
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A novel large thiophene-fused polycyclic aromatics 1 based on pyrene 5 has been synthesized,and its structure was confirmed by 1H NMR,13C NMR,MS,UV -vis and elemental analysis.The key steps of the synthesis involved the Stille cross-coupling reaction and followed by selectiveβ-βoxidative cyclization of pendant thienyl rings by FeCl3 under mild conditions. 相似文献
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2,6-Bis(arylmethylidene)cyclohexanones undergo a regioselective 1,3-dipolar cycloaddition reaction with the azomethine ylide derived from isatin and sarcosine by a decarboxylative route affording a series of 1-N-methyl-spiro[2.31]oxindole-spiro[3.211]611-arylmethylidenecyclohexanone-4-aryl-pyrrolidines which were further annulated to give a series of novel 1-N-methyl-spiro[2.31]oxindole-spiro[3.711](311-aryl)Δ111,711a-hexahydro-2H-indazole-4-aryl-pyrrolidines. The structures of which were established by spectroscopic techniques as well as single crystal X-ray analysis. 相似文献
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A new C27-steroidal glycoside from Ophiopogon japonicus 总被引:1,自引:0,他引:1
Jian Zhong Wang Li Ming Ye Xiao Bing Chen 《中国化学快报》2008,19(1):82-84
A new C27-steroidal glycoside with three known compounds were isolated from the tuber of Ophiopogonjaponicus (Thunb.) Ker-Gawl. Based on the spectral analysis, including HRMS, 1H NMR, 13C NMR, DEPT, 1H-1H COSY, HMQC and HMBC, their chemical structures were determined as pennogenin-3-O-α-L-rhamnopyranosyl-(1→ 2)-β-D-xylopyranosyl-(1→ 4)-13-D-gluco- pyranoside (1), pennogenin-3-O-α-L-rhamnopyranosyl-(1→ 2)-β-D-glucopyranoside (2), ophiopojaponin C (3) and ophiopogonin D (4). 2007 Jian Zhong Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 相似文献
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Four new chiral 1,2,3,4-tetrahydroisoquinoline-derived β-amino alcohols were synthesized from L-DOPA in good yields. The structures of the target compounds were confirmed by ^1H NMR, ^13C NMR and MS. 相似文献
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Anindita Bhowmick Prof. Dr. Goutam Brahmachari 《European journal of organic chemistry》2023,26(15):e202300192
An efficient and straightforward protocol for accessing a new series of functionalized 4-aminocoumarins from PIDA/I2-mediated decarboxylative C4-amination of coumarin-3-carboxylic acids via direct Csp2−H dehydrogenative C−N cross-coupling with secondary amines under ambient conditions has been accomplished. The notable advantages of this protocol are the tolerance of diverse functional groups, mild reaction conditions at ambient temperature, moderate to good yields, short reaction times (in minutes), high regioselectivity, gram-scale applicability, and eco-friendliness. This is the first report of decarboxylative Csp2−H cross-dehydrogenative C−N coupling of coumarin-3-carboxylic acids for synthesizing 4-aminocoumarins. 相似文献
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W. Schilf B. Kamie
ski A. Szady-Che
mieniecka E. Grech 《Journal of Molecular Structure》2004,700(1-3):105-108
In present work set of eight Schiff bases derived from substituted salicylaldehydes and aliphatic and aromatic amines has been studied in the solid state by 15N and 13C CPMAS NMR methods. 15N CPMAS NMR measurement is especially useful for investigation of the tautomerism in the compounds considered, owing to the large difference in the nitrogen chemical shifts of OH and NH tautomers. In the solid state, four of the compounds examined were shown by 15N CPMAS NMR to exist as OH tautomeric forms, and the remaining four as the corresponding NH forms with different stage of proton transfer process, from oxygen to nitrogen site.
This was confirmed by 13C CPMAS. The results reported were compared with those obtained for only two compounds in CDCl3 solutions (solubility problems). 相似文献
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Tetrabromoalkylthiacalix[4]arenes(1a and 1b) reacted with excess bis(tetraethylammonium)-bis(1,3- dithiole-2-thione-4,5-dithiol)zincate(2) to give thiacalix[4]arene-thiones(3a and 3b) in the presence of Na2S. Two novel bistetrathiafulvalene-attached thiacalix[4]arene assemblies(5a and 5b) formed via triethyl phosphite-mediated cross-coupling of thiacalix[4]arene-thiones(3a and 3b) and 4,5-biscyanoethylthio-1,3-dithiole-2-one(4). All the four new compounds were characterized by 1H NMR, 13C NMR, IR, MS spectra and elemental analysis. Meanwhile, the structures of thiacalix[4]arene-thiones(3a and 3b) were identified by X-ray analysis. In addition, the cyclic voltammograms of the resulting thiacalix[4]arenes containing electroactive TTF units(5a and 5b) were provided. 相似文献
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合成了21个混合三烃基锡羧酸酯。利用红外光谱、核磁共振谱(1H,13C,119Sn)和质谱表征了化合物的结构。对取代苯甲酸酯化合物,锡原子的化学位移δ(119Sn)与苯环上取代基的Hammett常数有很好的线性关系。化合物的生物活性测定结果表明,它们具有高效杀螨活性。 相似文献